Importance of Model Parameters in the Assessment of Intra-oral Remineralization

1992 ◽  
Vol 71 (3_suppl) ◽  
pp. 879-883 ◽  
Author(s):  
J.M. Ten Cate ◽  
Y.M. Van De Plassche-Simons ◽  
A.J.P. Van Strijp
Keyword(s):  
Statistical Significance ◽  
Model Parameters ◽  
Variable Parameters ◽  
Physiological Processes ◽  
Large Numbers ◽  
Demineralized Enamel ◽  
The World ◽  
Assessment Techniques ◽  
The Many

Since the introduction of the Intra-oral Cariogenicity Test by Koulourides et al. (1974), many groups around the world have been developing and using intra-oral models to test new caries-preventive products, as well as to study physiological processes in the oral cavity. In spite of the large numbers of papers reporting these methods, very little research has been done to determine the importance of the many variable parameters which influence the performance of these models. Among these, the following can be identified: (a) panelist criteria, (b) the use of sound vs. pre-demineralized enamel of human or bovine origin, (c) the use of gauze or a recess to accumulate plaque, (d) the method to create incipient lesions, (e) the duration of the experiment, (f) the number of panelists required for statistical significance to be obtained, (g) the assessment techniques for mineral and/or fluoride uptake/loss, and (h) the choice of contralateral, ‘cross-over’, or ‘monadic’ experimental designs. Our results, supported by data from the literature, indicate that the choices made with respect to these parameters are of paramount importance in determination of the outcome of the respective study.

Multilateralism with small and large numbers

1992 ◽  
Vol 46 (3) ◽  
pp. 681-708 ◽  
Author(s):  
Miles Kahler
Keyword(s):  
World Bank ◽  
International Conflict ◽  
The United States ◽  
International Governance ◽  
The World Bank ◽  
Large Numbers ◽  
The World ◽  
The Many ◽  
The International Monetary Fund ◽  
Organizing Principles

Multilateralism, international governance of the “many,” was defined by the United States after 1945 in terms of certain principles, particularly opposition to bilateral and discriminatory arrangements that were believed to enhance the leverage of the powerful over the weak and to increase international conflict. Postwar multilateralism also expressed an impulse to universality (John Ruggie's “generalized organizing principles”) that implied relatively low barriers to participation in these arrangements. A ticket of admission was always required, whether acceding to the General Agreement on Tariffs and Trade (GATT) or joining the International Monetary Fund (IMF) and the World Bank. Nevertheless, the price of that ticket was not set so high that less powerful or less wealthy states could not hope to participate.

The Large Novel and the Law of Large Numbers: Daniel Deronda and the Counterintuitive

Good Form ◽  
2019 ◽  
pp. 153-190
Author(s):  
Jesse Rosenthal
Keyword(s):  
Statistical Significance ◽  
Individual Case ◽  
Human Interaction ◽  
Daniel Deronda ◽  
Large Numbers ◽  
Conceptual Shift ◽  
State Of Affairs ◽  
The Many ◽  
The One ◽  
The Individual

This chapter assesses the counterintuitive: the ending that “feels wrong,” or that does not work out as it seems it should. Certainly, this could mean many things, from a poorly constructed novel to the pedagogy implied by naturalist accident. The form of the counterintuitive that structures much of George Eliot's Daniel Deronda (1876), however, and which enacts the novel's stern moral lesson, develops from Eliot's more social concerns. Eliot, throughout her writing career, worked with an idea of narrative intuition, and formal morality, connected with the model consisting of a working out of the identity between an individual and the larger group. In Deronda, though, with its consistent concentration on ideas of probability and statistical significance, one sees a conceptual shift in Eliot's thinking about the relation of the one and the many. In short: though the larger workings of human interaction indicate that a certain state of affairs shall certainly come about at the largest levels, this offers no indication of how or when this might resolve in the individual case.

scholarly journals The Plasticity of Our Fears: Affective Politics in the European Migration Crisis

Society ◽  
2021 ◽  
Author(s):  
Volker M. Heins
Keyword(s):  
Critical Variable ◽  
Albert Hirschman ◽  
Large Numbers ◽  
The World ◽  
German Sociologist ◽  
Migration Crisis ◽  
Immigration And Asylum ◽  
The Many ◽  
Migration Politics ◽  
European Migration

AbstractIn the field of migration politics, a dominant rhetoric argues that liberal immigration and asylum policies must be avoided because they will inevitably lead to anti-immigration backlashes that exacerbate the very conditions they were supposed to remedy. Drawing on the work of German sociologist Heinrich Popitz and empirical data on the aftereffects of the European migration crisis, the article criticizes this “rhetoric of reaction” (Albert Hirschman) for ignoring the many variables shaping the consequences of more open borders. Backlashes to immigration are real and pose a constraint for liberal immigration policies, but these backlashes are not necessarily politically successful. Societies react neither uniformly nor automatically to rising immigration. A critical variable is the fear engendered by the (real, expected, or imagined) arrival of large numbers of migrants, and this fear can be either ramped up to paranoid levels or calmed by a politics of hope aimed at restoring what Popitz called the “human openness to the world.”

The Perils of Primaxin

2014 ◽  
Author(s):  
Eugene H. Cordes
Keyword(s):  
Drug Discovery ◽  
Pharmaceutical Industry ◽  
Infectious Diseases ◽  
Bacterial Infections ◽  
Significant Fraction ◽  
Health Product ◽  
The Road ◽  
The World ◽  
The Many

The Perils of Pauline is a 1914 film serial in 20 episodes. In each episode, a villain, perhaps a pirate, menaces Pauline, played by Pearl White. In each episode, Pauline seems certain to meet her demise, only to escape or be rescued at the last possible moment. Outdoing the proverbial cat of nine lives, Pauline had 20. The Perils of Pauline bears more than a passing resemblance to drug discovery and development in which some villain, perhaps an issue of safety or efficacy, threatens the life of a project. I know of no better example of this than the course of getting the antibiotic Primaxin from the laboratory to the bedside. The perils of Primaxin plays out in a scientific serial of five episodes in which the project is rescued from impending disaster in each episode. The Primaxin story is one of the great tales of drug discovery in the world of antibiotics—the molecules that have power to prevent or cure bacterial infections. Primaxin is a triumph of the pharmaceutical industry in general and of Merck specifically. Victory did not come easily. The road from a drug discovery start to a marketable human health product is often rough, occasionally very rough, and sometimes impassable. The Primaxin story stands out for the number and nature of bumps and ruts that impeded passage. That Primaxin made it to the market for the benefit of countless patients with infectious diseases is a tribute to the wit and determination of the many scientists who saw it through. That story comes later. Let’s get started with some general background on the field of antibiotics. The next time you have the occasion to explore a cemetery, have a look at the tombstones for people born around 1900. A significant fraction of those tombstones will reveal that the date of death is within 10 years of the date of birth. Simply put, many people born around 1900 or earlier did not live to be 10 years old.

The many faces of STEM in materials science

1991 ◽  
Vol 49 ◽  
pp. 440-441
Author(s):  
John Silcox
Keyword(s):  
Materials Science ◽  
Auger Spectroscopy ◽  
Dark Field ◽  
High Tc Superconductors ◽  
High Tc ◽  
Acoustic Environment ◽  
Electromagnetic Vibration ◽  
The Many ◽  
Serial Mode

Determination of the microstructure and microchemistry of small features often provides the insight needed for the understanding of processes in real materials. In many cases, it is not adequate to use microscopy alone. Microdiffraction and microspectroscopic information such as EELS, X-ray microprobe analysis and Auger spectroscopy can all contribute vital parts of the picture. For a number of reasons, dedicated STEM offers considerable promise as a quantitative instrument. In this paper, we review progress towards effective quantitative use of STEM with illustrations drawn from studies of high Tc superconductors, compound semiconductors and metallization of H-terminated silicon.Intrinsically, STEM is a quantitative instrument. Images are acquired directly by detectors in serial mode which is particularly convenient for digital image acquisition, control and display. The VG HB501A at Cornell has been installed in a particularly stable electromagnetic, vibration and acoustic environment. Care has been paid to achieving UHV conditions (i.e., 10-10 Torr). Finally, it has been interfaced with a VAX 3200 work station by Kirkland. This permits, for example, the acquisition of bright field (or energy loss) images and dark field images simultaneously as quantitative arrays in perfect registration.

Enhanced information from biological materials through technological improvements in cryo-electron microscopy

1992 ◽  
Vol 50 (1) ◽  
pp. 788-789
Author(s):  
Marc J.C. de Jong ◽  
Wim M. Busing ◽  
Max T. Otten
Keyword(s):  
Electron Microscopy ◽  
Electron Beam ◽  
Biological Materials ◽  
Electron Crystallography ◽  
Cryo Electron Microscopy ◽  
Transmission Electron ◽  
The Many ◽  
Technological Improvements ◽  
Beam Damage

Biological materials damage rapidly in the electron beam, limiting the amount of information that can be obtained in the transmission electron microscope. The discovery that observation at cryo temperatures strongly reduces beam damage (in addition to making it unnecessaiy to use chemical fixatives, dehydration agents and stains, which introduce artefacts) has given an important step forward to preserving the ‘live’ situation and makes it possible to study the relation between function, chemical composition and morphology.Among the many cryo-applications, the most challenging is perhaps the determination of the atomic structure. Henderson and co-workers were able to determine the structure of the purple membrane by electron crystallography, providing an understanding of the membrane's working as a proton pump. As far as understood at present, the main stumbling block in achieving high resolution appears to be a random movement of atoms or molecules in the specimen within a fraction of a second after exposure to the electron beam, which destroys the highest-resolution detail sought.

The Collaborative Medical and Behavioral Management of Chronic Cough

2009 ◽  
Vol 19 (2) ◽  
pp. 49-57
Author(s):  
Brian E. Petty ◽  
Seth H. Dailey
Keyword(s):  
Medical Care ◽  
Chronic Cough ◽  
Therapeutic Management ◽  
Ambulatory Setting ◽  
Behavioral Management ◽  
Speech Language Pathologists ◽  
Speech Language Pathologist ◽  
The Many ◽  
Frequent Reason

Abstract Chronic cough is the most frequent reason cited by patients for seeking medical care in an ambulatory setting and may account for 10% to 38% of a pulmonologist's practice. Because chronic cough can be caused by or correlated with a wide array of disorders and behaviors, the diagnosis of etiologic factors and determination of appropriate therapeutic management in these cases can prove to be daunting for the physician and speech-language pathologist alike. This article will describe the phenomenon of chronic cough, discuss the many etiologic factors to consider, and review some of the more common ways in which speech-language pathologists and physicians collaborate to treat this challenging condition.

“All in a Garden Green”: Shakespeare's Staging of Garden Imagery

2019 ◽  
Vol 26 (2) ◽  
pp. 227-252
Author(s):  
Deborah Solomon
Keyword(s):  
Early Modern ◽  
Literary Tradition ◽  
The Public ◽  
The World ◽  
Audience Interaction ◽  
The Many ◽  
Green World

This essay draws attention to the surprising lack of scholarship on the staging of garden scenes in Shakespeare's oeuvre. In particular, it explores how garden scenes promote collaborative acts of audience agency and present new renditions of the familiar early modern contrast between the public and the private. Too often the mention of Shakespeare's gardens calls to mind literal rather than literary interpretations: the work of garden enthusiasts like Henry Ellacombe, Eleanour Sinclair Rohde, and Caroline Spurgeon, who present their copious gatherings of plant and flower references as proof that Shakespeare was a garden lover, or the many “Shakespeare Gardens” around the world, bringing to life such lists of plant references. This essay instead seeks to locate Shakespeare's garden imagery within a literary tradition more complex than these literalizations of Shakespeare's “flowers” would suggest. To stage a garden during the sixteenth and seventeenth centuries signified much more than a personal affinity for the green world; it served as a way of engaging time-honored literary comparisons between poetic forms, methods of audience interaction, and types of media. Through its metaphoric evocation of the commonplace tradition, in which flowers double as textual cuttings to be picked, revised, judged, and displayed, the staged garden offered a way to dramatize the tensions produced by creative practices involving collaborative composition and audience agency.

BIOASSAY CHARACTERISTICS OF INDIVIDUAL URINARY GONADOTROPHIN EXTRACTS

1963 ◽  
Vol 42 (2) ◽  
pp. 214-224
Author(s):  
Raymond C. Mellinger ◽  
Jalileh A. Mansour ◽  
Richmond W. Smith
Keyword(s):  
Reference Material ◽  
Young Women ◽  
Reference Standard ◽  
General Acceptance ◽  
Modifying Factors ◽  
Large Numbers ◽  
The World ◽  
Quantitative Bioassay ◽  
Different Parts ◽  
Age And Sex

ABSTRACT A reference standard is widely sought for use in the quantitative bioassay of pituitary gonadotrophin recovered from urine. The biologic similarity of pooled urinary extracts obtained from large numbers of subjects, utilizing groups of different age and sex, preparing and assaying the materials by varying techniques in different parts of the world, has lead to a general acceptance of such preparations as international gonadotrophin reference standards. In the present study, however, the extract of pooled urine from a small number of young women is shown to produce a significantly different bioassay response from that of the reference materials. Gonadotrophins of individual subjects likewise varied from the multiple subject standards in many instances. The cause of these differences is thought to be due to the modifying influence of non-hormonal substances extracted from urine with the gonadotrophin and not necessarily to variations in the gonadotrophins themselves. Such modifying factors might have similar effects in a comparative assay of pooled extracts contributed by many subjects, but produce significant variations when material from individual subjects is compared. It is concluded that the expression of potency of a gonadotrophic extract in terms of pooled reference material to which it is not essentially similar may diminish rather than enhance the validity of the assay.

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