Effect of finger millet (Eleusine coracana) buns supplementation on serum glucose and serum lipids level in type 2 diabetics

2017 ◽  
Vol 36 (04) ◽  
Author(s):  
Neha Tiwari ◽  
D. M. Shere
Keyword(s):  
Blood Glucose ◽  
Finger Millet ◽  
Serum Glucose ◽  
Eleusine Coracana ◽  
Control Group ◽  
Serum Triglycerides ◽  
Type 2 Diabetics ◽  
Experimental Group

The present study was conducted to show the long term effect of low glycemic index (GI) finger millet (Eleusine coracana) buns (GI = 36.57) on diabetics. This case control clinical trial was conducted on 30 type 2 diabetic subjects who were equally divided into 2 groups: experimental group (EG) and control group (CG). The EG patients were supplemented with four (200 g) finger millet flour buns for 60 days in comparison to control group without having any buns supplementation. All the samples supplemented to experimental group provided 23-25g of total dietary fibre per day. The metabolic parameters studied were serum glucose, serum cholesterol, serum LDL, serum HDL, serum triglycerides and serum VLDL. Blood glucose levels (both fasting and post prandial) and lipid profile (at fasting) of the subjects were assessed at baseline and after 60 days of supplementation. Significant reduction was recorded in fasting blood glucose (13.75%), post prandial blood glucose (14.43%), serum cholesterol (4.41%) and serum LDL (11.22%) and also a decrease in serum triglycerides (5.11%) and VLDL (4.74%). Serum HDL increased significantly by 14.98 per cent. Thus, it is concluded that finger millet as a low GI food product leads to modest improvement in long-term glycemic and lipidemic control in type 2 diabetics.

scholarly journals Effects of Fasting-Mimicking Diet and Specific Meal Replacement Foods on Blood Glucose Control in Patients with Type 2 Diabetes: A Randomized Controlled Trial

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Fang Tang ◽  
Xuan Lin
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Venous Blood ◽  
Fasting Blood Glucose ◽  
Blood Glucose Control ◽  
Density Lipoprotein ◽  
Control Group ◽  
Meal Replacement ◽  
Experimental Group

Type 2 diabetes represents a serious societal health problem due to the vulnerability to cardiovascular events. Diet therapy is the most basic treatment for type 2 diabetes. The present study was conducted to study the effect of a fasting-mimicking diet and specific meal replacement foods on blood glucose control in patients with type 2 diabetes. Our study included 100 patients with type 2 diabetes who underwent a physical examination which were enrolled and randomly assigned as 50 patients each to the test group (with low energy-specific meal replacement meals during a fasting-mimicking diet) and the control group (with specific meal replacement foods given normal adult doses). After 4 months, efficacy indicators which were fasting blood glucose, 2-hour postprandial venous blood glucose, and glycosylated haemoglobin of the experimental group were all lower than those of the control group ( P < 0.05 ); observation indicators that include body mass index, waist circumference, blood lipids (triglyceride, cholesterol, and low-density lipoprotein), and blood pressure levels were all lower than the control group, and high-density lipoprotein levels were all higher than the control group (all P < 0.05 ). Both groups of fasting blood glucose, 2-hour postprandial venous blood glucose, and blood pressure had a relatively stable downward trend, but the experimental group had a more significant decline. In conclusion, the study revealed that a fasting-mimicking diet and specific meal replacement foods can safely and effectively reduce weight and improve metabolic syndrome in patients with type 2 diabetes.

Manufacture of the Functional Noodle and its Effects on Postprandial 2h-blood Glucose and Serum Lipid Levels of Subjects with IGT

2020 ◽  
Vol 16 (4) ◽  
pp. 625-630
Author(s):  
Yong-Taek Kim ◽  
Zong-Do Jo ◽  
Hung-Mun Pang ◽  
Chan-Ok Paek ◽  
Chang-Sok Mun
Keyword(s):  
Blood Glucose ◽  
Control Group ◽  
Mixing Ratios ◽  
Group 4 ◽  
Ancient Times ◽  
And Control ◽  
Experimental Group ◽  
Optimal Mixing ◽  
Made In

Background: The earliest determinant of progression to type 2 diabetes is a loss of early insulin secretion, a defect which results in postprandial hyperglycemia and is often believed to reflect insulin resistance. In Asian countries including our country, noodle is the traditional food which has been eaten from ancient times and is taken one or two times a day. The functional noodle is a staple meeting nutritional requirements for the prevention and treatment of Impaired Glucose Tolerance (IGT). Methods: FNs were prepared using the noodle making machine according to Barak et al. with slight modifications. After giving FNs prepared by three mixing ratios of main materials to the IGT-induced rats for 30 days, the levels of postprandial 2h-blood glucose in all experimental groups and control group were measured to determinate the optimal mixing ratio of FN. After the IGT subjects in experimental group ate 200g of FN (dried weight) in exchange for a lunch for 60 days, the levels of postprandial 2h-blood glucose and of TG and TC in serum were measured to compare with that in the control group who had not undergone control in their diet. Results: After 30 days of experiment, the levels of postprandial 2h-blood glucose in rats of pl group 4 were lowest. The levels of postprandial 2h-blood glucose in the control group that most of them had not undergone control in their diet were increased, but that in experimental group who had taken FN decreased from 30 days of experiment to be significantly different after 60 days. The concentrations of serum TC and TG of IGT subjects in the experimental group were decreased compared with that in the control group, but significance among two groups was achieved only in the concentration of serum TC. Conclusion: FN made in the 4:3:3 ratio of powder of corn, powder of bean cake defatted and powder of peeled whole potato is more effective to decrease the levels of postprandial 2h-blood glucose. FN is a staple type of functional food that could be used for the treatment of IGT.

scholarly journals The Effect of Periodic Ketogenic Diet on Newly Diagnosed Overweight or Obese Patients with Type 2 Diabetes

2020 ◽  
Author(s):  
Sumei Li ◽  
Guoxin Lin ◽  
Jinxing Chen ◽  
Zhenxin Chen ◽  
Feipeng Xu ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Ketogenic Diet ◽  
Blood Lipid ◽  
Diet Group ◽  
Control Group ◽  
Obese Patients ◽  
Newly Diagnosed ◽  
Diet Control

Abstract BackgroundTo observe the effect of periodic ketogenic diet intervention on newly diagnosed overweight or obese patients with type 2 diabetes.Methods60 overweight or obese T2DM patients were randomly divided into ketogenic diet group and diabetes diet control group, 30 patients in each group. The changes and significance of blood glucose, blood lipid, body weight, insulin, uric acid and other indicators before and after the intervention were observed.ResultsThe Weight, BMI, Waist, TG, TC, LDL, HDL, FBG, FINS, HbA1c of the two groups decreased significantly compared with the previous period (P < 0.05). However, UA showed an increasing trend in the ketogenic diet group and no significant change in UA in the diabetic diet control group (P > 0.05). Long-term adherence to the ketogenic diet was not as strong as that of the diabetic diet.ConclusionThe phased-ketogenic diet can control not only weight but also blood glucose and blood lipid in patients with overweight or obese T2DM. But long-term persistence is difficult.

THE EFFECT OF EXERCISE CONSULTATION PROGRAM ON EXERCISE BEHAVIORAL CHANGES IN PATIENTS OF TYPE 2 DM WITH OVERWEIGHT : TRANSTHEORETICAL MODEL APPROACH

2016 ◽  
Vol 1 (1) ◽  
pp. 24
Author(s):  
Rinco Siregar ◽  
Karnirius Harefa ◽  
Eva Kartika Hasibuan
Keyword(s):  
Experimental Study ◽  
Blood Glucose ◽  
Transtheoretical Model ◽  
Behavioral Changes ◽  
Control Group ◽  
Chi Square ◽  
Significant Difference ◽  
Quasi Experimental ◽  
Experimental Group

The purpose of this quasi- experimental study was to determine the effect of exercise consultation program based on Transtheoretical Model (TTM) approach on exercise behavioral change, blood glucose and body mass index (BMI)  in patients of T2DM with overweight. The two comparison groups, quasi-experimental study were purposively designed for pre-test/post-test procedures; 61 patients of T2DM allocated into the experimental (31 patients) and the control (30 patients) groups. While the experimental group received the exercise consultation for 12 weeks, the control group received routine care. Comparative assessments on differences in exercise behavioral changes, blood glucose and BMI were examined both within and between groups using Chi-Square test and t-test. After receiving exercise consultation program, 54.8 % of participants of the experimental group had progressed to the action stage of change of TTM, while the majority of the participants in the control group (43.3%) remained in the same stages of TTM, and only 3.3 % of the participants had progressed to the maintenance stage. This proportion of exercise behavior change between the groups was significantly statistical different (Chi-Square = 000, p <0.05). Blood glucose significantly decreased in the experimental group (p < .05), but there was no significant difference in the control group.No significant difference of mean scores of BMI of participants between the experimental group and the control group post-intervention of exercise consultation program (p > .05). In conclusion, the exercise consultation program could promote the exercise behaviors. This also improves health outcome on blood glucose among patients of T2DM who.Keywords: transtheoretical model; physical exercise; type 2 diabetes

scholarly journals Individualized Meal Replacement Therapy Improves Clinically Relevant Long-Term Glycemic Control in Poorly Controlled Type 2 Diabetes Patients

Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1022 ◽  
Author(s):  
Kerstin Kempf ◽  
Martin Röhling ◽  
Katja Niedermeier ◽  
Babette Gärtner ◽  
Stephan Martin
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Glycemic Control ◽  
Control Group ◽  
Meal Replacement ◽  
Low Carbohydrate ◽  
Meal Replacements

Background Formula diets can improve glycemic control or can even induce remission in type 2 diabetes. We hypothesized that especially an individualized intense meal replacement by a low-carbohydrate formula diet with accompanied self-monitoring of blood glucose (SMBG) contributes to long-term improvements in HbA1c, weight, and cardiometabolic risk factors in poorly controlled type 2 diabetes. Methods Type 2 diabetes patients were randomized into either a moderate group (M-group) with two meal replacements/day (n = 160) or a stringent group (S-group) with three meal replacements/day (n = 149) during the first week of intervention (1300–1500 kcal/day). Subsequently, both groups reintroduced a low-carbohydrate lunch based on individual adaption due to SMBG in weeks 2–4. After week 4, breakfast was reintroduced until week 12. During the follow-up period, all of the participants were asked to continue replacing one meal per day until the 52-weeks follow-up. Additionally, an observational control group (n = 100) remained in routine care. Parameters were compared at baseline, after 12 and 52 weeks within and between all of the groups. Results 321 participants (83%) completed the acute meal replacement phase after 12 weeks and 279 participants (72%) the whole intervention after 52 weeks. Both intervention groups achieved improvements in HbA1c, fasting blood glucose, blood pressure, and weight (all p < 0.001) within 12 weeks. However, these results were not significantly different between both of the intervention groups. The estimated treatment difference in HbA1c reduction was (mean (95% confidence interval [CI]) -0.10% with 95% CI [−0.40; 0.21] also (p > 0.05) (S-group vs. M-group) not statistically different after 12 weeks. However, only the S-group showed a clinically relevant improvement in HbA1c of −0.81% [−1.06; −0.55] (p < 0.001) after 52 weeks of follow-up, whereas HbA1c was not statistically different between the M- and control group. Conclusion Individualized meal replacement with SMBG demonstrated beneficial effects on HbA1c and cardiometabolic parameters in type 2 diabetes. Furthermore, the initiation of a weight loss program with one week of full meal replacement (three meals per day) resulted in a clinically relevant long-term HbA1c reduction, as compared to an observational control group that had standard care.

scholarly journals EFFECT OF SGLT-2 INHIBITOR ON BONE TURNOVER IN OVERWEIGHT AND OBESE PATIENTS WITH TYPE 2 DIABETES

2021 ◽  
Author(s):  
WEN-TAO LV ◽  
QIU-MEI ZHANG ◽  
XIANG-WEN MENG
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Bone Turnover ◽  
Hypoglycemic Agents ◽  
Control Group ◽  
Obese Patients ◽  
Oral Hypoglycemic Agents ◽  
Significant Difference ◽  
Experimental Group

To investigate the effect of sodium glucose cotransporter 2 inhibitor (SGLT-2I) on bone turnover markers in overweight and obese patients with type 2 diabetes mellitus. Methods: according to the criteria of selection and exclusion, 42 patients with overweight and obese type 2 diabetes (BMI≥25kg/m2) were selected from October 2019 to May 2020. The patients were randomly divided into experimental group and control group, there were 18 cases in the experimental group and 24 cases in the control group. The experimental group was treated with SGLT-2I, and other oral hypoglycemic agents (or insulin) were added according to the blood glucose situation. The control group received oral hypoglycemic agents (non-SGLT-2I) and/or insulin and/or glucagon-like peptide-1 receptor agonist (GLP-1 RA). Every 28 days of follow-up, medication regimen was adjusted according to blood glucose and adverse reactions of patients. Fasting venous serum of the patients was collected at the beginning and again 24 weeks later and the levels of PINP and β-CTX were detected uniformly. SPSS 21.0 was used to compare the changes of clinical indexes before and after the treatment. Results: 1. In the experimental group, PINP, HbA1c, FPG and BMI decreased (p<0.05). 2. In the control group, HbA1c, FPG and PINP decreased (p<0.05). 3. Comparison between groups after 24 weeks of treatment: there was significant difference in BMI (p<0.05).

scholarly journals Study on Correlations Between Glycated Haemoglobin, Lipid Profiles and Blood Glucose Levels in Type 2 Diabetics Living at Moderate High Altitude

2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Rajashekar Rao B ◽  
Parineetha PB ◽  
Venkata Raman Vc
Keyword(s):  
Blood Glucose ◽  
Glycated Haemoglobin ◽  
Postprandial Glucose ◽  
Lipid Profiles ◽  
Atherogenic Index ◽  
Control Group ◽  
Glucose Levels ◽  
Group I ◽  
Type 2 Diabetics

Introduction: The study was conducted to look for the effects of polycythaemia on Glycosylated Haemoglobin (GHb) levels and to the see the correlations between the levels of haemoglobin, GHb, blood glucose, and lipid profiles including Atherogenic Index of plasma (AIP), in type 2 diabetics living 5800ft above sea level at Gangtok in Sikkim, India. GHb is used to predict the risk of long term complications of Diabetes mellitus (DM) like coronary artery disease (CAD). Materials and Methods: The study group consisted of Group I (Type 2 DM male patients with PPG levels 200mg/ dl) and age matched healthy males formed the control group. Results: In Group I, GHb levels correlated positively with AIP, but not with TC/HDL-C ratio. In Group II, both PPG and GHb levels correlated positively with Total cholesterol (TC), LDL Cholesterol, TC /HDL-C ratio and AIP. This shows that higher PPG levels are associated with more Atherogenic lipid profiles. Study also showed higher GHb levels in controls at 7.61%, and correlated positively with postprandial glucose (PPG) levels (r = 0.92). Conclusion: In predicting risk for future CAD, PPG levels and AIP can be used as an adjunct parameter.

scholarly journals Observation of Efficacy of Internet-Based Chronic Disease Management Model Combined with Modified Therapy of Bushenyiliu Decoction in Treating Patients with Type 2 Diabetes Mellitus and Prostate Cancer and Its Effect on Disease Control Rate

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Yi Wang ◽  
Ankang Yin ◽  
Tingting Bian ◽  
Xiangyu Zhao ◽  
Shijun Zheng ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Chronic Disease ◽  
Disease Management ◽  
Chronic Disease Management ◽  
Management Model ◽  
Control Group ◽  
Experimental Group

Objective. To explore the efficacy of Internet-based chronic disease management model combined with the modified therapy of Bushenyiliu decoction in treating patients with type 2 diabetes mellitus (T2DM) and prostate cancer and its effect on disease control rate (DCR). Methods. 120 patients with T2DM and prostate cancer admitted to the Affiliated Hospital of Yangzhou University, Yangzhou First People’s Hospital, from February 2019 to February 2020, were retrospectively analyzed and equally divided into the experimental group and the control group according to their admission order. Conventional treatment combined with the modified therapy of Bushenyiliu decoction was performed on all patients for 3 months, and the Internet-based chronic disease management model was adopted for patients in the experimental group additionally, so as to compare their short-term effect, survival time, disease progression, blood glucose indicators, immune function indicators, and type 2 Diabetes Self-Care Scale (2-DSCS) scores. Results. Compared with the control group, the experimental group obtained significantly higher DCR and objective remission rate (ORR) ( P < 0.05 ), higher survival time and disease progression ( P < 0.001 ), better blood glucose indicators and immune function indicators ( P < 0.001 ), and higher 2-DSCS scores ( P < 0.001 ) after treatment. Conclusion. Combining the Internet-based chronic disease management model with the modified therapy of Bushenyiliu decoction can effectively enhance the self-care ability of patients with T2DM and prostate cancer, improve their blood glucose level, promote their body immunity, and comprehensively optimize the cancer control effect, which should be promoted in practice.

scholarly journals Long-term effects of daily postprandial physical activity on blood glucose: a randomized controlled trial

2017 ◽  
Vol 42 (4) ◽  
pp. 430-437
Author(s):  
Håvard Nygaard ◽  
Eirik Grindaker ◽  
Bent Ronny Rønnestad ◽  
Gerd Holmboe-Ottesen ◽  
Arne Torbjørn Høstmark
Keyword(s):  
Physical Activity ◽  
Blood Glucose ◽  
High Risk ◽  
Controlled Trial ◽  
Intervention Group ◽  
Control Group ◽  
Long Term Effects ◽  
Post Test

Previous studies have shown that a bout of moderate or light postprandial physical activity effectively blunts the postprandial increase in blood glucose. The objective of this study was to test whether regular light postprandial physical activity can improve glycemia in persons with hyperglycemia or with a high risk of hyperglycemia. We randomized 56 participants to an intervention or a control group. They were diagnosed as hyperglycemic, not using antidiabetics, or were categorized as high-risk individuals for type 2 diabetes. The intervention group was instructed to undertake a minimum 30 min of daily light physical activity, starting a maximum of 30 min after a meal in addition to their usual physical activity for 12 weeks. The control group maintained their usual lifestyle. Blood samples were taken pre- and post-test. Forty participants completed the study and are included in the results. The self-reported increase in daily physical activity from before to within the study period was higher in the intervention group compared with control (41 ± 25 vs. 2 ± 16 min, p < 0.001). Activity diaries and accelerometer recordings supported this observation. The activity in the intervention group started earlier after the last meal compared with control (30 ± 13 vs. 100 ± 57 min, p = 0.001). There were no within- or between-group differences in any glycemic variable from pre- to post-test. In conclusion, the present study does not seem to support the notion that regular light postprandial physical activity improves blood glucose in the long term in persons with hyperglycemia or with high risk of hyperglycemia.

scholarly journals Evaluation of Jinlida Granules in Improvements to Standard-Reaching Rate of Blood Glucose and Type 2 Diabetes Mellitus Symptoms: Results of Secondary Analysis From 12-Week Trial

2021 ◽  
Author(s):  
De Jin ◽  
Yuqing Zhang ◽  
Yingying Duan ◽  
Xudong An ◽  
Xiaomin Kang ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Treatment Group ◽  
Clinical Symptoms ◽  
Secondary Analysis ◽  
Dry Mouth ◽  
Symptom Improvement ◽  
Control Group ◽  
Improvement Rate ◽  
Type 2 Diabetics

Abstract Background The previous study found that the Jinlida could significantly reduce levels of blood glucose and enhance the lowing-glucose action of metformin. However, the role of the standard-reaching rate of blood glucose and improving clinical symptoms in Jinlida has yet to be studied. We aimed to elaborate on the efficacy of Jinlida in Type 2 diabetics who experience clinical symptoms based on secondary analysis from the 12-week trial. Methods Data were analyzed from a 12-week, randomized, placebo-controlled, study of Jinlida. The standard-reaching rate of blood glucose, total symptom score, the efficacy of single symptom, symptom disappearance rate, symptom improvement rate was evaluated. Then, the correlation of the symptom effective rate and HbA1c was analyzed. Results 192 T2DM patients were randomly allocated to receive either Jinlida or a placebo for 12 consecutive weeks. The standard-reaching rate of HbA1c (<6.5%) was 25% in the treatment group when compared to 14.9% in the control group. (P=0.046); All the symptom exhibited a change difference, comparing the treatment group to the control group after 12 weeks’ intervention. (P< 0.05); Hunger, polyuria, dry mouth, sweating and dysphoria in chestpalms-soles symptoms exhibited a change difference in the treatment group, compared to that in the control group. (P<0.05). All the symptom exhibited a significant difference in symptom improvement rate. (P<0.05). Conclusions Jinlida glandule can effectively improve clinical symptoms of type 2 diabetics including thirsty, fatigue, hunger, polyuria, dry mouth, night-sweat, dysphoria in chenstplms-soles and constipation. It can be used as an effective adjuvant treatment for T2DM who experience those symptoms. However, these findings need to be further confirmed by evidence-based medicine.

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