Clinical factors affecting cerebral oxygenation in patients undergoing peritoneal dialysis

2021 ◽  
pp. 039139882110200
Author(s):  
Taisuke Kitano ◽  
Kiyonori Ito ◽  
Susumu Ookawara ◽  
Taro Hoshino ◽  
Hideyuki Hayasaka ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Peritoneal Dialysis ◽  
Linear Regression ◽  
Serum Albumin ◽  
Cerebral Oxygenation ◽  
Linear Regression Analysis ◽  
Albumin Concentration ◽  
Healthy Controls ◽  
Serum Albumin Concentration ◽  
Factors Affecting

Background: Although cerebral regional oxygen saturation (rSO2) is significantly lower in hemodialysis (HD) patients than that in healthy controls, investigations on cerebral oxygenation in peritoneal dialysis (PD) patients are limited. We aimed to confirm the cerebral oxygenation status and identify the factors affecting cerebral rSO2 in PD patients. Methods: Thirty-six PD patients (21 men and 15 women; mean age, 62.8 ± 12.7 years) were recruited. In addition, 27 healthy volunteers (17 men and 10 women; mean age, 43.5 ± 18.8 years) were recruited as a control group. Cerebral rSO2 was monitored at the forehead using an INVOS 5100c oxygen saturation monitor. Results: Cerebral rSO2 was significantly lower in PD patients than that in healthy controls (57.0 ± 7.3% vs 68.9 ± 8.6%, p < 0.001); moreover, cerebral rSO2 was significantly correlated with natural logarithm (Ln)-PD duration ( r = −0.389, p = 0.019) and serum albumin concentration ( r = 0.370, p = 0.026) in a simple linear regression analysis. Multivariable linear regression analysis was performed using variables that showed a significant correlation and p < 0.20 (serum creatinine, serum sodium, Ln-C-reactive protein, and dosage of erythropoiesis-stimulating agent) with the cerebral rSO2. Cerebral rSO2 was independently associated with Ln-PD duration (standardized coefficient: −0.339) and serum albumin concentration (standardized coefficient: 0.316). Conclusions: Cerebral rSO2 was significantly affected by the PD duration and serum albumin concentration. Further prospective studies are needed to clarify whether preventing a decrease in serum albumin concentration leads to the maintenance of cerebral oxygenation in patients undergoing PD.

Cerebral oxygenation improvement is associated with hemoglobin increase after hemodialysis initiation

2020 ◽  
Vol 43 (11) ◽  
pp. 695-700
Author(s):  
Kiyonori Ito ◽  
Susumu Ookawara ◽  
Yuichiro Ueda ◽  
Haruhisa Miyazawa ◽  
Takayuki Uchida ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Serum Albumin ◽  
Near Infrared ◽  
Cerebral Oxygenation ◽  
Linear Regression Analysis ◽  
Albumin Level ◽  
Hemoglobin Level ◽  
Multivariate Linear Regression Analysis ◽  
Clinical Parameters

Introduction: Near-infrared spectroscopy has been used to measure the regional oxygen saturation (rSO2) of the brain, and decreases in cerebral rSO2 have been reported to lead to cognitive impairment in patients undergoing hemodialysis. However, reports about the association between changes in cerebral oxygenation and clinical parameters at hemodialysis initiation, including hemoglobin level, are lacking. Methods: This study included 33 patients at the hemodialysis initiation phase. Cerebral rSO2 was monitored using an INVOS 5100C. Included patients were assessed twice (at hemodialysis initiation and 42.7 ± 20.8 days after the first measurement), and changes in cerebral rSO2 were compared with changes in clinical parameters. Results: Cerebral rSO2 at the second measurement significantly increased compared with that at hemodialysis initiation (57.2 ± 6.8% vs 54.4 ± 8.8%, p < 0.05). Changes in cerebral rSO2 represented a significant correlation with changes in hemoglobin level, pulse rate, and serum albumin level. Multivariate linear regression analysis was performed using significant factors in simple linear regression analysis. Changes in hemoglobin (standardized coefficient: 0.37) and serum albumin (standardized coefficient: 0.45) levels were identified as independent factors influencing the changes in cerebral rSO2. Conclusion: Cerebral rSO2 was low in the presence of low hemoglobin levels at hemodialysis initiation and improved in response to hemoglobin increase in addition to changes in serum albumin levels. Attention should be paid to changes in hemoglobin levels even at hemodialysis initiation to prevent the deterioration of cerebral oxygenation, and this might contribute to the maintenance of cognitive function in patients undergoing hemodialysis.

Argatroban pharmacokinetics and pharmacodynamics in critically ill cardiac surgical patients with suspected heparin-induced thrombocytopenia

2016 ◽  
Vol 115 (06) ◽  
pp. 1081-1089 ◽  
Author(s):  
Emanuel Zimmer ◽  
Martin Bek ◽  
Michael Wiessner ◽  
Cornelius Keyl ◽  
Dietmar Trenk
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Serum Albumin ◽  
Critically Ill ◽  
Half Life ◽  
Linear Regression Analysis ◽  
Surgical Patients ◽  
Target Range ◽  
Albumin Concentration ◽  
Plasma Half Life

SummaryOnly limited data are available on the pharmacokinetic and pharmacodynamic properties of argatroban in critically ill patients under clinical conditions. We determined plasma concentrations of argatroban, and its main metabolite M1, within a time period of 48 hours in 25 critically ill cardiac surgical patients, who were suspected of heparininduced thrombocytopenia and had the clinical need for anticoagulation. Argatroban infusion was started at 0.5 µg/kg/minute, and adjusted in 0.1–0.25 µg/kg/minute increments when the activated partial thromboplastin time (aPTT) was not within the target range. Median argatroban plasma half-life was 2.7 hours (interquartile range 1.8 to 7.3). Linear regression analysis revealed that argatroban half-life was significantly related to the total bilirubin concentration (R2 = 0.66, p< 0.001), as well as to the metabolism of argatroban, which was assessed by the ratio of the areas under the concentration time curves (AUC) of argatroban and M1 (R2 = 0.60, p< 0.001). Continuous veno-venous haemodialysis did not significantly affect argatroban plasma half-life. The predictive property of argatroban plasma levels for aPTT was low (R2 = 0.28, p< 0.001). Multiple linear regression analysis revealed significant contributions of age and serum albumin levels to the effect of argatroban on aPTT, expressed as the AUC ratio argatroban/aPTT (R2 = 0.67, adjusted R2 = 0.65, p< 0.001). In conclusion, argatroban plasma half-life is markedly increased in critically ill cardiac surgical patients, and further prolonged by hepatic dysfunction due to impaired metabolism. Patient age and serum albumin concentration significantly contribute to the variability in the anticoagulant activity of argatroban.

Relationships between magnesium and protein concentrations in serum.

1985 ◽  
Vol 31 (2) ◽  
pp. 244-246 ◽  
Author(s):  
M H Kroll ◽  
R J Elin
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Serum Albumin ◽  
Total Protein ◽  
Serum Magnesium ◽  
Linear Regression Analysis ◽  
Reference Interval ◽  
Magnesium Concentration ◽  
Total Serum ◽  
Albumin Concentration

Abstract We determined concentrations of magnesium, total protein, albumin, and globulin in more than 74 000 serum specimens from patients and noted a direct linear relationship between the concentration of magnesium in serum and the concentrations of total protein, albumin, and globulin in serum. Albumin and magnesium concentrations are linearly related at high and low albumin concentrations; within the reference interval, however, the magnesium concentration is independent of the albumin concentration. Linear regression analysis suggests that 25% of the total serum magnesium is bound to albumin and 8% to globulins.

scholarly journals Association between hepatic oxygenation on near-infrared spectroscopy and clinical factors in patients undergoing hemodialysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0259064
Author(s):  
Yuichiro Ueda ◽  
Susumu Ookawara ◽  
Kiyonori Ito ◽  
Yusuke Sasabuchi ◽  
Hideyuki Hayasaka ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Regression Analysis ◽  
Serum Albumin ◽  
Oxygen Saturation ◽  
Linear Regression Analysis ◽  
Splanchnic Circulation ◽  
Control Group ◽  
Albumin Concentration ◽  
Serum Albumin Concentration ◽  
History Of

The hepato-splanchnic circulation directly influences oxygenation of the abdominal organs and plays an important role in compensating for the blood volume reduction that occurs in the central circulation during hemodialysis (HD) with ultrafiltration. However, the hepato-splanchnic circulation and oxygenation cannot be easily evaluated in the clinical setting of HD therapy. We included 185 HD patients and 15 healthy volunteers as the control group in this study. Before HD, hepatic regional oxygen saturation (rSO2), a marker of hepatic oxygenation reflecting the hepato-splanchnic circulation and oxygenation, was monitored using an INVOS 5100c oxygen saturation monitor. Hepatic rSO2 was significantly lower in patients undergoing HD than in healthy controls (56.4 ± 14.9% vs. 76.2 ± 9.6%, p < 0.001). Multivariable regression analysis showed that hepatic rSO2 was independently associated with body mass index (BMI; standardized coefficient: 0.294), hemoglobin (Hb) level (standardized coefficient: 0.294), a history of cardiovascular disease (standardized coefficient: -0.157), mean blood pressure (BP; standardized coefficient: 0.154), and serum albumin concentration (standardized coefficient: 0.150) in Model 1 via a simple linear regression analysis. In Model 2 using the colloid osmotic pressure (COP) in place of serum albumin concentration, the COP (standardized coefficient: 0.134) was also identified as affecting hepatic rSO2. Basal hepatic oxygenation before HD might be affected by BMI, Hb levels, a history of cardiovascular disease, mean BP, serum albumin concentration, and the COP. Further prospective studies are needed to clarify whether changes in these parameters, including during HD, affect the hepato-splanchnic circulation and oxygenation in HD patients.

scholarly journals Factors Affecting Company's Capability in Performing Integrated Reporting: An Empirical Evidence From Indonesian Companies

2018 ◽  
Vol 7 (2) ◽  
pp. 141
Author(s):  
Putu Sukma Kurniawan ◽  
Made Arie Wahyuni
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Linear Regression Analysis ◽  
Institutional Ownership ◽  
Multiple Linear Regression Analysis ◽  
Managerial Ownership ◽  
Contrast Level ◽  
Integrated Reporting ◽  
Factors Affecting

<p>This study examines the factors that affect the company's capability to perform integrated reporting. The analysis used in testing the hypothesis is multiple linear regression analysis. Results show that company’s size has positive and significant connection and stakeholder’s pressure has negative and significant connection with the company’s capability in performing integrated reporting. In contrast, level of company’s profitability, company’s managerial ownership, and company’s institutional ownership did not have enough connection with company’s capability in performing integrated reporting.</p><p> </p>

Factors Affecting Towards Green Purchase Behavior Among Young Consumers in India

2018 ◽  
pp. 183-210
Author(s):  
Nagendra Kumar Sharma ◽  
Gyaneshwar Singh Kushwaha
Keyword(s):  
Factor Analysis ◽  
Regression Analysis ◽  
Linear Regression ◽  
Exploratory Factor Analysis ◽  
Linear Regression Analysis ◽  
Measurement Instrument ◽  
Purchase Behavior ◽  
Green Product ◽  
Factors Affecting ◽  
Young Consumers

The objective of the chapter is to examine the factors that are essential for the green purchase behavior among the young consumers in India. The study consists of 343 young respondents, who were surveyed with the help of structured measurement instrument. The sample has been analyzed with the help of exploratory factor analysis and linear regression analysis. It was found in the study that the awareness towards the green product, attitude towards eco-labeling, and satisfaction via green products are significantly and positively linked to the green purchase behavior, whereas the attitude towards green pricing and ecologically concerned consumers are not associated with the green purchase behavior.

scholarly journals Analysing Enabling Factors Affecting the On-site Productivity in Indian Construction Industry

2018 ◽  
Vol 49 (2) ◽  
pp. 185-193 ◽  
Author(s):  
Saurav Dixit
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Reliability Analysis ◽  
Construction Industry ◽  
Pearson Correlation ◽  
Linear Regression Analysis ◽  
Research Paper ◽  
Site Productivity ◽  
Factors Affecting ◽  
Construction Productivity

The growth in construction productivity is low and do not continue for a long span of time. The purpose of the present research paper is to analyse the factors affecting on-site construction productivity in Indian construction industry. The tools used for the analysis are reliability analysis to check the consistency of the data, Pearson correlation analysis to mathematically validate the factor analysis, and linear regression analysis to propose a framework of factors affecting construction productivity. The findings of the reliability analysis concludes that the all the factors having a value of more than 0.67, which is considered to be good for the study, and the findings of the study conclude that the most significant 3 attributes grouped in linear regression analysis change in scope (R2), revision in drawings (R15), and response to change orders (R3) having maximum impact over the construction productivity. The research paper attempts to provide an insight and better understanding of the factors affecting on-site construction productivity in India and the ways and means to control and improve construction productivity of construction projects."This paper is the revised version of the paper that has been published in the proceedings of the Creative Construction Conference 2018: Dixit, S., Mandal, S. N., Thanikal, J. V, & Saurabh, K. (2018). Critical Analysis of Factors Affecting the on-site Productivity in Indian Construction Industry, (July), 38–45. https://doi.org/10.3311/CCC2018-006"

Fasting Serum Ghrelin Level is Associated with Metabolic Syndrome in Peritoneal Dialysis Patients

2008 ◽  
Vol 28 (3_suppl) ◽  
pp. 196-200
Author(s):  
Chung-Jen Lee ◽  
Yi-Maun Subeq ◽  
Chih-Hsien Wang ◽  
Ru-Ping Lee ◽  
Te-Chao Fang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Regression Analysis ◽  
Peritoneal Dialysis ◽  
Waist Circumference ◽  
Linear Regression ◽  
Diagnostic Criteria ◽  
Linear Regression Analysis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Fasting Serum ◽  
Serum Ghrelin

⋄ Background Serum ghrelin levels are elevated in uremic patients. However, no data are available on the relationship between metabolic syndrome and serum ghrelin levels in peritoneal dialysis (PD) patients. ⋄ Methods Metabolic syndrome and its components were defined using diagnostic criteria recommended by the International Diabetes Federation. Fasting serum samples were taken from 30 PD patients. Serum ghrelin levels were measured by using a commercial enzyme-linked immunosorbent assay kit. ⋄ Results Of the 30 PD patients, 53.3% (16/30) had metabolic syndrome. Fasting serum ghrelin corrected inversely with metabolic syndrome among these PDs patients ( p = 0.002). By odds ratio (OR) analysis of metabolic syndrome and metabolic syndrome diagnostic criteria, the predictors for metabolic syndrome are fasting glucose [OR: 39.00; 95% confidence interval (CI): 3.80 to 399.85; p < 0.001], triglycerides (OR: 37.50; 95% CI: 3.64 to 386.51; p < 0.001), and waist circumference (OR: 4.20; 95% CI: 1.95 to 9.03; p < 0.001). Univariate linear regression analysis showed that body weight ( r = –0.461, p = 0.010), waist circumference ( r = –0.390, p = 0.033), and body mass index ( r = –0.438, p = 0.016) were negatively correlated with serum ghrelin, and serum high density lipoprotein [HDL ( r = 0.626, p < 0.001)] was positively correlated with serum ghrelin. Multivariate forward stepwise linear regression analysis of the significant variables showed that HDL ( R2 change = 0.392; p < 0.001) was the independent predictor of serum ghrelin in PD patients and explained 39.2% of the variance. ⋄ Conclusions These results indicate an inverse association between circulating fasting ghrelin and metabolic syndrome in PD patients. Serum HDL was associated with serum ghrelin among PD patients.

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