Migraine and cognitive function: Baseline findings from the Brazilian Longitudinal Study of Adult Health: ELSA-Brasil

Background The association between migraine and cognitive performance is unclear. We analyzed whether migraine is associated with cognitive performance among participants of the Brazilian Longitudinal Study of Adult Health, ELSA-Brasil. Methods Cross-sectional analysis, including participants with complete information about migraine and aura at baseline. Headache status (no headaches, non-migraine headaches, migraine without aura and migraine with aura), based on the International Headache Society classification, was used as the dependent variable in the multilinear regression models, using the category “no headache” as reference. Cognitive performance was measured with the Consortium to Establish a Registry for Alzheimer’s Disease word list memory test (CERAD-WLMT), the semantic fluency test (SFT), and the Trail Making Test version B (TMTB). Z-scores for each cognitive test and a composite global score were created and analyzed as dependent variables. Multivariate models were adjusted for age, gender, education, race, coronary heart disease, heart failure, hypertension, diabetes, dyslipidemia, body mass index, smoking, alcohol use, physical activity, depression, and anxiety. In women, the models were further adjusted for hormone replacement therapy. Results We analyzed 4208 participants. Of these, 19% presented migraine without aura and 10.3% presented migraine with aura. All migraine headaches were associated with poor cognitive performance (linear coefficient β; 95% CI) at TMTB −0.083 (−0.160; −0.008) and poorer global z-score −0.077 (−0.152; −0.002). Also, migraine without aura was associated with poor cognitive performance at TMTB −0.084 (−0.160, −0.008 and global z-score −0.077 (−0.152; −0.002). Conclusion In participants of the ELSA-study, all migraine headaches and migraine without aura were significantly and independently associated with poorer cognitive performance.

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Ideal vascular health and cognitive performance in the Brazilian Longitudinal Study of Adult Health

European Journal of Neurology ◽

10.1111/ene.14532 ◽

2020 ◽

Vol 28 (1) ◽

pp. 71-80

Author(s):

C. K. Suemoto ◽

C. Szlejf ◽

I.S. Santos ◽

A. R. Brunoni ◽

A.C. Goulart ◽

...

Keyword(s):

Longitudinal Study ◽

Cognitive Performance ◽

Vascular Health ◽

Adult Health

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Headache and psychiatry

Oxford Textbook of Headache Syndromes ◽

10.1093/med/9780198724322.003.0052 ◽

2020 ◽

pp. 475-483

Author(s):

Maurizio Pompili ◽

Dorian A. Lamis ◽

Frank Andrasik ◽

Paolo Martelletti

Keyword(s):

Mental Illness ◽

Chronic Migraine ◽

Migraine With Aura ◽

Migraine Headache ◽

Migraine Without Aura ◽

Psychiatric Comorbidity ◽

Somatic Symptoms ◽

Migraine Aura ◽

Migraine Headaches ◽

History Of

Patients suffering from different types of headache typically complain of numerous associated symptoms (e.g. behavioural and somatic), which may be partially related to psychiatric comorbidity. Somatic symptoms have been demonstrated to be more common in patients with chronic migraine, especially for severe headaches with accompanying depression or anxiety. Moreover, chronic migraine may be considered as distinct from an episodic type of migraine with aura, migraine without aura, and migraine aura without headache (without a history of characteristic migraine headaches). Accordingly, the present chapter explores the prevalence and impact of mental illness in patients diagnosed with migraine headache.

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Education Plays a Greater Role than Age in Cognitive Test Performance among Participants of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

International Journal of Epidemiology ◽

10.1093/ije/dyv096.503 ◽

2015 ◽

Vol 44 (suppl_1) ◽

pp. i265-i265 ◽

Cited By ~ 1

Author(s):

V. M. A. Passos ◽

L. Giatti ◽

I. Bensenor ◽

D. Chor ◽

S. M. Barreto

Keyword(s):

Longitudinal Study ◽

Test Performance ◽

Cognitive Test ◽

Adult Health ◽

Cognitive Test Performance

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The relationship between migraine and lipid sub-fractions among individuals without cardiovascular disease: A cross-sectional evaluation in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Cephalalgia ◽

10.1177/0333102417699181 ◽

2017 ◽

Vol 38 (3) ◽

pp. 528-542 ◽

Cited By ~ 4

Author(s):

Alessandra C Goulart ◽

Paulo A Lotufo ◽

Itamar S Santos ◽

Márcio S Bittencourt ◽

Raul D Santos ◽

...

Keyword(s):

Cardiovascular Disease ◽

Longitudinal Study ◽

Migraine Without Aura ◽

Density Ratio ◽

Adult Health ◽

Lipoprotein Subfractions ◽

Cross Sectional ◽

Lipid Disorders ◽

Triglyceride Rich Lipoprotein ◽

The Relationship

Introduction Recent studies have explored the relationship between dyslipidemia and migraine in a cardiovascular context. Thus, we aimed to evaluate the possible association between lipids, lipoprotein subfractions and migraine according to aura symptoms in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods 1,560 women and 1,595 men, without CVD or lipid disorders requiring medication, underwent a baseline clinical assessment. Total-cholesterol and its sub-fractions (LDL, VLDL and HDL subclass cholesterol); triglycerides and triglyceride-rich lipoprotein cholesterol [TRL-C (VLDL1+2-C VLDL3-C + IDL-C)] were determined by vertical auto profile (VAP). We also calculated logarithmic LDL density ratio [LLDR = ln ((LDL3-C + LDL4-C)/(LDL1-C + LDL2-C))], T-Chol/HDL-C and triglycerides/HDL-C ratios. Odds ratios (OR) with 95% confidence intervals (CI) were obtained to evaluate the relationship between lipids tertiles and migraine for both sexes. Results Main findings revealed positive associations between migraine without aura (MO) and the highest tertiles of VLDL-C (OR, 1.61; 95%CI, 1.07–2.40) and TRL-C (OR, 1.55; 95% CI, 1.03–2.34) in women. In men, the highest tertile of VLDL3-C (OR, 3.87; 95%CI, 1.23–12.19) was positively associated with MO, as well. Conclusions In middle-aged participants without CVD or lipid disorders requiring medication, the worst lipid profile was determined by the highest levels of TRL-C and their cholesterol-rich remnants in migraineurs without aura for both sexes.

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P2-533: IDEAL CARDIOVASCULAR HEALTH AND COGNITIVE PERFORMANCE IN THE BRAZILIAN LONGITUDINAL STUDY OF ADULT HEALTH STUDY (ELSA-BRASIL)

Alzheimer s & Dementia ◽

10.1016/j.jalz.2019.06.2941 ◽

2019 ◽

Vol 15 ◽

pp. P823-P823

Author(s):

Claudia K. Suemoto ◽

Claudia Szlefj ◽

Itamar Souza Santos ◽

Paulo A. Lotufo ◽

Isabela M. Bensenor

Keyword(s):

Longitudinal Study ◽

Cognitive Performance ◽

Cardiovascular Health ◽

Health Study ◽

Adult Health ◽

Ideal Cardiovascular Health

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Education plays a greater role than age in cognitive test performance among participants of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

BMC Neurology ◽

10.1186/s12883-015-0454-6 ◽

2015 ◽

Vol 15 (1) ◽

Cited By ~ 28

Author(s):

Valéria Maria de Azeredo Passos ◽

Luana Giatti ◽

Isabela Bensenor ◽

Henning Tiemeier ◽

M. Arfan Ikram ◽

...

Keyword(s):

Longitudinal Study ◽

Test Performance ◽

Cognitive Test ◽

Adult Health ◽

Cognitive Test Performance

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Migraine Headaches in Adolescents: A Student Population-Based Study in Monreale

Cephalalgia ◽

10.1046/j.1468-2982.1995.1501005.x ◽

1995 ◽

Vol 15 (1) ◽

pp. 5-12 ◽

Cited By ~ 81

Author(s):

V Raieli ◽

D Raimondo ◽

R Cammalleri ◽

R Camarda

Keyword(s):

Migraine With Aura ◽

Migraine Without Aura ◽

International Headache Society ◽

Epidemiological Survey ◽

Population Based ◽

Student Population ◽

Population Based Study ◽

Migraine Headaches ◽

Ihs Classification ◽

Juvenile Population

We assessed the prevalence of migraine headaches in an epidemiological survey of an 11 to 14-year-old student population. Migraine headaches were classified on the basis of questionnaires and neurological examination using the operational diagnostic criteria of the International Headache Society. Prevalence of migraine without aura (IHS code 1.1) was 2.35%; that of migraine with aura (IHS code 1.2) was 0.62%. Migraine without aura was equally distributed among males and females, whereas migraine with aura was preponderant in the female cohort. The prevalence of migraine headaches in males was constant through the ages studied, whereas the prevalence of migraine headaches in females reached a peak at age 12 and plateaued over the following two years. Although the new IHS classification criteria of migraines are reliable and exhaustive, some subcriteria may not be valid in a juvenile population. For instance, the duration of the pain in young migraineurs is often briefer than in adults, and the intensity of pain was almost always described as moderate or severe. Therefore, in order to increase the reliability and comprehensiveness of the IHS classification, minor modifications should be made.

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Serum folate levels and cognitive performance in the ELSA-Brasil baseline assessment

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20200074 ◽

2020 ◽

Vol 78 (11) ◽

pp. 672-680

Author(s):

Itamar de Souza SANTOS ◽

Claudia Kimie SUEMOTO ◽

José Benedito Ramos VALLADÃO-JUNIOR ◽

Simin LIU ◽

Sandhi Maria BARRETO ◽

...

Keyword(s):

Cognitive Function ◽

Cognitive Performance ◽

Serum Folate ◽

Cognitive Test ◽

Food Fortification ◽

Adult Health ◽

Baseline Assessment ◽

Linear Regression Models ◽

Cognitive Score ◽

Clinical Scenarios

ABSTRACT Background: Most studies that analyze the association between serum folate levels and cognitive function either restrict their assessments to specific clinical scenarios or do not include middle-aged individuals, to whom strategies for preventing cognitive impairment may be more feasible. Objective: To examine the association between serum folate levels and cognitive function in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline assessment. Methods: Data from 4,571 ELSA-Brasil participants who live in the state of São Paulo, aged 35-74 years, were analyzed. The word list learning, delayed recall, word recognition, verbal fluency, and Trail Making Test Part B consisted in the cognitive tests. For each test, age, sex, and education-specific standardized scores and a global cognitive score were calculated. Crude and adjusted linear regression models were used to examine the associations of serum folate levels with cognitive test scores. Results: In multivariable-adjusted models, serum folate was not associated with global cognitive score (β=-0.043; 95% confidence interval [95%CI] -0.135 to 0.050 for lowest vs. highest quintile group), nor with any cognitive test performance. We did not find associations between serum folate and global cognitive scores in subgroups stratified by age, sex, or use of vitamin supplements either. Conclusions: We did not find significant associations between serum folate and cognitive performance in this large sample, which is characterized by a context of food fortification policies and a consequent low frequency of folate deficiency. Positive results from previous studies may not apply to the increasingly common contexts in which food fortification is implemented, or to younger individuals.

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Abstract 95: Nutrition and Cognitive Decline Over 21-years: Results from the Atherosclerosis Risk in Communities Study (ARIC)

Stroke ◽

10.1161/str.48.suppl_1.95 ◽

2017 ◽

Vol 48 (suppl_1) ◽

Author(s):

Jennifer L Dearborn ◽

Aozhou Wu ◽

Lyn M Steffen ◽

David S Knopman ◽

Thomas H Mosley ◽

...

Keyword(s):

Cognitive Function ◽

Cognitive Decline ◽

Cognitive Performance ◽

Test Scores ◽

Population Based ◽

Word Recall ◽

Cognitive Test ◽

Z Score ◽

Balanced Diet ◽

Diet Pattern

Background: A healthy diet may be protective against cognitive decline by mechanisms that involve improved vascular risk factors such as hypertension and dysglycemia, and reduced systemic inflammation. In this population-based study, we hypothesized that midlife diet pattern would be associated with cognitive decline over 21-years. Methods: This study included 13,603 participants in the ARIC population-based cohort recruited from four U.S. sites who were aged 45 to 64 at baseline (1987-89) when diet was measured. Participants recorded diet using a 66-item food frequency questionnaire. Two dietary patterns, called “Meat and Fried” and the “Balanced Diet”, were named after the most representative foods that emerged from constructs derived from a principal component analysis of 30 food groups. A higher diet pattern score represented greater adherence. Cognitive testing, including the digit symbol substitution, the word fluency and delayed word recall tests, were combined to a z-score at each visit (visits 2, 1990-92; 4, 1996-98 and 5, 2011-2013). Test scores for participants not attending subsequent visits were imputed using Multiple Imputation by Chained Equations to account for cohort attrition. Cognitive performance at visit 2 was compared by tertile (T) of each diet pattern. Using mixed effects models with a random slope and intercept , we determined the 21-year change in cognitive function by diet pattern tertile, adjusting for demographics and medical history. Results: At visit 2, adherence to the Meat and Fried pattern was associated with lower cognitive test scores (z-score T3: -0.172, SD 0.985; T1: 0.149, SD 0.981, p-trend <0.001). Adherence to the Balanced Diet was not associated with differences in cognitive performance (z-score T3: 0.013, SD 0.988; T1 -0.036, SD 1.001, p-trend 0.10). 21-year change in cognitive function did not differ by adherence to diet pattern with adjustments (difference of the change in z-score for Meat and Fried, T3 vs. T1: 0.02, [CI -0.05 to 0.08]; Balanced Diet T3 vs. T1: -0.03, [CI -0.09 to 0.02]). Conclusion: Although participants with a diet pattern high in meat and fried foods had lower cognition at time of first assessment, diet patterns at midlife did not carry independent associations with cognitive decline.

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