scholarly journals Serum Fetuin-A Levels in Patients with Cardiovascular Disease: A Meta-Analysis

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Ze-Lin Sun ◽  
Qi-Ying Xie ◽  
Gong-Liang Guo ◽  
Ke Ma ◽  
Yuan-Yuan Huang
Keyword(s):  
Web Of Science ◽  
Meta Analysis ◽  
Serum Levels ◽  
Arterial Calcification ◽  
Cochrane Library ◽  
Healthy Controls ◽  
Case Control Studies ◽  
China National Knowledge Infrastructure ◽  
Fetuin A ◽  
Knowledge Infrastructure

Background. Fetuin-A (FA) suppresses arterial calcification, promotes insulin resistance, and appears to be elevated in patients with cardiovascular diseases (CVD), but the data is still inconsistent. To clarify the correlation between serum FA levels and the presence and severity of CVDs, we performed this meta-analysis.Method. Potential relevant studies were identified covering the following databases: PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, China BioMedicine (CBM), and China National Knowledge Infrastructure (CNKI) databases. Data from eligible studies were extracted and included in the meta-analysis using a random-effects model.Results. Ten case-control studies, including 1,281 patients with CVDs and 2,663 healthy controls, were included. The results showed significant differences in serum levels of FA between the CVDs patients and the healthy controls (SMD = 1.36, 95%CI: 0.37–2.36,P=0.007). Ethnicity-subgroup analysis implied that low serum FA levels are related to CVDs in Caucasians (SMD = 1.73, 95%CI: 0.20–3.26,P=0.026), but not in Asians (SMD = 1.04, 95%CI: −0.33–2.40,P=0.138).Conclusion. The data indicated that decreased serum FA level is correlated with the development of CVDs. FA might be clinically valuable for reflecting the progression of CVDs.

scholarly journals Serum and Salivary IgA, IgG, and IgM Levels in Oral Lichen Planus: A Systematic Review and Meta-Analysis of Case-Control Studies

2018 ◽  
Author(s):  
Hamid Reza Mozaffari ◽  
Elisa Zavattaro ◽  
Abas Abdolahnejad ◽  
Pia Lopez Jornet ◽  
Neda Omidpanah ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Serum Levels ◽  
Inflammatory Factors ◽  
Cochrane Library ◽  
Healthy Controls ◽  
Case Control Studies ◽  
Salivary Iga ◽  
Oral Lichen

Background and Aim: Immunoglobulins (IgA, IgG, and IgM) are significant anti-inflammatory factors. The meta-analysis aimed to assess the serum and salivary levels of Igs as more important immunoglobulins in patients affected by oral lichen planus (OLP) compared to the healthy controls. Materials and Methods: Four databases, including PubMed/Medline, Scopus, Web of Science, and Cochrane Library as well as Iranian databases were checked up to January 2018 without language restriction. The quality of each involved study was done using the NOS questionnaire. A random-effects model analysis was done by RevMan 5.3 software applying the mean difference (MD) plus 95% confidence intervals (CIs). The CMA 2.0 software was applied to calculate the publication bias among the studies. Results: Out of 70 studies found in the databases, eight studies were involved and analyzed in the meta-analysis. The meta-analysis included 282 OLP patients and 221 healthy controls. The pooled MDs of serum levels of  IgA, IgG, and IgM were -0.13 g/L [95%CI: -0.24, -0.02; P = 0.02], 1.01 g/L [95%CI: -0.91, 2.93; P = 0.30], and -0.06 g/L [95%CI: -0.25, 0.14; P = 0.56], respectively; whereas, the salivary IgA and IgG levels were 71.54 mg/L [95%CI: 12.01, 131.07; P = 0.02] and 0.59 mg/L [95%CI: -0.20, 1.38; P = 0.14], respectively. Conclusions: Considering the few studies performed on saliva, the results suggested that the salivary levels, especially IgA level had a higher diagnostic value than the serum levels. Therefore, the salivary immunoglobulins can play a significant function in the OLP pathogenesis.

Association between FSAP 1601G>A polymorphism and venous thromboembolism risk: A meta-analysis

2019 ◽  
Vol 35 (5) ◽  
pp. 345-353
Author(s):  
Li Da ◽  
Zhao Jiahui ◽  
Li Xiaoqiang
Keyword(s):  
Venous Thromboembolism ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Web Of Science ◽  
Meta Analysis ◽  
Factor Vii ◽  
Case Control Studies ◽  
China National Knowledge Infrastructure ◽  
Bias Assessment ◽  
Knowledge Infrastructure

Objective Previous several studies have shown that factor VII-activating protease (FSAP) gene 1601G>A polymorphism is related to the occurrence of venous thromboembolism, but the results are inconsistent and controversial. Therefore, we conducted a meta-analysis to explore the association between FSAP 1601G>A polymorphism and venous thromboembolism susceptibility. Methods We managed a systematic literature search through Pubmed, Embase, Web of Science, China National Knowledge Infrastructure, and WanFang databases to collect research data related to FSAP gene 1601G>A polymorphism and susceptibility to venous thromboembolism published before May 2019. Data analysis was performed through Revman 5.3 and Stata 12.0 software, the pooled odd ratios and 95% confidence intervals were calculated. Additionally, the sensitivity analysis and publication bias assessment were also performed. Results A total of seven case–control studies were included and evaluated, including 2411 venous thromboembolism cases and 2850 controls. The meta-analysis results revealed that the FSAP 1601G>A mutation is associated with venous thromboembolism risk, and statistically significance was observed under three genetic comparison models (A: G, odds ratio: 1.33, 95% confidence interval: 1.07–1.66; GA: GG, odds ratio: 1.34, 95% confidence interval: 1.06–1.68; and GA + AA: GG, odds ratio: 1.33, 95% confidence interval: 1.06–1.66). Conclusion This study demonstrated that the FSAP 1601G>A polymorphism may be associated with venous thromboembolism susceptibility.

scholarly journals Serum and Salivary IgA, IgG, and IgM Levels in Oral Lichen Planus: A Systematic Review and Meta-Analysis of Case-Control Studies

Medicina ◽  
2018 ◽  
Vol 54 (6) ◽  
pp. 99 ◽  
Author(s):  
Hamid Mozaffari ◽  
Elisa Zavattaro ◽  
Abas Abdolahnejad ◽  
Pia Lopez-Jornet ◽  
Neda Omidpanah ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Serum Levels ◽  
Inflammatory Factors ◽  
Cochrane Library ◽  
Healthy Controls ◽  
Case Control Studies ◽  
Salivary Iga ◽  
Oral Lichen

Immunoglobulins (IgA, IgG, and IgM) are significant anti-inflammatory factors. The meta-analysis aimed to assess the serum and salivary levels of Igs as more important immunoglobulins in patients affected by oral lichen planus (OLP) compared to the healthy controls. Four databases, including PubMed/Medline, Scopus, Web of Science, and Cochrane Library as well as Iranian databases were checked up to January 2018 without language restriction. The quality of each involved study was done using the Newcastle–Ottawa Quality Assessment Scale (NOS) questionnaire. A random-effects model analysis was done by RevMan 5.3 software applying the mean difference (MD) plus 95% confidence intervals (CIs). The CMA 2.0 software was applied to calculate the publication bias among the studies. Out of 70 studies found in the databases, 8 studies were involved and analyzed in the meta-analysis. The meta-analysis included 282 OLP patients and 221 healthy controls. The pooled MDs of serum levels of IgA, IgG, and IgM were −0.13 g/L [95% CI: −0.24, −0.02; P = 0.02], 1.01 g/L [95% CI: −0.91, 2.93; P = 0.30], and −0.06 g/L [95% CI: −0.25, 0.14; P = 0.56], respectively; whereas, the salivary IgA and IgG levels were 71.54 mg/L [95% CI: 12.01, 131.07; P = 0.02] and 0.59 mg/L [95% CI: −0.20, 1.38; P = 0.14], respectively. Considering the few studies performed on saliva, the results suggested that the salivary levels, especially IgA level had higher values than the serum levels. Therefore, the salivary immunoglobulins can play a significant function in the OLP pathogenesis.

scholarly journals TLR9 Rs352140 polymorphism contributes to a decreased risk of bacterial meningitis: evidence from a meta-analysis

2020 ◽  
Vol 148 ◽  
Author(s):  
Haiyi Xue ◽  
Huan Peng ◽  
Jiaoming Li ◽  
Mingming Li ◽  
Song Lu
Keyword(s):  
Bacterial Meningitis ◽  
Genetic Model ◽  
Meta Analysis ◽  
Relevant Literature ◽  
Cochrane Library ◽  
Case Control Studies ◽  
China National Knowledge Infrastructure ◽  
Knowledge Infrastructure ◽  
Increased Risk ◽  
The Cochrane Library

Abstract Some studies have suggested that the Toll-like receptor 9 polymorphism (TLR9 rs352140) is closely related to the risk of bacterial meningitis (BM), but this is subject to controversy. This study set out to estimate whether the TLR9 rs352140 polymorphism confers an increased risk of BM. Relevant literature databases were searched including PubMed, Embase, the Cochrane Library and China National Knowledge Infrastructure (CNKI) up to August 2020. Seven case-control studies from four publications were enrolled in the present meta-analysis. Odds ratios (OR) and confidence intervals (95% CI) were calculated to estimate associations between BM risk and the target polymorphism. Significant associations identified were allele contrast (A vs. G: OR 0.66, 95% CI 0.59–0.75, P = 0.000), homozygote comparison (AA vs. AG/GG: OR 0.62, 95% CI 0.49–0.78, P = 0.000), heterozygote comparison (A vs. G: OR 0.74, 95% CI 0.61–0.91, P = 0.005), recessive genetic model (AA vs. AG/GG: OR 0.78, 95% CI 0.65–0.93, P = 0.006) and dominant genetic model (AA vs. AG/GG: OR 0.70, 95% CI 0.57–0.85, P = 0.000). The findings indicate that, in contrast to some studies, the TLR9 rs352140 polymorphism is associated with a decreased risk for BM.

scholarly journals ERCC1 rs11615 polymorphism and chemosensitivity to platinum drugs in patients with ovarian cancer: a systematic review and meta-analysis

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Yuqiang Zhang ◽  
Sufen Cao ◽  
Chunyu Zhuang ◽  
Jiacheng Chen ◽  
Xiaojing Chen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Web Of Science ◽  
Meta Analysis ◽  
Asian Population ◽  
Caucasian Population ◽  
Cochrane Library ◽  
Platinum Drugs ◽  
China National Knowledge Infrastructure ◽  
Knowledge Infrastructure ◽  
The Relationship

Abstract Objective To explore the relationship between ERCC1 rs11615 polymorphism and chemosensitivity to platinum drugs in ovarian cancer by the method of meta-analysis. Methods Pubmed, Web of Science, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), and China Wanfang databases were comprehensively searched up to September 2020, to identify the relationship between ERCC1 rs11615 polymorphism and chemosensitivity of ovarian cancer. The data was analyzed by Stata 15.0 statistic software. Results A total of 10 published papers were included, including 1866 patients with ovarian cancer. The results showed that compared allele C at ERCC1 rs11615 locus with allele T, the pooled OR was 0.92 (95%CI:0.68 ~ 1.24, P > 0.05). There were no significant differences in recessive, dominant, homozygous, and heterozygous models. In accordance with a subgroup analysis of Ethnicity, all genotypes were statistically significant in the Asian population. In the allelic, dominant, recessive, homozygous and heterozygous models, the OR was 0.70 (95%CI:0.51 ~ 0.95), 0.20 (95%CI:0.07 ~ 0.56), 0.79 (95%CI:0.63 ~ 1.00), 0.21 (95%CI:0.07 ~ 0.59), 0.19 (95%CI:0.07 ~ 0.54), respectively, while in the Caucasian population, no statistically significant genotype was found. Conclusion The ERCC1 rs11615 polymorphism is associated with chemosensitivity in patients with ovarian cancer, especially in the Asian population, but not in the Caucasian population.

scholarly journals Comparison of Efficacy Between Steroid Therapy and Observation Therapy in the Treatment of Traumatic Optic Neuropathy-a Meta-analysis

2021 ◽  
Author(s):  
Peipei Zhang ◽  
Chao Xue ◽  
Ying Chen ◽  
Xuening Su
Keyword(s):  
Steroid Therapy ◽  
Optic Neuropathy ◽  
Randomized Clinical Trials ◽  
Web Of Science ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Traumatic Optic Neuropathy ◽  
China National Knowledge Infrastructure ◽  
Knowledge Infrastructure ◽  
Better Than

Abstract Background: Until now, the exact pathophysiology of traumatic optic neuropathy(TON) is still unclear, its management has remained controversial. The effect of steroid in TON remains unclear. The purpose of this study is to compare the effect of steroid therapy with observation therapy in the treatment of traumatic optic neuropathy(TON). Methods: A systematic literature search was performed in data sources including CENTRAL, PubMed, EMBASE, Web of Science, Cochrane Library, MEDLINE, Chinese databases including Wanfang and China National Knowledge Infrastructure for to find relevant studies. The statistical analysis was performed by RevMan 5.3 software.Results: Eight studies including 263 eyes were enrolled in this study. The rate of improvement of VA in the steroid group was not better than that of the observation group (OR=2.17, 95%, CI=1.23-3.83, P=0.007), with no heterogeneity (I2=0,P=0.43).Conclusions: Patients with TON receiving steroid treatment may not have a better visual recovery than observation therapy. Steroid therapy is not recommend in patients with TON. Further larger randomized clinical trials are needed to evaluate the effect of steroid therapy for TON in the future.

scholarly journals Predictive Performance of Serum β-hCG MoM Levels for Preeclampsia Screening: A Meta-Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiao Zhang ◽  
Zhao Huangfu ◽  
Fangxin Shi ◽  
Zhen Xiao
Keyword(s):  
Predictive Value ◽  
Meta Analysis ◽  
Serum Levels ◽  
First Trimester ◽  
Healthy Controls ◽  
Second Trimester ◽  
Case Control Studies ◽  
China National Knowledge Infrastructure ◽  
Predictive Capacity ◽  
Β Hcg

ObjectiveThe aim of the present study was to investigate the predictive value of using the multiple of the median (MoM) of β-human chorionic gonadotropin (β-hCG) levels in patients with preeclampsia (PE) and healthy pregnant women.MethodsElectronic databases including PubMed, EBSCO, Ovid, Web of Science, China National Knowledge Infrastructure (CNKI), SinoMed, Wangfang and the Weipu Journal were searched up to May 31, 2020. Two reviewers independently selected the articles and extracted data on study characteristics, quality and results. A random-effects model was employed, and standardized mean difference and 95% confidence intervals were calculated. Twenty-one case-control studies were analyzed in the present meta-analysis, including a total of 2,266 cases and 25,872 healthy controls.ResultsWomen who were diagnosed with PE were found to have higher early second-trimester levels of serum β-hCG MoM compared with healthy controls, although the levels in the first trimester were not significantly different. Ethnicity subgroup analysis demonstrated that the MoM of β-hCG serum levels was significantly higher in PE patients in both Asian and Caucasian populations during the early second trimester.ConclusionThe MoM of β-hCG serum levels was found to be a valuable clinical indicator for predicting PE in the early second trimester, but had little predictive value in the first trimester. However, further assessment of the predictive capacity of β-hCG within larger, diverse populations is required.

scholarly journals The CEBPE rs2239633 genetic polymorphism on susceptibility to childhood acute lymphoblastic leukemia: an updated meta-analysis

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Jin Liu ◽  
Gu Weiling ◽  
Li Xueqin ◽  
Xie Liang ◽  
Wang Linhong ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Meta Analysis ◽  
Case Control ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Cochrane Library ◽  
Case Control Studies ◽  
China National Knowledge Infrastructure ◽  
Knowledge Infrastructure ◽  
The Impact

Abstract Objectives We performed an updated meta-analysis to clarify the relationship between the CEBPE rs2239633 polymorphism and the childhood acute lymphoblastic leukemia (CALL) susceptibility. Methods All the case-control studies were updated on October 5, 2020, through Web of Science, PubMed, Cochrane Library, Embase, and China National Knowledge Infrastructure (CNKI) electronic database. The heterogeneity in the study was tested by the Q test and I2, and then the random ratio or fixed effect was utilized to merge the odds ratios (OR) and 95% confidence interval (CI). We also performed sensitivity analysis to estimate the impact of individual studies on aggregate estimates. Publication bias was investigated by using funnel plot and Egger’s regression test. All statistical analyses were performed using Stata 12.0. Results A total of 20 case-control studies were selected, including 7014 patients and 16,428 controls. There was no association of CEBPE rs2239633 polymorphism with CALL (CC vs CT + TT: OR = 1.08, 95% CI = 0.94–1.26; CC + CT vs TT: OR = 1.10, 95% CI = 0.94–1.30; C vs T: OR = 1.02, 95% CI = 0.92–1.13). In the subgroup analysis by ethnicity, there is no significant association of this polymorphism and CALL risks among Asian and Caucasian populations in the three genetic models (CC vs CT + TT, CC + CT vs TT, and C vs T). Conclusion This meta-analysis found no significant association between the CEBPE rs2239633 polymorphism and susceptibility to CALL.

scholarly journals Associations between ERAP1 Gene Polymorphisms and Psoriasis Susceptibility: A Meta-Analysis of Case-Control Studies

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Xiujuan Wu ◽  
Zongfeng Zhao
Keyword(s):  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Case Control ◽  
Cochrane Library ◽  
Case Control Studies ◽  
China National Knowledge Infrastructure ◽  
Knowledge Infrastructure ◽  
Increased Risk ◽  
Newcastle Ottawa Scale ◽  
Relationship Of

This study is to investigate the relationship of endoplasmic reticulum aminopeptidase 1 (ERAP1) gene polymorphisms with psoriasis. Five databases of PubMed, China National Knowledge Infrastructure (CNKI), Embase, Web of Science, and Cochrane Library were searched for potential studies until 25 December 2019. Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of included studies. Meta-analysis was performed with PRISMA. A total of 9 case-control studies including 4858 psoriasis cases and 10,542 healthy controls were included. Three loci of ERAP1 gene polymorphisms (rs26653, rs30187, and rs27524) were evaluated in this meta-analysis. There was no significant association between rs26653 polymorphism and risk of psoriasis (C vs. G, OR = 1.01 , 95% CI: 0.80-1.28, P = 0.93 ). However, there was a significant association between rs30187 polymorphisms and psoriasis susceptibility (T vs. C, OR = 1.23 , 95% CI: 1.15-1.32, P < 0.00001 ) and a significant association between rs27524 polymorphisms and psoriasis susceptibility (A vs. G, OR = 1.17 , 95% CI: 1.09-1.25, P < 0.00001 ). For there were insufficient data of rs27044, rs151823, rs2248374, and rs2910686, we only conducted a systematic review for them. The rs30187 (C/T) and rs27524 (G/A) polymorphisms of ERAP1 are associated with increased risk of psoriasis. However, no significant association is observed between rs26653 (G/C) polymorphism and risk of psoriasis.

Association between ALDH2 Gene Polymorphism and Late-onset Alzheimer Disease: An Up-to-date Meta-analysis

2020 ◽  
Vol 17 (2) ◽  
pp. 105-111
Author(s):  
Haitao Liu ◽  
Wei Ge ◽  
Wei Chen ◽  
Xue Kong ◽  
Weiming Jian ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Large Scale ◽  
Late Onset ◽  
Meta Analysis ◽  
Case Control ◽  
Cochrane Library ◽  
Positive Trend ◽  
Case Control Studies ◽  
China National Knowledge Infrastructure ◽  
Aldh2 Gene

Objectives: Previous case-control studies have focused on the relationship between ALDH2 gene polymorphism and late-onset Alzheimer's Disease (LOAD), but no definite unified conclusion has been reached. Therefore, the correlation between ALDH2 Glu504Lys polymorphism and LOAD remains controversial. To analyze the correlation between ALDH2 polymorphism and the risk of LOAD, we implemented this up-to-date meta-analysis to assess the probable association. Methods: Studies were searched through China National Knowledge Infrastructure (CNKI), VIP Database for Chinese Technical Periodicals, China Biology Medicine, PubMed, Cochrane Library, Clinical- Trials.gov, Embase, and MEDLINE from January 1, 1994 to December 31, 2018, without any restrictions on language and ethnicity. Results: Five studies of 1057 LOAD patients and 1136 healthy controls met our criteria for the analysis. Statistically, the ALDH2 GA/AA genotype was not linked with raising LOAD risk (odds ratio (OR) = 1.48, 95% confidence interval (CI) = 0.96-2.28, p = 0.07). In subgroup analysis, the phenomenon that men with ALDH2*2 had higher risk for LOAD (OR = 1.72, 95%CI = 1.10-2.67, p = 0.02) was observed. Conclusions: This study comprehends only five existing case-control studies and the result is negative. The positive trend might appear when the sample size is enlarged. In the future, more large-scale casecontrol or cohort studies should be done to enhance the association between ALDH2 polymorphism and AD or other neurodegenerative diseases.

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