The relationship between migraine and lipid sub-fractions among individuals without cardiovascular disease: A cross-sectional evaluation in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Cephalalgia ◽  
2017 ◽  
Vol 38 (3) ◽  
pp. 528-542 ◽  
Author(s):  
Alessandra C Goulart ◽  
Paulo A Lotufo ◽  
Itamar S Santos ◽  
Márcio S Bittencourt ◽  
Raul D Santos ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Longitudinal Study ◽  
Migraine Without Aura ◽  
Density Ratio ◽  
Adult Health ◽  
Lipoprotein Subfractions ◽  
Cross Sectional ◽  
Lipid Disorders ◽  
Triglyceride Rich Lipoprotein ◽  
The Relationship

Introduction Recent studies have explored the relationship between dyslipidemia and migraine in a cardiovascular context. Thus, we aimed to evaluate the possible association between lipids, lipoprotein subfractions and migraine according to aura symptoms in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods 1,560 women and 1,595 men, without CVD or lipid disorders requiring medication, underwent a baseline clinical assessment. Total-cholesterol and its sub-fractions (LDL, VLDL and HDL subclass cholesterol); triglycerides and triglyceride-rich lipoprotein cholesterol [TRL-C (VLDL1+2-C VLDL3-C + IDL-C)] were determined by vertical auto profile (VAP). We also calculated logarithmic LDL density ratio [LLDR = ln ((LDL3-C + LDL4-C)/(LDL1-C + LDL2-C))], T-Chol/HDL-C and triglycerides/HDL-C ratios. Odds ratios (OR) with 95% confidence intervals (CI) were obtained to evaluate the relationship between lipids tertiles and migraine for both sexes. Results Main findings revealed positive associations between migraine without aura (MO) and the highest tertiles of VLDL-C (OR, 1.61; 95%CI, 1.07–2.40) and TRL-C (OR, 1.55; 95% CI, 1.03–2.34) in women. In men, the highest tertile of VLDL3-C (OR, 3.87; 95%CI, 1.23–12.19) was positively associated with MO, as well. Conclusions In middle-aged participants without CVD or lipid disorders requiring medication, the worst lipid profile was determined by the highest levels of TRL-C and their cholesterol-rich remnants in migraineurs without aura for both sexes.

Gender aspects of the relationship between migraine and cardiovascular risk factors: A cross-sectional evaluation in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Cephalalgia ◽  
2015 ◽  
Vol 35 (12) ◽  
pp. 1103-1114 ◽  
Author(s):  
Alessandra C Goulart ◽  
Itamar S Santos ◽  
Paulo A Lotufo ◽  
Isabela M Benseñor
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Longitudinal Study ◽  
Cardiovascular Risk Factors ◽  
Multinomial Logistic Regression ◽  
Inverse Association ◽  
Adult Health ◽  
Regression Analyses ◽  
Cross Sectional ◽  
The Relationship

Background The relationship between cardiovascular risk factors (CVRF) and migraine is controversial and might be different in both genders. These associations were evaluated in Brazilian middle-aged men and women from the Longitudinal Study of Adult Health (ELSA-Brasil). Methods The cross-sectional relationship between our main outcome, which was migraine headache (definite, probable and overall), and CVRF was evaluated in the total sample and according to gender. We calculated frequencies and odds ratios (95% CI) for this relationship using binary and multinomial logistic regression analyses in crude, age-adjusted and multivariable models adjusted by potential confounders. Results Of 14,953 individuals who completed the data about headache and CVRF, the frequency of one-year migraine was of 29.5% (22.5% in women and 7.0% in men). In the multivariable-adjusted regression analyses, an inverse association between hypertension (OR, 0.53; 95% CI, 0.36–0.79), metabolic syndrome (OR, 0.65; 95% CI, 0.43–0.99) and definite migraine were confirmed for men, but not for women. In the opposite direction, a positive association between migraine headaches (definite, probable and overall) and dyslipidemia (overall migraine OR, 1.25; 95% CI, 1.13–1.38) was observed only for women, but not for men. Conclusions A gender influence on the relationship between migraine and CVRF was verified in the ELSA-Brasil.

Abstract P197: The Relationship Between Thyroid-Stimulating Hormone Levels and Lipoprotein Subfractions in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Erique J Peixoto-Miranda ◽  
Alessandra C Goulart ◽  
Marcio S Bittencourt ◽  
Michael Blaha ◽  
Steven Jones ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Multinomial Logistic Regression ◽  
Thyroid Stimulating Hormone ◽  
Lipoprotein Cholesterol ◽  
Lipid Lowering ◽  
Adult Health ◽  
Middle Aged ◽  
Lipoprotein Subfractions ◽  
Triglyceride Rich Lipoprotein ◽  
Stimulating Hormone

Background and purpose: Although the relation between thyroid disorders and heart diseases had been described since decades ago, the association of thyroid-stimulating hormone (TSH) and lipoproteins is not very well elucidated. Hypothesis: to verify if there are associations with TSH levels, lipid and lipoprotein subfractions in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods: We evaluated at the ELSA-Brasil baseline (2008-2010) 3,742 middle-aged participants (1,960 women and 1,782 women) without previous cardiovascular disease and people who were taking neither drugs that can interfere with thyroid function nor lipid-lowering agents. All of them had their levels of total-cholesterol and its sub-fractions (LDL, VLDL and HDL subclasses); triglycerides and triglyceride-rich lipoprotein cholesterol [TRL-C (VLDL1+2-C VLDL3-C + IDL-C)] determined by ultracentrifugation (Vertical Auto Profile, Atherotech). We also calculated T-Chol/HDL-C and triglycerides/HDL-C ratios. The application multinomial logistic regression model obtained odds ratios (OR) with its respective 95% confidence interval (95% CI). They are presented as adjusted for age, sex, educational level, hypertension, diabetes, and smoking. Lipids tertiles were evaluated as dependent variables, the quintiles of TSH were considered as an independent variable, using first quintiles of TSH as the reference. Results: The main associations obtained were between the highest levels of TSH (5th quintile) with the highest levels (3rd tertiles) of VLDL-C, OR=1.55 (95%CI, 1.18-2.04); triglycerides, OR=1.71 (95%CI, 1.30-2.24); VLDL-3-C, OR=1.48 (95%CI, 1.13-1.94); TC/HDL-C ratio, OR=1.37 (95%CI; 1.04-1.81) and TG/HDL-C ratio, OR=1.71 (95%CI; 1.29-2.26). A positive association between the lowest levels of HDL3-C (1st tertile) and the highest of TSH was also verified with OR= 1.43 (95%CI, 1.10-1.87). In women, we found positive associations with the 5th TSH quintiles and the 3rd tertiles of VLDL-C, OR 1.68;(95%CI 1.18-2.41); non-HDL-C, OR,1.50; (95%CI,1.04-2.16); Triglyceride-rich Lipoprotein Cholesterol,OR 1.42 (95%CI 1.00-2.02); VLDL3-C (OR,1.68;95%CI 1.16-2.45), TC/HDL-C ratio (OR 1.86;95% CI 1.29-2.69) and TG/HDL-C-ratio (OR 1.62;95%CI 1.12-2.35). In men, we found associations between the 5th quintile of TSH and the 3rd tertiles of TG (OR 1.59; 95%CI 1.07-2.36) and TG/HDL-C-ratio (OR 1.71; 95%CI 1.15-2.55). Conclusions: In this sample of middle-aged participants from ELSA-Brasil, an unfavorable lipid profile, which included triglyceride-rich lipoproteins and their remnants were mostly associated with high levels of TSH. In the other hand, we observed a risky association between the lowest levels of HDL3-C and the highest levels of TSH. The majority of our findings were mainly reproduced among women.

Adiponectin and leptin levels in migraineurs: Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

2020 ◽  
Vol 3 ◽  
pp. 251581632096696
Author(s):  
Alessandra C Goulart ◽  
Bianca de Almeida-Pititto ◽  
Paulo A Lotufo ◽  
Itamar S Santos ◽  
Sandra RG Ferreira ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Regression Models ◽  
P Value ◽  
Adult Health ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
The Third ◽  
Disease Associations ◽  
Relationship Of ◽  
The Relationship

Background: Relationships of adipokines (ADP) with migraine are not well-established. We examined the relationship of adiponectin and leptin with migraine by aura symptoms. Methods: In a baseline cross-sectional data of Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), associations of ADP levels and migraine were assessed in a sample of 257 nondiabetic subjects, free from cardiovascular disease. Associations of ADP tertiles (dependent variable) and migraine status were tested using logistic regression models. Categories of migraine were created as follows: no headache (reference), migraine with aura (MA), and migraine without aura (MO) in all sample and by sex. Odds ratio (OR) with respective 95% confidence interval (CI) adjusted for age, sex, body mass index, and metabolic syndrome. Results: Among participants (46 years ± SD: 4.8), 47.5% were women and 36.2% had migraine (16.7% MA). Median values of leptin (ng/mL) increased gradually across subgroup: no headache: 9.5 (interquartile range (IQR): 5.5–15.7) versus MO: 17.0 (IQR: 10.9–34.2) versus MA: 20.9 (IQR: 11.7–29.3), overall p value <0.0001, but not for adiponectin levels. After full adjustment, the third of leptin was positively associated with MA (OR 2.89 (1.00–8.4)) and the second of adiponectin was associated with MO (OR 2.76; 95% CI: 1.09–6.96, p = 0.03). Positive associations with MA, second (OR 3.81; 95% CI: 1.07–13.59; p = 0.04) and third tertile of leptin (6.54; 95% CI: 1.74–24.57, p = 0.005), were also observed in women, but not in men. Conclusions: Positive associations between ADP and migraine, particularly between MA and leptin levels in women, raise the possibility of adipocytokines and play a role in migraine pathophysiology.

Life course socioeconomic adversities and 10-year risk of cardiovascular disease: cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health

2016 ◽  
Vol 62 (2) ◽  
pp. 283-292 ◽  
Author(s):  
Dayse Rodrigues de Sousa Andrade ◽  
Lidyane V. Camelo ◽  
Rodrigo Citton P. dos Reis ◽  
Itamar S. Santos ◽  
Antonio Luiz Ribeiro ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Longitudinal Study ◽  
Life Course ◽  
Adult Health ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Sectional Analysis

Relative risk of cardiovascular disease is higher in women with type 2 diabetes, but not in those with prediabetes, as compared with men

2020 ◽  
Author(s):  
Elena Succurro ◽  
Teresa Vanessa Fiorentino ◽  
Sofia Miceli ◽  
Maria Perticone ◽  
Angela Sciacqua ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Longitudinal Study ◽  
Relative Risk ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Adverse Outcomes ◽  
Cross Sectional ◽  
Normal Glucose

<b>Objective</b>: Most, but not all studies suggested that women with type 2 diabetes have higher relative risk (RR) for cardiovascular disease (CVD) than men. More uncertainty exists on whether the RR for CVD is higher in prediabetic women compared to men. <p><b>Research Design and Methods</b>: In a cross-sectional study, in 3540 normal glucose tolerant (NGT), prediabetic, and diabetic adults, we compared the RR for prevalent non-fatal CVD between men and women. In a longitudinal study including 1658 NGT, prediabetic, and diabetic adults, we compared the RR for incident major adverse outcomes, including all-cause death, coronary heart disease, and cerebrovascular disease events after 5.6 years follow-up. </p> <p><b>Results:</b> Women with prediabetes and diabetes exhibited greater relative differences in BMI, waist circumference, blood pressure, total, LDL and HDL cholesterol, triglycerides, fasting glucose, hsCRP, and white blood cell count than men with prediabetes and diabetes when compared with their NGT counterparts. We found a higher RR for prevalent CVD in diabetic women (RR 9.29; 95% CI 4.73-18.25; <i>P</i><0.0001) than in men (RR 4.56; 95% CI 3.07-6.77; <i>P</i><0.0001), but no difference in RR for CVD was observed comparing prediabetic women and men. In the longitudinal study, we found that diabetic, but not prediabetic women have higher RR (RR 5.25; 95% CI 3.22-8.56; <i>P</i><0.0001) of incident major adverse outcomes than their male counterparts (RR 2.72; 95% CI 1.81-4.08; <i>P</i><0.0001).</p> <p><b>Conclusions:</b> This study suggests that diabetic, but not prediabetic, women have higher RR for prevalent and incident major adverse outcomes than men. </p>

Thyrotrophin levels and coronary artery calcification: Cross-sectional results of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

2017 ◽  
Vol 87 (5) ◽  
pp. 597-604 ◽  
Author(s):  
Érique José F. Peixoto de Miranda ◽  
Márcio Sommer Bittencourt ◽  
Henrique Lane Staniak ◽  
Alexandre C. Pereira ◽  
Murilo Foppa ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Adult Health ◽  
Cross Sectional

scholarly journals Prevalence of Sarcopenic Obesity Using Different Definitions and the Relationship With Strength and Physical Performance in the Canadian Longitudinal Study of Aging

2021 ◽  
Vol 11 ◽  
Author(s):  
Sarah A. Purcell ◽  
Michelle Mackenzie ◽  
Thiago G. Barbosa-Silva ◽  
Isabelle J. Dionne ◽  
Sunita Ghosh ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Physical Performance ◽  
Gait Speed ◽  
Walking Speed ◽  
Handgrip Strength ◽  
Sarcopenic Obesity ◽  
Cross Sectional ◽  
X Ray ◽  
The Relationship ◽  
Negative Health Outcomes

Sarcopenic obesity is associated with several negative health outcomes. However, the prevalence of this condition – and the relationship to physical performance parameters – varies across definitions. The aim of this cross-sectional investigation was to describe the prevalence of sarcopenic obesity using different published definitions and their relationship with handgrip strength and walking speed in older Canadian adults. Individuals aged 65+ in the Canadian Longitudinal Study on Aging (n = 11,803; 49.6% male, 50.4% female) were included. Body composition was measured using dual X-ray absorptiometry. Sarcopenic obesity was defined using 29 definitions. Low handgrip strength was identified as &lt; 27 kg in males and &lt; 16 kg in females and poor physical performance was defined as gait speed ≤ 0.8 m/s. The prevalence of sarcopenic obesity ranged from 0.1 to 85.3% in males, and from 0 to 80.4% in females. Sarcopenic obesity was frequently associated with low handgrip strength (p &lt; 0.05) in both males (14/17 definitions, 82.4%) and females (21/29 definitions, 72.4%). In very few definitions, sarcopenic obesity was associated with slow gait speed (males: 1/17 definitions [6.7%]; females: 2/29 [6.9%]). In conclusion, the prevalence of sarcopenic obesity varied greatly according to definitions and sarcopenic obesity was frequently associated with low handgrip strength.

scholarly journals The relationship between periodontitis and diabetic retinopathy: A cross-sectional longitudinal study

2020 ◽  
Vol 13 (2) ◽  
Author(s):  
Hani Basher Albalawi ◽  
Naif Mamdouh Alali ◽  
Saad H. ALEnezi ◽  
Hyder O Mirghani
Keyword(s):  
Diabetic Retinopathy ◽  
Longitudinal Study ◽  
Cross Sectional ◽  
The Relationship
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