Autopsy Findings in Turtle Flesh Poisoning

1988 ◽  
Vol 28 (2) ◽  
pp. 142-144 ◽  
Author(s):  
N. Chandrasiri ◽  
P. L. Ariyananda ◽  
S. S. D. Fernando

There is a paucity of literature in Sri Lanka and internationally on autopsy findings of turtle flesh poisoning. Of the five varieties of endemic sea turtles in Sri Lanka, only the Hawksbill type (Eretmochelys imbricata – locally termed Pothu Kesbawa, Leli Kesbawa, Pana Kesbawa) is poisonous. Of the two cases described one is a breast-fed child of age 1 year 3 months and the other of 13 years. The younger child did not eat the flesh but was breast fed by his mother before becoming ill, but after she had eaten the flesh. The main findings are in the lungs. There is gross thickening of the alveolar septa with interstitial oedema with haemorrhage and micro-thrombi in the lumen of pulmonary arterioles. There is a remarkable lack of intra-alveolar oedema. The brain showed interstitial oedema. Myocardial fibres showed diffuse degeneration, necrosis and interstitial oedema with an acellular reaction. The toxic substance as postulated may be a component of a variety of algae present only in certain seasons.

2020 ◽  
Vol 10 (3-4) ◽  
pp. 158-165
Author(s):  
Yalini Thivaharan ◽  
Indira Deepthi Gamage Kitulwatte

Introduction: Investigation into explosions is one of the major areas in forensic medicine and pathology. Medico legal issues associated with these deaths are diverse and forensic experts are often expected to make clarifications. Assistance of a methodical scientific investigation of such a death in evaluation of unanswered medico legal issues, of an autopsy of one of the victims of Easter Sunday explosions is discussed. Case history: The deceased was a 15-year-old girl who was participating in the Easter mass at St. Sebastian’s Church - Kattuwapaitya, Negombo, Sri Lanka when a suicide bomber blew himself up. The mother of the deceased noticed the deceased being rushed to the hospital. However, she was pronounced dead on admission. Pre-autopsy radiology revealed spherical shrapnel in the temporal region. At autopsy, the fatal injury was found on the head and a detailed study revealed skull fractures associated with penetration by 3 shrapnels. There was a keyhole lesion among the penetrations. Internal examination revealed an extensive dural tear underlying the compound fracture. The brain was grossly edematous with lacerations on the frontal and parietal lobes associated with localized subarachnoid hemorrhage. There were multiple underlying contusions on bilateral frontal white matter. Small subarachnoid haemorrhage was noted on the basal aspect of the brain. Discussion: Careful evaluation of the autopsy findings assisted in formulating the opinion scientifically on event reconstruction including the proximity of the victim to the epicenter of explosion and nature of explosive device, period of survival, mechanism of causation of skull fractures and the mechanism of death in addition to the cause of death. Conclusion: A forensic pathologist following a meticulous autopsy examination, along with a team of ballistic experts and specially trained police personnel play a pivotal task in analyzing a scene of explosion and an autopsy of a victim, in concluding the case and in bringing justice to all the victims and survivors of the catastrophe.


1976 ◽  
Vol 44 (1) ◽  
pp. 92-95 ◽  
Author(s):  
Skip Jacques ◽  
Donald B. Freshwater ◽  
C. Hunter Shelden

✓ The authors report a case of primary osteogenic sarcoma of the brain. Negative autopsy findings, complete bone radiographs, and bone-scanning techniques were consistent with a primary tumor focus in the right temporoparietal region of the brain. The authors suggest an origin from a primitive multipotential mesenchymal cell.


2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Thao-Thy Pham ◽  
Chuchard Punsawad ◽  
Supattra Glaharn ◽  
Simon F. De Meyer ◽  
Parnpen Viriyavejakul ◽  
...  

Abstract Background Malaria-associated acute respiratory distress syndrome (MA-ARDS) is an understudied complication of malaria and is characterized by pulmonary inflammation and disruption of the alveolar-capillary membrane. Its pathogenesis remains poorly understood. Since endothelial activation plays an important role in other malarial complications, the expression of two endothelial activation markers, von Willebrand factor (VWF) and angiopoietin-2 (ANG-2), was investigated in the lungs of patients with MA-ARDS. Methods Post-mortem lung sections of Plasmodium falciparum-infected patients without alveolar oedema (NA), P. falciparum-infected patients with alveolar oedema (MA-ARDS), and uninfected people who died accidentally with no pathological changes to the lungs (CON) were immunohistochemically stained for VWF and ANG-2, and were evaluated with semi-quantitative analysis. Results Alveolar oedematous VWF and ANG-2 and intravascular VWF staining were significantly increased in patients with MA-ARDS versus infected and uninfected control groups. The levels of VWF in the alveolar septa and endothelial lining of large blood vessels of patients with MA-ARDS was significantly decreased compared to controls. ANG-2 expression was increased in the alveolar septa of malaria patients without alveolar oedema versus control patients, while ANG-2+ leukocytes were increased in the alveoli in both infected patient groups. Conclusions This study documents a high level of VWF and ANG-2, two endothelial activation markers in the oedematous alveoli of post-mortem lung sections of Thai patients with MA-ARDS. Decreased detection of VWF in the endothelial lining of blood vessels, in parallel with an increased presence of intravascular VWF staining suggests marked endothelial activation and Weibel–Palade body release in the lungs of patients with MA-ARDS.


2016 ◽  
Vol 9 (1) ◽  
pp. 30-33
Author(s):  
Monireh Khordadmehr ◽  
Fereydoon Rezazadeh ◽  
Javad Ashrafi-Helan ◽  
Mir Mohsen Hosseini-Ghomi

Abstract Pyrrolizidine alkaloids (PAs) are natural phytotoxins found in thousands of plant species around the world. They are probably the most common poisonous plants affecting livestock, wildlife and humans. The disease occurs almost entirely as a consequence of chronic poisoning and in general ends fatally. In the present study, PAs poisoning was investigated in a gazelle with hepatic encephalopathy associated with severe neurologic signs. The main clinical signs included head pressing, progressive depression and weakness, ataxia and reluctance to move, turn the head to the left and to paddle, hyperesthesia and decreased food intake. Histopathological examination revealed major lesions in the liver consisting of severe hepatocyte megalocytosis and hypertrophy with nuclei enlargement, mild bile duct hyperplasia, centriacinar fatty change and hepatocellular necrosis. Moreover, pulmonary congestion and edema with endothelium necrosis and alveolar septa thickening, severe congestion in vessels of the brain and meninges, and myocardial necrosis were observed.


Author(s):  
I. G. Yaroshovych ◽  
B. P. Tchaikovskyj ◽  
B. M. Mykychak ◽  
T. S. Yaroshovych

In the list of environmental pollutants, mercury is one of the first places. It is mercury, its inorganic and especially organic compounds belong to extremely toxic substances of the first class of danger.Mercury has been known since ancient times, it is mentioned in the writings of Aristotle, Theophrastus, Pliny the Elder, Vitruvius and other ancient scholars. The Latin name for this metal is “Hydrargium”, given to mercury by Greek physician Dioscorides (1st century B.C.), means in translation “silver water”. The most important and ancient in Ukraine is the Mykytiv mercury deposit, which was opened in 1879. and operated since 1885. Production of mercury until 1914 was 300–400 t/year (most of it was exported). After the revolution and the war it was slowly recovered (127 tons in 1926), in 1935–1940 it is annually brought to about 300 tons. After the Second World War, the Mykytiv deposit was built. Discovered in it reserves (up to a depth of 300 m) were evaluated in 6.000 tons in 1927, after deep drilling was introduced in the 1960s. they have increased slightly. In the world economy, mercury is widely used in the electrical engineering and instrument industry, laboratory and medical practice, in the production of chlorine/alkali, in agriculture (included in fertilizers), in small-scale mining of gold and silver and other fields. No other chemical element belonging to the first class of danger has such wide use in production processes, products, substances and such multivariate penetration into the organism (with air, food, water, through the skin) as mercury and its compounds. The main source of mercury poisoning is mercury vapor and dust of mercury compounds. The toxicity of metallic mercury is due to the fact that while inhaling its vapors more than 80 % of the mercury is absorbed by the brain, kidneys and other internal organs, leading to he devastating consequences primarily on the central nervous system and kidneys. Mercury semi withdrawal period from humans is from 35 to 96 days. The average semi withdrawal period from the blood is 65 days, from hair 72 days, in total from the organism - 76 days. A longer semi withdrawal period of mercury from the brain than from other organs has been recorded in experimental animal searches. In humans, high levels of mercury in brain tissue were detected 10 years after it ceased contact with a toxic substance. Mercury poisoning can be acute or chronic. In everyday life, most often find the second option.


2021 ◽  
Vol 8 (6) ◽  
pp. e1081
Author(s):  
Mai Yamakawa ◽  
Keenan O. Hogan ◽  
John Leever ◽  
Yasir N. Jassam

Background and ObjectivesTo describe the autopsy findings and neuropathologic evaluation of autoimmune meningoencephalomyelitis associated with glial fibrillary acidic protein (GFAP) antibody.MethodsWe reviewed the clinical course, imaging, laboratory, and autopsy findings of a patient with autoimmune meningoencephalomyelitis associated with GFAP antibody who had a refractory course to multiple immunosuppressive therapies.ResultsThe patient was a 70-year-old man who was diagnosed as GFAP antibody-associated autoimmune meningoencephalomyelitis. MRI of the head showed linear perivascular enhancement in the midbrain and the basal ganglia. Despite treatment with high-dose corticosteroids, plasma exchange, IV immunoglobulins, and cyclophosphamide, he died with devastating neurologic complications. Autopsy revealed a coexistent neuroendocrine tumor in the small intestine and diffuse inflammation in the brain parenchyma, perivascular spaces, and leptomeninges, with predominant T-cells, macrophages, and activated microglia. B-cells and plasma cells were absent. There was no astrocyte involvement with change in GFAP immunostaining.DiscussionThis case illustrates autoimmune meningoencephalomyelitis associated with GFAP antibody in the CSF and coexistent neuroendocrine tumor. The autopsy findings were nonspecific and did not demonstrate astrocyte involvement. Further accumulation of cases is warranted to delineate the utility and pathogenic significance of the GFAP autoantibody.


2021 ◽  
Author(s):  
H.M.K.K.M.B. Herath ◽  
W.R. de Mel

Abstract Today, millions of peoples are suffering due to the lack of a functional arm preventing from doing things. In Sri Lanka there are about over thousands of people are suffering from disabilities. Sri Lanka Ministry of Health state that the number of disabled persons in Sri Lanka will be increased by 24.2% by 2025. Most of them will suffer from hand disabilities. Disabling a hand costs huge disadvantages to a human being. Living without a hand will be a major problem for those who having hand disabilities. The aim of this project is to give a solution to those who suffer from hand disabilities and make their life efficient and easy. The biosignal-based controlling system is the next step in order to achieve more accuracy. Bio-signals are referring as the Electroencephalography (EEG), Electromyogram (EMG) and Electrocardiogram (ECG) signals. The robot hand motions and movements of the fingers will be completely dependent on the brainwaves which human beings will produce. This project mainly focused on Electroencephalography (EEG) signals also known as the brain waves. The methodology of this project is based on the field of robotics, artificial intelligence (AI), anatomy, neuroanatomy, and biosignal.


2017 ◽  
Vol 29 (5) ◽  
pp. 700-703 ◽  
Author(s):  
Ian K. Hawkins ◽  
Marcia Ilha ◽  
Eman Anis ◽  
Rebecca P. Wilkes

Listeriosis is a disease of humans and domestic mammals (mainly ruminants) with variable manifestations, primarily encephalitis, septicemia, and abortion. Although Listeria monocytogenes readily causes illness in ruminants, the prevalence among domestic South American camelids (llamas and alpacas) is low and has not been documented in their wild counterparts, the vicuna and guanaco. We describe herein the clinical signs, autopsy findings, and histopathology of septicemia and suppurative meningoencephalitis caused by L. monocytogenes in 2 neonatal llamas ( Llama glama) from the same herd. L. monocytogenes was isolated in pure culture and identified by real-time PCR on fresh and paraffin-embedded tissue samples of the brain from both crias. This presentation of septicemic listeriosis with meningoencephalitis in 2 animals from the same group is unusual, especially among llamas.


1988 ◽  
Vol 33 (7) ◽  
pp. 628-630 ◽  
Author(s):  
M. Fisman

Two cases are presented to illustrate some of the issues that arise in the management of patients diagnosed as suffering from the dementia syndrome of depression (Pseudodementia). Case 1 illustrates the dilemma of relatively normal autopsy findings in the brain in a patient presenting with a history of depression and dementia. Case 2 deals with a patient successfully treated for depression 14 years after the diagnosis of presenile dementia. Issues raised include the problem of labelling and the Rip Van Winkle situation of unanticipated recovery 14 years after this diagnosis was made. A planned approach to the treatment of pseudodementia systematically exploring available treatment options is recommended.


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