The Impact of Exercise on Age-Related Physiological Changes and Pathological Manifestations

2003 ◽  
Vol 16 (1) ◽  
pp. 5-14
Author(s):  
Angela C. Cafiero ◽  
Carol A. Maritz

The most inactive Americans are over the age of 65. Age-related physiological changes affect the ability to perform certain types of exercise. The cardiovascular and musculoskeletal systems are directly affected by these age-related changes, resulting in the modification of an exercise regimen. Individualized exercise programs depend on comorbidities, which limit the risks and maximize the benefits of exercise. Evidence supports the benefits of wellness exercise programs. The type of exercise beneficial for an individual is dependent on his or her overall health, disease state, and medications. Age-related physiological changes lead to the development of a wide range of chronic disorders that are often mistakenly assumed to be part of the normal aging process. The purpose of this article is to review the age-related physiological changes associated with exercise, the benefits and risks of exercise, and the wellness guidelines for initiating exercise in an individual over 65 years old. Included in this article is a discussion of the specific exercise guidelines for osteoarthritis, osteoporosis, obesity, psychological health, and diabetes mellitus.

2018 ◽  
Vol 33 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Dianna T Kenny ◽  
Tim Driscoll ◽  
Bronwen J Ackermann

BACKGROUND: The physical and psychological demands of playing a musical instrument are likely to be affected by age-related decline in function, including physical, cognitive, psychological, and organ-related changes. However, the complex neurophysiological demands of playing a musical instrument may delay many normal aging-related changes. AIM: This study compared professional classical musicians of different ages, using a range of physical and psychological measures, to discover how increasing age might affect work performance and to identify possible risk and protective factors for physical and psychological health as the musicians age. SUBJECTS: 377 professional orchestral musicians from eight Australian orchestras (70% response rate), ages 18 to 68 yrs (mean 42.1). Multiple standardized physical and psychological tools were used to evaluate the impact of age on a range of physical and mental health variables. RESULTS: Age was not statistically associated with frequency or severity of performance-related musculoskeletal disorders, ratings of perceived exertion, QuickDASH scores, use of beta-blockers, workplace satisfaction, and most psychological tests. Differences were observed on SPIN (social anxiety) scores, with lowest scores in the oldest age group (10.66 in 55+ yrs vs 17.83 in 18-30 yrs, p=0.016). Older musicians had higher BMIs and fewer practice sessions per day than younger musicians and also were more likely to consume alcohol on 5+ days/wk (44% vs 9%, p=0.003). CONCLUSION: Advancing age does not appear to exert undue negative impacts on physical and psychological health or performance capacity of professional orchestral musicians. However, dwindling numbers in the older age groups may suggest a "survivor" effect, whereby those who develop significant age-related decrements may cease professional performance at earlier ages. Longitudinal studies on the professional trajectories of professional orchestral musicians are needed to explore this question further.


2018 ◽  
Vol 4 (1) ◽  
pp. e000368 ◽  
Author(s):  
Andrew Mark Edwards ◽  
Lia Dutton-Challis ◽  
David Cottrell ◽  
Joshua H Guy ◽  
Florentina Johanna Hettinga

ObjectiveThe positive effect of an audience on performance is anecdotally well known, but the impact of such social facilitation to both performance and the motivation to exercise have not been thoroughly explored. The aim of this study was therefore to investigate verbal encouragement as a means to promote positive behavioural adherence to exercise and augmented performance. MethodsTwelve untrained but active individuals (seven female), age 24±3 years participated in this study. Exercise conditions with external verbal encouragement (EVE) and without external verbal encouragement (WEVE) were compared in both endurance (20 min) and sprint (2 × 30 s Wingate) cycling tasks in a randomised crossover design. Results were analysed by separate 2 (EVE/WEVE) × 2 (sprint/endurance) within-subjects analyses of variance for each dependent variable. Statistical significance was set at p≤0.05. ResultsEVE resulted in a significant increase,F(1,11)=15.37, p=0.002,ηp2=0.58 in the average power generated by participants in each exercise bout on the cycle ergometer. EVE also had a significant effect on reported motivation to exercise the next day,F(1,11)=5.5, p=0.04,ηp2=0.33, which did not differ between type of exercise.ConclusionExternal encouragement in both sprint and endurance activities resulted in large improvements in performance and motivation to continue an exercise regimen the next day, which has important implications for health, adherence and maximising physical performance using a practical intervention.


2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Peter Baker ◽  
Vivien Cooper ◽  
Winnie Tsang ◽  
Isabelle Garnett ◽  
Noelle Blackman

Purpose There is an established literature supporting the idea that families who have children and adults who have a learning disability and/or autism have a greater vulnerability to mental health problems or poor psychological health. There are shortcomings in this literature in that there is a little consideration of the impact the families interaction with services has on their well-being. It is argued that complex post-traumatic stress disorder (CPTSD), with its focus on prolonged chronic exposure to trauma experiences and the recognition that this can occur in adulthood, may well be an appropriate framework to enable a better understanding of the experiences of families. Design/methodology/approach A total of 214 family members completed a co-produced online survey in relation to potential traumatic events, impacts and support. Findings The experiences of family carers of children and adults with a learning disability and/or who are autistic would appear to be multi-layered and complex, with many experiencing a wide range of traumatic events with the associated emotional and personal sequela. The reported responses are consistent with CPTSD with 10% of having received a diagnosis of PTSD. Their experience was that the system failed not only to provide support but also created additional trauma. Practical implications A trauma-informed approach needs to be adopted by agencies and professionals that serve families to ensure they understand their potential contribution to the trauma families experience. Originality/value To the best of the authors’ knowledge, this is the first study that has attempted to examine the experience of families using the framework of CPTSD.


2019 ◽  
Vol 2 (2) ◽  
pp. 73-92
Author(s):  
Ruqia Safdar Bajwa ◽  
Hamida Bibi

Psychological health directly affects life satisfaction especially to those women who face social and family pressure about their infertility. A wide range of research studies comparing fertile and infertile women documented that there is negative impact of infertility on subjective well-being and global life satisfaction (Abbey et al., 1991, 1992; Callan, 1987; Callan& Hennessey, 1988). The present study was aimed to investigate the impact of psychological health on life satisfaction among fertile and infertile females. Through the convenience sampling technique, a sample of 310 (N=310) fertile and infertile women was selected whose age ranged between 25 to 50 years. Demographic variables included age, employment status, level of education, duration of marital life, type of marriage and family system for both fertile and infertile females. To be included in sample, Women must have been diagnosed with infertility (primary or secondary), they must not have adopted any child, and marriage duration must be at least 2 years and must not have past history of psychiatric illness. General Health Questionnaire (GHQ-28) was used for current psychological health and Satisfaction with Life Scale (SWLS) was used to measure life satisfaction. Data was analyzed by using SPSS version 21. Descriptive statistics, Regression analysis, ANOVA and t-test were used to analyze the data. Results have shown that psychological health has impact on life satisfaction in both fertile and infertile groups of women. Furthermore, results show that level of life satisfaction and psychological health is more prevalent in educated and employed women as compared to uneducated and unemployed women. To conclude, this study will be helpful in resolving psychological problems of the infertile females. Education can increase awareness about infertility and infertile females can meet the challenges of the society and can stand with better health and emotions.


2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
Y Natt och Dag ◽  
K Mehlig ◽  
A Rosengren ◽  
L Lissner ◽  
M Rosvall

Abstract Background The contemporary increase in psychological distress observed in many countries is, by itself, a public health issue of great concern. Methods This prospective study aims to investigate the impact of psychological distress on incident cardiovascular disease, in different age groups and also with respect to sex, among participants in the Gothenburg-based InterGene Study cohort. This cohort comprises a total of 3614 men and women, aged 25-75 years. Included in the present study were individuals who were free of previous CVD diagnoses and who fully completed all baseline examinations. Inclusions took place during 2001-2004. Psychological distress at baseline was assessed by self-rating depression and anxiety scales. A wide range of physiological and behavioral parameters were also assessed, which allowed for relevant adjustments. The outcome was incident CVD, and with a 12 year follow-up. Cox-regression analyses were performed. Results The results showed an increased risk of incident CVD with higher scores on each of the scales. The majority of the findings persisted after adjustments for relevant confounders. It was most common for young women to score high on the anxiety and depression scales. Conclusions The associations between psychological distress and later life cardiovascular disease calls for enhanced public health measures aiming at ameliorating psychological health, not least in younger age groups. Key messages There was an increased risk of incident CVD with higher scores on psychosocial distress scales. The majority of the findings persisted after adjustments for relevant confounders.


Author(s):  
Joan Fitzpatrick

Early modern dietaries are prose texts recommending the best way to maintain physical and psychological well-being. This modern spelling edition is the first to make available to a modern audience three of the most important dietaries from the sixteenth century. The dietaries contained in this volume are Thomas Elyot's Castle of Health, Andrew Boorde's Compendious Regiment, and William Bullein's Government of Health, all popular and influential works that were typical of the genre. These works are here introduced, contextualized and, most importantly, edited for the first time, thus making them more readily available to scholars and students of Renaissance culture. Dietaries illuminate attitudes to food and diet in the period as well as ideas about how lifestyle impacts upon physical and psychological health, for example how much and what type of exercise one should take and how to sleep (for how long and in what position). Introductory material explores the dietary genre, its relationship to humanism, humoral theory, and the wide range of authorities with which the dietary authories engaged. The volume also provides an introduction to each of the works, including a biography of the author and a discussion of what is distinct about their book as well as an examination of the bibliographical and publication history of their dietary. In addition, the reader will benefit from comprehensive explanatory notes and appendices that provide prefaces to earlier editions, a glossary of words commonly used, and a list of authorities and works cited or alluded to in the dietaries.


2006 ◽  
Vol 100 (4) ◽  
pp. 1385-1391 ◽  
Author(s):  
Hannah J. Zhang ◽  
Susan R. Doctrow ◽  
Larry W. Oberley ◽  
Kevin C. Kregel

One postulated mechanism for the reduction in stress tolerance with aging is a decline in the regulation of stress-responsive genes, such as inducible heat shock protein 72 (HSP70). Increased levels of oxidative stress are also associated with aging, but it is unclear what impact a prooxidant environment might have on HSP70 gene expression. This study utilized a superoxide dismutase/catalase mimetic (Eukarion-189) to evaluate the impact of a change in redox environment on age-related HSP70 responses to a physiologically relevant heat challenge. Results demonstrate that liver HSP70 mRNA and protein levels are reduced in old compared with young rats at selected time points over a 48-h recovery period following a heat-stress protocol. While chronic systemic administration of Eukarion-189 suppressed hyperthermia-induced liver HSP70 mRNA expression in both age groups, HSP70 protein accumulation was blunted in old rats but not in their young counterparts. These data suggest that a decline in HSP70 mRNA levels may be responsible for the reduction in HSP70 protein observed in old animals after heat stress. Furthermore, improvements in redox status were associated with reduced HSP70 mRNA levels in both young and old rats, but differential effects were manifested on protein expression, suggesting that HSP70 induction is differentially regulated with aging. These findings highlight the integrated mechanisms of stress protein regulation in eukaryotic organisms responding to environmental stress, which likely involve interactions between a wide range of cellular signals.


2019 ◽  
Vol 34 (6) ◽  
pp. 632-643 ◽  
Author(s):  
Vamanjore Aboobaker Naushad ◽  
Joost JLM Bierens ◽  
Kunnummel Purayil Nishan ◽  
Chirakkal Paramba Firjeeth ◽  
Osama Hashim Mohammad ◽  
...  

AbstractIntroduction:Medical responders are at-risk of experiencing a wide range of negative psychological health conditions following a disaster.Aim:Published literature was reviewed on the adverse psychological health outcomes in medical responders to various disasters and mass casualties in order to: (1) assess the psychological impact of disasters on medical responders; and (2) identify the possible risk factors associated with psychological impacts on medical responders.Methods:A literature search of PubMed, Discovery Service, Science Direct, Google Scholar, and Cochrane databases for studies on the prevalence/risk factors of posttraumatic stress disorder (PTSD) and other mental disorders in medical responders of disasters and mass casualties was carried out using pre-determined keywords. Two reviewers screened the 3,545 abstracts and 28 full-length articles which were included for final review.Results:Depression and PTSD were the most studied outcomes in medical responders. Nurses reported higher levels of adverse outcomes than physicians. Lack of social support and communication, maladaptive coping, and lack of training were important risk factors for developing negative psychological outcomes across all types of disasters.Conclusions:Disasters have significant adverse effects on the mental well-being of medical responders. The prevalence rates and presumptive risk factors varied among three different types of disasters. There are certain high-risk, vulnerable groups among medical responders, as well as certain risk factors for adverse psychological outcomes. Adapting preventive measures and mitigation strategies aimed at high-risk groups would be beneficial in decreasing negative outcomes.


2017 ◽  
Vol 61 (3) ◽  
pp. 379-388 ◽  
Author(s):  
Jessica M. Hoffman ◽  
Yang Lyu ◽  
Scott D. Pletcher ◽  
Daniel E.L. Promislow

Age is the single greatest risk factor for a wide range of diseases, and as the mean age of human populations grows steadily older, the impact of this risk factor grows as well. Laboratory studies on the basic biology of ageing have shed light on numerous genetic pathways that have strong effects on lifespan. However, we still do not know the degree to which the pathways that affect ageing in the lab also influence variation in rates of ageing and age-related disease in human populations. Similarly, despite considerable effort, we have yet to identify reliable and reproducible ‘biomarkers’, which are predictors of one’s biological as opposed to chronological age. One challenge lies in the enormous mechanistic distance between genotype and downstream ageing phenotypes. Here, we consider the power of studying ‘endophenotypes’ in the context of ageing. Endophenotypes are the various molecular domains that exist at intermediate levels of organization between the genotype and phenotype. We focus our attention specifically on proteins and metabolites. Proteomic and metabolomic profiling has the potential to help identify the underlying causal mechanisms that link genotype to phenotype. We present a brief review of proteomics and metabolomics in ageing research with a focus on the potential of a systems biology and network-centric perspective in geroscience. While network analyses to study ageing utilizing proteomics and metabolomics are in their infancy, they may be the powerful model needed to discover underlying biological processes that influence natural variation in ageing, age-related disease, and longevity.


2000 ◽  
Vol 39 (05) ◽  
pp. 127-132 ◽  
Author(s):  
Nicole Sieweke ◽  
K. H. Bohuslavizki ◽  
W. U. Kampen ◽  
M. Zuhayra ◽  
M. Clausen ◽  
...  

Summary Aim of this study was to validate a recently introduced new and easy-to-perform method for quantifying bone uptake of Tc-99m-labelled diphosphonate in a routine clinical setting and to establish a normal data base for bone uptake depending on age and gender. Methods: In 49 women (14-79 years) and 47 men (6-89 years) with normal bone scans as well as in 49 women (33-81 years) and 37 men (27-88 years) with metastatic bone disease whole-body bone scans were acquired at 3 min and 3-4 hours p.i. to calculate bone uptake after correction for both urinary excretion and soft tissue retention. Results: Bone uptake values of various age-related subgroups showed no significant differences between men and women (p >0.05 ). Furthermore, no differences could be proven between age-matched subgroups of normals and patients with less than 10 metastatic bone lesions, while patients with wide-spread bone metastases revealed significantly increased uptake values. In both men and women highest bone uptake was obtained (p <0.05 ) in subjects younger than 20 years with active epiphyseal growth plates. In men, bone uptake slowly decreased with age up to 60 years and then showed a tendency towards increasing uptake values. In women, the mean uptake reached a minimun in the decade 20-29 years and then slowly increased with a positive linear correlation of age and uptake in subjects older than 55 years (r = 0.57). Conclusion: Since the results proposed in this study are in good agreement with data from literature, the new method used for quantification could be validated in a large number of patients. Furthermore, age- and sexrelated normal bone uptake values of Tc-99m-HDP covering a wide range of age could be presented for this method as a basis for further studies on bone uptake.


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