Treatment Practices and Outcomes of Elderly Women with Breast Cancer in a Community Hospital

2014 ◽  
Vol 80 (7) ◽  
pp. 714-719
Author(s):  
Rosewellv Mackey ◽  
Gopal Chandru Kowdley
Keyword(s):  
Breast Cancer ◽  
Survival Data ◽  
Community Hospital ◽  
Elderly Women ◽  
Specific Treatment ◽  
The Elderly ◽  
Study Groups ◽  
Younger Women ◽  
Treatment Practices ◽  
The Impact

There is a paucity of clinical data available on specific treatment in the oncogeriatric population with breast cancer. The purpose of this study was to evaluate treatment patterns and survival outcomes in the elderly to address any disparities at our community hospital. We retrospectively identified a total of 1749 patients diagnosed and treated for breast cancer at our institution between 2001 and 2011. Patient demographics, surgical treatment, stage of disease, tumor characteristics, adjuvant therapy, and 5-year survival data were obtained from tumor registry records. Comparisons between study groups were made using the Pearson χ2 test and Student's t test. We found more favorable prognostic makers among women older than 70 years of age. Of the women with lymph node-positive disease, 84 per cent of those younger than 70 years and 33 per cent in the older than 70 years of age study group received chemotherapy. Adjuvant chemotherapy and radiation therapy were more frequently performed in the younger group. Overall 5-year survival was 90 per cent and 71 per cent for younger than 70 years and older than 70 years groups, respectively. Women older than 70 years of age have more favorable breast cancer characteristics compared with younger women and received less aggressive treatment and experienced a higher mortality rate. Prospective trials are needed to assess the impact of aggressive multimodality therapy in this oncogeriatric population.

scholarly journals Evaluation of Postural Stability in Young and Elderly Women

2018 ◽  
Vol 10 (1) ◽  
pp. 134-140
Author(s):  
Tomasz Marciniak ◽  
Ida Wiszomirska ◽  
Lidia Ilnicka
Keyword(s):  
Effect Size ◽  
Postural Stability ◽  
Elderly Women ◽  
The Elderly ◽  
Relative Difference ◽  
Younger Women ◽  
Balance System ◽  
Eyes Open ◽  
Comparison Of The Results ◽  
The Impact

AbstractStudy aim: Assessment of postural stability performed on an unstable stabilometry platform. Comparison of the results ob­tained by two groups consisting of elderly (OW) (60+ years old) and younger women (YW).Material and methods: Seventy-three female volunteers were divided into two groups: 40 young women (20.2 ± 1.75), and 32 elderly women (68.3 ± 7.43). Participants performed five stability tests on Biodex Balance System SD: three 20-second tries, the Postural Stability Test (PST) and the Fall Risk Test (FRT). Three stability indexes - overall (OSI), anterior-posterior (APSI), and medial-lateral (MLSI) - both with eyes open (EO) and closed (EC) were analyzed. The impact of vision on balance was calculated as EC-EO. Also effect size was calculated and evaluated.Results: All of the parameters differed significantly between groups in favour of YW. The largest difference in significance as well as effect size was noted for FRT, p < 0.001 and 1.86 respectively. Tries measure the impact of vision on balance (EC-EO). The results concerning tries with EC-EO showed the strongest discrimination between groups - OSI p = 0.0088 (relative differ­ence 0.23 ± 0.26) and APSI p = 0.0268 (relative difference 0.17 ± 0.2). YW had a significantly better outcome.Conclusions: YW had better results in all of the parameters taken into consideration, with most of them being significant. This confirms that all of the regressive changes appearing with age influence balance. Lack of visual input (EC) in OW caused sig­nificantly worse results in most of the measured parameters, showing that vision is a very important factor for balance mainte­nance in the elderly.

scholarly journals Health-Related Quality of Life of Elderly Women with Fall Experiences

2021 ◽  
Vol 18 (15) ◽  
pp. 7804
Author(s):  
Jiyoung Song ◽  
Eunwon Lee
Keyword(s):  
Quality Of Life ◽  
Elderly Women ◽  
The Elderly ◽  
Basic Data ◽  
Health Related Quality ◽  
High Quality ◽  
Related Quality ◽  
Health Related ◽  
The Impact

This study aimed to describe the health-related quality of life of elderly women with experience in fall treatment as well as to prepare basic data for the development of interventions to improve the quality of life for this group. The study was based on raw data from the 2019 Korea Community Health Survey. Using the SPSS program, the characteristics of the subjects were tested by frequency, percentage, and chi-square test. To establish the impact of fall experience on the health-related quality of life of elderly women, the OR and 95% CI were calculated using multiple logistic regression analysis. Of the 4260 people surveyed, 44.7% of the elderly women said they had a high quality of life, whereas 55.3% of the elderly women said they had a low quality of life. A younger age was associated with a better-rated health-related quality of life. Those who lived in a city and had a high level of education tended to describe a high quality of life. The quality of life was considered high by those who exercised, but low by those who were obese or diabetic. The results of this study can lead to a better understanding of the experiences of elderly women who have experienced falls, and they can be used as basic data for the development of related health programs.

Breast Cancer in the Elderly

2007 ◽  
Vol 25 (14) ◽  
pp. 1882-1890 ◽  
Author(s):  
Diana Crivellari ◽  
Matti Aapro ◽  
Robert Leonard ◽  
Gunter von Minckwitz ◽  
Etienne Brain ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Trials ◽  
Life Expectancy ◽  
Cancer Patients ◽  
Disease Free Survival ◽  
Cost Benefit ◽  
The Elderly ◽  
Breast Cancer Patients ◽  
Younger Women ◽  
Based Medicine

Screening and adjuvant postoperative therapies have increased survival among women with breast cancer. These tools are seldom applied in elderly patients, although the usually reported incidence of breast cancer is close to 50% in women 65 years or older, reaching 47% after 70 years in the updated Surveillance, Epidemiology, and End Results (SEER) database. Elderly breast cancer patients, even if in good medical health, were frequently excluded from adjuvant clinical trials. Women age 70 years who are fit actually have a median life expectancy of 15.5 years, ie, half of them will live much longer and will remain exposed for enough time to the potentially preventable risks of a relapse and specific death. In the last few years, a new concern about this issue has developed. Treatment now faces two major end points, as in younger women: to improve disease-free survival in the early stages, and to palliate symptoms in advanced disease. However, in both settings, the absolute benefit of treatment is critical because protecting quality of life and all its related aspects (especially functional status and independence), is crucial in older persons who have more limited life expectancy. Furthermore, the new hormonal compounds (aromatase inhibitors) and chemotherapeutic drugs (capecitabine, liposomal doxorubicin), are potentially less toxic than and equally as effective as older more established therapies. These new treatments bring new challenges including higher cost, and defining their benefit in elderly breast cancer must include an analysis of the cost/benefit ratio. These issues emphasize the urgent need to develop and support clinical trials for this older population of breast cancer patients both in the adjuvant and metastatic settings, a move that will take us from a prejudiced, age-based medicine to an evidence-based medicine.

scholarly journals Quality of Life and Depressive Signs and Symptoms of the Elderly Women with Breast Cancer

10.3823/2055 ◽  
2016 ◽  
Author(s):  
Nathacha Adriela Lima de Carvalho ◽  
Maria do Livramento Fortes Figueiredo ◽  
Chrystiany Plácido de Brito Vieira ◽  
Jaqueline Carvalho e Silva Sales ◽  
Maria Helena Barros Araújo Luz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Elderly Women ◽  
Signs And Symptoms ◽  
The Elderly

The role of radiotherapy in elderly women with early-stage breast cancer treated with breast conserving surgery

2018 ◽  
Vol 104 (6) ◽  
pp. 429-433 ◽  
Author(s):  
Mariacarla Valli ◽  
Simona Cima ◽  
Paola Fanti ◽  
Barbara Muoio ◽  
Alessandra Vanetti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Elderly Women ◽  
Early Stage ◽  
Conservative Surgery ◽  
Early Stage Breast Cancer ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Significant Difference ◽  
The Impact

Objective: To analyze the impact of adjuvant radiotherapy (RT) on ipsilateral breast recurrence (IBR) and overall survival (OS) in patients older than 69 years with early-stage breast cancer. Methods: From January 2007 to June 2015, we analyzed retrospectively 137 women with estrogen receptor–positive T1–2 invasive breast cancer, with negative axillary lymph nodes, dividing them into 2 subgroups: 70 to 79 years and older than 79 years. Results: After a median follow-up of 43.2 months, the 3-year IBR-free survival in patients treated with surgery plus RT was 98.8% and 92.1% in patients treated with surgery alone, with a significant difference ( p = .01). Radiotherapy did not impact overall survival ( p = .10). A higher percentage of patients aged between 70 and 79 years received RT after conservative surgery if compared with the older subgroup ( p < .01). Conclusions: In elderly women, adjuvant RT reduced the IBR, but did not improve OS.

scholarly journals The use of radiation in the elderly

2007 ◽  
Vol 10 (1) ◽  
pp. 1-3 ◽  
Author(s):  
L. A. Schnaper ◽  
K. S. Hughes
Keyword(s):  
Breast Cancer ◽  
Clinical Trials ◽  
Radiation Therapy ◽  
Randomized Trial ◽  
Postmenopausal Women ◽  
Older Women ◽  
Systemic Therapy ◽  
Elderly Women ◽  
The Elderly

Despite the fact that breast cancer is predominantly a disease of postmenopausal women, there have been no uniform recommendations for both locoregional and systemic therapy for women over 70. Until recently, older women have been excluded from clinical trials. This study is the first randomized trial that addresses the use of radiation therapy following lumpectomy in a favorable cohort of elderly women.

THE IMPACT OF CO-RESIDENT SPOUSES AND SONS ON ELDERLY MORTALITY IN RURAL BANGLADESH

2000 ◽  
Vol 32 (1) ◽  
pp. 89-98 ◽  
Author(s):  
M. OMAR RAHMAN
Keyword(s):  
Elderly Women ◽  
Economic Status ◽  
Elderly Person ◽  
The Elderly ◽  
Elderly Men ◽  
Old People ◽  
Prospective Data ◽  
Rural Bangladesh ◽  
Adult Sons ◽  
The Impact

This paper uses prospective data from the Matlab surveillance system in rural Bangladesh to demonstrate that initially co-resident spouses and sons have a major impact on the subsequent mortality of old people, with significant differences by the sex of the elderly person, and the age of the son. Spouses significantly reduce mortality by similar magnitudes for both elderly men and women. On the other hand, co-resident adult sons reduce mortality for elderly women much more than for elderly men, with younger sons being more beneficial than older sons. Furthermore, both married and unmarried females appear to benefit equally from co-resident adult sons. Finally, this analysis suggests that the impact of spouses and sons on mortality in old age is not substantially mediated through changes in elderly economic status.

Breast cancer in the elderly.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e11506-e11506
Author(s):  
Dilek Erdem ◽  
Bahiddin Yilmaz ◽  
Fatih Mehmet Cilingir ◽  
Selim Kocasarac ◽  
Fatih Teker ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Disease ◽  
Elderly Women ◽  
Ductal Carcinoma ◽  
Disease Status ◽  
The Elderly ◽  
Breast Cancer Patients ◽  
Abdominal Ultrasonography ◽  
Age Related ◽  
Patient Decision

e11506 Background: Breast cancer is one of the age-related tumors that accompany with population ageing and approximately 50 % of this disease occur in 65 years of age or older and also more than 30 % occur after age of 70. This study aims to examine characteristics of patients with breast cancer 65 years or older. Methods: The study was carried out on a series of 177 breast cancer patient followed up at our outpatient clinic who are 65 years or older chosen among 848 breast cancer patients during the period 1995-2012. Physical examination, annual chest x-ray, mammography, abdominal ultrasonography and bone scan were the tools to assess the disease status. SPSS 16 was used. Results: The mean age was 70.8 years old (range 65-85 years). There was only one patient whose age is older than 85 years. 85 % of histopathology was infiltratif ductal carcinoma. 83 % of patients underwent mastectomy while 92 % was performed axillary dissection. 56 % had node positivity and 54 % had 2 cm or bigger tumor. ER/PR status was both negative in 54 women (30 %) and both positive in 82 of them. Also cerbB2 was negative in most of the patients (70 %). At the diagnosis, 20 patients (11.3 %) had metastatic disease and 157 were without metastases. Totally 44 patients (32 %) had metastatic disease and most of them (29 patients) had bone disease. Only 52 did not have endocrine therapy with 48 % had tamoxifen as a part of hormonal therapy. Most of them received radiotherapy (54 %). DFS was within 7-182 months with a median of 54 months. PFS was between 2-60 months and patients had a median OS about 61 months. 30 patients died because several causes owing to ageing causes. Conclusions: Breast cancer is the most significant cancer of women and the screening modalities with adjuvant postoperative therapies have increased survival. Acute and chronic medical conditions, nutritional status, poly-pharmacy, level of activity, disease-spesific symptoms and patient decision all need to be taken into consideration. Both in early and advanced stages of the disease, quality of life and related aspects have critical importance in elderly women who have more limited life-expectancy. It is also essential that women with breast cancer 65 years and older be included in trials and that they be recommended the best therapies available.

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