scholarly journals New local treatment for photoaging using a formulation containing piroxicam 0.8% and sunscreen

2019 ◽  
Vol 47 (7) ◽  
pp. 3127-3132
Author(s):  
Mauro Mazzeo ◽  
Laura Diluvio ◽  
Monia Di Prete ◽  
Sara Mazzilli ◽  
Virginia Garofalo ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Dna Damage ◽  
Adverse Effects ◽  
Local Treatment ◽  
Skin Aging ◽  
Reliable Effect ◽  
Complex Process ◽  
New Formulation ◽  
Effective Use ◽  
Skin Quality

Objective Skin aging is a complex process influenced by several factors that cause DNA damage and alter the extracellular matrix. The anti-inflammatory drug piroxicam can counteract photocarcinogenesis and photoaging by blocking cyclooxygenases-1 and 2, matrix metalloproteinases, and ornithine decarboxylase, and inducing apoptosis. Methods We conducted an open observational study in 50 adults with moderate to severe signs of photoaging treated with a new local formulation of piroxicam 0.8% plus sunscreen for 16 weeks. Photoaging was assessed using a validated dermoscopic photoaging scale. Each patient’s own perception of their skin quality was assessed using a graphic scale. Results The new formulation demonstrated a reliable effect on photoaging after 16 weeks, based on improved median dermoscopic photoaging and skin-quality scores. No patients experienced any adverse effects. Conclusions To the best of our knowledge, this study provides the first evidence for the safe and effective use of a local piroxicam formulation for the treatment of moderate to severe photoaging.

Potential adverse effects of prophylactic bilateral salpingo-oophorectomy on skin aging in premenopausal women undergoing hysterectomy for benign conditions

2016 ◽  
Vol 23 (2) ◽  
pp. 138-142 ◽  
Author(s):  
Emrah Töz ◽  
Aykut Özcan ◽  
Deniz Balsak ◽  
Muhittin Eftal Avc ◽  
Arzu Görgülü Eraslan ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Premenopausal Women ◽  
Skin Aging

scholarly journals The use of hyaluronic acid and polymethylmethacrylate in the skin aging process in a comparative analysis (the advantages, disadvantages and adverse effects of each filler)

2020 ◽  
Vol 7 (2) ◽  
pp. 50-59
Author(s):  
Gisele Gonçalves de Carvalho ◽  
Marilia Fagury Videira Marceliano-Alves ◽  
Vanessa Hamberger Morett ◽  
Priscilla Rueles Figueiredo ◽  
Paula Avelar da Silva Ribeiro Goulart ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Comparative Analysis ◽  
Adverse Effects ◽  
Aging Process ◽  
Skin Aging

scholarly journals The role of local retinoids in eliminating signs of skin aging

2021 ◽  
Vol 97 (4) ◽  
pp. 60-70
Author(s):  
Vera I. Albanova
Keyword(s):  
Skin Irritation ◽  
Skin Neoplasms ◽  
Skin Aging ◽  
Biological Aging ◽  
Ultraviolet Rays ◽  
Entire Group ◽  
Chronological Aging ◽  
Slowing Down ◽  
Complex Process ◽  
The Many

Skin aging is a complex process involving both internal (chronological aging) and external (biological aging) factors. Slowing down the proliferative and immune processes in the epidermis, reducing the activity of fibroblasts and vascularization of the dermis during chronological aging lead to thinning, dryness, hypersensitivity, vulnerability and superficial wrinkles. Exposure to ultraviolet rays, pollutants, climate, and thermal factors cause keratinocyte disorganization, enhanced melanogenesis, collagen dystrophy, solar elastosis, and disorder of microcirculation. The main signs of external skin aging are deep wrinkles, sagging, pigmentation, telangiectasia, skin neoplasms. Among the local anti-aging agents, retinoids occupy a leading place, as they eliminate the main signs of skin aging. Of the entire group of retinoids, retinoic acids are the most active. However, the possibility of skin irritation limits their use. Therapeutic and cosmetic products with retinol esters (retinol palmitate) have a minimal irritating effect and can be used both for the prevention of skin aging and the elimination of its signs. Oral use of isotretinoin as an anti-aging agent is undesirable due to the many side effects and contraindications.

scholarly journals Characterization of Collagen I Fiber Thickness, Density, and Orientation in the Human Skin In Vivo Using Second-Harmonic Generation Imaging

Photonics ◽  
2021 ◽  
Vol 8 (9) ◽  
pp. 404
Author(s):  
Marius Kröger ◽  
Johannes Schleusener ◽  
Sora Jung ◽  
Maxim E. Darvin
Keyword(s):  
Extracellular Matrix ◽  
Second Harmonic Generation ◽  
Harmonic Generation ◽  
Skin Diseases ◽  
Second Harmonic ◽  
Skin Aging ◽  
Collagen I ◽  
Fast Fourier Transformation ◽  
Occurrence Matrix

The assessment of dermal alterations is necessary to monitor skin aging, cancer, and other skin diseases and alterations. The gold standard of morphologic diagnostics is still histopathology. Here, we proposed parameters to distinguish morphologically different collagen I structures in the extracellular matrix and to characterize varying collagen I structures in the skin with similar SAAID (SHG-to-AF Aging Index of Dermis, SHG—second-harmonic generation; AF—autofluorescence) values. Test datasets for the papillary and reticular extracellular matrix from images in 24 female subjects, 36 to 50 years of age, were generated. Parameters for SAAID, edge detection, and fast Fourier transformation directionality were determined. Additionally, textural analyses based on the grey level co-occurrence matrix (GLCM) were conducted. At first, changes in the GLCM parameters were determined in the native greyscale images and, furthermore, in the Hilbert-transformed images. Our results demonstrate a robust set of parameters for noninvasive in vivo classification for morphologically different collagen I structures in the skin, with similar and different SAAID values. We anticipate our method to enable an automated prevention and monitoring system with an age- and gender-specific algorithm.

Fine structure of the regressing interdigital membranes during the formation of the digits of the chick embryo leg bud

Development ◽  
1983 ◽  
Vol 78 (1) ◽  
pp. 195-209
Author(s):  
J. M. Hurle ◽  
M. A. Fernandez-Teran
Keyword(s):  
Extracellular Matrix ◽  
Fine Structure ◽  
Chick Embryo ◽  
Basal Lamina ◽  
Ultrastructural Study ◽  
Active Role ◽  
Epithelial Tissue ◽  
Complex Process ◽  
Cell Processes ◽  
Collagenous Material

There is recent evidence showing that in addition to the well-known mesenchymal necrotic mechanism involved in the disappearance of the interdigital membranes, the ectodermal tissue may also play an active role in the formation of the free digits of most vertebrates. Ultrastructural study of the regressing interdigital membrane of the chick leg revealed significant changes at the epitheliomesenchymal interface. Disruptions of the ectodermal basal lamina and an intense deposition of collagenous material were the most conspicuous changes observed in the extracellular matrix. In addition the basal ectodermal cells showed prominent cell processes projected into the mesenchymal core of the membrane, and mesenchymal macrophages appeared to migrate through the epithelial tissue to be detached into the amniotic sac. It is concluded from our results that the elimination of the interdigital membranes is a complex process requiring the interaction of all the tissue components of the membrane.

scholarly journals Extracellular matrix regulation of fibroblast function: redefining our perspective on skin aging

2018 ◽  
Vol 12 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Megan A. Cole ◽  
Taihao Quan ◽  
John J. Voorhees ◽  
Gary J. Fisher
Keyword(s):  
Extracellular Matrix ◽  
Skin Aging

scholarly journals Tubulin Beta-3 Chain as a New Candidate Protein Biomarker of Human Skin Aging: A Preliminary Study

2017 ◽  
Vol 2017 ◽  
pp. 1-21 ◽  
Author(s):  
Sylvia G. Lehmann ◽  
Sandrine Bourgoin-Voillard ◽  
Michel Seve ◽  
Walid Rachidi
Keyword(s):  
Gene Expression ◽  
Elderly Women ◽  
Skin Aging ◽  
Primary Keratinocytes ◽  
Cellular Processes ◽  
Complex Process ◽  
Skin Biopsies ◽  
Candidate Protein ◽  
Preliminary Study ◽  
Human Primary Keratinocytes

Skin aging is a complex process, and a lot of efforts have been made to identify new and specific targets that could help to diagnose, prevent, and treat skin aging. Several studies concerning skin aging have analyzed the changes in gene expression, and very few investigations have been performed at the protein level. Moreover, none of these proteomic studies has used a global quantitative labeled proteomic offgel approach that allows a more accurate description of aging phenotype. We applied such an approach on human primary keratinocytes obtained from sun-nonexposed skin biopsies of young and elderly women. A total of 517 unique proteins were identified, and 58 proteins were significantly differentially expressed with 40 that were downregulated and 18 upregulated with aging. Gene ontology and pathway analysis performed on these 58 putative biomarkers of skin aging evidenced that these dysregulated proteins were mostly involved in metabolism and cellular processes such as cell cycle and signaling pathways. Change of expression of tubulin beta-3 chain was confirmed by western blot on samples originated from several donors. Thus, this study suggested the tubulin beta-3 chain has a promising biomarker in skin aging.

scholarly journals LB764 Reverting dermal and epidermal alterations associated to photo-aging: Extracellular matrix rebuilding and decreasing DNA-damage markers

2016 ◽  
Vol 136 (8) ◽  
pp. B3
Author(s):  
K. Kadoya ◽  
C. Mazur ◽  
T. Fleck ◽  
R.C. Mehta ◽  
V.L. Vega ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Dna Damage

scholarly journals Examination of Reading Strategies Metacognitive Awareness Levels of French Foreign Language Students in Terms of Various Variables

2021 ◽  
Vol 11 (5) ◽  
pp. 31
Author(s):  
Zühre Yılmaz Güngör
Keyword(s):  
Foreign Language ◽  
Reading Strategies ◽  
Metacognitive Awareness ◽  
French Language ◽  
Metacognitive Skills ◽  
Course Success ◽  
Complex Process ◽  
Significant Difference ◽  
Faculty Of Education ◽  
Effective Use

The act of reading is a complex process in which learners rush their cognitive and metacognitive skills to fonction. The effective use of metacognitive skills is regarded as an important feature becoming prominent in successful reading. In order to exercise reading strategies effectively, students are required to have developed metacognitive awareness. In this study, the level of metacognitive awareness of reading strategies and whether metacognitive awareness varies according to variables such as gender and reading course success have been examined in the 1st grade students studying at Anadolu University Faculty of Education Program of French Language Teaching Program. 32 students voluntarily participated in the study, 19 of whom were Females and 13 of whom were Males. The data of the study have been collected with the Turkish version of the 30-item 5-point Likert-type Metacognitive Awareness of Reading Strategies Inventory (MARSI) developed by Mokhtari & Reichard (2002) and adapted into Turkish by Öztürk (2012). According to the findings, students' reading strategies were revealed to have high levels of metacognitive awareness. However, it has been further observed that the level of metacognitive awareness of students' reading course success grades and reading strategies did not make a significant difference in terms of gender. Similarly, it has been observed that there was no significant difference between the students' reading strategies and metacognitive awareness levels and their success grades in the reading course.

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