Experimental investigation on powder processing and its flow properties of AlSi10Mg alloy with niobium carbide for additive manufacturing

In this study, aluminium-silicon alloy AlSi10Mg powder of spherical morphology was mixed with niobium carbide powder had irregular morphology in weight percentages of 2, 4, 6 and 8 and processed in a planetary ball mill apparatus. The optimal conditions for powder processing were a mixing time of 1.95 h and a speed of 71 RPM without milling balls. The use of milling balls was avoided to maintain the morphology of AlSi10Mg from degradation and improve the flowability of composite powder. To evaluate the flowability of processed powders, flow properties such as apparent density, tapped density, Hausner’s ratio, Carr index, static angle of repose and Hall flow rate were determined. Selective laser melting was used to fabricate AlSi10Mg composite specimens with varying percentages of niobium carbide. Finally, at 6% niobium carbide, the selective laser melting cube specimen had a maximum relative density of 99.21%.

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Improving Micromeritic Properties of Ibuprofen: An Agglomeration Approach

Bangladesh Pharmaceutical Journal ◽

10.3329/bpj.v20i1.32098 ◽

2017 ◽

Vol 20 (1) ◽

pp. 90-98

Author(s):

Md Sazzadul Islam ◽

Md Saiful Islam Pathan

Keyword(s):

Water Solubility ◽

Tween 80 ◽

Pharmaceutical Journal ◽

Angle Of Repose ◽

Release Behavior ◽

Flow Properties ◽

Physical Form ◽

Reduced Compressibility ◽

The Common ◽

Tapped Density

Ibuprofen is one of the common NSAIDs having poor water solubility, low dissolution, weak flow properties and reduced compressibility. These downsides of ibuprofen crystal upraise crucial challenges during development of a dosage form. The aim of this present work was to modify the physical form of ibuprofen by changing micromeritic properties. Seven different formulations of ibuprofen agglomerates such as F-1, F-2, F-3, F-4, F-5, F-6 and F-7 were prepared to convert the needle shaped ibuprofen crystals into agglomerates so that the desired micromeritic properties can be achieved. In this study, agglomerates of ibuprofen were prepared by Quasi emulsion solvent diffusion (QESD) method in association with two surfactants (sodium lauryl sulphateand Tween 80) at three different concentrations for each. The micromeritic properties of the prepared agglomerates were evaluated for bulk density, tapped density, Carrs index, Hausners ratio, angle of repose along with the release behavior of agglomerates. From dissolution study, it was observed that the release of drug was directly proportional to the surfactant concentration. Here, it was also revealed that there was no interaction among ibuprofen and other excipients as evident from DSC and FTIR studies.Bangladesh Pharmaceutical Journal 20(1): 90-98, 2017

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Characterization of IN 625 recycled metal powder used for selective laser melting

Manufacturing Review ◽

10.1051/mfreview/2020002 ◽

2020 ◽

Vol 7 ◽

pp. 5

Author(s):

Mihaela Raluca Condruz ◽

Gheorghe Matache ◽

Alexandru Paraschiv

Keyword(s):

Selective Laser Melting ◽

Angle Of Repose ◽

Spherical Particles ◽

Powder Size ◽

Metal Powders ◽

Laser Melting ◽

Hausner Ratio ◽

Roundness Deviation ◽

D Values ◽

Over Time

Additive manufacturing of high-quality materials by Selective Laser Melting depends not only on establishing appropriate process parameters, but also on the characteristics of the metal powders used and their stability over time or after recycling. The aim of the research was to characterize the IN 625 powder used over multiple manufacturing cycles with a Lasertec 30 SLM machine. In order to achieve the research's goal, virgin and recirculated powder's physical and technological characteristics were investigated. A decrease in all D-values (D10, D50, D90) of the powder size distribution was observed after multiple recirculation cycles showing a decrease of the powder dimensional range over time. Both virgin and recirculated powders are composed of mainly spherical particles, but elongated particles and satellite particles were observed as well. The dimensional evolution analysis showed a deviation from the powder ideal roundness, deviation that is more pronounced over multiple recirculation cycles. It was experimentally determined that the powders present a good flowability based on the flow rate value obtained for both virgin and recirculated powders, confirmed also by the Hausner ratio and angle of repose.

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Flow properties of tool steel powders for selective laser melting – influence of thermal and mechanical powder treatments

Powder Metallurgy ◽

10.1080/00325899.2017.1344451 ◽

2017 ◽

Vol 60 (5) ◽

pp. 353-362 ◽

Cited By ~ 4

Author(s):

Sepehr Hatami ◽

Ola Lyckfeldt ◽

Lenny Tönnäng ◽

Karin Fransson

Keyword(s):

Selective Laser Melting ◽

Tool Steel ◽

Flow Properties ◽

Laser Melting

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Optimisation Of Process Parameters In High Energy Mixing As A Method Of Cohesive Powder Flowability Improvement

Chemical and Process Engineering ◽

10.1515/cpe-2015-0032 ◽

2015 ◽

Vol 36 (4) ◽

pp. 449-460 ◽

Cited By ~ 2

Author(s):

Karolina Leś ◽

Karol Kowalski ◽

Ireneusz Opaliński

Keyword(s):

Response Surface Methodology ◽

Response Surface ◽

Powder Processing ◽

Mixing Time ◽

High Energy ◽

Angle Of Repose ◽

Process Variables ◽

Compressibility Index ◽

Cohesive Powder ◽

Optimal Values

Abstract Flowability of fine, highly cohesive calcium carbonate powder was improved using high energy mixing (dry coating) method consisting in coating of CaCO3 particles with a small amount of Aerosil nanoparticles in a planetary ball mill. As measures of flowability the angle of repose and compressibility index were used. As process variables the mixing speed, mixing time, and the amount of Aerosil and amount of isopropanol were chosen. To obtain optimal values of the process variables, a Response Surface Methodology (RSM) based on Central Composite Rotatable Design (CCRD) was applied. To match the RSM requirements it was necessary to perform a total of 31 experimental tests needed to complete mathematical model equations. The equations that are second-order response functions representing the angle of repose and compressibility index were expressed as functions of all the process variables. Predicted values of the responses were found to be in a good agreement with experimental values. The models were presented as 3-D response surface plots from which the optimal values of the process variables could be correctly assigned. The proposed, mechanochemical method of powder treatment coupled with response surface methodology is a new, effective approach to flowability of cohesive powder improvement and powder processing optimisation.

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Formulation Design and in Vitro Evaluation of Oral Disintegrating Tablets of Selegiline

International Journal of Applied Pharmaceutical Sciences and Research ◽

10.21477/ijapsr.v2i04.9603 ◽

2017 ◽

Vol 2 (04) ◽

pp. 107-113

Author(s):

K Sunand ◽

V Sandhya ◽

A Swapna ◽

K Prasanth ◽

A Vijaya ◽

...

Keyword(s):

Angle Of Repose ◽

Flow Properties ◽

Compression Method ◽

Sodium Starch Glycolate ◽

Control Evaluation ◽

Tapped Density ◽

Evaluation Parameters ◽

Fast Disintegrating Tablets ◽

Good Flow

In the present work, an attempt has been made to develop fast disintegrating tablets of Selegiline, were as sodium starch glycolate, cross povidone and cross carmellose sodium were employed as super disintegrating agents to enhance the solubility and dissolution rate of drug molecule. Formulations were prepared by direct compression method using 6mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed good flow properties such as angle of repose, bulk density and tapped density. The prepared tablets have shown good post compression parameters and they passed all the quality control evaluation parameters as per IP limits. Among all the formulations F2 formulation showed maximum percentage drug release i.e., 97.26 % in 45 min, hence it is considered as optimized formulation. The F2 formulation contains SSG as super disintegrate in the concentration of 24mg.

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Development of Corn Starch-Neusilin UFL2 Conjugate as Tablet Superdisintegrant: Formulation and Evaluation of Fast Disintegrating Tablets

Journal of Drug Delivery ◽

10.1155/2014/827035 ◽

2014 ◽

Vol 2014 ◽

pp. 1-13 ◽

Cited By ~ 5

Author(s):

Prateek Juneja ◽

Birender Kaur ◽

Oluwatoyin A. Odeku ◽

Inderbir Singh

Keyword(s):

Plastic Deformation ◽

Corn Starch ◽

Angle Of Repose ◽

Powder Flow ◽

Microwave Method ◽

Flow Properties ◽

Physical Chemical ◽

Fast Disintegrating Tablet ◽

Tapped Density ◽

Fast Disintegrating Tablets

In the present study, corn Starch-Neusilin UFL2 conjugates were prepared by physical, chemical, and microwave methods with the aim of using the conjugates as tablet superdisintegrant. Various powder tests, namely, angle of repose, bulk density, tapped density, Hausner’s ratio, Carr’s index, swelling index, and powder porosity were conducted on the samples. The conjugates were characterized by ATR-FTIR, XRD, DSC, and SEM techniques. Heckel and Kawakita models were applied to carry out compression studies for the prepared conjugates. Fast disintegrating tablets of domperidone were prepared using corn starch and corn Starch-Neusilin UFL2 conjugates as tablet superdisintegrants in different concentrations. Conjugates were found to possess good powder flow and tabletting properties. Heckel analysis indicated that the conjugates prepared by microwave method showed the slowest onset of plastic deformation while Kawakita analysis indicated that the conjugates prepared by microwave method exhibited the highest amount of total plastic deformation. The study revealed that the corn Starch-Neusilin UFL2 conjugates possess improved powder flow properties and could be a promising superdisintegrant for preparing fast disintegrating tablet. Also, the results sugessted that the microwave method was found to be most effective for the preparation of corn Starch-Neusilin UFL2 conjugates.

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Formulation and evaluation of floating bioadhesive Doxofylline tablets

International Journal of Drug Delivery ◽

10.5138/09750215.1871 ◽

2017 ◽

Vol 8 (4) ◽

Author(s):

Bhukya Nagaraju ◽

B Ramu ◽

S V Saibaba ◽

B Rajkamal

Keyword(s):

Quality Control ◽

Angle Of Repose ◽

Direct Compression ◽

Flow Properties ◽

Compression Method ◽

Retarding Effect ◽

Control Evaluation ◽

Tapped Density ◽

Evaluation Parameters ◽

Gastro Retentive

In the present work, an attempt has been made to develop gastro retentive floating tablets of Doxofylline .HPMC K4M and carbopol were used as controlled release polymers. All the formulations were prepared by direct compression method on 12 station rotary tablet punching machine. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. FH 5 was the best optimized floating formulation because it released drug completely in 12hrs.It was also observed that the increasing concentration of polymers had a retarding effect on the drug release from the polymer matrices.

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