scholarly journals Endocrine disrupting chemicals: Impact on human health, wildlife and the environment

2019 ◽  
Vol 102 (1) ◽  
pp. 3-42 ◽  
Author(s):  
Telma Encarnação ◽  
Alberto ACC Pais ◽  
Maria G Campos ◽  
Hugh D Burrows
Keyword(s):  
Human Health ◽  
Polybrominated Diphenyl Ethers ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine System ◽  
World Health ◽  
Endocrine Society ◽  
Endocrine Disrupting ◽  
Health Organization ◽  
Household Cleaning Products

Endocrine disrupting chemicals are a group of pollutants that can affect the endocrine system and lead to diseases and dysfunctions across the lifespan of organisms. They are omnipresent. They are in the air we breathe, in the food we eat and in the water we drink. They can be found in our everyday lives through personal care products, household cleaning products, furniture and in children’s toys. Every year, hundreds of new chemicals are produced and released onto the market without being tested, and they reach our bodies through everyday products. Permanent exposure to those chemicals may intensify or even become the main cause for the development of diseases such as type 2 diabetes, obesity, cardiovascular diseases and certain types of cancer. In recent years, legislation and regulations have been implemented, which aim to control the release of potentially adverse endocrine disrupting chemicals, often invoking the precautionary principle. The objective of this review is to provide an overview of research on environmental aspects of endocrine disrupting chemicals and their effects on human health, based on evidence from animal and human studies. Emphasis is given to three ubiquitous and persistent groups of chemicals, polychlorinated biphenyls, polybrominated diphenyl ethers and organochlorine pesticides, and on two non-persistent, but ubiquitous, bisphenol A and phthalates. Some selected historical cases are also presented and successful cases of regulation and legislation described. These led to a decrease in exposure and consequent minimization of the effects of these compounds. Recommendations from experts on this field, World Health Organization, scientific reports and from the Endocrine Society are included.

scholarly journals Endocrine Disrupting Chemicals: Sources, Effects And Treatments

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Muhammad Aqeel Ashraf ◽  
Mesmire Wilson
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Endocrine System ◽  
Environmental Chemicals ◽  
United Nations Environment Programme ◽  
World Health ◽  
Hormonal Changes ◽  
Endocrine Society ◽  
Endocrine Disrupting ◽  
Health Organization ◽  
International Experts

AbstractHormonal changes in humans and animals can be attributed to endocrine disrupting chemicals (EDCs). Studies have found that excessive exposure to natural and artificial environmental chemicals and toxins can have adverse effects on the endocrine system and reproductive health. The endocrine system creates and releases hormones that regulate the development of organs and how they function. Any disruption to hormones affects the development and functioning of the reproductive system, the brain and the neurological system. Research and reports on the subject have been published by international experts and organizations including the World Health Organization (WHO), United Nations Environment Programme (UNEP), International Labour Organization (ILO) and Endocrine Society. To fully comprehend the effect of EDCs on humans and wildlife, it is essential to understand epigenetics and its transgenerational effects on hormone development. Here, we extensively explore and review the research on the sources of EDCs, their effects and why exposure to EDCs is of concern, and treatments for EDC exposure.

scholarly journals The Exposure of Fetuses and Children to Endocrine Disrupting Chemicals: A European Society for Paediatric Endocrinology (ESPE) and Pediatric Endocrine Society (PES) Call to Action Statement

2011 ◽  
Vol 96 (10) ◽  
pp. 3056-3058 ◽  
Author(s):  
Niels E. Skakkebaek ◽  
Jorma Toppari ◽  
Olle Söder ◽  
Catherine M. Gordon ◽  
Sara Divall ◽  
...  
Keyword(s):  
European Society ◽  
Endocrine Disrupting Chemicals ◽  
Clinical Work ◽  
Endocrine Disrupters ◽  
World Health ◽  
Endocrine Society ◽  
Paediatric Endocrinology ◽  
Endocrine Disrupting ◽  
Working Groups ◽  
Health Organization

Abstract Objective: During recent years, evidence has accumulated that both wildlife species and humans are exposed to ubiquitous endocrine-disrupting chemicals. Some are persistent in our bodies; others are nonpersistent but are produced in large quantities. Hitherto, the bulk of research in this area has been carried out by basic and experimental scientists and wildlife researchers. Relatively few clinical scientists have been engaged in research on this topic to date. The aim of this statement is to have pediatric endocrinologists consider the issue of endocrine disrupters in their clinical work and research. Participants: Six pediatric endocrinologists who belonged to working groups on endocrine disrupters endorsed by the European Society for Paediatric Endocrinology (ESPE) and the Pediatric Endocrine Society (PES) participated, including three members from each society. Meetings were limited to the members of the working groups. No funding was associated with the work. Evidence: Important data sources were publications from the World Health Organization, the European Science Foundation, and The Endocrine Society. Several of the participants have made long-standing contributions to the field of endocrine disruption. No unpublished work was considered. Consensus Process: The statement was written by the committee members together, using e-mail and phone. A draft was submitted to the Boards of the ESPE and PES. After some changes, the draft was accepted by both Boards. Conclusions: Pediatric endocrinologists are urged to be alert to the possible significance of endocrine-disrupting chemicals when assessing both clinical problems and research data where etiologies of endocrine symptoms or diseases are unknown.

Bioanalytical methodologies for clinical investigation of endocrine-disrupting chemicals: a comprehensive update

Bioanalysis ◽  
2021 ◽  
Author(s):  
Rajesh Pradhan ◽  
Siddhanth Hejmady ◽  
Rajeev Taliyan ◽  
Gautam Singhvi ◽  
Rajesh Khadgawat ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Human Health ◽  
Clinical Investigation ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine System ◽  
Detection Methods ◽  
Low Doses ◽  
In Vitro Bioassay ◽  
Endocrine Disrupting

Endocrine-disrupting chemicals (EDCs) are xenobiotics that disrupt the endocrine system in humans at ecologically significant concentrations. Various substances are exposed to human health via routes including food, water, air and skin that result in disastrous maladies at low doses as well. Therefore EDCs need a meticulous strategy of analysis for dependable and consistent monitoring in humans. The management and risk assessment necessitate advancements in the detection methodologies of EDCs. Hyphenated MS-based chromatograph and other validated laboratory analysis methods are widely available and employed. Besides, in vitro bioassay techniques and biosensors are also used to conduct accurate toxicological tests. This article provides a revision of various bioanalytical detection methods and technologies for the clinical estimation of EDCs.

scholarly journals Endocrine disrupting chemicals vs longevity in the COVID-19 era: Public health implications

2020 ◽  
Vol 61 (2) ◽  
pp. 83-87
Author(s):  
Evangelos Polychronopoulos ◽  
George Balias ◽  
Maria Skouroliakou ◽  
Chrysa Kapartziani ◽  
Paraskevi Kalofiri ◽  
...  
Keyword(s):  
Public Health ◽  
Flame Retardants ◽  
Endocrine Disrupting Chemicals ◽  
Normal Function ◽  
World Health ◽  
Global Public Health ◽  
Endocrine Disrupting ◽  
Health Circles ◽  
Polycyclic Aromatic ◽  
Health Organization

Endocrine disrupting chemicals (EDCs) are a controversial topic within scientific, regulatory, socio-economic, and public health circles. Nonetheless, every community's physical environment is currently under siege from various EDCs, many of which are still unknown. EDCs affect the normal function of the endocrine, neurological, and immune systems, consequently diminishing successful development, reproductive adulthood, and decreasing survival. Beyond any doubt, adverse effects of EDCs are a consequence of multiple everyday exposures to hundreds of chemicals in unknown environmental doses such as pesticides, insecticides, polycyclic aromatic hydrocarbons, dioxins, polychlorinated biphenyls, dichlorodiphenyltrichloroethane, brominated flame retardants, and parabens. Considering that thousands of other known endocrine disruptors fly under the radar of scientific and medical communities due to existing methodological pitfalls, the situation is quite precarious. In 2012, the World Health Organization published a report emphasizing that EDCs are a major and emerging global public health threat. The combined power of informed consumers, industry innovations, and government regulations is the driving force in this fight. Therefore, research advancements, public health infrastructure, and environmental protection agencies are the fundamental pillars in combating the ever-growing issue of EDCs.

scholarly journals Endocrine Disrupting Chemicals: Current Understanding, New Testing Strategies and Future Research Needs

2021 ◽  
Vol 22 (2) ◽  
pp. 933
Author(s):  
Maria E. Street ◽  
Karine Audouze ◽  
Juliette Legler ◽  
Hideko Sone ◽  
Paola Palanza
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Endocrine System ◽  
Current Understanding ◽  
Future Research ◽  
Developmental Origins ◽  
Research Needs ◽  
Important Class ◽  
Testing Strategies ◽  
Endocrine Disrupting ◽  
Health And Disease

Endocrine disrupting chemicals (EDCs) are exogenous chemicals which can disrupt any action of the endocrine system, and are an important class of substances which play a role in the Developmental Origins of Health and Disease (DOHaD) [...]

scholarly journals Epidemiological Approaches to the Effects of Endocrine Disrupting Chemicals on Human Health

2000 ◽  
Vol 21 (6) ◽  
pp. 361-367 ◽  
Author(s):  
MASAHARU YAMAMOTO ◽  
HIROTO NAKADAIRA ◽  
KAZUTOSHI NAKAMURA ◽  
KAZUO ENDOH
Keyword(s):  
Human Health ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine Disrupting

scholarly journals Assessment of quality of life in type 2 diabetes mellitus patients using World Health Organization quality of life-BREF questionnaire and appraisal of diabetes scale - a cross-sectional study

2021 ◽  
Vol 15 (3) ◽  
Author(s):  
Supriya Patil ◽  
Yamini Patil ◽  
Sanjay Kumar Patil
Keyword(s):  
Quality Of Life ◽  
Cross Sectional Study ◽  
World Health ◽  
Diabetic Patients ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Mean ◽  
Health Organization

Diabetes is a chronic metabolic disorder that disturbs the quality of life (QOL) of patients. Therefore, evaluation of diabetes- related QOL could be a key outcome measure for its management. This study assessed the QOL in type 2 diabetes mellitus (T2DM) patients using the World Health Organization (WHO) quality of life (QOL)˗BREF questionnaire and disease-specific appraisal of diabetes scale (ADS). In this cross-sectional study, 520 T2DM patients were included. Patients’ demographic data, clinical information was collected through interviews, and the WHOQOL-BREF instrument and ADS were used for the QOL of patients. Statistical analysis was performed by using R software (Version 3.6.0). The mean ADS scores were lower in controlled diabetic subjects (18.50±3.08) and higher in uncontrolled diabetic subjects (19.29±2.73) (P<0.05). For WHOQOL-BREF, the mean scores for all the domains (overall general health, physical, psychological, social, and environmental) were significantly higher in controlled diabetic subjects (P<0.001). In addition, the age, duration of diabetes, associated comorbidities, treatment, and HbA1c level of patients showed a highly significant correlation with WHOQOL-BREF (P<0.001). Diabetic patients had poor-to-average QOL. Therefore, public health measures and education of diabetic patients are essential to create more awareness for improving the QOL of T2DM.

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