The Plasma Atherogenic Index is an Independent Predictor of Arterial Stiffness in Healthy Koreans

The plasma atherogenic index (AIP) has been suggested as a useful independent predictor of cardiovascular diseases (CVDs) in high CV risk patients. We investigated the association between AIP and arterial stiffness measured by brachial–ankle pulse wave velocity (baPWV) in healthy adults. A total of 3468 healthy subjects without any metabolic or CV diseases were enrolled. Anthropometric and CV risk factors were measured. The AIP was defined as the base 10 logarithm of the ratio of the concentration of triglycerides to high-density lipoprotein-cholesterol. Subjects were classified into AIP quartiles. There were gradual deteriorations in metabolic parameters and increase in baPWV across the increasing AIP quartiles. In a fully adjusted analysis, compared with Q1 (lowest quartile) group, the odds ratio (95% confidence interval) for increased baPWV was higher in Q2 1.51, Q3 1.64, and Q4 (highest quartile) 2.77 among men, and Q2 1.09, Q3 1.55, and Q4 1.83 among women (all P trend <0 .05). There was a strong association between AIP and baPWV, and a higher AIP was an independent predictor of increased arterial stiffness in healthy Korean men and women. The AIP may be a simple screening tool for subclinical atherosclerosis.

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Relationship between blood lipid and arterial stiffness in hypertension

Clinical & Investigative Medicine ◽

10.25011/cim.v42i3.33092 ◽

2019 ◽

Vol 42 (3) ◽

pp. E47-E55 ◽

Cited By ~ 1

Author(s):

Xiao-bei Si ◽

Wei Liu

Keyword(s):

Risk Factors ◽

Arterial Stiffness ◽

Pulse Wave Velocity ◽

High Density Lipoprotein ◽

Wave Velocity ◽

Pulse Wave ◽

Density Lipoprotein ◽

High Density ◽

Atherogenic Index ◽

History Of

Purpose: To explore the relationship between blood lipids and pulse wave velocity (PWV). Methods: We retrospectively selected subjects who had undergone treatment in an outpatient or inpatient clinic. The subjects were sub-grouped into four groups: Group A (no history of hypertension and dyslipidemia), Group B (a history of dyslipidemia but not hypertension), Group C (a history of hypertension but not dyslipidemia) and Group D (a history of both hypertension and dyslipidemia). We determined brachial-ankle pulse wave velocity (baPWV), atherogenic index of plasma (AIP), non-high-density lipoprotein (non-HDL-C), total cholesterol/high density lipoprotein (TC/HDL-C) and atherogenic indices (AI) for hypertension and non-hypertension and dyslipidemia and non-dyslipidemia patients. Results: A total of 380 subjects were included. Uric acid, systolic pressure, diastolic pressure, pulse pressure and mean arterial pressure were significantly different among the groups. The prevalence of coronary arterial disease and diabetes mellitus, age, body mass index, heart rate, blood glucose, creatinine, urea, smoking history and alcohol consumption did not differ among groups. The baPWV was significantly different between both hypertension/nonhypertension and dyslipidemia/non-dyslipidemia patients. In hypertension patients (in Group C and D), partial correlation analysis showed that ΔbaPWV correlated with TC, HDL-C, AI, AIP and TC/HDL-C but not LDL-C, triglyceride (TG) or non-HDL-C. Conclusion: Hypertension and/or dyslipidemia may be risk factors for arterial stiffness. In hypertension patients, TC, HDL-C, AIP, AI and TC/HDL-C might correlate to arterial stiffness and pathological increases in these levels may indicate risk factors for arterial stiffness.

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Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry Study

10.21203/rs.3.rs-31909/v2 ◽

2020 ◽

Author(s):

Minghui Li ◽

Aihua Zhan ◽

Xiao Huang ◽

Lihua Hu ◽

Wei Zhou ◽

...

Keyword(s):

Arterial Stiffness ◽

Pulse Wave ◽

Fasting Glucose ◽

Independent Predictor ◽

Positive Association ◽

Regression Analyses ◽

Registry Study ◽

Hypertensive Patients ◽

Tyg Index ◽

Triglyceride Glucose Index

Abstract Background: Data are limited on whether TyG index is an independent predictor of arterial stiffness in hypertensive patients. The purpose of this study was to assess the association between the TyG index and arterial stiffness, and examined whether there were effect modifiers, in hypertensive patients. Methods: This study included 4718 hypertensive adults, a subset of the China H-type Hypertension Registry Study. The TyG index was calculated as ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Arterial stiffness was determined by measuring brachial-ankle pulse wave velocity (baPWV). Results: The overall mean TyG index was 8.84. Multivariate linear regression analyses showed that TyG index was independently and positively associated with baPWV (β, 1.02; 95% confidence interval [CI] 0.83, 1.20). Consistently, Multiple logistic analyses showed a positive association between TyG index risk of elevated baPWV (> 75th percentile) (odds ratio [OR], 2.12; 95% CI 1.80, 2.50). Analyses using restricted cubic spline confirmed that the associations of TyG index with baPWV and elevated baPWV were linear. Subgroup analyses showed that stronger associations between TyG index and baPWV were detected in men (all P for interaction < 0.05).Conclusion: TyG index was independently and positively associated with baPWV and elevated baPWV among hypertensive patients, especially in men. The data suggest that TyG index may serve as a simple and effective tool for arterial stiffness risk assessment in daily clinical practice.

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The Relationship Between the Atherogenic Index of Plasma and Arterial Stiffness in Essential Hypertensive Patients from China: A Cross-Sectional Study

10.21203/rs.3.rs-215251/v1 ◽

2021 ◽

Author(s):

Juan Yin ◽

Minghui Li ◽

Lingling Yu ◽

Feng Hu ◽

Yu Yu ◽

...

Keyword(s):

Essential Hypertension ◽

Arterial Stiffness ◽

Linear Regression Analysis ◽

Density Lipoprotein ◽

Cross Sectional Study ◽

Atherogenic Index ◽

Multivariate Linear Regression Analysis ◽

Sectional Study ◽

Cross Sectional ◽

Atherogenic Index Of Plasma

Abstract Background: The atherogenic index of plasma (AIP) always remains in a potential association with the arterial stiffness, however, in large hypertensive patient populations, this relation is not fully discovered and needs to be studied in depth. The present analysis thus sought to further explore the association that exists between AIP and arterial stiffness in patients diagnosed with arterial hypertension in China.Methods: This cross-sectional study analyzed 4744 Chinese individuals with essential hypertension. AIP was defined as the base 10 logarithm of the ratio of plasma of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-c) levels indicates as in molar concentrations. Measurement of arterial stiffness was carried out via brachial-ankle pulse wave velocity (baPWV).Results: Data were adjusted for potential confounding variables, after which a multivariate linear regression analysis revealed AIP to be positively correlated with baPWV (β = 1.34, 95% CI: 0.96 to 1.72, P < 0.001). When AIP was instead treated as a categorical variable divided into quartiles, this same relationship was observed (P for trend < 0.001). We additionally found AIP and baPWV had a stronger positive association in individuals with a body mass index (BMI) < 24 kg/m2 (P for interaction < 0.05).Conclusion: AIP and arterial stiffness were positively correlated in essential hypertension patients in China, especially in those with a BMI < 24 kg/m2.

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Abstract 412: Obesity is an Independent Predictor Of Arterial Stiffness

Hypertension ◽

10.1161/hyp.62.suppl_1.a412 ◽

2013 ◽

Vol 62 (suppl_1) ◽

Author(s):

Mohan Thanikachalam ◽

Shasha Bai ◽

Vijayakumar Harivanzan ◽

Ragavendra R Baliga ◽

William T Abraham ◽

...

Keyword(s):

Blood Pressure ◽

Regression Analysis ◽

Arterial Stiffness ◽

Multivariate Regression ◽

Independent Predictor ◽

Density Lipoprotein ◽

Multivariate Regression Analysis ◽

Population Based ◽

Cross Sectional Survey ◽

Cross Sectional

Background Arterial stiffness assessed by carotid-femoral pulse wave velocity (PWV) is an independent predictor of cardiovascular morbidity and mortality. We aimed to investigate how various measures of obesity affect arterial stiffness. Methods We conducted a population-based cross-sectional survey in 8,042 South Indians above the age of 20 years. Following completion of a detailed medical history questionnaire, all participants underwent haemodynamic screening including brachial and central blood pressure, and PWV measurements using a high-fidelity applanation tonometry. The study included anthropometric measurements and fasting blood for total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and blood glucose (BG) levels. After the exclusion of people with previous history of diabetes, hypertension and dyslipidemia on drug therapy, 5,841 subjects (mean age 41.6 years; 58% women) constituted the study sample Results In an univariate analysis, PWV correlated positively with age, mean blood pressure (MAP), heart rate (HR), body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), body fat percent (BF%), TC, TG, LDL and BG levels (P <0.001) and negatively with HDL levels (P=0.005). In a multivariate regression analysis, majority of the PWV variability in the model was accounted for by MAP and age, (cumulative adjusted R2 change of 32.79% as compared to the total adjusted R2 change of 35.25%). However, BMI (β= 0.042; adjusted R2 change=2.83%; p<0.001) independently correlated with PWV and its contribution to the PWV variability was far more significant compared to LDL, BG and TG (cumulative adjusted R2 change=1.08%). Multivariate regression analysis using the WC, WHR, or BF% instead of the BMI continued to demonstrate a significant independent effect of obesity parameters on PWV. Conclusion: In a large a population-based cross-sectional survey the study demonstrates a positive, independent association between obesity parameters and increased arterial stiffness.

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Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry Study

10.21203/rs.3.rs-31909/v1 ◽

2020 ◽

Author(s):

Minghui Li ◽

Aihua Zhan ◽

Xiao Huang ◽

Lihua Hu ◽

Wei Zhou ◽

...

Keyword(s):

Arterial Stiffness ◽

Pulse Wave ◽

Fasting Glucose ◽

Independent Predictor ◽

Positive Association ◽

Registry Study ◽

Hypertensive Patients ◽

Tyg Index ◽

Triglyceride Glucose Index ◽

Background Data

Abstract Background: Data are limited on whether TyG index is an independent predictor of arterial stiffness in hypertensive patients. The purpose of this study was to assess the association between the TyG index and arterial stiffness, and examined whether there were effect modifiers, in hypertensive patients.Methods: This study included 4718 hypertensive adults, a subset of the China H-type Hypertension Registry Study. The TyG index was calculated as ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Arterial stiffness was determined by measuring brachial-ankle pulse wave velocity (baPWV). Results: The overall mean TyG index was 8.84. Multivariate linear regression analyses showed that TyG index was independently and positively correlated with baPWV (β, 0.97; 95% confidence interval [CI] 0.78, 1.17). Consistently, Multiple logistic analyses showed a positive association between TyG index risk of elevated baPWV (> 75th percentile) (odds ratio [OR], 2.03; 95% CI 1.70, 2.41). Analyses using restricted cubic spline confirmed that the associations of TyG index with baPWV and elevated baPWV were linear. Subgroup analyses showed that stronger associations between TyG index and baPWV were detected in men (all P for interaction < 0.05).Conclusion: TyG index was independently and positively correlated with baPWV and elevated baPWV among hypertensive patients, especially in men. The data suggest that TyG index may serve as a simple and effective tool for arterial stiffness risk assessment in daily clinical practice.

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Abstract 108: Relative Contributions of Arterial Stiffness and Hypertension to CVD Risk: The Framingham Heart Study

Hypertension ◽

10.1161/hyp.68.suppl_1.108 ◽

2016 ◽

Vol 68 (suppl_1) ◽

Author(s):

Teemu J Niiranen ◽

Bindu Kalesan ◽

Naomi M Hamburg ◽

Emelia J Benjamin ◽

Gary F Mitchell ◽

...

Keyword(s):

Arterial Stiffness ◽

Pulse Wave ◽

Independent Predictor ◽

Community Dwelling ◽

Limited Data ◽

Cvd Risk Factors ◽

Cvd Risk ◽

Adjusted Risk ◽

Heart Study

Introduction: The presence and implications of abnormal arterial stiffness, a potential independent predictor of outcomes, in community-dwelling treated hypertensives is unknown. Furthermore, limited data exist regarding the risk of cardiovascular disease (CVD) associated with arterial stiffness across the entire range of blood pressure. Methods: We measured carotid-femoral pulse wave velocity (PWV) and classical CVD risk factors in participants of The Framingham Offspring Cohort. The participants were divided into 4 groups according to hypertension (yes/no), and PWV status (high/low based on age- and sex-specific median values) and followed up for CVD events (CVD death, myocardial infarction, unstable angina, heart failure, and stroke). Results: We studied 2127 community-dwelling individuals (60 years, 57% women). 60% (233 of 390) of controlled and 90% (232 of 258) of uncontrolled treated hypertensives had high PWV. The multivariable-adjusted risk for CVD events ( n =248, median follow-up 12.6 years; Figure) rose from normotension with low PWV (reference) to normotension with high PWV (hazard ratio [HR] 1.33, 95% confidence interval [95% CI] 0.86-2.05) and from hypertension with low PWV (HR 1.53, 95% CI 1.00-2.34) to hypertension with high PWV (HR 2.31, 95% CI 1.58-3.36). Conclusions: A substantial proportion of treated hypertensives have high arterial stiffness, a finding that may explain some of the notable residual CVD risk associated in this group. High PWV is associated with a trend towards increasing CVD risk in both non-hypertensives and hypertensives supporting the use of arterial stiffness measurements in both populations.

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PENGARUH KADAR TRIGLISERIDA TERHADAP KEKAKUAN ARTERI PADA MODEL HEWAN TIKUS WISTAR JANTAN

Kartika Jurnal Ilmiah Farmasi ◽

10.26874/kjif.v7i2.307 ◽

2020 ◽

Vol 7 (2) ◽

pp. 102

Author(s):

Patonah Hasimun ◽

Hasballah Zakaria

Keyword(s):

Cardiovascular Disease ◽

Heart Rate ◽

Arterial Stiffness ◽

High Fat Diet ◽

Pulse Wave ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Serum Triglyceride ◽

Positive Control ◽

Control Group

ABSTRAK Hasil studi epidemiologi diketahui bahwa trigliserida merupakan salah satu factor resiko independent terjadinya penyakit kardiovaskular walaupun target kadar low density lipoprotein (LDL) telah tercapai dengan obat statin. Diduga terdapat hubungan antara kadar trigliserida dengan elastisitas arteri. Kekakuan arteri telah diakui berkaitan erat dengan penyakit kardiovaskular. Penelitian ini bertujuan untuk mengetahui efek hipertrigliseridemia terhadap tingkat kekakuan arteri pada model hewan tikus Wistar yang diinduksi pakan tinggi lemak dan fruktosa 25%. Sejumlah 10 ekor tikus dikelompokkan secara acak menjadi 2 kelompok terdiri dari kelompok control normal menerima pakan normal dan kelompok control positif menerima pakan tinggi lemak dan air minum fruktosa 25% selama 28 hari. Pengukuran pulse wave velocity (PWV), denyut jantung, dan kadar trigliserida serum dilakukan pada hari ke 28. Hasil menunjukkan, kelompok kontrol positif mengalami kenaikan kadar trigliserida serum yang disertai dengan meningkatnya nilai PWV dan denyut jantung yang menunjukkan terjadinya kekakuan arteri yang berbeda bermakna secara statistik terhadap kelompok kontrol normal (p<0.05). Hasil dapat disimpulkan bahwa terdapat hubungan positif antara kadar trigliserida dengan kekakuan arteri. Semakin tinggi kadar trigliserida meningkatkan kekakuan arteri sehingga resiko kardiovaskular semakin meningkat. Kata kunci : trigliserida, kekakuan arteri, denyut jantung, kardiovaskular ABSTRACT Epidemiological studies report that triglycerides are an independent risk factor for cardiovascular disease even though the target level of low density lipoprotein (LDL) has been achieved with statin drugs. It is suspected that there is a relationship between triglyceride levels and arterial elasticity. Arterial stiffness has been recognized as being closely related to cardiovascular disease. This study aims to determine the effect of hypertriglyceridemia on arterial stiffness in animal models of Wistar rats induced by a high-fat diet and 25% fructose in drinking water. A total of 10 rats were randomly divided into 2 groups consisting of a normal control group receiving normal feed and a positive control group receiving a high-fat diet and 25% fructose in drinking water for 28 days. Measurements of pulse wave velocity (PWV), heart rate, and serum triglyceride levels were carried out on day 28. The positive control group experienced an increase in serum triglyceride levels accompanied by an increase in PWV and heart rate that was statistically significantly different (p <0.05) compared to the group normal. The results concluded that there was a positive relationship between triglyceride levels and arterial stiffness. Higher triglyceride levels increase arterial stiffness. it increases the risk of cardiovascular disease. Keywords : triglyceride, arterial stiffness, heart rate, cardiovascular

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Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry Study

Cardiovascular Diabetology ◽

10.1186/s12933-020-01124-2 ◽

2020 ◽

Vol 19 (1) ◽

Cited By ~ 1

Author(s):

Minghui Li ◽

Aihua Zhan ◽

Xiao Huang ◽

Lihua Hu ◽

Wei Zhou ◽

...

Keyword(s):

Arterial Stiffness ◽

Pulse Wave ◽

Fasting Glucose ◽

Independent Predictor ◽

Positive Association ◽

Regression Analyses ◽

Registry Study ◽

Hypertensive Patients ◽

Tyg Index ◽

Triglyceride Glucose Index

Abstract Background Data are limited on whether TyG index is an independent predictor of arterial stiffness in hypertensive patients. The purpose of this study was to assess the association between the TyG index and arterial stiffness, and examined whether there were effect modifiers, in hypertensive patients. Methods This study included 4718 hypertensive adults, a subset of the China H-type Hypertension Registry Study. The TyG index was calculated as ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Arterial stiffness was determined by measuring brachial-ankle pulse wave velocity (baPWV). Results The overall mean TyG index was 8.84. Multivariate linear regression analyses showed that TyG index was independently and positively associated with baPWV (β, 1.02; 95% confidence interval [CI] 0.83, 1.20). Consistently, Multiple logistic analyses showed a positive association between TyG index risk of elevated baPWV (> 75th percentile) (odds ratio [OR], 2.12; 95% CI 1.80, 2.50). Analyses using restricted cubic spline confirmed that the associations of TyG index with baPWV and elevated baPWV were linear. Subgroup analyses showed that stronger associations between TyG index and baPWV were detected in men (all P for interaction < 0.05). Conclusion TyG index was independently and positively associated with baPWV and elevated baPWV among hypertensive patients, especially in men. The data suggest that TyG index may serve as a simple and effective tool for arterial stiffness risk assessment in daily clinical practice.

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Pulse Wave Velocity Is Associated with Increased Plasma oxLDL in Ageing but Not with FGF21 and Habitual Exercise

Antioxidants ◽

10.3390/antiox9030221 ◽

2020 ◽

Vol 9 (3) ◽

pp. 221

Author(s):

Shuen Yee Lee ◽

Stephen F. Burns ◽

Kenneth K.C. Ng ◽

David J. Stensel ◽

Liang Zhong ◽

...

Keyword(s):

Oxidative Stress ◽

Arterial Stiffness ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Plasma Concentrations ◽

Age Groups ◽

Density Lipoprotein ◽

Fibroblast Growth Factor 21 ◽

Habitual Exercise

Fibroblast growth factor 21 (FGF21) and adiponectin increase the expression of genes involved in antioxidant pathways, but their roles in mediating oxidative stress and arterial stiffness with ageing and habitual exercise remain unknown. We explored the role of the FGF21–adiponectin axis in mediating oxidative stress and arterial stiffness with ageing and habitual exercise. Eighty age- and sex-matched healthy individuals were assigned to younger sedentary or active (18–36 years old, n = 20 each) and older sedentary or active (45–80 years old, n = 20 each) groups. Arterial stiffness was measured indirectly using pulse wave velocity (PWV). Fasted plasma concentrations of FGF21, adiponectin and oxidized low-density lipoprotein (oxLDL) were measured. PWV was 0.2-fold higher and oxLDL concentration was 25.6% higher (both p < 0.001) in older than younger adults, despite no difference in FGF21 concentration (p = 0.097) between age groups. PWV (p = 0.09) and oxLDL concentration (p = 0.275) did not differ between activity groups but FGF21 concentration was 9% lower in active than sedentary individuals (p = 0.011). Adiponectin concentration did not differ by age (p = 0.642) or exercise habits (p = 0.821). In conclusion, age, but not habitual exercise, was associated with higher oxidative stress and arterial stiffness. FGF21 and adiponectin did not differ between younger and older adults, meaning that it is unlikely that they mediate oxidative stress and arterial stiffness in healthy adults.

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Usefullnes of atherogenic indices and Ca-LDL level to predict subclinical atherosclerosis in patients with psoriatic arthritis?

Advances in Rheumatology ◽

10.1186/s42358-019-0096-2 ◽

2019 ◽

Vol 59 (1) ◽

Cited By ~ 1

Author(s):

Duygu Tecer ◽

Ismihan Sunar ◽

Ali Erhan Ozdemirel ◽

Rabia Tural ◽

Orhan Kucuksahin ◽

...

Keyword(s):

Psoriatic Arthritis ◽

Subclinical Atherosclerosis ◽

Statistical Significance ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Atherogenic Index ◽

Model Assessment ◽

Amyloid A

Abstract Background To investigate the link between carbamylated low-density lipoprotein (ca-LDL), atherogenic index of plasma (AIP), atherogenic coefficient (AC), Castelli’s risk indices I and II (CRI I and II) and subclinic atherosclerosis in psoriatic arthritis (PsA). Methods Thirty-ninepatients and 19 age, sex, body mass index matched healthy controls were included. Insulin resistance (IR) was assessed with homeostasis of model assessment-IR (HOMA-IR). Carotid intima-media thickness (CIMT) was measured at both common carotid arteries and mean CIMT was calculated. Results The mean age was 49.50 ± 11.86 years and 64.1% were females in PsA group. In the PsA group, CIMT and HOMA-IR were significantly higher (p = 0.003, p = 0.043, respectively). AIP, AC, TG/HDL, CRI-1, CRI-2 and ca-LDL levels were similar between groups. In PsA group, CIMT was positively correlated with HOMA-IR, TG/HDL and AIP. Although ca-LDL was positively correlated with serum amyloid A (r = 0.744, p < 0.001), no correlation was detected between ca-LDL and CIMT (r = 0.215, p = 0.195). PsA patients with IR tended to have higher ca-LDL levels than patients without IR, but this difference lacked statistical significance (33.65 ± 26.94, 28.63 ± 28.06, respectively, p = 0.237). Conclusions A significant increase in CIMT was seen in PsA patients without clinically evident cardiovascular disease or any traditional atherosclerosis risk factors. CIMT was correlated with HOMA-IR, TG/HDL and AIP.

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