Cloud-Top Properties of Growing Cumulus prior to Convective Initiation as Measured by Meteosat Second Generation. Part I: Infrared Fields

2010 ◽  
Vol 49 (3) ◽  
pp. 521-534 ◽  
Author(s):  
John R. Mecikalski ◽  
Wayne M. MacKenzie ◽  
Marianne Koenig ◽  
Sam Muller
Keyword(s):  
Second Generation ◽  
Principal Component ◽  
Convective Cloud ◽  
Convective Cell ◽  
Limited Information ◽  
Cumulus Clouds ◽  
Convective Initiation ◽  
Ongoing Research ◽  
First Occurrence ◽  
Physical Attributes

Abstract Infrared (IR) data from the Meteosat Second Generation (MSG) satellite are used to understand cloud-top signatures for growing cumulus clouds prior to known convective initiation (CI) events, or the first occurrence of a ≥35-dBZ echo from a new convective cloud. In the process, this study proposes how MSG IR fields may be used to infer three physical attributes of growing cumuli, cloud depth, cloud-top glaciation, and updraft strength, with limited information redundancy. These three aspects are observed as unique signatures within MSG IR data, for which this study seeks to relate to previous research, as well as develop a new understanding on which subset of IR information best identifies these attributes. Data from 123 subjectively identified CI events observed during the 2007 Convection and Orograpically Induced Precipitation Study (COPS) field experiment conducted over southern Germany and northeastern France are processed, per convective cell, to meet this study’s objectives. A total of 67 IR “interest fields” are initially assessed for growing cumulus clouds, with correlation and principal component analyses used to highlight the top 21 fields that are considered the best candidates for describing the three attributes. Using between 6 and 8 fields per category, a method is then proposed on how growing convective clouds may be quantified per 3-km2 pixel (or per cumulus cloud object) toward inferring each attribute. No independent CI-nowcasting analysis is performed, which instead is the subject of ongoing research.

scholarly journals Analysis of Outflow Boundary Collisions in North-Central Alabama

2009 ◽  
Vol 24 (6) ◽  
pp. 1680-1690 ◽  
Author(s):  
Stephen J. Harrison ◽  
John R. Mecikalski ◽  
Kevin R. Knupp
Keyword(s):  
Elevation Angle ◽  
Convective Cloud ◽  
Time Of Day ◽  
Radar Reflectivity ◽  
Cumulus Clouds ◽  
Convective Initiation ◽  
North Central ◽  
Radar Echo ◽  
First Occurrence ◽  
Outflow Boundary

Abstract Ninety-four outflow boundary (OB) collisions were documented in north-central Alabama over the summers of 2005–07 using the Advanced Radar for Meteorological and Operational Research (ARMOR) dual-polarimetric radar located at the Huntsville, Alabama, airport. These data were used to extend and verify previous research and to look for new correlations among the various factors that lead to convective initiation (CI) from OB collisions more frequently. For this study, CI is defined as the first occurrence of a ≥35-dBZ radar echo at an elevation angle of 0.8° and within 10 km of the point of collision, from a convective cloud. The radar reflectivity and angle of collision between both OBs along with time of day at which CI occurs most often were analyzed. Also, the presence of cumulus clouds along either/both OBs, or within the area of collision, was examined using Geostationary Operational Environmental Satellite-12 (GOES-12) visible imagery. A more detailed analysis of 23 of the 94 OBs that passed over the Mobile Integrated Profiling System instruments examines the relation among radar reflectivity, updraft magnitude, and water vapor enhancements. This analysis indicates that OB updraft magnitude is positively correlated with OB reflectivity factor. The main findings are that when OBs collide in a more head-on manner, when both colliding OBs have radar reflectivity values of 15 dBZ or greater, or when cumulus clouds preexist along at least one OB, CI is produced at a greater rate. These results, using a much larger dataset than had previously been used for colliding OBs, are subsequently compared with two existing studies.

Cloud-Top Properties of Growing Cumulus prior to Convective Initiation as Measured by Meteosat Second Generation. Part II: Use of Visible Reflectance

2010 ◽  
Vol 49 (12) ◽  
pp. 2544-2558 ◽  
Author(s):  
John R. Mecikalski ◽  
Wayne M. MacKenzie ◽  
Marianne König ◽  
Sam Muller
Keyword(s):  
Second Generation ◽  
Near Infrared ◽  
Research Effort ◽  
Principal Component ◽  
Cumulus Clouds ◽  
Convective Initiation ◽  
Convective Clouds ◽  
Unique Information ◽  
Distance Fields ◽  
Sampling Distance

Abstract This study is a companion research effort to “Part I,” which emphasized use of infrared data for understanding various aspects of growing convective clouds in the Meteosat Second Generation (MSG) satellite’s Spinning Enhanced Visible and Infrared Imager (SEVIRI) imagery. Reflectance and derived brightness variability (BV) fields from MSG SEVIRI are used here to understand relationships between cloud-top signatures and physical processes for growing cumulus clouds prior to known convective initiation (CI) events, or the first occurrence of a ≥35-dBZ echo from a new convective cloud. This study uses daytime SEVIRI visible (VIS) and near-infrared (NIR) reflectances from 0.6 to 3.9 μm (3-km sampling distance), as well as high-resolution visible (1-km sampling distance) fields. Data from 123 CI events observed during the 2007 Convection and Orographically Induced Precipitation Study (COPS) field experiment conducted over southern Germany and northeastern France are processed, per convective cell, so to meet this study’s objectives. These data are those used in Part I. A total of 27 VIS–NIR and BV “interest fields” are initially assessed for growing cumulus clouds, with correlation and principal component analyses used to highlight the fields that contain the most unique information for describing principally cloud-top glaciation, as well as the presence of vigorous updrafts. Time changes in 1.6- and 3.9-μm reflectances, as well as BV in advance of CI, are shown to contain the most unique information related to the formation and increase in size of ice hydrometeors. Several methods are proposed on how results from this analysis may be used to monitor growing convective clouds per MSG pixel or per cumulus cloud “object” over 1-h time frames.

Forecasting Convective Initiation by Monitoring the Evolution of Moving Cumulus in Daytime GOES Imagery

2006 ◽  
Vol 134 (1) ◽  
pp. 49-78 ◽  
Author(s):  
John R. Mecikalski ◽  
Kristopher M. Bedka
Keyword(s):  
Significant Advance ◽  
Cumulus Convection ◽  
Cumulus Cloud ◽  
Cumulus Clouds ◽  
Convective Initiation ◽  
Convective Clouds ◽  
Predictive Skill ◽  
Cloud Properties ◽  
Radar Echo ◽  
First Occurrence

Abstract This study identifies the precursor signals of convective initiation within sequences of 1-km-resolution visible (VIS) and 4–8-km infrared (IR) imagery from the Geostationary Operational Environmental Satellite (GOES) instrument. Convective initiation (CI) is defined for this study as the first detection of Weather Surveillance Radar-1988 Doppler (WSR-88D) reflectivities ≥35 dBZ produced by convective clouds. Results indicate that CI may be forecasted ∼30–45 min in advance through the monitoring of key IR fields for convective clouds. This is made possible by the coincident use of three components of GOES data: 1) a cumulus cloud “mask” at 1-km resolution using VIS and IR data, 2) satellite-derived atmospheric motion vectors (AMVs) for tracking individual cumulus clouds, and 3) IR brightness temperature (TB) and multispectral band-differencing time trends. In effect, these techniques isolate only the cumulus convection in satellite imagery, track moving cumulus convection, and evaluate various IR cloud properties in time. Convective initiation is predicted by accumulating information within a satellite pixel that is attributed to the first occurrence of a ≥35 dBZ radar echo. Through the incorporation of satellite tracking of moving cumulus clouds, this work represents a significant advance in the use of routinely available GOES data for monitoring aspects of cumulus clouds important for nowcasting CI (0–1-h forecasts). Once cumulus cloud tracking is established, eight predictor fields based on Lagrangian trends in IR data are used to characterize cloud conditions consistent with CI. Cumulus cloud pixels for which ≥7 of the 8 CI indicators are satisfied are labeled as having high CI potential, assuming an extrapolation of past trends into the future. Comparison to future WSR-88D imagery then measures the method's predictive skill. Convective initiation predictability is demonstrated using several convective events—one during IHOP_2002—that occur over a variety of synoptic and mesoscale forcing regimes.

A Statistical Evaluation of GOES Cloud-Top Properties for Nowcasting Convective Initiation

2008 ◽  
Vol 136 (12) ◽  
pp. 4899-4914 ◽  
Author(s):  
John R. Mecikalski ◽  
Kristopher M. Bedka ◽  
Simon J. Paech ◽  
Leslie A. Litten
Keyword(s):  
Statistical Evaluation ◽  
Probability Of Detection ◽  
Future Research ◽  
Relative Importance ◽  
Cumulus Clouds ◽  
Convective Initiation ◽  
Skill Scores ◽  
Study Results ◽  
Radar Echo ◽  
First Occurrence

Abstract The goal of this project is to validate and extend a study by Mecikalski and Bedka that capitalized on information the Geostationary Operational Environmental Satellite (GOES) instruments provide for nowcasting (i.e., 0–1-h forecasting) convective initiation through the real-time monitoring of cloud-top properties for moving cumuli. Convective initiation (CI) is defined as the first occurrence of a ≥35-dBZ radar echo from a cumuliform cloud. Mecikalski and Bedka’s study concluded that eight infrared GOES-based “interest fields” of growing cumulus clouds should be monitored over 15–30-min intervals toward predicting CI: the transition of cloud-top brightness temperature to below 0°C, cloud-top cooling rates, and instantaneous and time trends of channel differences 6.5–10.7 and 13.3–10.7 μm. The study results are as follows: 1) measures of accuracy and uncertainty of Mecikalski and Bedka’s algorithm via commonly used skill scoring procedures, and 2) a report on the relative importance of each interest field to nowcasting CI using GOES. It is found that for nonpropagating convective events, the skill scores are dependent on which CI interest fields are considered per pixel and are optimized when three–four fields are met for a given 1-km GOES pixel in terms of probability of detection, and threat and Heidke skill scores. The lowest false-alarm rates are found when one field is used: that associated with cloud-top glaciation 30 min prior to CI. Subsequent recommendations for future research toward improving Mecikalski and Bedka’s study are suggested especially with regard to constraining CI nowcasts when inhibiting factors are present (e.g., capping inversions).

A Critical Review of Second-generation anti-EGFR Monoclonal Antibodies in Metastatic Colorectal Cancer

2020 ◽  
Vol 21 ◽  
Author(s):  
Daniel Sur ◽  
Andrei Havasi ◽  
Alecsandra Gorzo ◽  
Claudia Burz
Keyword(s):  
Colorectal Cancer ◽  
Drug Resistance ◽  
Clinical Trials ◽  
Monoclonal Antibodies ◽  
Metastatic Colorectal Cancer ◽  
Second Generation ◽  
Current Data ◽  
Braf Mutations ◽  
Durable Response ◽  
Ongoing Research

Background: Anti-EGFR monoclonal antibodies (mAbs) have become a relevant solution for the treatment of patients with metastatic colorectal cancer. Current anti-EGFR monoclonal antibodies face a series of problems, including resistance and non-durable response, and RAS and BRAF mutations serve as exclusion criteria for treatment with anti-EGFR mAbs. Advances in molecular tumor profiling and information on subsequent pathways responsible for disease progression and drug resistance helped develop a new generation of anti-EGFR mAbs. These second-generation mAbs have been developed to overcome existing resistance mechanisms and to limit common side effects. For the moment, existing literature suggests that these novel anti-EGFR mAbs are far from finding their way to clinical practice soon. Objective: In this review, we summarize and evaluate current data regarding ongoing research and completed clinical trials for different second-generation anti-EGFR monoclonal antibodies. Conclusion: Anti-EGFR mAbs exhibit efficacy in advanced colorectal cancer, but second-generation mAbs failed to prove their benefit in the treatment of metastatic colorectal cancer. Understanding the biological basis of primary and acquired drug resistance could allow scientists to design better clinical trials and develop improved second-generation mAbs.

scholarly journals Physical and Chemical Properties of Soil in the Sahelian Region: Case Study in Nioro du Rip, Senegal

2020 ◽  
pp. 73-82
Author(s):  
Landing Biaye ◽  
Fary Diome ◽  
Seybatou Diop ◽  
Modou Mbaye ◽  
Djibril Tine ◽  
...  
Keyword(s):  
Agricultural Land ◽  
Organic Matter Content ◽  
Chemical Properties ◽  
Principal Component ◽  
Fertility Level ◽  
Physical And Chemical Properties ◽  
Limited Information ◽  
Geochemical Composition ◽  
Physical And Chemical ◽  
And Chemical Properties

The locality of Nioro du Rip is facing intense erosion, loss of agricultural land, soil pollution and soil degradation. Today, there is limited information about the soil physical and chemical properties in the locality. In this work, we describe the main essential factors or mechanism that control the evolution of the soil in the study area. The physical and chemical properties of soils encountered along a NE-SW transect in are analyzed in this paper. The statistical analysis results revealed low structural stability of soils in general, due to their low organic matter content and exchangeable bases and their predominantly silty texture. A net trend towards acidification, which is more pronounced in the lower-bottom and terrace soils, provides information on the conditions that are increasingly unfavorable to agricultural development. The multivariate principal component analysis (PCA) identified the preponderance of two factors among the four primarily involved in soil geochemical composition. These include a mineralization process (expressed through the first principal component (PC1), which causes soils to be rich in elements (Ca2+, K+,C, N, MO) controlling their structure and fertility level;  The PC2 axis expresses the spatial differentiation phenomenon of the soil granulometric composition: soils forming cluster poles according to their textural affinity in the projection of the plane formed by these two components , with on one side the sandy-dominated soils of the shallows and terraces and on the other the clay-dominated soils of the plateau and the slope. A clear reversal of textural polarity in the studied topo sequence that must be blamed on the strong water erosion in this area.

scholarly journals Distinct gene expression patterns in vector-residing Leishmania infantum identify parasite stage-enriched markers

2019 ◽  
Author(s):  
Iliano V. Coutinho-Abreu ◽  
Tiago D. Serafim ◽  
Claudio Meneses ◽  
Shaden Kamhawi ◽  
Fabiano Oliveira ◽  
...  
Keyword(s):  
Leishmania Infantum ◽  
Developmental Stages ◽  
Expression Patterns ◽  
Principal Component ◽  
Sand Fly ◽  
Parasite Development ◽  
Lutzomyia Longipalpis ◽  
Specific Marker ◽  
Limited Information ◽  
Natural Sand

AbstractPromastigotes of Leishmania infantum undergo a series of extracellular developmental stages inside the natural sand fly vector Lutzomyia longipalpis to reach the infectious stage, the metacyclic promastigote. There is limited information regarding the expression profile of L. infantum developmental stages inside the sand fly vector, and molecular markers that can distinguish the different parasite stages are lacking. We performed RNAseq on unaltered midguts of the sand fly Lutzomyia longipalpis after infection with L. infantum parasites. RNAseq was carried out at various time points throughout parasite development. Principal component analysis mapped the sequences corresponding to the procyclic, nectomonad, leptomonad or metacyclic promastigote stage into distinct positions, with the procyclic stage being the most divergent population. Transcriptional levels across genes varied on average between 10- to 100-fold. Comparison between procyclic and nectomonad promastigotes resulted in 836 differentially expressed (DE) genes; between nectomonad and leptomonad promastigotes in 113 DE genes; and between leptomonad and metacyclic promastigotes in 302 DE genes. Most of the DE genes do not overlap across stages, highlighting the uniqueness of each stage. Furthermore, the different stages of Leishmania parasites exhibited specific transcriptional enrichment across chromosomes. Using the transcriptional signatures exhibited by distinct Leishmania stages during their development in the sand fly midgut, we determined the genes predominantly enriched in each stage, identifying multiple stage-specific markers for L. Infantum. Leading stage-specific marker candidates include genes encoding a zinc transporter in procyclics, a beta-fructofuranidase in nectomonads, a surface antigen-like protein in leptomonads, and an amastin-like surface protein in metacyclics. Overall, these findings demonstrate the transcriptional plasticity of the Leishmania parasite inside the sand fly vector and provide a repertoire of stage-specific markers for further development as molecular tools for epidemiological studies.

Multi-proxy study of the Cretaceous-Paleogene (K-Pg) boundary in deep-sea turbiditic sediments in the Uzgruň section (Outer Flysch Carpathians, Czech Republic)

2021 ◽  
Author(s):  
Šimon Kdýr ◽  
Tiiu Elbra ◽  
Miroslav Bubík ◽  
Petr Schnabl ◽  
Lilian Švábenická
Keyword(s):  
Magnetic Susceptibility ◽  
Czech Republic ◽  
Detection Limit ◽  
Remanent Magnetization ◽  
Magnetic Particles ◽  
Principal Component ◽  
Natural Remanent Magnetization ◽  
Ongoing Research ◽  
Small Stream ◽  
Magnetic Methods

<p>The composite profile, with 4 studied sections, is located near the Uzgruň village (Czech Republic) next to a small stream. The profile is composed of Late Maastrichtian to Palaeocene flysch sediments and the K-Pg boundary is set in claystones within this turbiditic setting. Ongoing research of local paleoenvironment and stratigraphy is based on paleo- and rock-magnetic methods, micropaleontology and geochemistry to obtain more detailed view of the local situation during the K-Pg extinction event. Based on biostratigraphy, two dinocyst zones (Bubík et al., 2002): Palynodium grallator and Carpatella cornuta (first occurrence in the Danian), two calcareous nannofossil zones in the Upper Maastrichtian, and the agglutinated foraminifer zone Rzehakina fissistomata in the Paleogene were distinguished. Biostratigraphic data support the K-Pg boundary interval. The uppermost Maastrichtian is indicated by nannofossil species Micula prinsii, UC26d<sup>TP</sup> zone. Basal Paleogene non-calcareous strata contain dinocyst Carpatella cornuta and agglutinated foraminifers of Rzehakina fissistomata zone. The presence of low-latitude nannofossil taxa M. prinsii and Ceratolithoides kamptneri show input of warm waters during the uppermost Maastrichtian. Several rock-magnetic methods, such as acquisition of Isothermal remanent magnetization (IRM), acquisition of Anhysteretic remanent magnetization (ARM), Anisotropy of magnetic susceptibility (AMS), Field dependence of magnetic susceptibility (HD) and Frequency dependence of magnetic susceptibility (FD), were applied to estimate behaviour and origin of magnetic particles. Natural remanent magnetization (NRM) values of samples range from 0.09 to 2.48 mA/m. Volume normalized magnetic susceptibility (MS) show values from 130 up to 1197 SI*10-6. There is no increase observed in MS across stratigraphic boundary due to turbiditic evolution of sediment. Due to character of sediments, we applied alternating field (AF) demagnetization and used principal component analysis (PCA; Kirschvink, 1980) for estimation of characteristic remanent component. Most of the K/Pg sections worldwide have well documented Iridium anomaly. In Uzgruň, the preliminary results show that although the values are not as pronounced, the Ir at K-Pg boundary is still higher than in surrounding sediments. For tracing of Deccan traps effect we plan to apply mercury (Hg)/total organic carbon (TOC) stratigraphy. TOC content of 20 pilot samples is low, but not under detection limit of the instrumentation (mean value 0.92 wt%). One sample reached value 4.41 wt% of TOC. Sulphur contents are reaching 1 wt%, but several samples were under detection limit of the instrumentation. Sulphur concentrations suggest more reduction conditions of burial.</p><p>Current research is supported by Czech Science Foundation project no. 19-07516S and is in accordance with research plan no. RVO67985831.</p><p>Bubík, M., Adamová, M., Bąk, M., Franců, J., Gedl, P., Mikuláš, R., Švábenická, L., & Uchman, A. (2002). Výsledky výzkumu hranice křída/terciér v magurském flyši u Uzgruně. Geologické výzkumy na Moravě a ve Slezsku, 9, 18–22</p><p>L. Kirschvink (1980), The least-squares line and plane and the analysis of palaeomagnetic data, Geophysical Journal International, 62(3), 699–718, https://doi.org/10.1111/j.1365-246X.1980.tb02601.x</p>

Application of Meteosat second generation data towards improving the nowcasting of convective initiation

2010 ◽  
Vol 17 (4) ◽  
pp. 442-451 ◽  
Author(s):  
Christopher W. Siewert ◽  
Marianne Koenig ◽  
John R. Mecikalski
Keyword(s):  
Second Generation ◽  
Convective Initiation
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