Fasting Serum Ghrelin Level is Associated with Metabolic Syndrome in Peritoneal Dialysis Patients

⋄ Background Serum ghrelin levels are elevated in uremic patients. However, no data are available on the relationship between metabolic syndrome and serum ghrelin levels in peritoneal dialysis (PD) patients. ⋄ Methods Metabolic syndrome and its components were defined using diagnostic criteria recommended by the International Diabetes Federation. Fasting serum samples were taken from 30 PD patients. Serum ghrelin levels were measured by using a commercial enzyme-linked immunosorbent assay kit. ⋄ Results Of the 30 PD patients, 53.3% (16/30) had metabolic syndrome. Fasting serum ghrelin corrected inversely with metabolic syndrome among these PDs patients ( p = 0.002). By odds ratio (OR) analysis of metabolic syndrome and metabolic syndrome diagnostic criteria, the predictors for metabolic syndrome are fasting glucose [OR: 39.00; 95% confidence interval (CI): 3.80 to 399.85; p < 0.001], triglycerides (OR: 37.50; 95% CI: 3.64 to 386.51; p < 0.001), and waist circumference (OR: 4.20; 95% CI: 1.95 to 9.03; p < 0.001). Univariate linear regression analysis showed that body weight ( r = –0.461, p = 0.010), waist circumference ( r = –0.390, p = 0.033), and body mass index ( r = –0.438, p = 0.016) were negatively correlated with serum ghrelin, and serum high density lipoprotein [HDL ( r = 0.626, p < 0.001)] was positively correlated with serum ghrelin. Multivariate forward stepwise linear regression analysis of the significant variables showed that HDL ( R2 change = 0.392; p < 0.001) was the independent predictor of serum ghrelin in PD patients and explained 39.2% of the variance. ⋄ Conclusions These results indicate an inverse association between circulating fasting ghrelin and metabolic syndrome in PD patients. Serum HDL was associated with serum ghrelin among PD patients.

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Haptoglobin 2-2 Genotype Is Associated with TNF-αand IL-6 Levels in Subjects with Obesity

Disease Markers ◽

10.1155/2014/912756 ◽

2014 ◽

Vol 2014 ◽

pp. 1-5 ◽

Cited By ~ 5

Author(s):

Brissia Lazalde ◽

Héctor M. Huerta-Guerrero ◽

Luis E. Simental-Mendía ◽

Martha Rodríguez-Morán ◽

Fernando Guerrero-Romero

Keyword(s):

Regression Analysis ◽

Waist Circumference ◽

Linear Regression ◽

Multiple Linear Regression ◽

Body Fat ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Total Body Fat ◽

Obese Subjects ◽

Total Body

Objective. To evaluate the association between Haptoglobin (HP) gene polymorphisms with inflammatory status in obese subjects.Materials and Methods. A cross-sectional study was carried out. A total of 276 apparently healthy men and nonpregnant obese women were enrolled and allocated according to theHPgenotype into theHP1/HP1,HP2/HP1, andHP2/HP2groups. Distribution ofHPgenotypes was 49, 87, and 140 for theHP1/HP1,HP2/HP1, andHP2/HP2, respectively. TheHPgenotype was determined using the polymerase chain reaction method. A multiple linear regression analysis adjusted by age, sex, waist circumference, and total body fat was used to determine the association betweenHPgenotypes with TNF-α, IL-6, and high-sensitivity C-reactive protein (hsCRP) levels.Results. A multiple linear regression analysis adjusted by sex, waist circumference, and total body fat was performed showing a significant association between theHP2/HP2genotype and TNF-α(β= 0.180; 95% CI 14.41–159.64,P= 0.01) and IL-6 (β= 0.188; 95% CI 1.53–12.72,P= 0.01) levels, but not with hsCRP (β= −0.008; 95% CI −1.64–1.47,P= 0.914) levels, whereas theHP2/HP1genotype showed no association compared with theHP1/HP1genotype (control group).Conclusion. Results of our study show that theHP2/HP2genotype is associated with elevated TNF-αand IL-6, but not with hsCRP, levels in obese subjects.

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Abstract P269: Circulating Fatty Acids, Determinants and Use as Biomarkers for Dietary Intake: The CoDAM and Hoorn Study

Circulation ◽

10.1161/circ.133.suppl_1.p269 ◽

2016 ◽

Vol 133 (suppl_1) ◽

Author(s):

Anne J Wanders ◽

Sabine E De Hoon ◽

Marjan Alssema ◽

Edith J Feskens ◽

Geertruida J Van Woudenbergh ◽

...

Keyword(s):

Fatty Acids ◽

Regression Analysis ◽

Waist Circumference ◽

Linear Regression ◽

Dietary Intake ◽

Alcohol Intake ◽

Linear Regression Analysis ◽

Epa And Dha ◽

Health Factors ◽

Multivariable Linear Regression Analysis

Objective: To increase the understanding of circulating fatty acids (FA) as biomarkers of FA intake, we investigated (1) determinants of circulating proportions of linoleic acid (LA), alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA); and (2) the effect of demographic, lifestyle, and health factors on the relation between circulating and self-reported intake of LA, ALA, EPA, and DHA. Hypothesis: We hypothesized that demographic, lifestyle, and health factors influence the relation between circulating and self-reported intake of FA. Methods: Cross-sectional analysis in combined data from the CoDAM (n=472) and Hoorn study (n=708). Dietary FA intakes (% of total FA) were calculated from a validated 79-item semi-quantitative food frequency questionnaire. Fasting total fatty acids (% of total FA) in plasma (CoDAM) or serum (Hoorn) were measured by gas liquid chromatography. The variation in circulating proportions of FA explained by demographic, lifestyle and health factors was calculated by multivariable linear regression analysis. Correlation coefficients between circulating proportions of FA and self-reported FA intakes were calculated by standardized multivariable linear regression analysis adjusted for demographic, lifestyle, and health factors. To assess the influence of specific factors on correlations, stratified analyses were performed and interactions were calculated. Results: Self-reported intakes were the primary determinants of circulating proportions of LA (partial R2: 7%), ALA (2%), EPA (9%) and DHA (16%). Standardized regression coefficients between circulating and self-reported FA were: LA β=0.280 (95% Confidence Interval: 0.227-0.333), ALA β=0.130 (0.071-0.188), EPA β=0.338 (0.281-0.395), and DHA β=0.450 (0.397-0.503). Other determinants of circulating FA were the use of lipid lowering drugs, waist circumference and sex for LA; prevalence of type 2 diabetes mellitus, age, sex, and alcohol intake for EPA; and age for DHA. The correlation between circulating and dietary LA was stronger among people with a lower vs higher waist circumference and higher vs lower alcohol intake (interaction: p<0.05). In women, the correlation between circulating and dietary EPA and DHA was weaker than in men, and the correlation between circulating and dietary DHA was higher with higher alcohol intake. Underreporting of energy intake did not affect the correlations. Conclusion: Self-reported intake of FA is the primary, but not the only determinant of circulating proportions of LA, ALA, EPA and DHA. This analysis indicates that demographic, lifestyle, and health characteristics may influence the relation between circulating proportions and self-reported intake of FA. Improved understanding is needed of factors determining circulating FA and the implication for their use as biomarkers of dietary intake in different subgroups.

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P1421SERUM OSTEOPROTEGERIN LEVEL IS NEGATIVELY ASSOCIATED WITH BONE MINERAL DENSITY IN PATIENTS UNDERGOING HEMODIALYSIS

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa142.p1421 ◽

2020 ◽

Vol 35 (Supplement_3) ◽

Author(s):

Chia-Wen Lu ◽

Jia-Sian Hou ◽

Bang-Gee Hsu

Keyword(s):

Bone Mineral Density ◽

Body Weight ◽

Regression Analysis ◽

Linear Regression ◽

Bone Mineral ◽

Linear Regression Analysis ◽

Hemodialysis Patients ◽

Enzyme Linked Immunosorbent Assay ◽

Mineral Density ◽

Study Results

Abstract Background and Aims Osteoprotegerin, a potent osteoclast activation inhibitor, decreases bone resorption and positively affects bone mineral density (BMD). Our aim was to evaluate the relationship between BMD and fasting serum osteoprotegerin concentration in hemodialysis patients. Method Fasting blood samples were obtained from 75 chronic hemodialysis patients. BMD was measured by dual energy X-ray absorptiometry in lumbar vertebrae (L2-L4). Serum osteoprotegerin levels were measured using a commercial enzyme-linked immunosorbent assay. Results A total of 7 patients (9.3%) had osteoporosis and 20 patients (26.7%) had osteopenia in hemodialysis patients. Older age (p = 0.023), increased serum osteoprotegerin (p < 0.001), urea reduction rate (URR, p = 0.021), Kt/V (p = 0.027), while decreased height (p < 0.001), body weight (p < 0.001), body mass index (BMI; p < 0.001), and logarithmically transformed triglyceride (log-triglyceride, p = 0.020) was significantly correlated with low lumbar T-score cut-off points between groups (normal, osteopenia, and osteoporosis) in hemodialysis patients. Female patients had lower lumbar BMD than male hemodialysis patients (p = 0.002). Univariate linear regression analysis indicated lumbar BMD were positively correlated with height (p < 0.001), body weight (p < 0.001), BMI (p < 0.001), log-triglyceride (p = 0.004), creatinine (p = 0.016), while negatively correlated with age (p = 0.001), alkaline phosphatase (p = 0.016), URR (p = 0.012), Kt/V (p = 0.013), and osteoprotegerin (p < 0.001) among the hemodialysis patients. Multivariate forward stepwise linear regression analysis of the significant variables revealed that female hemodialysis patient (adjusted R2 change = 0.040; p = 0.003), body weight (adjusted R2 change = 0.126; p = 0.001), kt/V (adjusted R2 change = 0.024; p = 0.034) and osteoprotegerin (adjusted R2 change = 0.332; p < 0.001) were the independent predictors of lumbar BMD values in the hemodialysis patients. Conclusion Our study results revealed that increased serum osteoprotegerin levels were independently associated with decreased BMD in the lumbar spine, and with increased risk of osteoporosis in hemodialysis patients.

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Clinical factors affecting cerebral oxygenation in patients undergoing peritoneal dialysis

The International Journal of Artificial Organs ◽

10.1177/03913988211020017 ◽

2021 ◽

pp. 039139882110200

Author(s):

Taisuke Kitano ◽

Kiyonori Ito ◽

Susumu Ookawara ◽

Taro Hoshino ◽

Hideyuki Hayasaka ◽

...

Keyword(s):

Regression Analysis ◽

Peritoneal Dialysis ◽

Linear Regression ◽

Serum Albumin ◽

Cerebral Oxygenation ◽

Linear Regression Analysis ◽

Albumin Concentration ◽

Healthy Controls ◽

Serum Albumin Concentration ◽

Factors Affecting

Background: Although cerebral regional oxygen saturation (rSO2) is significantly lower in hemodialysis (HD) patients than that in healthy controls, investigations on cerebral oxygenation in peritoneal dialysis (PD) patients are limited. We aimed to confirm the cerebral oxygenation status and identify the factors affecting cerebral rSO2 in PD patients. Methods: Thirty-six PD patients (21 men and 15 women; mean age, 62.8 ± 12.7 years) were recruited. In addition, 27 healthy volunteers (17 men and 10 women; mean age, 43.5 ± 18.8 years) were recruited as a control group. Cerebral rSO2 was monitored at the forehead using an INVOS 5100c oxygen saturation monitor. Results: Cerebral rSO2 was significantly lower in PD patients than that in healthy controls (57.0 ± 7.3% vs 68.9 ± 8.6%, p < 0.001); moreover, cerebral rSO2 was significantly correlated with natural logarithm (Ln)-PD duration ( r = −0.389, p = 0.019) and serum albumin concentration ( r = 0.370, p = 0.026) in a simple linear regression analysis. Multivariable linear regression analysis was performed using variables that showed a significant correlation and p < 0.20 (serum creatinine, serum sodium, Ln-C-reactive protein, and dosage of erythropoiesis-stimulating agent) with the cerebral rSO2. Cerebral rSO2 was independently associated with Ln-PD duration (standardized coefficient: −0.339) and serum albumin concentration (standardized coefficient: 0.316). Conclusions: Cerebral rSO2 was significantly affected by the PD duration and serum albumin concentration. Further prospective studies are needed to clarify whether preventing a decrease in serum albumin concentration leads to the maintenance of cerebral oxygenation in patients undergoing PD.

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Serum Osteopontin Level Correlates with Carotid-Femoral Pulse Wave Velocity in Geriatric Persons

BioMed Research International ◽

10.1155/2014/570698 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 7

Author(s):

Chung-Jen Lee ◽

Ji-Hung Wang ◽

Yu-Chih Chen ◽

Mei-Ling Chen ◽

Chiu-Fen Yang ◽

...

Keyword(s):

Blood Pressure ◽

Regression Analysis ◽

Linear Regression ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Linear Regression Analysis ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Enzyme Linked Immunosorbent Assay

Osteopontin (OPN) is involved in the regulation of vascular calcification processes. The aim of this study was to evaluate the relationship between fasting serum OPN concentration and carotid-femoral pulse wave velocity (cfPWV) in geriatric persons. Fasting blood samples were obtained from 93 geriatric persons. cfPWV were performed by SphygmoCor system. Serum OPN levels were measured using a commercially available enzyme-linked immunosorbent assay. Geriatric adults who had diabetes (P=0.007) or dyslipidemia (P=0.029) had higher cfPWV levels than those without diabetes or dyslipidemia. The univariable linear regression analysis showed that age (P=0.002), waist circumference (P=0.048), body mass index (P=0.004), systolic blood pressure (P=0.001), diastolic blood pressure (P=0.036), pulse pressure (P=0.017), creatinine (P=0.002), and log-OPN level (P=0.001) were positively correlated with cfPWV levels, while the high-density lipoprotein cholesterol (HDL-cholesterol) level (P=0.007) and glomerular filtration rate (P=0.001) were negatively correlated with cfPWV levels among the geriatric adults. Multivariable forward stepwise linear regression analysis of the significant variables also showed that log-OPN (β=0.233,R2=0.123, regression coefficient: 1.868,P=0.011) was still an independent predictor of cfPWV levels in geriatric persons.

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Metabolic syndrome and its components are associated with thyroid volume in adolescents

BMC Endocrine Disorders ◽

10.1186/s12902-021-00833-3 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Yang Xiao ◽

Jingjing Mao ◽

Xiaodong Mao ◽

Qifeng Wang ◽

Xingjia Li ◽

...

Keyword(s):

Metabolic Syndrome ◽

Waist Circumference ◽

Linear Regression ◽

Multiple Linear Regression ◽

Diagnostic Criteria ◽

Thyroid Volume ◽

Normal Group ◽

Obese Group ◽

Model Assessment ◽

Detection Rates

Abstract Objective To explore the association between metabolic syndrome (MetS) and its component and thyroid volume in Chinese adolescents, and to compare the detection rate of MetS under the three different diagnostic criteria. Methods A total of 1097 school students (610 males and 487 females, ages 12–15 years) were enrolled. All the participants underwent physical examination, biochemical test, and thyroid gland ultrasonography. The thyroid volume of normal, overweight and obese group was compared. We also analyzed the association between the number of MetS components and thyroid volume. Linear and multiple linear regression were applied to explore the association between metabolic parameters and thyroid volume. Results The thyroid volume of the males in overweight (t = 3.784, P < 0.001) and obese group (t = 5.068, P < 0.001) was significantly larger than that in normal group; the thyroid volume of the females in overweight group (t = 4.627,P < 0.001) was significantly larger than that of normal group. As the number of MetS components increased, the thyroid volume also increased significantly (F = 10.64, P < 0.01). Height, weight, body mass index (BMI), waist circumference, hip circumference, systolic blood pressure, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), uric acid and triglyceride were all positively associated with thyroid volume in the adolescents (P all < 0.001). Meanwhile, there was a negative association between high-density lipoprotein cholesterol (HDL-C) and thyroid volume (P < 0.001). According to multiple linear regression, waist circumference (β = 0.029, 95 %CI: 0.015 ~ 0.042; P < 0.01) and waist height ratio (β = 3.317, 95 %CI: 1.661 ~ 4.973; P < 0.01) were predict factors of thyroid volume. No statistical difference was found in the detection rates of metabolic syndrome under the three diagnostic criteria. Conclusions Overweight, obesity and metabolic syndrome was associated with adolescent thyroid volume. Central obesity may be an independent risk factor for thyroid enlargement in adolescents.

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Positive Associations between Adipocyte Fatty Acid-Binding Protein Level and Central Arterial Stiffness in Peritoneal Dialysis Patients

International Journal of Hypertension ◽

10.1155/2021/8849115 ◽

2021 ◽

Vol 2021 ◽

pp. 1-8

Author(s):

Cheng-Hao Sung ◽

Bang-Gee Hsu ◽

Jen-Pi Tasi ◽

Chih-Hsien Wang ◽

Chiu-Huang Kuo

Keyword(s):

Regression Analysis ◽

Peritoneal Dialysis ◽

Fatty Acid ◽

Arterial Stiffness ◽

Fatty Acid Binding Protein ◽

Binding Protein ◽

Linear Regression Analysis ◽

Enzyme Linked Immunosorbent Assay ◽

Fatty Acid Binding ◽

Acid Binding Protein

Background. Adipocyte fatty acid-binding protein (A-FABP) plays essential roles in lipolysis, insulin resistance, and atherosclerosis. This study aimed to evaluate the relationship between serum A-FABP levels and carotid-femoral pulse wave velocity (cfPWV) in peritoneal dialysis (PD) patients. Methods. This study obtained fasting blood samples from 76 PD patients. A validated tonometry system was used to measure cfPWV. Patients with cfPWV values >10 m/s were classified into the high arterial stiffness group, whereas patients with values ≤10 m/s were classified into the low arterial stiffness group, according to the ESH-ESC 2013 guidelines. Serum A-FABP levels were measured using a commercial enzyme-linked immunosorbent assay kit. Results. Twenty-five (32.9%) of the 76 PD patients were classified in the high arterial stiffness group. Compared with the patients in the low arterial stiffness group, the high arterial stiffness group was older ( P = 0.002) and had a longer PD vintage ( P = 0.011), higher diastolic blood pressure (DBP, P = 0.036), higher fasting glucose levels ( P = 0.012), higher serum C reactive protein levels ( P = 0.001), and higher serum A-FABP levels ( P < 0.001). A multivariate logistic regression analysis of the factors significantly associated with central arterial stiffness revealed that A-FABP (odds ratio (OR): 1.165, 95% confidence interval (CI): 1.056–1.284, P = 0.002), age (OR: 1.423, 95% CI: 1.153–1.757, P = 0.001), PD vintage (OR: 1.049, 95% CI: 1.015–1.085, P = 0.005), and DBP (OR: 1.152, 95% CI: 1.033–1.285, P = 0.011) were independent predictors of central arterial stiffness in PD patients. Furthermore, serum A-FABP levels (β = 0.476, adjusted R2 change: 0.197, P < 0.001) were significantly positively correlated with cfPWV according to the multivariable forward stepwise linear regression analysis. Conclusions. A-FABP levels are an independent marker of central arterial stiffness in PD patients.

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Relation of Serum Hepcidin Levels and Restless Legs Syndrome in Patients Undergoing Peritoneal Dialysis

Frontiers in Medicine ◽

10.3389/fmed.2021.685601 ◽

2021 ◽

Vol 8 ◽

Author(s):

Yanhong Guo ◽

Yuan Sang ◽

Tian Pu ◽

Xiaodan Li ◽

Yulin Wang ◽

...

Keyword(s):

Regression Analysis ◽

Peritoneal Dialysis ◽

Linear Regression ◽

Restless Legs Syndrome ◽

Linear Regression Analysis ◽

Multivariate Linear Regression Analysis ◽

Hepcidin Level ◽

Restless Legs ◽

Determinant Factors ◽

Serum Hepcidin

Introduction: Restless legs syndrome is a common and severe complication in patients undergoing peritoneal dialysis (PD), which seriously affects the life quality and prognosis of patients undergoing PD. Unfortunately, there are still no effective prevention and treatment measures. Serum hepcidin was demonstrated to be related to primary restless legs syndrome (RLS), whereas there are no studies on the relationship between serum hepcidin and RLS in patients undergoing PD. We aimed to evaluate the role and function of serum hepcidin in patients undergoing PD with RLS.Methods: A total of 51 patients undergoing PD with RLS and 102 age-and gender-matched patients undergoing PD without RLS were included. We collected the clinical data including serum hepcidin of those patients undergoing PD. We scored the severity of RLS according to the International restless leg Syndrome Research Group rating scale (IRLS). We compared the clinical characteristics of the two groups and evaluated the determinant factors of RLS by Logistic regression analysis. In addition, we evaluated the diagnostic value of serum hepcidin in patients undergoing PD with RLS by receiver operating characteristic (ROC) curve. We also analyzed the influencing factors of IRLS by multivariate linear regression analysis.Results: The duration of PD, serum hepcidin, and calcium were found to be significantly higher in patients undergoing PD with RLS than those patients undergoing PD without RLS (P < 0.001, P < 0.001, and P = 0.002, respectively). The level of hemoglobin, albumin, and RKF were significantly lower in patients undergoing PD with RLS (P = 0.002, P = 0.042, and P < 0.001, respectively). The duration of PD [odds ratio (OR) 1.038, 95% CI: 1.017, 1.060, P < 0.001], hemoglobulin level (OR 0.969, 95% CI: 0.944, 0.995, P = 0.019), calcium level (OR 9.224, 95% CI: 1.261, 67.450, P = 0.029), albumin level (OR 0.835, 95% CI: 0.757, 0.921, P < 0.001), hepcidin level (OR 1.023, 95% CI: 1.009, 1.038, P = 0.001), and RKF (OR 0.65, 95% CI: 0.495, 0.856, P = 0.002) are independent determinant factors of RLS in patients undergoing PD. Multivariate linear regression analysis revealed that, in addition to albumin, they were also independently associated with the severity of RLS.Conclusion: A significant relation was detected between serum hepcidin level and RLS in patients undergoing PD.

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ASYMPTOMATIC HYPERURICEMIA AS A POTENTIAL METABOLIC RISK FACTOR FOR CORONARY ARTERY CALCIFICATION IN PATIENTS WITH ATRIAL FIBRILLATION OR HEART FAILURE

Journal of IMAB - Annual Proceeding (Scientific Papers) ◽

10.5272/jimab.2021271.3634 ◽

2021 ◽

Vol 27 (1) ◽

pp. 3634-3642

Author(s):

Milena Pasheva ◽

◽

Yoto Yotov ◽

Miglena Nikolova ◽

Daniela Gerova ◽

...

Keyword(s):

Risk Factors ◽

Heart Failure ◽

Atrial Fibrillation ◽

Regression Analysis ◽

Waist Circumference ◽

Linear Regression ◽

Multiple Linear Regression ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Medical Documentation

Purpose: To assess the role of asymptomatic hyperuricemia for the presence and severity of coronary arterial calcium (CAC) in adults with different cardiovascular (CV) pathology and its association with conventional CV risk factors. Material/Methods: Adults (n=81) of both genders were divided into controls: with moderate- to high risk without known CVD; AF-group: CVD-patients with paroxysmal or persistent atrial fibrillation in sinus rhythm, HF–group: heart failure subjects with preserved ejection fraction. A structured interview was performed at admittance for evaluation of the classical CVD risk factors. CAC score (CACS) was determined by multislice computed tomography. Routine laboratory parameters, including uric acid (UA), were extracted from medical documentation. Descriptive statistics, Mann-Whitney U-test, one-way ANOVA, chi-square test, Spearman's correlation, and multiple linear regression analysis were applied. The predictive power of serum UA was evaluated using receiver operating characteristic (ROC) analysis. Statistical significance was considered at p<0.05. Results: Serum UA was significantly higher in subjects with CACS=1-99AU (p=0.030), and with CACS≥100AU (p=0.067) vs. patients without CACS. Within the UA tertiles, highest CACS was found in the tertile with highest serum UA. UA revealed positive relation with CACS (r=0.35, p=0.002), age (r=0.25, p=0.027), body mass index (0.27, p=0.017), waist circumference (r=0.44, p<0.0001), triglycerides (r=0.29, p=0.001), and creatinine (r=0.54, p<0.0001). Multiple linear regression analysis revealed significant association between UA as dependent variable and waist circumference (β=0.63, p=0.061), serum triglycerides (β=0.37, p=0.028), creatinine levels (β=0.45, p<0.0001). Conclusions: Asymptomatic hyperuricaemia could be an important metabolic factor negatively affecting the chronic cardio-vascular pathology besides the conventional risk factors.

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Arterial Endothelial Function and Related Factors in Elderly Patients With Essential Hypertension and Abdominal Obesity

American Journal of Hypertension ◽

10.1093/ajh/hpaa135 ◽

2020 ◽

Vol 33 (12) ◽

pp. 1146-1147

Author(s):

He-ling Huang ◽

Yi-hua Shen ◽

Xiao-qi Cai ◽

Ling-yu Zhang ◽

Liang-di Xie

Keyword(s):

Blood Pressure ◽

Regression Analysis ◽

Essential Hypertension ◽

Waist Circumference ◽

Linear Regression ◽

Elderly Patients ◽

Abdominal Obesity ◽

Pulse Pressure ◽

Linear Regression Analysis ◽

Related Factors

Abstract Background To investigate arterial endothelial function and related factors in elderly patients with both essential hypertension and abdominal obesity. Methods A total of 658 elderly patients (≥60 years old) with essential hypertension and 64 elderly subjects without hypertension were recruited. Hypertension and obesity were defined based on blood pressure (≥140/90 mm Hg) and waist circumference (male ≥90, female ≥85 cm), respectively. Endothelium-dependent dilatation (EDD) of anterior tibial artery induced by reactive hyperemia was examined by high-resolution vascular ultrasound. Pearson correlation analysis, factorial analysis, and multiple linear regression analysis were undertaken to examine the related factors of EDD. Results Factorial analysis showed that hypertension and abdominal obesity were influence factors of EDD, but there was no interaction between them. From normotensive without abdominal obesity, normotensive with abdominal obesity, hypertensive without abdominal obesity, to hypertensive with abdominal obesity, a gradual decline in EDD was observed (9.37 ± 1.11%, 8.59 ± 0.99%, 7.70 ± 0.30%, and 6.75 ± 0.26%, respectively, P < 0.05). In elderly hypertensive patients with abdominal obesity, EDD correlated with waist circumference (r = −0.139, P < 0.05), systolic blood pressure (r = −0.245, P < 0.05), pulse pressure (r = −0.287, P < 0.05), and fasting glucose level (r = −0.131, P < 0.05). Multivariate linear regression analysis revealed that EDD was associated with pulse pressure (β = −0.280, P < 0.001) and waist circumference (β = − 0.141, P = 0.009). Conclusions In elderly patients with essential hypertension and central obesity, EDD is impaired, and negatively correlated with pulse pressure and waist circumference.

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