scholarly journals The missing link: Enhanced functional connectivity between amygdala and visceroceptive cortex in migraine

Cephalalgia ◽  
2013 ◽  
Vol 33 (15) ◽  
pp. 1264-1268 ◽  
Author(s):  
Nouchine Hadjikhani ◽  
Noreen Ward ◽  
Jasmine Boshyan ◽  
Vitaly Napadow ◽  
Yumi Maeda ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Functional Connectivity ◽  
Resting State ◽  
Healthy Subjects ◽  
Spreading Depression ◽  
Migraine Aura ◽  
Migraine Pain ◽  
Tunnel Syndrome ◽  
Chronic Pain Conditions

Background Migraine is a neurovascular disorder in which altered functional connectivity between pain-modulating circuits and the limbic system may play a role. Cortical spreading depression (CSD), which underlies migraine aura (MWA), induces C-fos expression in the amygdala. The role of CSD and amygdala connectivity in migraine without aura (MwoA) is less clear and may differentiate migraine from other chronic pain disorders. Methods Using resting-state functional MRI, we compared functional connectivity between the amygdala and the cortex in MWA and MWoA patients as well as in healthy subjects and in two other chronic pain conditions not associated with CSD: trigeminal neuralgia (TGN) and carpal tunnel syndrome (CTS). Results Amygdala connectivity in both MWA and MWoA was increased to the visceroceptive insula relative to all other groups examined. Conclusion The observed increased connectivity within the limbic/viscerosensory network, present only in migraineurs, adds to the evidence of a neurolimbic pain network dysfunction and may reflect repetitive episodes of CSD leading to the development of migraine pain.

scholarly journals Unique Profile of Spreading Depression in a Primate Model

2002 ◽  
Vol 22 (7) ◽  
pp. 835-842 ◽  
Author(s):  
Chiaki Yokota ◽  
Yuji Kuge ◽  
Yasuhiro Hasegawa ◽  
Masafumi Tagaya ◽  
Takeo Abumiya ◽  
...  
Keyword(s):  
Direct Current ◽  
Spreading Depression ◽  
Direct Evidence ◽  
Ischemic Brain Injury ◽  
Migraine Aura ◽  
Primate Model ◽  
Ischemic Brain ◽  
Cynomolgus Monkeys ◽  
Positron Emission

Spreading depression (SD) is considered to play a role in pathologic conditions of humans such as in the evolution of ischemic brain injury and migraine aura. Because many studies have demonstrated spreading hypoperfusion in patients with migraine and persistent hypoperfusion in nonprimate animal models of SD, these changes in cerebral blood flow (CBF) were regarded as an epiphenomenon of SD. However, there is no direct evidence of the occurrence of SD in primates. The authors attempted to elicit SD by applying 3.3 mol/L potassium chloride to the cerebral cortex of nine male cynomolgus monkeys. The CBF was monitored by positron emission tomography in five animals. Propagated direct-current shifts were found by the two neighboring microelectrodes only in one animal. The direct-current wave propagated at a speed of 4 mm/min and its amplitude was 20 mV, being consistent with the SD findings. Except in one animal with 6 SD episodes, SD waves were recorded infrequently at the rostral site (none in three animals, once in three, and twice in two). Focal hyperemia accompanied SD. Neither spreading hypoperfusion nor persistent hypoperfusion was found. These unique features of SD in primates raise a doubt as to whether the role of SD in nonprimate animals is the same as that in stroke and migraine in humans.

scholarly journals Resting-state brain functional connectivity in patients with chronic pain who responded to subanesthetic-dose ketamine

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yasushi Motoyama ◽  
Yoshitetsu Oshiro ◽  
Yumiko Takao ◽  
Hitoaki Sato ◽  
Norihiko Obata ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Functional Connectivity ◽  
Resting State ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Predictive Marker ◽  
Significant Negative Correlation ◽  
Improvement Rate ◽  
Numerical Rating ◽  
Brain Functional Connectivity

Abstract Ketamine has been used to treat chronic pain; however, it is still unknown as to what types of chronic pain is ketamine effective against. To identify the effect of administration of subanesthetic-dose ketamine in patients with chronic pain and to clarify the mechanism of the effect, we retrospectively investigated brain functional connectivity using resting-state functional magnetic resonance imaging (rs-fMRI). Patients were divided into responders (Group R: ≥50% improvement on Numerical Rating Scale) and non-responders (Group NR). We compared the differences in terms of brain functional connectivity by seed-to-voxel correlation analysis. Two-sample t-test revealed significant lower connectivity between the medial prefrontal cortex (mPFC) and precuneus in Group R. We also found a significant negative correlation between the improvement rate and functional connectivity strength between the mPFC and precuneus. These findings suggest that subanesthetic-dose ketamine is effective in patients with chronic pain whose brain functional connectivity between the mPFC and precuneus is low. We believe that the current study explored for the first time the correlation between brain functional connectivity and the effect of subanesthetic-dose ketamine for chronic pain and indicated the possibility of use of the predictive marker in pharmacological treatment of chronic pain.

scholarly journals The role of illness perception and emotions on quality of life in fibromyalgia compared with other chronic pain conditions

Reumatismo ◽  
2012 ◽  
Vol 64 (3) ◽  
Author(s):  
M. Capraro ◽  
M. Della Valle ◽  
M. Podswiadek ◽  
P. De Sandre ◽  
E. Sgnaolin ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Pain ◽  
Illness Perception ◽  
Chronic Pain Conditions

Role of local network oscillations in resting-state functional connectivity

NeuroImage ◽  
2011 ◽  
Vol 57 (1) ◽  
pp. 130-139 ◽  
Author(s):  
Joana Cabral ◽  
Etienne Hugues ◽  
Olaf Sporns ◽  
Gustavo Deco
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Local Network ◽  
Resting State Functional Connectivity ◽  
Network Oscillations

scholarly journals Intact corticostriatal and altered subcortical circuits in chronic pain

2021 ◽  
Author(s):  
Su Hyoun Park ◽  
Anne K. Baker ◽  
Vinit Krishna ◽  
Katherine T. Martucci
Keyword(s):  
Chronic Pain ◽  
Functional Connectivity ◽  
Resting State ◽  
Chronic Back Pain ◽  
Healthy Controls ◽  
Significant Group ◽  
Total Mood Disturbance ◽  
Subcortical Regions ◽  
The Right ◽  
Clinical Measures

Previous research has demonstrated the importance of the corticostriatal circuit in chronic pain. By focusing on nucleus accumbens (NAcc) circuits related to reward, we aimed to clarify how altered brain reward systems contribute to chronic pain. Using resting-state functional magnetic resonance imaging, we compared NAcc-medial prefrontal cortex (MPFC) functional connectivity in patients with fibromyalgia vs. healthy controls. Among patients, we analyzed the extent to which functional connectivity correlated with clinical measures. We also examined NAcc functional connectivity to subcortical regions. Lastly, we compared our results to a separate dataset of patients with chronic back pain. We identified robust NAcc-MPFC functional connectivity among patients with fibromyalgia and healthy controls, with no significant group differences. We found a positive correlational trend between NAcc-MPFC functional connectivity and total mood disturbance. Notably, patients with fibromyalgia showed significantly reduced functional connectivity of the right NAcc with mesolimbic circuit regions compared to controls. These results were largely similar to the results from the separate dataset. Our results provide novel evidence of intact corticostriatal but altered subcortical functional connectivity of the NAcc during resting-state in chronic pain and suggest that measured connectivity may relate to changes in mood and the level of cognitive demand during fMRI-based measurement.

scholarly journals Brain Imaging Biomarkers for Chronic Pain

2022 ◽  
Vol 12 ◽  
Author(s):  
Zhengwu Zhang ◽  
Jennifer S. Gewandter ◽  
Paul Geha
Keyword(s):  
Chronic Pain ◽  
Brain Imaging ◽  
Substance Misuse ◽  
Clinical Applications ◽  
Imaging Biomarkers ◽  
Costs And Benefits ◽  
Brain Circuitry ◽  
Chronic Pain Conditions ◽  
The Brain

The prevalence of chronic pain has reached epidemic levels. In addition to personal suffering chronic pain is associated with psychiatric and medical co-morbidities, notably substance misuse, and a huge a societal cost amounting to hundreds of billions of dollars annually in medical cost, lost wages, and productivity. Chronic pain does not have a cure or quantitative diagnostic or prognostic tools. In this manuscript we provide evidence that this situation is about to change. We first start by summarizing our current understanding of the role of the brain in the pathogenesis of chronic pain. We particularly focus on the concept of learning in the emergence of chronic pain, and the implication of the limbic brain circuitry and dopaminergic signaling, which underly emotional learning and decision making, in this process. Next, we summarize data from our labs and from other groups on the latest brain imaging findings in different chronic pain conditions focusing on results with significant potential for translation into clinical applications. The gaps in the study of chronic pain and brain imaging are highlighted in throughout the overview. Finally, we conclude by discussing the costs and benefits of using brain biomarkers of chronic pain and compare to other potential markers.

Resting-State Cortical Connectivity Underlying Cognitive-Motor Interactions in Gait and Postural Tasks in Young Adults

Neurology ◽  
2021 ◽  
Vol 98 (1 Supplement 1) ◽  
pp. S3.2-S3
Author(s):  
Nathan Morelli ◽  
Nathan Johnson ◽  
Kimberly Kaiser ◽  
Richard Andreatta ◽  
Nicholas Heebner ◽  
...  
Keyword(s):  
Young Adults ◽  
Functional Connectivity ◽  
Postural Control ◽  
Cognitive Performance ◽  
Dual Task ◽  
Resting State ◽  
Gait Speed ◽  
Network Connectivity ◽  
The Relationship

ObjectiveThe purpose of this study is to determine the relationship between intra- and internetwork connectivity and DTC of postural, gait, and cognitive performance in healthy, young adults.BackgroundDual-task (DT) deficits persist after return to activity in those recovering from a sports related concussion. However, little is known about the relationship of cortical network function to DT capacity. Current evidence regarding the relationship between network connectivity and dual-task balance and gait performance is limited by focusing on older adults and those with cognitive impairments, using a condensed set of task demands, and neglecting the role of connectivity in the ability to adapt to minimize DT cost (DTC).Design/MethodsTwelve adults (7 females; age: 23.41 ± 2.74 years; height: 1.73 ± 0.10 m; weight: 72.66 ± 11.25 kg) volunteered for this study. Participants completed resting-state functional magnetic resonance imaging, as well as single and DT variants of the Concussion Balance Test, Sensory Organization Test, and gait. Functional connectivity within and between the default mode (DMN), salience (SAL), and sensorimotor (SMN) networks were calculated for all subjects. Pearson's correlations were used to assess the association of connectivity to balance and gait speed DTC.ResultsInter-network connectivity between to DMN to the SAL and SMN demonstrated moderate to strong association to DTC of gait speed and postural control during tasks which perturbed sensory environments (r = −0.59 to 0.94, p < 0.05). There was no relationship between connectivity and DTC of cognitive performance during DT (r = −0.50 to 0.54, p > 0.05).ConclusionsOur findings highlight the role of the SAL, SMN, and DMN in cognitive-motor interactions during gait and postural control. Furthermore, functional connectivity underlying DT gait and static postural control performance express inverse relationships, suggesting task-dependent differences in system level processing.

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