The effects of glucose-free and glucose-containing dialysate during dialysis in MHD patients: a prospective cross-over study

Perfusion ◽  
2021 ◽  
pp. 026765912110427
Author(s):  
Minxia Li ◽  
Yuehong Li ◽  
Jiaxuan Lv ◽  
Huiying Xu ◽  
Xianglan Wu ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Free Group ◽  
Serum Sodium ◽  
Serum Sodium Level ◽  
Serum Glucose ◽  
Maintenance Hemodialysis ◽  
Control Methods ◽  
Lower Serum ◽  
Old Patients

Objective: To investigate the effects of glucose-free and glucose-containing dialysates during dialysis in maintenance hemodialysis (MHD) patients by the prospective cross-over study, and detect glucose control methods in MHD patients. Methods: A total of 66 MHD 18–75 years old patients in our hospital from Nov. 2019 to Mar. 2020 were recruited. All patients underwent HD with 4 hours per time, three times per week. Glucose-free dialysate (glucose-free group) and then 5.55 mmol/L glucose-containing dialysate (glucose-5.55 group) were used alternately in dialysis. The demographics and parameters of pre- and post-dialysis were recorded. Results: A total of 60 patients were analyzed, and 28 patients among them had type 2 diabetes. Serum glucose pre and post dialysis were 8.64 ± 4.18 mmol/L versus 5.74 ± 1.82 mmol/L (p < 0.01) in glucose-free dialysate, and 9.31 ± 4.89 mmol/L versus 7.80 ± 2.59 mmol/L (p < 0.01) in glucose-5.55 dialysate. The post-dialysis blood glucose of glucose-free group was lower than glucose-5.55 group (5.74 ± 1.82 vs 7.80 ± 2.59, p < 0.01). About 18 (30.00%) patients in glucose-free group and 1 patient (1.67%) in glucose-5.55 group whose blood glucose was lower than 4.44 mmol/L (p < 0.01). About 29 patients (48.33%) in glucose-free group and 17 patients (28.33%; p = 0.02) in glucose-5.55 group have hunger feeling. Serum sodium level in the glucose-free group was higher than that in Glucose-5.55 group (137.92 ± 1.64 vs 136.70 ± 1.64, p < 0.01). Post-dialysis blood glucose had no significant differences between patients not using diabetes-related medication (13 patients) and patients using diabetes-related medication (15 patients) in glucose-free group (7.13 ± 1.78 mmol/L vs 6.08 ± 2.84 mmol/L, p = 0.23) and glucose-5.55 group (9.22 ± 2.59 mmol/L vs 9.35 ± 2.88 mmol/L, p = 0.90). Conclusions: Glucose-free and glucose-5.55 dialysate both decrease the blood glucose post-dialysis. Dialysates containing 5.55 mmol/L glucose can reduce the incidence of hypoglycemia and lower serum sodium, but have no effect on blood pressure during dialysis. Stopping insulin and oral anti-diabetic drugs once before dialysis may not affect the control of blood glucose.

Effect of finger millet (Eleusine coracana) buns supplementation on serum glucose and serum lipids level in type 2 diabetics

2017 ◽  
Vol 36 (04) ◽  
Author(s):  
Neha Tiwari ◽  
D. M. Shere
Keyword(s):  
Blood Glucose ◽  
Finger Millet ◽  
Serum Glucose ◽  
Eleusine Coracana ◽  
Control Group ◽  
Serum Triglycerides ◽  
Type 2 Diabetics ◽  
Experimental Group

The present study was conducted to show the long term effect of low glycemic index (GI) finger millet (Eleusine coracana) buns (GI = 36.57) on diabetics. This case control clinical trial was conducted on 30 type 2 diabetic subjects who were equally divided into 2 groups: experimental group (EG) and control group (CG). The EG patients were supplemented with four (200 g) finger millet flour buns for 60 days in comparison to control group without having any buns supplementation. All the samples supplemented to experimental group provided 23-25g of total dietary fibre per day. The metabolic parameters studied were serum glucose, serum cholesterol, serum LDL, serum HDL, serum triglycerides and serum VLDL. Blood glucose levels (both fasting and post prandial) and lipid profile (at fasting) of the subjects were assessed at baseline and after 60 days of supplementation. Significant reduction was recorded in fasting blood glucose (13.75%), post prandial blood glucose (14.43%), serum cholesterol (4.41%) and serum LDL (11.22%) and also a decrease in serum triglycerides (5.11%) and VLDL (4.74%). Serum HDL increased significantly by 14.98 per cent. Thus, it is concluded that finger millet as a low GI food product leads to modest improvement in long-term glycemic and lipidemic control in type 2 diabetics.

scholarly journals Effectiveness of Solution-based Therapy on Self-Compassion and Reducing Blood Glucose in Elderly Patients with Type 2 Diabetes

2020 ◽  
pp. 158-164
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Elderly Patients ◽  
Control Group ◽  
Old Patients ◽  
Statistical Population ◽  
Self Compassion ◽  
Effect Of Treatment

Introduction and Objectives: One of the problems of diabetes in the elderly is the likelihood of another condition that makes it more difficult to control blood sugar. This study aimed to investigate the effectiveness of solution-based therapy on self-compassion and blood glucose reduction in elderly patients with type 2 diabetes. Materials and Methods: This quasi-experimental study was conducted based on a pretest-posttest design with a control group and follow-up. The statistical population of the study consisted of 60-75-year-old patients with type 2 diabetes referring to Iranian Diabetes Association treatment centers in Tehran, Iran. A total of 36 patients were selected and randomly assigned into two groups of experimental and control. The data were collected using a self-compassion questionnaire and glycated hemoglobin test (HbA1c). The HbA1c test was also administered two months after the end of the training to follow-up and evaluate the sustainability of the treatment effects. The data were analyzed in SPSS software (version 26) through repeated measure ANOVA. Results: The results showed that the solution-based therapy increased self-compassion in the posttest phase (P<0.01), and the effect of treatment was maintained after two months (P<0.01). Moreover, solution-based therapy reduced blood glucose levels in the posttest phase (P<0.01) and retained the effect of treatment after two months (P<0.01). Conclusion: It can be concluded that solution-based therapy has effects on self-compassion and hyperglycemia in elderly patients with type 2 diabetes; moreover, it can be used in treatment centers to improve the status of patients with diabetes.

scholarly journals Efficacy of the Hydroalcoholic Extract of Tribulus terrestris on the Serum Glucose and Lipid Profile of Women With Diabetes Mellitus

2016 ◽  
Vol 21 (4) ◽  
pp. NP91-NP97 ◽  
Author(s):  
Nasrin Babadaei Samani ◽  
Azam Jokar ◽  
Mahmood Soveid ◽  
Mojtaba Heydari ◽  
Seyed Hamdollah Mosavat
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Lipid Profile ◽  
Diabetes Mellitus Type 2 ◽  
Density Lipoprotein ◽  
Serum Glucose ◽  
Diabetes Mellitus Type ◽  
Tribulus Terrestris ◽  
Hydroalcoholic Extract

Aim. Considering traditional use of Tribulus terrestris in diabetes and proven antihyperglycemic and antihyperlipidemic effects of T terrestris in animal studies, we aimed to evaluate the efficacy of the hydroalcoholic extract of T terrestris on the serum glucose and lipid profile of women with non–insulin-dependent diabetes mellitus. Methods. Ninety-eight women with diabetes mellitus type 2 were randomly allocated to receive the T terrestris (1000 mg/d) or placebo for 3 months. The patients were evaluated in terms of the fasting blood glucose, 2-hour postprandial glucose, glycosylated hemoglobin, and lipid profile. Results. Tribulus terrestris showed a significant blood glucose–lowering effect in diabetic women compared to placebo ( P < .05). Also, the total cholesterol and low-density lipoprotein of T terrestris group was significantly reduced compared with placebo, while no significant effect was observed in the triglyceride and high-density lipoprotein levels. Conclusions. The study showed preliminary promising hypoglycemic effect of T terrestris in women with diabetes mellitus type 2.

scholarly journals Association between lower serum sodium levels and clinical outcomes in insomnia patients

2020 ◽  
Author(s):  
Eunjin Bae ◽  
Tae Won Lee ◽  
Ha Nee Jang ◽  
Hyun Seop Cho ◽  
Se-Ho Chang ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Serum Sodium ◽  
Sodium Level ◽  
Serum Sodium Level ◽  
Kidney Injury ◽  
Chronic Respiratory Disease ◽  
Lower Serum ◽  
Risk Of Death ◽  
Kaplan Meier ◽  
Calcium Phosphorus

Abstract Background The association of lower serum sodium levels with clinical outcomes in insomnia patients remains unclear. We explored whether lower serum sodium is associated with poor clinical outcomes in patients with insomnia. Methods We retrospectively enrolled patients with a diagnosis of insomnia from January 2011 to December 2012. We divided participants into three groups according to initial serum sodium level: tertile 1 (< 138 mmol/L), tertile 2 (138.0–140.9 mmol/L), and tertile 3 (≥ 141.0 mmol/L). To calculate the relative risk of death, hazard ratios (HRs) and 95% confidence intervals (CIs) were obtained using Cox proportional hazard models. Result A total of 412 patients with insomnia were included, of whom 13.6% (n = 56) had hyponatremia. Patients with lower serum sodium concentrations were older and had lower hemoglobin, calcium, phosphorus, and albumin levels. At the median follow-up of 49.4 months, 44 patients had died and 62 experienced acute kidney injury (AKI). Kaplan-Meier analysis showed significantly higher mortality in patients in the lowest tertile for serum sodium. Lowest tertile of serum sodium, AKI, and chronic respiratory disease were associated with all-cause mortality. In addition, lowest tertile of serum sodium was also significantly associated with AKI. Conclusions The lowest tertile of serum sodium was associated with a higher mortality and AKI rate in insomnia patients. Our results suggest serum sodium level could be used one of the prognostic factor in insomniacs and physicians should be careful to take care of them when they present lower sodium level.

scholarly journals Lower serum sodium level predicts poor clinical outcomes in patients with insomnia

2020 ◽  
Author(s):  
Eunjin Bae ◽  
Tae Won Lee ◽  
Ha Nee Jang ◽  
Hyun Seop Cho ◽  
Sehyun Jung ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Serum Sodium ◽  
Sodium Level ◽  
Serum Sodium Level ◽  
Kidney Injury ◽  
Lower Serum ◽  
Risk Of Death ◽  
Kaplan Meier ◽  
Hazard Ratios ◽  
Calcium Phosphorus

Abstract Background The association of lower serum sodium levels with clinical outcomes in insomnia patients remains unclear. We explored whether lower serum sodium is associated with poor clinical outcomes in patients with insomnia. Methods We retrospectively enrolled patients with a diagnosis of insomnia from January 2011 to December 2012. We divided participants into three groups according to initial serum sodium level: tertile 1 (< 138 mmol/L), tertile 2 (138.0–140.9 mmol/L), and tertile 3 (≥ 141.0 mmol/L). To calculate the relative risk of death, hazard ratios (HRs) and 95% confidence intervals (CIs) were obtained using Cox proportional hazard models. Result A total of 412 patients with insomnia were included, of whom 13.6% (n = 56) had hyponatremia. Patients with lower serum sodium concentrations were older and had lower hemoglobin, calcium, phosphorus, and albumin levels. At the median follow-up of 49.4 months, 44 patients had died and 62 experienced acute kidney injury (AKI). Kaplan-Meier analysis showed significantly higher mortality in patients in the lowest tertile for serum sodium. Lowest tertile of serum sodium, and AKI were associated with all-cause mortality. However, lowest tertile of serum sodium was not significantly associated with AKI. Conclusions The lowest tertile of serum sodium was associated with a higher mortality rate in insomnia patients. Our results suggest serum sodium level could be used one of the prognostic factor in insomniacs and physicians should be careful to take care of them when they present lower sodium level.

scholarly journals A non-invasive method to estimate glucose levels in salivary secretions of diabetic patients

2019 ◽  
Vol 8 (1) ◽  
pp. 60
Author(s):  
Pramod Kumar Reddy Peddi ◽  
Chandra Babu Singanamala ◽  
Cheemalavagupalli Mounija
Keyword(s):  
Blood Glucose ◽  
Serum Glucose ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Glucose Levels ◽  
Oral Rinse ◽  
Non Invasive ◽  
Blood Glucose Levels ◽  
Type 2 Diabetic

Background: Aim of the study is to correlate between blood glucose levels and salivary glucose levels in type 2 diabetic patients, to study the relationship between salivary glucose levels and serum glucose levels in type 2 diabetic patients and to determine whether salivary glucose levels could be used as a non-invasive tool for the measurement of glycemic control in type 2 diabetics. This requirement of multiple pricking at regular intervals for monitoring serum glucose levels in the body is physically and psychologically traumatic to the patient. This necessitates a non-invasive procedure like salivary glucose estimation.Methods: The study population consisted of two groups: Group 1 consisted of 20 controlled diabetics and Group 2 consisted of 20 diabetics based on their random blood and salivary glucose levels. Two milliliters of peripheral blood were collected for the estimation of random blood glucose levels. Unstimulated saliva was collected by the oral rinse technique for the estimation of salivary glucose.Results: ANOVA single factor and Pearson correlation coefficient was carried out to know the statistical significance between the two groups. The salivary glucose levels were significantly higher in controlled and when compared with the diabetics. The salivary glucose levels showed a significant correlation with blood glucose levels, suggesting that salivary glucose levels can be used as a monitoring tool for predicting glycemic in diabetic patients.Conclusions: The present study found that estimation of salivary glucose levels can be used as a non-invasive, painless technique for the measurement of diabetic status of a patient in a dental set up.

The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes

2015 ◽  
Vol 12 (2) ◽  
Author(s):  
Farzad Shidfar ◽  
Asadollah Rajab ◽  
Tayebeh Rahideh ◽  
Nafiseh Khandouzi ◽  
Sharieh Hosseini ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Zingiber Officinale ◽  
Serum Glucose ◽  
Double Blind ◽  
Old Patients ◽  
Reactive Protein ◽  
Total Antioxidant ◽  
Glycemic Indices ◽  
Serum Paraoxonase

Abstract: Ginger (: A double-blind, placebo-controlled, randomized clinical trial was conducted on 20–60 -year-old patients with type 2 diabetes who did not receive insulin. Participants in the intervention and control groups were received 3 g of powdered ginger or placebo (lactose) (in capsules) daily for 3 months. Glycemic indices, total antioxidant capacity (TAC), malondialdehyde (MDA), C-reactive protein (CRP), serum paraoxonase, dietary intake and physical activity were measured at the beginning and end of the study, and after 12 h fasting.: Comparison of the indices after 3 months showed that the differences between the ginger and placebo groups were statistically significant as follows: serum glucose (–19.41±18.83 vs. 1.63±4.28 mg/dL, p<0.001), HbA: This report shows that the 3 months supplementation of ginger improved glycemic indices, TAC and PON-1 activity in patients with type 2 diabetes.

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