Dimensional evaluation of patient-specific 3D printing using calcium phosphate cement for craniofacial bone reconstruction

The 3D printing process is highlighted nowadays as a possibility to generate individual parts with complex geometries. Moreover, the development of 3D printing hardware, software and parameters permits the manufacture of parts that can be not only used as prototypes, but are also made from materials that are suitable for implantation. In this way, this study investigates the process involved in the production of patient-specific craniofacial implants using calcium phosphate cement, and its dimensional accuracy. The implants were previously generated in a computer-aided design environment based on the patient’s tomographic data. The fabrication of the implants was carried out in a commercial 3D powder printing system using alfa-tricalcium phosphate powder and an aqueous solution of Na2HPO4 as a binder. The fit of the 3D printed implants was measured by three-dimensional laser scanning and by checking the right adjustment to the patient’s anatomical biomodel. The printed parts presented a good degree of fitting and accuracy.

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Additive Manufacturing for Guided Bone Regeneration: A Perspective for Alveolar Ridge Augmentation

International Journal of Molecular Sciences ◽

10.3390/ijms19113308 ◽

2018 ◽

Vol 19 (11) ◽

pp. 3308 ◽

Cited By ~ 18

Author(s):

Patrick Rider ◽

Željka Kačarević ◽

Said Alkildani ◽

Sujith Retnasingh ◽

Reinhard Schnettler ◽

...

Keyword(s):

3D Printing ◽

Computer Aided Design ◽

Selective Laser Sintering ◽

Three Dimensional ◽

Tissue Scaffolds ◽

Patient Specific ◽

Alveolar Ridge ◽

Ridge Augmentation ◽

Permanent Implants ◽

Extrusion Printing

Three-dimensional (3D) printing has become an important tool in the field of tissue engineering and its further development will lead to completely new clinical possibilities. The ability to create tissue scaffolds with controllable characteristics, such as internal architecture, porosity, and interconnectivity make it highly desirable in comparison to conventional techniques, which lack a defined structure and repeatability between scaffolds. Furthermore, 3D printing allows for the production of scaffolds with patient-specific dimensions using computer-aided design. The availability of commercially available 3D printed permanent implants is on the rise; however, there are yet to be any commercially available biodegradable/bioresorbable devices. This review will compare the main 3D printing techniques of: stereolithography; selective laser sintering; powder bed inkjet printing and extrusion printing; for the fabrication of biodegradable/bioresorbable bone tissue scaffolds; and, discuss their potential for dental applications, specifically augmentation of the alveolar ridge.

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Results of studying the dimensional accuracy of the bases of complete removable prostheses made using 3D printing and traditional technologies

Стоматология для всех ◽

10.35556/idr-2020-4(93)34-39 ◽

2020 ◽

pp. 34-39

Author(s):

Vokulova Yu.A. Vokulova ◽

E.N. Zhulev

Keyword(s):

3D Printing ◽

Traditional Method ◽

Laser Scanning ◽

Laser Scanner ◽

Digital Technologies ◽

Dimensional Accuracy ◽

3D Printer ◽

Significance Level ◽

Average Value ◽

The Difference

This article presents the results of studying the dimensional accuracy of the bases of complete removable prostheses made using a 3D printer and the traditional method. Bases of complete removable prostheses were made using an intraoral laser scanner iTero Cadent (USA) and a 3D printer Asiga Max UV (Australia). To study the dimensional accuracy of the bases of complete removable prostheses, we used the DentalCAD 2.2 Valletta software. The Nonparametric Wilcoxon W-test was used for statistical analysis of the obtained data. We found that the average value of the difference with the standard for bases made using digital technologies is 0.08744±0.0484 mm. The average value of the difference with the standard for bases made by the traditional method is 0.5654±0.1611 mm. Based on these data, we concluded that the bases of complete removable prostheses made using modern digital technologies (intraoral laser scanning and 3D printer) have a higher dimensional accuracy compared to the bases of complete removable prostheses made using the traditional method with a significance level of p<0.05 (Wilcoxon's W-test=0, p=0.031). Keywords: digital technologies in dentistry, digital impressions, intraoral scanner, 3D printing, ExoCAD, complete removable dentures.

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3D Printing & Pharmaceutical Manufacturing: Opportunities and Challenges

International Journal of Bioassays ◽

10.21746/ijbio.2016.01.006 ◽

2016 ◽

Vol 5 (01) ◽

pp. 4723 ◽

Cited By ~ 5

Author(s):

Bhusnure O. G.* ◽

Gholve V. S. ◽

Sugave B. K. ◽

Dongre R. C. ◽

Gore S. A. ◽

...

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

3D Printing ◽

Computer Aided Design ◽

Patient Specific ◽

Computer Design ◽

3D Scaffolds ◽

Engineering Research ◽

Advantages And Disadvantages ◽

Computer Aided

Many researchers have attempted to use computer-aided design (C.A.D) and computer-aided manufacturing (CAM) to realize a scaffold that provides a three-dimensional (3D) environment for regeneration of tissues and organs. As a result, several 3D printing technologies, including stereolithography, deposition modeling, inkjet-based printing and selective laser sintering have been developed. Because these 3D printing technologies use computers for design and fabrication, and they can fabricate 3D scaffolds as designed; as a consequence, they can be standardized. Growth of target tissues and organs requires the presence of appropriate growth factors, so fabrication of 3Dscaffold systems that release these biomolecules has been explored. A drug delivery system (D.D.S) that administrates a pharmaceutical compound to achieve a therapeutic effect in cells, animals and humans is a key technology that delivers biomolecules without side effects caused by excessive doses. 3D printing technologies and D. D. Ss have been assembled successfully, so new possibilities for improved tissue regeneration have been suggested. If the interaction between cells and scaffold system with biomolecules can be understood and controlled, and if an optimal 3D tissue regenerating environment is realized, 3D printing technologies will become an important aspect of tissue engineering research in the near future. 3D Printing promises to produce complex biomedical devices according to computer design using patient-specific anatomical data. Since its initial use as pre-surgical visualization models and tooling molds, 3D Printing has slowly evolved to create one-of-a-kind devices, implants, scaffolds for tissue engineering, diagnostic platforms, and drug delivery systems. Fuelled by the recent explosion in public interest and access to affordable printers, there is renewed interest to combine stem cells with custom 3D scaffolds for personalized regenerative medicine. Before 3D Printing can be used routinely for the regeneration of complex tissues (e.g. bone, cartilage, muscles, vessels, nerves in the craniomaxillofacial complex), and complex organs with intricate 3D microarchitecture (e.g. liver, lymphoid organs), several technological limitations must be addressed. Until recently, tablet designs had been restricted to the relatively small number of shapes that are easily achievable using traditional manufacturing methods. As 3D printing capabilities develop further, safety and regulatory concerns are addressed and the cost of the technology falls, contract manufacturers and pharmaceutical companies that experiment with these 3D printing innovations are likely to gain a competitive edge. This review compose the basics, types & techniques used, advantages and disadvantages of 3D printing

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3D laser scanning and digital restoration of an archaeological find

MATEC Web of Conferences ◽

10.1051/matecconf/201817803013 ◽

2018 ◽

Vol 178 ◽

pp. 03013 ◽

Cited By ~ 3

Author(s):

Stergios Fragkos ◽

Emanuel Tzimtzimis ◽

Dimitrios Tzetzis ◽

Oana Dodun ◽

Panagiotis Kyratsis

Keyword(s):

3D Printing ◽

Laser Scanning ◽

Three Dimensional ◽

3D Laser Scanning ◽

Analytical Methodology ◽

3D Cad ◽

Digital Restoration ◽

Computer Based ◽

Ancient Ceramic ◽

Digital Archaeology

The current paper demonstrates the digital recreation and 3D printing of a missing fragment of an ancient ceramic pottery following digitization using a three dimensional laser scanning. The resulting pointcloud of the laser scans was treated with a series of advanced software for the creation of surfaces and ultimately for a digital model. An analytical methodology is presented revealing the step by step approach, which is an innovative way of recreating a missing fragment. Such approach aims to demonstrate the level of contribution that the ever evolving computer based technologies and 3D printing could bring to cultural heritage. The reverse engineering method presented for the reconstruction of a ceramic pottery, which is a part of the larger field of digital archaeology, is believed to benefit a variety of interested parties including 3D CAD users and designers, archaeologists and museum curators.

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An Application of Integrated 3D Technologies for Replicas in Cultural Heritage

ISPRS International Journal of Geo-Information ◽

10.3390/ijgi8060285 ◽

2019 ◽

Vol 8 (6) ◽

pp. 285 ◽

Cited By ~ 4

Author(s):

Balletti ◽

Ballarin

Keyword(s):

3D Printing ◽

Cultural Heritage ◽

Laser Scanning ◽

Low Cost ◽

Three Dimensional ◽

Digital Data ◽

Survey Analysis ◽

Critical Issues ◽

Data Acquisition And Processing ◽

Short Time

In recent decades, 3D acquisition by laser scanning or digital photogrammetry has become one of the standard methods of documenting cultural heritage, because it permits one to analyze the shape, geometry, and location of any artefact without necessarily coming into contact with it. The recording of three-dimensional metrical data of an asset allows one to preserve and monitor, but also to understand and explain the history and cultural heritage shared. In essence, it constitutes a digital archive of the state of an artefact, which can be used for various purposes, be remodeled, or kept safely stored. With the introduction of 3D printing, digital data can once again take on material form and become physical objects from the corresponding mathematical models in a relatively short time and often at low cost. This possibility has led to a different consideration of the concept of virtual data, no longer necessarily linked to simple visual fruition. The importance of creating high-resolution physical copies has been reassessed in light of different types of events that increasingly threaten the protection of cultural heritage. The aim of this research is to analyze the critical issues in the production process of the replicas, focusing on potential problems in data acquisition and processing and on the accuracy of the resulting 3D printing. The metric precision of the printed model with 3D technology are fundamental for everything concerning geomatics and must be related to the same characteristics of the digital model obtained through the survey analysis.

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Investigation of three-dimensional printing materials for printing aorta model replicating Type B aortic dissection

Current Medical Imaging Formerly Current Medical Imaging Reviews ◽

10.2174/1573405617666210218102046 ◽

2021 ◽

Vol 17 ◽

Author(s):

Chia-An Wu ◽

Andrew Squelch ◽

Zhonghua Sun

Keyword(s):

3D Printing ◽

Aortic Dissection ◽

Three Dimensional ◽

Ct Images ◽

Patient Specific ◽

Type B ◽

Type B Aortic Dissection ◽

Ct Attenuation ◽

Significant Difference ◽

3D Printed

Aim: To determine a printing material that has both elastic property and radiology equivalence close to real aorta for simulation of endovascular stent graft repair of aortic dissection. Background: With the rapid development of three-dimensional (3D) printing technology, a patient-specific 3D printed model is able to help surgeons to make better treatment plan for Type B aortic dissection patients. However, the radiological properties of most 3D printing materials have not been well characterized. This study aims to investigate the appropriate materials for printing human aorta with mechanical and radiological properties similar to the real aortic computed tomography (CT) attenuation. Objective: Quantitative assessment of CT attenuation of different materials used in 3D printed models of aortic dissection for developing patient-specific 3D printed aorta models to simulate type B aortic dissection. Method: A 25-mm length of aorta model was segmented from a patient’s image dataset with diagnosis of type B aortic dissection. Four different elastic commercial 3D printing materials, namely Agilus A40 and A50, Visijet CE-NT A30 and A70 were selected and printed with different hardness. Totally four models were printed out and conducted CT scanned twice on a 192-slice CT scanner using the standard aortic CT angiography protocol, with and without contrast inside the lumen.Five reference points with region of interest (ROI) of 1.77 mm2 were selected at the aortic wall and intimal flap and their Hounsfield units (HU) were measured and compared with the CT attenuation of original CT images. The comparison between the patient’s aorta and models was performed through a paired-sample t-test to determine if there is any significant difference. Result: The mean CT attenuation of aortic wall of the original CT images was 80.7 HU. Analysis of images without using contrast medium showed that the material of Agilus A50 produced the mean CT attenuation of 82.6 HU, which is similar to that of original CT images. The CT attenuation measured at images acquired with other three materials was significantly lower than that of original images (p<0.05). After adding contrast medium, Visijet CE-NT A30 had an average CT attenuation of 90.6 HU, which is close to that of the original images with statistically significant difference (p>0.05). In contrast, the CT attenuation measured at images acquired with other three materials (Agilus A40, A50 and Visiject CE-NT A70) was 129 HU, 135 HU and 129.6 HU, respectively, which is significantly higher than that of original CT images (p<0.05). Conclusion: Both Visijet CE-NT and Agilus have tensile strength and elongation close to real patient’s tissue properties producing similar CT attenuation. Visijet CE-NT A30 is considered the appropriate material for printing aorta to simulate contrast-enhanced CT imaging of type B aortic dissection. Due to lack of body phantom in the experiments, further research with simulation of realistic anatomical body environment should be conducted.

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Accuracy Assessment of Molded, Patient-Specific Polymethylmethacrylate Craniofacial Implants Compared to Their 3D Printed Originals

Journal of Clinical Medicine ◽

10.3390/jcm9030832 ◽

2020 ◽

Vol 9 (3) ◽

pp. 832 ◽

Cited By ~ 1

Author(s):

Dave Chamo ◽

Bilal Msallem ◽

Neha Sharma ◽

Soheila Aghlmandi ◽

Christoph Kunz ◽

...

Keyword(s):

Computer Aided Design ◽

Accuracy Assessment ◽

Three Dimensional ◽

Production Costs ◽

Patient Specific ◽

Patient Specific Implants ◽

3D Printed ◽

Cost Efficient ◽

Craniofacial Implants ◽

Aided Design

The use of patient-specific implants (PSIs) in craniofacial surgery is often limited due to a lack of expertise and/or production costs. Therefore, a simple and cost-efficient template-based fabrication workflow has been developed to overcome these disadvantages. The aim of this study is to assess the accuracy of PSIs made from their original templates. For a representative cranial defect (CRD) and a temporo-orbital defect (TOD), ten PSIs were made from polymethylmethacrylate (PMMA) using computer-aided design (CAD) and three-dimensional (3D) printing technology. These customized implants were measured and compared with their original 3D printed templates. The implants for the CRD revealed a root mean square (RMS) value ranging from 1.128 to 0.469 mm with a median RMS (Q1 to Q3) of 0.574 (0.528 to 0.701) mm. Those for the TOD revealed an RMS value ranging from 1.079 to 0.630 mm with a median RMS (Q1 to Q3) of 0.843 (0.635 to 0.943) mm. This study demonstrates that a highly precise duplication of PSIs can be achieved using this template-molding workflow. Thus, virtually planned implants can be accurately transferred into haptic PSIs. This workflow appears to offer a sophisticated solution for craniofacial reconstruction and continues to prove itself in daily clinical practice.

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Main Clinical Use of Additive Manufacturing (Three-Dimensional Printing) in Finland Restricted to the Head and Neck Area in 2016–2017

Scandinavian Journal of Surgery ◽

10.1177/1457496919840958 ◽

2019 ◽

Vol 109 (2) ◽

pp. 166-173 ◽

Cited By ~ 3

Author(s):

A.B.V. Pettersson ◽

M. Salmi ◽

P. Vallittu ◽

W. Serlo ◽

J. Tuomi ◽

...

Keyword(s):

Additive Manufacturing ◽

Computer Aided Design ◽

Three Dimensional ◽

Patient Specific ◽

Future Research ◽

Imaging Data ◽

University Hospitals ◽

Three Dimensional Printing ◽

Dimensional Printing ◽

Head Area

Background and Aims: Additive manufacturing or three-dimensional printing is a novel production methodology for producing patient-specific models, medical aids, tools, and implants. However, the clinical impact of this technology is unknown. In this study, we sought to characterize the clinical adoption of medical additive manufacturing in Finland in 2016–2017. We focused on non-dental usage at university hospitals. Materials and Methods: A questionnaire containing five questions was sent by email to all operative, radiologic, and oncologic departments of all university hospitals in Finland. Respondents who reported extensive use of medical additive manufacturing were contacted with additional, personalized questions. Results: Of the 115 questionnaires sent, 58 received answers. Of the responders, 41% identified as non-users, including all general/gastrointestinal (GI) and vascular surgeons, urologists, and gynecologists; 23% identified as experimenters or previous users; and 36% identified as heavy users. Usage was concentrated around the head area by various specialties (neurosurgical, craniomaxillofacial, ear, nose and throat diseases (ENT), plastic surgery). Applications included repair of cranial vault defects and malformations, surgical oncology, trauma, and cleft palate reconstruction. Some routine usage was also reported in orthopedics. In addition to these patient-specific uses, we identified several off-the-shelf medical components that were produced by additive manufacturing, while some important patient-specific components were produced by traditional methodologies such as milling. Conclusion: During 2016–2017, medical additive manufacturing in Finland was routinely used at university hospitals for several applications in the head area. Outside of this area, usage was much less common. Future research should include all patient-specific products created by a computer-aided design/manufacture workflow from imaging data, instead of concentrating on the production methodology.

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Digital Design and 3D Printing of Aortic Arch Reconstruction in HLHS for Surgical Simulation and Training

World Journal for Pediatric and Congenital Heart Surgery ◽

10.1177/2150135118771323 ◽

2018 ◽

Vol 9 (4) ◽

pp. 454-458 ◽

Cited By ~ 8

Author(s):

Sarah A. Chen ◽

Chin Siang Ong ◽

Nagina Malguria ◽

Luca A. Vricella ◽

Juan R. Garcia ◽

...

Keyword(s):

3D Printing ◽

Aortic Arch ◽

Surgical Simulation ◽

Three Dimensional ◽

3D Models ◽

Digital Design ◽

Patient Specific ◽

Aortic Arch Reconstruction ◽

Arch Reconstruction ◽

And Training

Purpose: Patients with hypoplastic left heart syndrome (HLHS) present a diverse spectrum of aortic arch morphology. Suboptimal geometry of the reconstructed aortic arch may result from inappropriate size and shape of an implanted patch and may be associated with poor outcomes. Meanwhile, advances in diagnostic imaging, computer-aided design, and three-dimensional (3D) printing technology have enabled the creation of 3D models. The purpose of this study is to create a surgical simulation and training model for aortic arch reconstruction. Description: Specialized segmentation software was used to isolate aortic arch anatomy from HLHS computed tomography scan images to create digital 3D models. Three-dimensional modeling software was used to modify the exported segmented models and digitally design printable customized patches that were optimally sized for arch reconstruction. Evaluation: Life-sized models of HLHS aortic arch anatomy and a digitally derived customized patch were 3D printed to allow simulation of surgical suturing and reconstruction. The patient-specific customized patch was successfully used for surgical simulation. Conclusions: Feasibility of digital design and 3D printing of patient-specific patches for aortic arch reconstruction has been demonstrated. The technology facilitates surgical simulation. Surgical training that leads to an understanding of optimal aortic patch geometry is one element that may potentially influence outcomes for patients with HLHS.

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