Epidemiological and clinical features of migraine in the pediatric population of Northern Italy

Cephalalgia ◽  
2015 ◽  
Vol 36 (6) ◽  
pp. 510-517 ◽  
Author(s):  
V Tarasco ◽  
G Grasso ◽  
A Versace ◽  
E Castagno ◽  
F Ricceri ◽  
...  
Keyword(s):  
Clinical Features ◽  
Pediatric Population ◽  
Positive Family History ◽  
Age Groups ◽  
Significant Loss ◽  
Pediatric Migraine ◽  
Pediatric Headache ◽  
Associated Symptoms ◽  
History Of ◽  
Headache Center

Aim The aim of this article is to analyze the epidemiological and clinical features of migraine in a pediatric headache center. Methods A retrospective study was performed over six years. Hospital record databases were screened for the diagnosis of migraine with aura (MA) or without aura (MO), based on the ICHD-II criteria. Statistical analysis: Fisher’s test or Mann-Whitney U test, significance at p < 0.05. Results Migraine was diagnosed in 495 children (29.7% MA, 70.3% MO). The majority of diagnoses were made between ages 9 and 14 years. After stratification for age into five groups, we observed an increase of diagnoses in females, with a peak after the age of 15 years, and an increase of MA. In both groups, the attacks were usually severe, infrequent (<1–3/month) lasting <2 hours, and associated with nausea/vomiting, photophobia, phonophobia (more frequent in MO). Osmophobia was reported in 24.7% of the patients with MO. Dizziness was more frequent in patients with MA. Visual auras were the most common occurrence (87.1%). Confusional state was observed in 10.88% of the patients. A positive family history of headache was observed in >88% of the patients. Conclusion We describe the characteristics of pediatric migraine based on the ICHD-II criteria, showing a likely significant loss of diagnoses using the ICHD-III beta. The incidence of migraine increases with age. MO occurs more commonly and shows more frequent attacks and a higher prevalence of associated symptoms, in particular osmophobia. Although males are prevalent in the entire sample, the proportion of females is higher among patients with MA in all of the age groups. Phenotype and sexual prevalence of migraine acquire adult characteristics and become more frequent in females from the onset of puberty.

scholarly journals Analysis of response of epidermal melasma to 70% glycolic acid peel

2020 ◽  
Vol 6 (2) ◽  
pp. 174
Author(s):  
Kumaravel Sadagopan ◽  
Namratha Chintakula
Keyword(s):  
Glycolic Acid ◽  
Therapeutic Response ◽  
Positive Family History ◽  
Age Groups ◽  
Sun Exposure ◽  
Severity Index ◽  
Common Pattern ◽  
Duration Of Illness ◽  
Chemical Peels ◽  
History Of

<p class="abstract"><strong>Background:</strong> Melasma is an acquired disorder which presents as light brown to dark muddy brown macules (hypermelanosis) symmetrically and bilaterally on face mainly in areas which are exposed to sun and is seen more commonly among women. Chemical peels are said to be second line of management in melasma among which glycolic acid peel is considered as a gold standard. Aim of present study was to analyse the therapeutic response of epidermal melasma to 70% glycolic acid peel.</p><p class="abstract"><strong>Methods:</strong> 30 subjects were included in the study. Baseline melasma area and severity index (MASI) score of each epidermal melasma patient was recorded and were treated with 70% glycolic acid peel once in 3weeks for 3months and analysed response after 3 months using MASI scores.<strong></strong></p><p class="abstract"><strong>Results:</strong> Peak incidence of melasma was seen between age groups 31-40 years with female to male ratio 9:1, malar pattern being the most common pattern with majority of the patient’s duration of illness &gt;1 year. 30% had positive family history. 26.6% had history of daily sun exposure &gt;1 hour. 63% reduction of MASI score present. Most common side effects were erythema and burning.</p><p class="abstract"><strong>Conclusions:</strong> 70%<strong> </strong>glycolic acid along with sunscreen showed significant results in the improvement of melasma with 63% reduction in MASI score 12.97±5.15 to 4.69±1.92.</p>

scholarly journals Some Risk Factors of Chronic Functional Constipation Identified in a Pediatric Population Sample from Romania

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Claudia Olaru ◽  
Smaranda Diaconescu ◽  
Laura Trandafir ◽  
Nicoleta Gimiga ◽  
Gabriela Stefanescu ◽  
...  
Keyword(s):  
Family History ◽  
Dietary Habits ◽  
Pediatric Population ◽  
Positive Family History ◽  
Population Sample ◽  
Control Sample ◽  
Functional Constipation ◽  
Control Group ◽  
Significant Difference ◽  
History Of

We conducted an observational study over a 1-year period, including 234 children aged 4–18 years and their caregivers and a matching control group. 60.73% of the children from the study group were males. Average age for the onset of constipation was 26.39 months. The frequency of defecation was 1/4.59 days (1/1.13 days in the control group). 38.49% of the patients in the sample group had a positive family history of functional constipation. The majority of children with functional constipation come from single-parent families, are raised by relatives, or come from orphanages. Constipated subjects had their last meal of the day at later hours and consumed fast foods more frequently than the children in the control sample. We found a statistically significant difference between groups regarding obesity/overweight and constipation (χ2=104.94,  df=2,  p<0.001) and regarding physical activity and constipation (χ2=18.419;  df=3;  p<0.001). There was a positive correlation between the number of hours spent watching television/using the computer and the occurrence of the disease (F= 92.162,p<0.001, and 95% Cl). Children from broken families, with positive family history, defective dietary habits, obesity and sedentary behavior, are at higher risk to develop chronic functional constipation.

scholarly journals The Early Prelinguistic Skills in Iranian Infants and Toddlers

2021 ◽  
Vol 19 (4) ◽  
pp. 441-454
Author(s):  
Narges Bayat ◽  
◽  
Atieh Ashtari ◽  
Mohsen Vahedi ◽  
◽  
...  
Keyword(s):  
Family History ◽  
Speech Therapy ◽  
Positive Family History ◽  
Age Groups ◽  
Language Disorders ◽  
Cross Sectional ◽  
History Of ◽  
The Impact ◽  
Children's Development ◽  
Children’S Development

Objectives: The prelinguistic skills which pave the way for language development have always been an area of research in the Speech Therapy field. Although studying these skills is important, there is a study gap among Persian children. Therefore, this study explored prelinguistic skills among a sample of Persian-speaking children aged 6 to 24 months and made a comparison between different age groups. We also studied the effects of gender and family history of speech-language disorders on children’s prelinguistic abilities. Methods: In the present study, 277 mothers of Iranian Persian-speaking children aged 6 to 24 months were asked to fill a research-made checklist that evaluated the prelinguistic skills of their children. This study was cross-sectional and was conducted in Tehran City, Iran, in 2021. Children’s abilities in different age groups were compared using the analysis of variance (ANOVA), Scheffe test, the Kruskal-Wallis test, and the post-hoc test. The differences between the total scores of the two genders were also determined using the Mann-Whitney U test. Results: Comparing the prelinguistic skills in different age groups indicated a statistically significant increase in the scores as children grow up. Children with a positive family history of speech-language disorders scored lower on the checklist than the others (91.03±17.37). Furthermore, there were statistically significant differences between the two genders in developing gesture, vocalization, first words, social interaction, imitation, and play; girls had higher scores. Conclusion: Based on the studies conducted in different countries, prelinguistic skills develop as children grow up; these skills facilitate language acquisition and other social skills. The present study also demonstrated the development of these skills alongside children’s development. This similarity between Persian-speaking children and other children from different cultures and languages, as well as better performance in children with a negative family history of speech-language impairments, confirm the role of genetic factors in children’s development. Moreover, the differences in the development of some prelinguistic skills between girls and boys reveal the impact of various factors, such as social factors, on prelinguistic skills development.

scholarly journals Childhood eating disorders: British national surveillance study

2011 ◽  
Vol 198 (4) ◽  
pp. 295-301 ◽  
Author(s):  
Dasha E. Nicholls ◽  
Richard Lynn ◽  
Russell M. Viner
Keyword(s):  
Eating Disorders ◽  
Clinical Features ◽  
Early Onset ◽  
Surveillance System ◽  
Age Groups ◽  
Child And Adolescent Psychiatry ◽  
Outcome Data ◽  
Feeding Difficulties ◽  
History Of ◽  
Set Up

BackgroundThe incidence of eating disorders appears stable overall, but may be increasing in younger age groups. Data on incidence, clinical features and outcome of early-onset eating disorders are sparse.AimsTo identify new cases of early-onset eating disorders (<13 years) presenting to secondary care over 1 year and to describe clinical features, management and 1-year outcomes.MethodSurveillance over 14 months through the established British Paediatric Surveillance System, and a novel child and adolescent psychiatry surveillance system set up for this purpose.ResultsOverall incidence was 3.01/100 000 (208 individuals). In total, 37% met criteria for anorexia nervosa; 1.4% for bulimia nervosa; and 43% for eating disorder not otherwise specified. Nineteen per cent showed determined food avoidance and underweight without weight/shape concerns. Rates of comorbidity were 41%; family history of psychiatric disorder 44%; and early feeding difficulties 21%. Time to presentation was >8 months. A total of 50% were admitted to hospital, typically soon after diagnosis. Outcome data were available for 76% of individuals. At 1 year, 73% were reported improved, 6% worse and 10% unchanged (11% unknown). Most were still in treatment, and seven were hospital in-patients for most of the year.ConclusionsChildhood eating disorders represent a significant clinical burden to paediatric and mental health services. Efforts to improve early detection are needed. These data provide a baseline to monitor changing trends in incidence.

scholarly journals POS1326 FAMILIAL PERIODIC FEVER, APHTHOUS STOMATITIS, PHARYNGITIS AND ADENITIS (PFAPA)SYNDROME; IS IT A SEPARATE DISEASE?

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 945.2-945
Author(s):  
Y. Butbul
Keyword(s):  
Family History ◽  
Pediatric Population ◽  
Periodic Fever ◽  
Positive Family History ◽  
Aphthous Stomatitis ◽  
M694v Mutation ◽  
Fever Syndromes ◽  
History Of ◽  
Pfapa Syndrome ◽  
Sporadic Disease

Background:Periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome (PFAPA) is the most common periodic fever syndrome in the pediatric population. Unlike other periodic fever syndromes, the pathogenesis and genetics of PFAPA is unknown. Until recently, PFAPA was believed to be a sporadic disease, yet family clustering has been widely observed and current research indicates that heredity is likely.Objectives:To identify demographic and clinical differences between patients with PFAPA who have a positive family history (FH+) compared to those with PFAPA with no family history (FH-) that can reveal if heritable and sporadic subtypes of this disorder exist.Methods:In a database comprising demographic and clinical data of 273 pediatric PFAPA patients treated at two tertiary centers in Israel, 31(14.3%) of patients were PFAPA FH+. Data from patients with FH+ for PFAPA was compared to data from those with FH- of the disorder. Furthermore, family members (FMs) of those with FH+ were contacted via telephone for more demography and clinical details.Results:FH+ group had more headaches (32% vs.2%; p= 0.016), myalgia (56% vs. 19%; p= 0.001), higher carrier frequency of M694V mutation (54% vs. 25%; p=0.053), greater family history of FMF (30% vs. 15%; p=0.096) and better outcomes with colchicine (82% vs. 52%; p=0.096) compared to those with FH-. FMs displayed almost identical characteristics to the FH+ group except for greater arthralgia during flares (64% vs. 23%; p=0.008) and compared to the FH- group, more oral aphthae (68% vs. 43%; p=0.002), myalgia/arthralgia (64% vs. 19%/16%; p<0.0001), and higher rates of FH of FMF (45% vs.15%; p=0.003).Conclusion:Our findings suggest that FH+ had probably different subset of disease with higher frequency of family history of FMF arthralgia, myalgia and better response to colchicine. Colchicine prophylaxis for PFAPA should be considered in FH+.Disclosure of Interests:None declared

Evaluation of the Clinical Features of 81 Patients with COVID-19: An Unpredictable Disease in Children

2020 ◽  
Author(s):  
Hayrettin Temel ◽  
Mehmet Gündüz ◽  
Hüseyin Arslan ◽  
Füsun Ünal ◽  
Emine Atağ ◽  
...  
Keyword(s):  
Clinical Features ◽  
Pediatric Patients ◽  
Clinical Laboratory ◽  
Tertiary Care ◽  
Age Groups ◽  
Signs And Symptoms ◽  
Asymptomatic Infection ◽  
Care Hospital ◽  
Significant Difference ◽  
History Of

Abstract Objective Data on the prognosis of clinical features of pediatric patients affected by the coronavirus disease 2019 (COVID-19) pandemic is insufficient. This study aimed to examine the clinical, laboratory, and radiology findings of pediatric patients diagnosed with COVID-19. Methods A total of 81 pediatric patients with a confirmed diagnosis of COVID-19 who were admitted to the pediatric clinics of our tertiary care hospital in Istanbul between March 22 and May 1, 2020, were included in the study. Results Of the patients, 40 (49.6%) were boys and 41 (50.6%) were girls. The mean age of the patients was 9.3 ± 5.5 years (range: 1 month–16 years). The most common symptoms were cough (28.4%) and fever (25.9%). A total of 26 patients (32.1%) had pharyngeal erythema. There was no significant difference between age groups in terms of symptoms, findings, clinical picture, history of contact, and clinical course (p > 0.001 for each). Abnormal findings were observed in seven (8.6%) patients on chest X-ray, and in four patients (4.9%) on thorax computed tomography. Only three of the patients were hospitalized and all of them discharged with healing. Conclusion The present study is the most comprehensive study on children diagnosed with COVID-19 in our country, which showed that the COVID-19 picture was mild in pediatric patients, but the signs and symptoms in children were not specific to the disease. Our findings also showed that the rate of asymptomatic infection in children was high and that it was difficult to recognize COVID-19 in children.

Clinical Features of Hypertension in Frequent and Heavy Alcohol Drinkers

1982 ◽  
Vol 27 (3) ◽  
pp. 207-211 ◽  
Author(s):  
L. E. Ramsay
Keyword(s):  
Alcohol Use ◽  
Clinical Features ◽  
Positive Family History ◽  
Vascular Complications ◽  
Hypertensive Patients ◽  
Lower Blood ◽  
History Of ◽  
Family History Of Hypertension ◽  
One Year ◽  
Alcohol Users

An association between regular alcohol use and hypertension is firmly established. The clinical features of hypertensive patients who used alcohol frequently or heavily were compared with those of age and sex matched hypertensive patients who used alcohol only occasionally or never. Regular alcohol use was associated with milder hypertension, lower blood urea concentrations and fewer electrocardiographic abnormalities. However, there was no evidence that major vascular complications, including myocardial infarction, were less common in regular drinkers, perhaps because of their associated heavy cigarette smoking. Regular alcohol users were as likely to give a positive family history of hypertension, but were less likely to have an abnormal intravenous pyelogram. Heavy drinkers were twice as likely to default within one year.

Comparison of the Prevalence of Infantile Colic Between Pediatric Migraine and Other Types of Pediatric Headache

2020 ◽  
Vol 35 (9) ◽  
pp. 607-611
Author(s):  
Yoel Levinsky ◽  
Tal Eidlitz-Markus
Keyword(s):  
International Headache Society ◽  
Primary Headache ◽  
Historical Study ◽  
Infantile Colic ◽  
Cross Sectional ◽  
Pediatric Migraine ◽  
Pediatric Headache ◽  
History Of ◽  
The Difference ◽  
Beta Version

Background/Objective: The International Headache Society lists infantile colic under “episodic syndromes that may be associated with migraine” in the ICHD3-beta version of its classification of headache disorders. The aim of this study was to examine whether this association is specific to migraine or applies to all pediatric headache types. Methods: A cross-sectional historical study was conducted including 219 patients aged 3-18 years who presented to a tertiary pediatric headache clinic in 2016-2017. Parents were asked a series of questions to determine if their child had had infantile colic as defined in the ICHD3-beta version. The prevalence of a positive history of colic was compared between children diagnosed with migraine or other primary headache types. Results: There were 132 girls (60.2%) and 87 boys (39.8%) of mean age 12.8 ± 3.48 years at presentation. Migraine headache was diagnosed in 170 patients (77.6%) and other types primary of headache (9 in total) in 49 patients (22.3%). Fifty-one patients had a history of infantile colic. They included 45 patients in the migraine group (26.5%) and 5 in the comparison groups (10.2%); the difference in the rate of colic was statistically significant ( P = .0196; OR 3.17, 95% CI 0.1.17-6.17). There was no association of specific migraine parameters or symptoms with infantile colic. Conclusion: There appears to be an association of infantile colic with pediatric migraine but not with other types of pediatric headache. These findings reinforce the theory that infantile colic has common pathogenic roots with migraine.

Familial Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis (PFAPA) Syndrome; is it a Separate Disease?

2021 ◽  
Author(s):  
Tamar Veres ◽  
Gil Amarilyo ◽  
Sabreen Abu Ahmad ◽  
Maryam Abu Rumi ◽  
Riva Brik ◽  
...  
Keyword(s):  
Family History ◽  
Clinical Data ◽  
Carrier Frequency ◽  
Pediatric Population ◽  
Periodic Fever ◽  
Positive Family History ◽  
Periodic Fever Syndrome ◽  
M694v Mutation ◽  
History Of ◽  
Pfapa Syndrome

Abstract Introduction: PFAPA is the most common periodic fever syndrome in the pediatric population yet pathogenesis is unknown. PFAPA was believed to be sporadic but family clustering has been widely observed.Objective: To identify demographic and clinical differences between patients with PFAPA and a positive family history (FH+) compared to those with PFAPA with no family history (FH-).Methods: In a database comprising demographic and clinical data of 273 pediatric PFAPA patients treated at two tertiary centers in Israel, 31 (14.3%) of patients were PFAPA FH+. Data from patients with FH+ for PFAPA was compared to data from those with FH- of the disorder. Furthermore, family members (FMs) of those with FH+ were contacted via telephone for more demography and clinical details. Results: FH+ group had more headaches (32% vs.2%; p= 0.016), myalgia (56% vs. 19%; p= 0.001), higher carrier frequency of M694V mutation (54% vs. 25%; p=0.053), greater family history of FMF (30% vs. 15%; p=0.096) and better outcomes with colchicine (82% vs. 52%; p=0.096) compared to those with FH-. FMs displayed almost identical characteristics to the FH+ group except for greater arthralgia during flares (64% vs. 23%; p=0.008) and compared to the FH- group, more oral aphthae (68% vs. 43%; p=0.002), myalgia/arthralgia (64% vs. 19%/16%; p<0.0001), and higher rates of FH of FMF (45% vs.15%; p=0.003). Conclusions: Our findings suggest that FH+ likely experience a different subset of disease with higher frequency of family history of FMF, arthralgia, myalgia and better response to colchicine compared to FH-. Colchicine prophylaxis for PFAPA should be considered in FH+.

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