The Effects of Thermal Degradation Products of Hydraulic Fluids Type C on the Carboxyhaemoglobin Level in Wistar SPF Rats

1993 ◽  
Vol 11 (5) ◽  
pp. 394-406 ◽  
Author(s):  
J. Van Dam ◽  
P. Daenens
Keyword(s):  
Thermal Decomposition ◽  
Carbon Monoxide ◽  
Thermal Degradation ◽  
Chromatographic Method ◽  
Degradation Products ◽  
Minute Volume ◽  
Hydraulic Fluids ◽  
Type C ◽  
Thermal Degradation Products ◽  
Gas Chromatographic Method

The carboxyhaemoglobin (COHb) levels of Wistar SPF rats were measured after exposure to a thermal decomposition mixture of hydraulic fluids type C. The evaluation of the obtained results was realised by using a mathematical carbon monoxide loading model. Significant lower COHb levels than expected were seen. This can be explained by a reduction of the respira tory minute volume due to the presence of sensory irritating products in the decomposition mixture. The COHb levels after liberation of carbon monoxide (CO) from the blood and the CO levels in the inhalation chamber of the thermal decomposition apparatus were measured by a capillary gas chromatographic method.

Acute Inhalation Toxicity in Rats Exposed to Thermal Degradation Products of Hydraulic Fluids Type C

1994 ◽  
Vol 12 (5) ◽  
pp. 411-423 ◽  
Author(s):  
J. Van Dam ◽  
P. Daenens ◽  
E.K. Yerbeken
Keyword(s):  
Thermal Decomposition ◽  
Quantitative Data ◽  
Degradation Products ◽  
Decomposition Temperature ◽  
Inhalation Toxicity ◽  
Histological Damage ◽  
Safety And Health ◽  
Hydraulic Fluids ◽  
Different Temperatures ◽  
Type C

The acute inhalation toxicity of the thermal decomposition prod ucts of Hydraulic fluids type C was assessed in rats. These fluids consist of a mixture of water, ethylene glycol, polyalkylene glycol and some minor addi tives. Glissosafe® 610 was used as a model. Animals were exposed for one hour to atmospheres resulting from spraying the fluid on a plate heated to 500 °C, 600 ° C or 700°C. They were followed for fourteen days after exposure following the prescriptions of the Sixth Report of the Safety and Health Commission of the European Community. Additional tests were done to follow the evolution of histological damage at one, two, three, five and seven days after exposure to the different temperatures. These results were compared with some quantitative data of the major decomposition products. No mortality occurred. Only slight and transient respiratory discomfort was noticed during exposure due to the presence of sensory irritating products. The effects on growth were virtually nil, except for some slight initial retardation during the first day post-exposure. Histological damage was most pronounced at a decomposition temperature of 500°C. These results correlated with the quantitative data of the sensory irritating components. Out of this thermal decomposition mixture, formaldehyde seems to contribute most to the toxic ef fects.

Qualitative and Quantitative Determination of Thermal Degradation Products of Type C Hydraulic Fluids

1994 ◽  
Vol 12 (4) ◽  
pp. 376-387 ◽  
Author(s):  
J. Van Dam ◽  
L. Laruelle ◽  
P. Daenens
Keyword(s):  
Mass Spectrometry ◽  
Capillary Column ◽  
Degradation Products ◽  
Gas Chromatography Mass Spectrometry ◽  
Qualitative And Quantitative Analysis ◽  
Qualitative And Quantitative ◽  
Hydraulic Fluids ◽  
Type C ◽  
Thermal Degradation Products

A qualitative and quantitative analysis of the thermal decompo sition mixtures of some type C hydraulic fluids has been done. The decomposi tion products were identified by gas chromatography/mass spectrometry. Due to the nature of some decomposition compounds, a specific pre-column derivatization technique in combination with a well-adapted capillary column was necessary.

Exposure to airborne isocyanates and other thermal degradation products at polyurethane-processing workplaces

2002 ◽  
Vol 4 (5) ◽  
pp. 717-721 ◽  
Author(s):  
Maj-Len Henriks-Eckerman ◽  
Jarmo Välimaa ◽  
Christina Rosenberg ◽  
Kimmo Peltonen ◽  
Kerstin Engström
Keyword(s):  
Thermal Degradation ◽  
Degradation Products ◽  
Thermal Degradation Products

The thermal degradation of μ-Diphenylacetylene-bis(tricarbonylcobalt)

1973 ◽  
Vol 26 (8) ◽  
pp. 1791 ◽  
Author(s):  
RS Dickson ◽  
LJ Michel
Keyword(s):  
Differential Scanning Calorimetry ◽  
Thermal Decomposition ◽  
Carbon Monoxide ◽  
Thermal Degradation ◽  
Organic Compounds ◽  
Degradation Mechanism ◽  
Scanning Calorimetry ◽  
Organic Products ◽  
Suitable Temperature ◽  
Degradation Reaction

The thermal decomposition of Co2(CO)6(PhC2Ph) has been investigated in detail. Differential scanning calorimetry was used to determine the most suitable temperature range for the study. At 180�, Co2(CO)6(PhC2Ph) decomposes to form cobalt, carbon monoxide, tetraphenylcyclopentadienone, hexaphenylbenzene, and other organic compounds. Variation in the temperature, the time, and the solvent used for the degradation reaction causes significant changes in the yields of the organic products. An investigation of the effects of adding stoichiometric amounts of free alkyne, tetra-phenylcyclopentadienone, and hexaphenylbenzene has been initiated in an attempt to understand the degradation mechanism.

scholarly journals The Use of Cryogenic Temperature Gas Chromatography for the Determination of Carbon Monoxide and Carbon Dioxide in Cigarette Smoke

1972 ◽  
Vol 6 (4) ◽  
Author(s):  
G.P. Morie ◽  
C.H. Sloan
Keyword(s):  
Carbon Dioxide ◽  
Gas Chromatography ◽  
Carbon Monoxide ◽  
Liquid Nitrogen ◽  
Cigarette Smoke ◽  
Cryogenic Temperature ◽  
Chromatographic Method ◽  
Porapak Q ◽  
Gas Chromatographic Method

AbstractA gas chromatographic method for the determination of carbon monoxide and carbon dioxide in cigarette smoke was developed. A column containing Porapak Q packing and a cryogenic temperature programmer which employed liquid nitrogen to cool the column to subambient temperatures was used. The separation of N

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