Safety and Performance Evaluation of Su2ura Approximation, a New Suturing Device, in Pigs

2021 ◽  
pp. 019262332110679
Author(s):  
Yuval Ramot ◽  
Serge Rousselle ◽  
Michal Steiner ◽  
Yossi Lavie ◽  
Nati Ezov ◽  
...  
Keyword(s):  
Minimal Invasive Surgery ◽  
Minimal Invasive ◽  
Experimental Conditions ◽  
Single Action ◽  
Treatment Groups ◽  
Novel Device ◽  
Fibrotic Scar ◽  
And Performance ◽  
Tissue Approximation

One of the challenging aspects of minimal invasive surgery (MIS) is intracorporal suturing, which can be significantly time-consuming. Therefore, there is a rising need for devices that can facilitate the suturing procedure in MIS. Su2ura Approximation Device (Su2ura Approximation) is a novel device developed to utilize the insertion of anchors threaded with stitches to allow a single action placement of a suture. The objective of this study was to evaluate the long-term safety and tissue approximation of Su2ura Approximation in comparison to Endo Stitch + Surgidac sutures in female domestic pigs. All incision sites were successfully closed by both methods. Firm consolidation within and around the incision site was noted in several animals in both treatment groups, which corresponded histopathologically to islands of ectopic cartilage or bone spicules within the fibrotic scar. These changes reflect heterotopic ossification that is commonly seen in the healing of abdominal operation sites in pigs. No other abnormal findings were observed throughout the study period. In conclusion, the use of Su2ura Approximation under the present experimental conditions revealed no safety concerns.

scholarly journals Clinical outcomes of 154 hand-assisted laparoscopic surgeries for left sided colon and rectal cancer: single center experience

2013 ◽  
Vol 12 (3) ◽  
pp. 144-151
Author(s):  
Audrius Dulskas ◽  
Narimantas Evaldas Samalavičius ◽  
Rakesh Kumar Gupta ◽  
Darius Kazanavičius ◽  
Kęstutis Petrulis ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Laparoscopic Surgery ◽  
Laparoscopic Colectomy ◽  
Minimal Invasive Surgery ◽  
Minimal Invasive ◽  
Trocar Site ◽  
Colon And Rectal Cancer ◽  
Vilnius University ◽  
Colorectal Resections

Background / objectiveHALS technique has provided all the benefits of a minimal invasive surgery, is a safe and effective procedure. Our study was aimed to describe characteristics of patients admitted to Institute of Oncology, Vilnius University due to left sided colon and rectal cancer for hand-assisted laparoscopic surgery (HALS), colorectal resections performed, intraoperative, postoperative, incision and trocar site long-term clinical outcomes.Laparoscopic colectomy is avoided because of its technical difficulty, steep learning curve, and increased operative times. Hand-assisted laparoscopic colectomy is an alternative technique that addresses these problems while preserving the short-term benefits of laparoscopic colectomy. Our study was aimed to describe characteristics of patients admitted due to left sided colon and rectal cancer for hand-assisted laparoscopic surgery (HALS), colorectal resections performed, intraoperative, postoperative, incision and trocar site long-term clinical outcomes.MethodsA prospectively maintained database was used to identify all patients who underwent HALS for left sided colon and rectal cancer at the Institute of Oncology, Vilnius University, from July 1, 2009, when HALS using transumbilical handport incision was started, to October 1, 2013.Results154 HALS colorectal resections were performed. The patients’ mean age was 63±11 years. There were 79 male and 75 female patients. BMI was 27.3 ± 5.8 kg/m2. Forty-four patients (28.5%) have experienced a prior abdominal surgery. The mean HALS time is 105 minutes (55–185). Conversion rate was 3.2% (5/154). The average number of lymph nodes harvested was 15 (3–49). The median of return of gastrointestinal function was 2.5 days (2.2–4.5). The median length of hospital stay was 6.8days (3 – 31). Postoperative complication rate was 9.7%. Two patients (1.3%) demanded explorative laparotomy. Postoperative mortality rate was 0.65%. There were 4 (2.6%) incisional hernias seen on a mean follow-up of 7.0±3.4 months.ConclusionsHALS technique has provided all the benefits of a minimal invasive surgery. HALS colorectal resection is a safe and effective procedure.Keywords: Hand assisted laparoscopic surgery (HALS); Laparoscopic colectomy; Outcomes.Ranka asistuojamų 154 laparoskopinių kolektomijų dėl kairės pusės storosios ir tiesiosios žarnos vėžio rezultatai: vieno centro patirtis Įvadas/ tikslasHALS technika apima visus minimaliai invazyvios chirurgijos privalumus, yra saugi ir efektyvi. Šioje studijoje prospektyviai nagrinėjama pacientų, kuriems dėl kairės pusės storosios ar tiesiosios žarnos vėžio Vilniaus universiteto Onkologijos institutebuvo atlikta ranka asistuojama laparoskopinė kolektomija (HALS), demografiniai rodikliai, procedūros pobūdis, intraoperaciniai ir pooperaciniai duomenys. Pasaulyje kas dešimta kolektomija atliekama laparoskopiškai. Laparoskopija nėra dažna dėl techninių sunkumų, ilgos mokymosi kreivės, ilgesnės operacijos trukmės. Ranka asistuojama laparoskopinė kolektomija minėtų trūkumų neturi.Ligoniai ir metodaiProspektyviai buvo išanalizuotas 154 pacientas, kuriam 2009 07 01 – 2013 10 01 metais Vilniaus universiteto Onkologijos institute buvo atlikta HALS operacija dėl kairės pusės storosios ar tiesiosos žarnos vėžio.RezultataiAtlikta 154 HALS kolorektalinės rezekcijos. Pacientų amžius – 63±11 metai. Operuota 79 vyrai ir 75 moterys. KMI buvo 27,3 ± 5,8 kg/m2. 44 pacientams (28,6 %), anamnezės duomenimis, buvo atliktos pilvo operacijos. Vidutinė operacijos trukmė – 105 minutės (55–185). Konversijų dažnis – 3,2 % (5/154). Vidutinis pašalintų limfmazgių skaičius buvo 15 (3–49). Gastrointestinė funkcija atsitaisė per 2,5 dienos (2,2–4,5). Pooperacinio periodo trukmė – 6,8 dienos (3–31). 9,7 % atvejų pasitaikė komplikacijų. Dviem pacientams (1,3 %) atlikta relaparotomija. Pooperacinio mirtingumo dažnis buvo 0,65 %. Keturiems pacientams (2,6 %) diagnozuotos pooperacinės išvaržos (stebėjimo vidurkis 7,0±3,4 mėn.).IšvadosHALS technika apima visus minimaliai invazyvios chirurgijos privalumus, yra saugi ir efektyvi.Reikšminiai žodžiai: Ranka asistuojama laparoskopinė chirurgija (HALS), laparoskopinė kolektomija, baigtys.

Minimal invasive surgery for intracardiac tumors – report of 19 consecutive patients

2010 ◽  
Vol 58 (S 01) ◽  
Author(s):  
T Bossert ◽  
P Krieg ◽  
T Sandhaus ◽  
P Kley-Madaus ◽  
K Hekmat
Keyword(s):  
Invasive Surgery ◽  
Minimal Invasive Surgery ◽  
Minimal Invasive ◽  
Intracardiac Tumors

Relevance Predictability in Information Retrieval Systems

1967 ◽  
Vol 06 (02) ◽  
pp. 45-51 ◽  
Author(s):  
A. Kent ◽  
J. Belzer ◽  
M. Kuhfeerst ◽  
E. D. Dym ◽  
D. L. Shirey ◽  
...  
Keyword(s):  
Information Retrieval ◽  
Experimental Conditions ◽  
Treatment Groups ◽  
Retrieval Systems ◽  
Significant Difference ◽  
Information Retrieval Systems ◽  
High Predictability ◽  
Intermediate Response ◽  
Quantitative Indicators ◽  
Level Of Processing

An experiment is described which attempts to derive quantitative indicators regarding the potential relevance predictability of the intermediate stimuli used to represent documents in information retrieval systems. In effect, since the decision to peruse an entire document is often predicated upon the examination of one »level of processing« of the document (e.g., the citation and/or abstract), it became interesting to analyze the properties of what constitutes »relevance«. However, prior to such an analysis, an even more elementary step had to be made, namely, to determine what portions of a document should be examined.An evaluation of the ability of intermediate response products (IRPs), functioning as cues to the information content of full documents, to predict the relevance determination that would be subsequently made on these documents by motivated users of information retrieval systems, was made under controlled experimental conditions. The hypothesis that there might be other intermediate response products (selected extracts from the document, i.e., first paragraph, last paragraph, and the combination of first and last paragraph), that would be as representative of the full document as the traditional IRPs (citation and abstract) was tested systematically. The results showed that:1. there is no significant difference among the several IRP treatment groups on the number of cue evaluations of relevancy which match the subsequent user relevancy decision on the document;2. first and last paragraph combinations have consistently predicted relevancy to a higher degree than the other IRPs;3. abstracts were undistinguished as predictors; and4. the apparent high predictability rating for citations was not substantive.Some of these results are quite different than would be expected from previous work with unmotivated subjects.

STEREOTYPE THREAT AND STEREOTYPE LIFT: THE CASE OF 10 YEAR OLD GIRLS AND BOYS

2016 ◽  
Vol 12 (4) ◽  
pp. 21-32
Author(s):  
Anna Kwiatkowska ◽  
Małgorzata Mróz
Keyword(s):  
Stereotype Threat ◽  
Cognitive Performance ◽  
Significant Interaction ◽  
Self Esteem ◽  
The Self ◽  
Experimental Conditions ◽  
Significant Interaction Effect ◽  
Significant Drop ◽  
Stereotype Lift ◽  
And Performance

The aim of this study was to examine the effects of stereotypical and counter-stereotypicalinformation on the self-esteem and cognitive performance of 10-year-old children. Our sampleconsisted of 37 girls and 37 boys. Children were presented with 10 “mathematical” puzzles in threeexperimental conditions: stereotypical (boys are better), counter-stereotypical (girls are better), andthe control condition (no particular information). Self-esteem was measured using a non-verbaltask. The results showed a significant interaction effect of “condition x sex” on self-esteem andperformance. Girls revealed no significant differences between control and experimental conditions,while boys showed a significant drop in self-esteem and performance in the counter-stereotypicalcondition as compared to the control condition and a significant lift in self-esteem and performancein the stereotypical condition as compared to the control condition.

Design and planning of the balanced scorecard: A case study

2007 ◽  
Vol 26 (3) ◽  
pp. 217-227
Author(s):  
Ming-Hon Hwang ◽  
Hsin Rau
Keyword(s):  
Performance Evaluation ◽  
Balanced Scorecard ◽  
Process Management ◽  
Planning Process ◽  
Company Performance ◽  
Correct Process ◽  
The Balanced Scorecard ◽  
Strategy Planning ◽  
And Performance

In the industrial economy, evaluating company performance based on financial results was good enough. However, in the current globalized and highly competitive environment, maintaining long term competitiveness requires companies to engage in overall strategic planning and performance evaluation. The balanced scorecard is a tool or method for balancing an organization's performance and can react to situations where a company's direction becomes disoriented. This approach assists in strategy planning, process management, and performance evaluation from four perspectives, including financial, customer, internal process, and learning and growth. Good strategy planning provides companies with a correct management direction, correct process management ensures the efficient execution of plans, and correct performance evaluation illustrates the execution results. This study mainly focuses on how a large rubber company in Taiwan utilizes the balanced scorecard in its organization. As the technical perspective is important in the rubber keypad industry, besides the four above perspectives, this company has added the technical perspective. By introducing this company and its progress in implementing the balanced scorecard, this study hopes to provide other companies, especially rubber companies, with a planning direction and reference for the future implementation of the balanced scorecard.

Optimal adaptive inspection and maintenance for redundant systems

2021 ◽  
pp. 1748006X2110201
Author(s):  
Chaochao Lin ◽  
Matteo Pozzi
Keyword(s):  
Engineering Systems ◽  
Discounted Cost ◽  
Markov Decision ◽  
Inspection And Maintenance ◽  
And Performance ◽  
Partially Observable ◽  
Series Systems ◽  
Selection Of ◽  
Redundant Systems

Optimal exploration of engineering systems can be guided by the principle of Value of Information (VoI), which accounts for the topological important of components, their reliability and the management costs. For series systems, in most cases higher inspection priority should be given to unreliable components. For redundant systems such as parallel systems, analysis of one-shot decision problems shows that higher inspection priority should be given to more reliable components. This paper investigates the optimal exploration of redundant systems in long-term decision making with sequential inspection and repairing. When the expected, cumulated, discounted cost is considered, it may become more efficient to give higher inspection priority to less reliable components, in order to preserve system redundancy. To investigate this problem, we develop a Partially Observable Markov Decision Process (POMDP) framework for sequential inspection and maintenance of redundant systems, where the VoI analysis is embedded in the optimal selection of exploratory actions. We investigate the use of alternative approximate POMDP solvers for parallel and more general systems, compare their computation complexities and performance, and show how the inspection priorities depend on the economic discount factor, the degradation rate, the inspection precision, and the repair cost.

scholarly journals Rituximab-Containing Risk-Adapted Treatment Strategy in Nodular Lymphocyte Predominant Hodgkin Lymphoma: 7-Years Follow-Up

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1760
Author(s):  
Novella Pugliese ◽  
Marco Picardi ◽  
Roberta Della Pepa ◽  
Claudia Giordano ◽  
Francesco Muriano ◽  
...  
Keyword(s):  
Side Effects ◽  
Hodgkin Lymphoma ◽  
Prognostic Score ◽  
Single Agent ◽  
Response To Therapy ◽  
Baseline Risk ◽  
Historical Cohort ◽  
Treatment Groups

Background: Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare variant of HL that accounts for 5% of all HL cases. The expression of CD20 on neoplastic lymphocytes provides a suitable target for novel treatments based on Rituximab. Due to its rarity, consolidated and widely accepted treatment guidelines are still lacking for this disease. Methods: Between 1 December 2007 and 28 February 2018, sixteen consecutive newly diagnosed adult patients with NLPHL received Rituximab (induction ± maintenance)-based therapy, according to the baseline risk of German Hodgkin Study Group prognostic score system. The treatment efficacy and safety of the Rituximab-group were compared to those of a historical cohort of 12 patients with NLPHL who received Doxorubicin, Bleomycin, Vinblastine, Dacarbazine (ABVD) chemotherapy followed by radiotherapy (RT), if needed, according to a similar baseline risk. The primary outcome was progression-free survival (PFS) and secondary outcomes were overall survival (OS) and side-effects (according to the Common Terminology Criteria for Adverse Events, v4.03). Results: After a 7-year follow-up (range, 1–11 years), PFS was 100% for patients treated with the Rituximab-containing regimen versus 66% for patients of the historical cohort (p = 0.036). Four patients in the latter group showed insufficient response to therapy. The PFS for early favorable and early unfavorable NLPHLs was similar between treatment groups, while a better PFS was recorded for advanced-stages treated with the Rituximab-containing regimen. The OS was similar for the two treatment groups. Short- and long-term side-effects were more frequently observed in the historical cohort. Grade ≥3 neutropenia was more frequent in the historical cohort compared with the Rituximab-group (58.3% vs. 18.7%, respectively; p = 0.03). Long-term non-hematological toxicities were observed more frequently in the historical cohort. Conclusion: Our results confirm the value of Rituximab in NLPHL therapy and show that Rituximab (single-agent) induction and maintenance in a limited-stage, or Rituximab with ABVD only in the presence of risk factors, give excellent results while sparing cytotoxic agent- and/or RT-related damage. Furthermore, Rituximab inclusion in advanced-stage therapeutic strategy seems to improve PFS compared to conventional chemo-radiotherapy.

scholarly journals The long-term bio-behavioural effects of juvenile sildenafil treatment in Sprague-Dawley versus Flinders Sensitive Line rats

2021 ◽  
pp. 1-20
Author(s):  
Juandré Lambertus Bernardus Saayman ◽  
Stephanus Frederik Steyn ◽  
Christiaan Beyers Brink
Keyword(s):  
Sprague Dawley ◽  
Long Term Effects ◽  
Bdnf Level ◽  
Treatment Groups ◽  
Sd Rats ◽  
Behavioural Effects ◽  
Sensitive Line ◽  
Level Analysis ◽  
Flinders Sensitive Line

Abstract Objective: To investigate the long-term effects of juvenile sub-chronic sildenafil (SIL) treatment on the depressive-like behaviour and hippocampal brain-derived neurotrophic factor (BDNF) levels of adult Sprague-Dawley (SD) versus Flinders Sensitive Line (FSL) rats. Methods: SD and FSL rats were divided into pre-pubertal and pubertal groups, whereafter 14-day saline or SIL treatment was initiated. Pre-pubertal and pubertal rats were treated from postnatal day 21 (PND21) and PND35, respectively. The open field and forced swim tests (FST) were performed on PND60, followed by hippocampal BDNF level analysis one day later. Results: FSL rats displayed greater immobility in the FST compared to SD rats (p < 0.0001), which was reduced by SIL (p < 0.0001), regardless of treatment period. Hippocampal BDNF levels were unaltered by SIL in all treatment groups (p > 0.05). Conclusion: Juvenile sub-chronic SIL treatment reduces the risk of depressive-like behaviour manifesting during young adulthood in genetically susceptible rats.

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