scholarly journals Evaluation and Comparison of Condylar Head Inclination With Respect to Glenoid Fossa in Cleft, Class III, and Class I Individuals

2020 ◽  
pp. 030157422096341
Author(s):  
Prutha Ganesh Khakhar ◽  
Pallavi Daigavane ◽  
Ranjit Kamble ◽  
Priyanka Niranjane ◽  
Hamza Dargahwala ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
P Value ◽  
Glenoid Fossa ◽  
Class Iii ◽  
Group 4 ◽  
Bilateral Cleft Lip ◽  
Condylar Head ◽  
Group 3 ◽  
Group 2

Background: Cleft lip and palate are the most common congenital craniofacial defects, which need early intervention with a multidisciplinary approach including surgeons, orthodontists, speech therapists, pedodontists, etc. Craniofacial growth is affected the most, leading to marked skeletal discrepancies. Constricted maxillary arch is one of the reasons for faulty occlusal inclined planes which results in abnormal loading of condyles, thus leading to temporomandibular disorders (TMDs) in cleft. Condylar head inclination helps to evaluate the position of condyle in the glenoid fossa. Thus, changing the position of condylar head in the glenoid fossa at an early age prevents further worsening of TMD condition. The purpose of this study was to evaluate condylar inclination in individuals with cleft lip and palate and compare it with non-cleft individuals. Method: The study comprised of 40 subjects aged between 9 and 12 years, divided into 4 groups (10 in each)—unilateral cleft lip and palate (UCLP), bilateral cleft lip and palate (BCLP), and class III and class I malocclusion. Scanned three-dimensional digital volume tomography (3D-DVT) images were taken, and condylar head inclination was evaluated and compared. Result: Significant findings were obtained when group 1 was compared to group 2, group 3, and group 4 ( P-value = .001). Also, when group 2 was compared to group 3 and group 4, the values were statistically significant with P-value = .001. Conclusion: Condylar head inclination was found to be most anteriorly angulated in the class III group compared to all the other groups. Unilateral cleft lip and palate had more anteriorly angulated condyle than bilateral cleft lip and palate.

scholarly journals Analysis of Instagram® Posts Referring to Cleft Lip

2020 ◽  
Vol 17 (20) ◽  
pp. 7404
Author(s):  
Magdalena Sycinska-Dziarnowska ◽  
Piotr Stepien ◽  
Joanna Janiszewska-Olszowska ◽  
Katarzyna Grocholewicz ◽  
Maciej Jedlinski ◽  
...  
Keyword(s):  
Congenital Anomaly ◽  
Social Media ◽  
Cleft Lip ◽  
Medical Information ◽  
Cleft Lip And Palate ◽  
Group 4 ◽  
Group 3 ◽  
The Difference ◽  
Group 2 ◽  
Group 1

Background: Social media has become a source of medical information. Cleft lip and palate is a visible congenital anomaly. The aim of the study was to analyze Instagram® posts on the topic of cleft lip. Methods: Instagram® posts with “#cleftlip” from March 2014–March 2017 were accessed. Separate lists of expressions (hashtags, meaningful words, words with emojis or emojis alone) were prepared for primary posts and for replies. Thirty expressions statistically most frequent in primary versus secondary posts and 30 in secondary versus primary posts were identified (Group 1) as well as 30 English words or hashtags (Group 2), non-English words or hashtags (Group 3) and emojis (Group 4). The frequencies of expressions were compared (Z-test for the difference of two population proportions). Results: There were 34,129 posts, (5427 primary posts and 28,702 replies), containing 62,163 expressions, (35,004 in primary posts). The occurrence of all expressions was 454,162, (225,418 in primary posts and 228,744 in replies). Posts with positive expressions such as “beautiful”, “love”, “cute”, “great”, “awesome” occurred more often than these with negative ones. In replies all emojis were positive. Conclusions: Numerous Instagram® posts referring to cleft lip are published and do provoke discussion. People express their solidarity and sympathize with persons affected by cleft.

scholarly journals Hepato curative effects of Silymarin and Cymbopogoncitratus stem infusion: RCT

2021 ◽  
Vol 15 (6) ◽  
pp. 1966-1969
Author(s):  
Sidra Mumal ◽  
Abdul Azeem ◽  
Talal Zafar ◽  
Hina Aslam ◽  
Tasneem Murad ◽  
...  
Keyword(s):  
Synergistic Effects ◽  
Serum Markers ◽  
Control Group ◽  
P Value ◽  
Trial Methodology ◽  
Adult Rats ◽  
Sinusoidal Dilatation ◽  
Group 4 ◽  
Group 3 ◽  
Group 2

People all around the world suffer from liver diseases, which is a serious health problem. Purpose: To observe the synergistic effects of Silymarin and Cymbopogoncitratus stem infusion on liver in acetaminophen induced hepatotoxicity in rats. Study Design: Laboratory-Based Randomized Control Trial. Methodology: Total forty adult rats were divided into four groups (10 each). Group 1 was taken as control group. After initial sampling at day 0, Acetaminophen (300 mg/kg) was injected to 30 rats via intra-peritoneal route. At day 8, rats were further divided into three groups. Group 2 was a disease control group. Group 3 was given Silymarin (100 mg/kg) and group 4 was treated with Silymarin (100 mg/kg) plus Cymbopogoncitratus stem infusion (130 mg/kg) through gavage method for fourteen days. At day 21, rats were sacrificed for histological examination after terminal sampling. Statistical Analysis: Mean± SEM was calculated and analyzed through SPSS 20. P-value less than 0.05 was considered statistically significant. Results: Rats from group 2 showed marked elevation (p<0.05) in serum markers. There was marked sinusoidal dilatation and necrosis present in group 2 rats.Silymarinin group 3 and Silymarin plus Cymbopogoncitratus stem infusion in group 4 significantly lowered the biochemical enzymes as well as considerably reversed the histological changes in comparison to group 2 rats. Conclusion: We concluded in present study that synergism was observed in group 4 rats. There was more reversal of hepatic injury in group 4 rats. Key words: Cymbopogoncitratus, Silymarin and Synergism.

Craniofacial Morphology of Dutch Patients with Bilateral Cleft Lip and Palate and Noncleft Controls at the Age of 15 Years

2008 ◽  
Vol 45 (6) ◽  
pp. 661-666 ◽  
Author(s):  
Geer M. van den Dungen ◽  
Edwin M. Ongkosuwito ◽  
Irene H. A. Aartman ◽  
Birte Prahl-Andersen
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Pearson Correlation ◽  
Correlation Coefficients ◽  
Craniofacial Morphology ◽  
Control Group ◽  
Class Iii ◽  
Cross Sectional ◽  
Significant Difference ◽  
Bilateral Cleft Lip

Objective: Comparison of craniofacial morphology in bilateral cleft lip and palate patients to that of a noncleft control group at the age of 15 years. Design: A cross-sectional study of cephalometric data. Subjects and Methods: Cephalometric records of 41 consecutive patients (32 boys and 9 girls) with nonsyndromic complete bilateral cleft lip and palate born between 1973 and 1987. The patients were treated by the cleft teams of the Erasmus Medical Centre in Rotterdam and the VU University Amsterdam. The control group of normal Dutch subjects was followed in the Nijmegen Growth Study. From this population, mean cephalometric data were used. Differences in cephalometric measurements and other variables were calculated between the bilateral cleft lip and palate group and the control group. Results: Independent-sample t tests indicated that there was a statistically significant difference between the mean of the cephalometric values of the bilateral cleft lip and palate patients and the control group with respect to all cephalometric variables. Pearson correlation coefficients calculated between angle ANB and the number of operators, number of surgical procedures before 15 years of age, and the year of birth were not significant. Conclusions: Bilateral cleft lip and palate patients treated in the Amsterdam and Rotterdam cleft centers differed significantly from the control group in all measurements. A Class III development due to a less forward positioned maxilla was observed. The vertical measurements indicated a more divergent growth pattern in bilateral cleft lip and palate patients (Ans-Me/N-Me, GoGn-SN, and SN-FFH).

Serum and Bronchoalveolar Lavage Fluid 25(OH)Vitamin D3 Levels in HIV-1 and Tuberculosis: A Cross-Sectional Study from a Tertiary Care Center in North India

2018 ◽  
Vol 16 (2) ◽  
pp. 167-173
Author(s):  
Sanjeev Sinha ◽  
Kartik Gupta ◽  
Dibyakanti Mandal ◽  
B.K. Das ◽  
R.M. Pandey
Keyword(s):  
Vitamin D ◽  
Lavage Fluid ◽  
Cross Sectional Study ◽  
P Value ◽  
Vitamin D Metabolites ◽  
Cross Sectional ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Background: Vitamin D is an immunomodulator, and its deficiency is associated with Tuberculosis (TB) infection. Bronchoalveolar lavage fluid (BALF) is a rich milieu of macrophages that form the first line of defense against invading TB bacilli. As there is an increased prevalence of vitamin D deficiency in TB and human immunodeficiency virus-1 (HIV-1) subjects, we intend exploring the possibility of a localized deficiency of vitamin D metabolites in BALF of these patients. Objective: The primary objective was to assess the level of 25D3 in serum and BALF of subjects and look for a significant difference among patients and controls. The secondary objective was to find a correlation between serum and BALF 25D3 levels. Methods: We performed a cross-sectional study with subjects divided into four groups: Controls (group 1), HIV positive without active TB (group 2), active TB without HIV (group 3), and HIV-TB coinfection (group 4). BALF and serum 25D3 levels were compared between the groups. Results: Among the 149 (an immunomodulator) successive subjects enrolled, there were 40 subjects in group 1 (HIV-TB-), 48 in group 2 (HIV+TB-), 37 in group 3 (HIV-TB+), and 24 in group 4 (HIV+TB+). Females constituted 31.6% of the study subjects. In groups 3 and 4, there were significantly lower serum 25D3 levels compared to group 1 (p-value group 3: 0.002; group 4: 0.012). In groups 2, 3, and 4, there were significantly lower BALF 25D3 levels compared to group 1 (p-value group 2: 0.000; group 3: 0.000; group 4: 0.001). There was a significant correlation between serum and BALF 25D3 levels (Spearman’s rank correlation coefficient 0.318, p-value = 0.0001). Conclusion: Lower levels of serum and BALF 25D3 were observed in HIV, TB, and HIV-TB coinfected patients. Localized deficiency of vitamin D metabolites might be associated with increased vulnerability to TB infection.

Oral and Nasal Malodor in Patients with and without Cleft Lip and Palate Who Had Undergone Orthodontic Therapy

2008 ◽  
Vol 45 (5) ◽  
pp. 481-484 ◽  
Author(s):  
Cenk Doruk ◽  
Fırat Öztürk ◽  
Hakan Özdemir ◽  
Ruhi Nalçaci
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Therapy Group ◽  
Plaque Index ◽  
Gingival Index ◽  
Oral Malodor ◽  
Orthodontic Therapy ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Objective: To compare oral and nasal malodor in patients with and without cleft lip and palate (CLP) who had undergone orthodontic therapy. Setting: University of Cumhuriyet, Sivas, Turkey. Patients: The study included 33 patients. Group 1 was composed of 11 patients with CLP. Measurements were taken while they were undergoing treatment with orthodontic fixed appliances. Group 2 included 11 individuals without CLP; measurements were taken during fixed orthodontic therapy. Group 3 consisted of 11 individuals without CLP who did not receive orthodontic therapy. Intervention: Oral malodor, nasal malodor, Gingival Index, Plaque Index, and probing depths were evaluated in each group. Results: Plaque Index, Gingival Index, and probing depths showed no significant differences between groups 1 and 2. In contrast, oral malodor was significantly different between the two groups (p < .05). Groups 2 and 3 showed differences in gingival and plaque indices but not in probing depths and oral malodor. All healthy nostrils in Group 1, Group 2, and Group 3 were significantly different from affected nostrils in the CLP patients. There was significant malodor in affected nostrils when compared with nonaffected nostrils in group 1 (p < .05). Conclusion: Oral malodor was increased in patients with CLP. Nasal malodor level was also higher in affected nostrils of the CLP patients compared to nostrils of healthy subjects.

scholarly journals Pre-treatment Factors Affecting Post-treatment Velopharyngeal Incompetency in Patients with Unilateral Cleft Lip and Palate Treated with Maxillary Rigid External Distraction

2020 ◽  
Vol 54 (3) ◽  
pp. 226-232
Author(s):  
S. S. Agarwal ◽  
Sanjay Londhe ◽  
Rajat Mitra ◽  
Sanjeev Datana
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Study Groups ◽  
P Value ◽  
Factors Affecting ◽  
Lateral Cephalograms ◽  
Significant Difference ◽  
Pre Treatment ◽  
Group 2 ◽  
Velopharyngeal Function

Introduction: Maxillary advancement (MA) with rigid external distraction (RED) to correct mid-face deficiency in adult cases with cleft lip and palate (CLP) may trigger velopharyngeal incompetency (VPI) post-surgically. Aim and objectives: To determine pre-treatment factors affecting worsening of post-surgical VPI in patients with repaired unilateral CLP who underwent MA with RED. Material and methods: Treatment records of 10 patients with unilateral CLP who underwent MA with RED were selected from institutional archives. All patients underwent clinical evaluation of velopharyngeal function at T1 (1 week before surgery) and T2 (3 months after surgery). Based on post-surgical VPI status, patients were divided into 2 groups: group 1 (no change in VPI) and group 2 (worsened VPI). Lateral cephalograms were manually traced at T1 and T2 to determine the changes in length of soft palate (LSP) and pharyngeal depth (PD) at T2. The information regarding amount of MA and presence of pre-surgical VPI was obtained from case sheets of patients. Results: Mean LSP and PD at T2 were higher compared to T1 ( p-value < .001). No significant difference was observed in mean pre-surgical age, gender, pre-surgical LSP, and pre-surgical PD between the study groups ( p-value > .05 for all). The worsened VPI post-surgically was significantly associated with the presence of VPI pre-surgically and also with the amount of MA ( p-value < .05 for both). Conclusions: Amount of MA and presence of pre-surgical VPI are most important factors affecting post-surgical VPI. Prospective studies are recommended to validate the findings of this study.

Dentocraniofacial Morphology of 12 Japanese Subjects with Unilateral Cleft Lip and Palate with a Severe Class III Malocclusion: A Cephalometric Study at the Pretreatment Stage of Surgical Orthodontic Treatment

2001 ◽  
Vol 38 (6) ◽  
pp. 597-605 ◽  
Author(s):  
Chizu Tateishi ◽  
Keiji Moriyama ◽  
Teruko Takano-Yamamoto
Keyword(s):  
Orthodontic Treatment ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Effective Length ◽  
Maxillary Incisor ◽  
Class Iii ◽  
Class Iii Malocclusion ◽  
Group 2 ◽  
Japanese Male Subjects ◽  
Male Subjects

Objective: The present study clarifies the dentocraniofacial morphology of patients with cleft lip and palate (CLP) with severe Class III malocclusion prior to surgical orthodontic treatment. Methods: The sample was 12 Japanese male subjects with repaired complete unilateral CLP (surgical CLP group; 21.2 ± 1.92 years in mean age). Two sets of patients without CLP Class III malocclusion, consisting of 19 male subjects treated by surgical orthodontic treatment (surgical Class III group; 23.4 ± 6.35 years in mean age) and 14 male subjects treated by nonsurgical orthodontic treatment (nonsurgical Class III group; 18.7 ± 3.49 years in mean age) were used as controls. Analyses were performed using lateral and posteroanterior (P-A) cephalograms. Results: (1) The surgical CLP group showed significantly smaller values for overjet, SNA angle, and inclination of the maxillary incisor as compared with those of the surgical and nonsurgical Class III controls. The values of SNB, mandibular effective length, and ramus height in the surgical CLP group were significantly smaller than those of the surgical Class III group but were similar to those of the nonsurgical Class III group. (2) The mandible and the upper and lower dental arches deviated laterally toward the cleft side. The displacement of the mandible was correlated with that of the maxilla. These results show that CLP patients who required surgical orthodontic treatment had a characteristic dentocraniofacial morphology, compared to controls without CLP with Class III malocclusion.

scholarly journals Pachydrusen in Fellow Eyes Predict Response to Aflibercept Monotherapy in Patients with Polypoidal Choroidal Vasculopathy

2020 ◽  
Vol 9 (8) ◽  
pp. 2459 ◽  
Author(s):  
Yoshiko Fukuda ◽  
Yoichi Sakurada ◽  
Atsushi Sugiyama ◽  
Seigo Yoneyama ◽  
Mio Matsubara ◽  
...  
Keyword(s):  
Polypoidal Choroidal Vasculopathy ◽  
Lower Percentage ◽  
P Value ◽  
First Year ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Choroidal Vasculopathy ◽  
Fellow Eyes ◽  
Group 1

We investigated whether responses to as-needed intravitreal aflibercept injections (IAIs) for polypoidal choroidal vasculopathy (PCV) differed among patients based upon drusen characteristics in fellow eyes. 110 eyes from 110 patients with PCV received 3 monthly IAI and thereafter Pro re nata (PRN) IAI over 12 months. Patients were classified into 4 groups depending on fellow eye findings. Group 1 (n = 16): pachydrusen; Group 2 (n = 45): no drusen; Group 3 (n = 35): soft drusen; Group4 (n = 14) PCV/scarring. Best-corrected visual acuity improved at 12 months in all groups, but not significantly in Group 1 and Group 4; however, visual improvement was similar among the groups after adjusting baseline confounders. Group 1 had a significantly lower percentage of eyes needing retreatment (all p < 0.001; Group 1: 16.7%; Group 2: 50.8%; Group 3: 80%; Group 4: 85.7%). The mean number of retreatments was least in Group 1 among the groups (all p-value < 0.003; Group 1: 0.50 ± 1.32; Group 2: 1.73 ± 2.08; Group 3:2.71 ± 1.99; Group 3: 2.71 ± 2.16). Patients with pachydrusen in fellow eyes were less likely to require additional IAI following the loading dose and may be ideal candidates for aflibercept monotherapy in their first year.

Anterior Segmental Distraction for a Class III Maxillary Prosthetic Defect in a Cleft Palate Patient

2011 ◽  
Vol 37 (4) ◽  
pp. 457-461 ◽  
Author(s):  
Joseph E Van Sickels ◽  
Behruz Abadi ◽  
Reed Attisha
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Class Iii ◽  
Upper Lip ◽  
Skeletal Class ◽  
Bilateral Cleft Lip ◽  
Maxillary Dentition ◽  
Partially Dentate ◽  
Palate Patient ◽  
Maxillary Distraction

Abstract Reconstruction of a partially dentate skeletal Class III patient who has had repair of a bilateral cleft lip and palate can be challenging. In this article we present our results with a segmental maxillary distraction to esthetically restore the support of the upper lip and functionally reconstruct the anterior maxillary dentition with implants. Prosthetic considerations were critical to determine the vector of distraction to achieve ideal results.

scholarly journals Mandibular and glenoid fossa changes after bone-anchored maxillary protraction therapy in patients with UCLP: A 3-D preliminary assessment

2016 ◽  
Vol 87 (3) ◽  
pp. 423-431 ◽  
Author(s):  
Marilia Yatabe ◽  
Daniela Garib ◽  
Renato Faco ◽  
Hugo de Clerck ◽  
Bernardo Souki ◽  
...  
Keyword(s):  
Multiple Testing ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Three Dimensional ◽  
T Test ◽  
Glenoid Fossa ◽  
Class Iii ◽  
Lateral Direction ◽  
Maxillary Protraction ◽  
Gonial Angle

ABSTRACT Objective: To assess mandibular and glenoid fossa (GF) changes after bone-anchored maxillary protraction (BAMP) therapy in patients with unilateral complete cleft lip and palate (UCLP). Materials and Methods: The cleft group (CG) comprised 19 patients with (mean initial age of 11.8 years). The noncleft group (NCG) comprised 24 patients without clefts (mean initial age of 11.7 years). Both groups had Class III malocclusion and were treated with BAMP therapy for 18 and 12 months, respectively. Cone-beam computed tomography (CBCT) exams were performed before and after treatment and superimposed on the anterior cranial fossa (ACF). Mandibular rotations and three-dimensional linear displacements of the mandible and GF were quantified. A t-test corrected for multiple testing (Holm-Bonferroni method) and a paired t-test were used to compare, respectively, the CG and NCG and cleft vs noncleft sides (P &lt; .05). Results: Immediately after active treatment, the GF was displaced posteriorly and laterally in both groups relative to the ACF. The overall GF changes in the CG were significantly smaller than in the NCG. Condylar displacement was similar in both groups, following a posterior and lateral direction. The gonial angle was displaced similarly posteriorly, laterally, and inferiorly in both groups. The intercondylar line rotated in opposite directions in the CG and NCG groups. In the CG, most changes of the GF and mandible were symmetrical. Conclusions: Overall GF and mandibular changes after BAMP therapy were similar in patients with and without clefts. The exception was the posterior remodeling of the GF that was slightly smaller in patients with UCLP.

Sign in / Sign up

Export Citation Format

Share Document