Prevalence and determinants of anal human papillomavirus infection in men who have sex with men and transgender women

Human papillomavirus (HPV) prevalence varies by population. This study investigated anal HPV type detection risk by country in a population of men who have sex with men (MSM) and transgender women (TW) at risk of HIV. Sexually active HIV-1-uninfected MSM and TW were enrolled at eight sites: four in the United States (US), two in Thailand, one in Peru, and one in South Africa. Baseline anal HPV swabs were collected, and DNA typing was performed. One hundred and ninety-five participants, 76 (42%) from the US, had a mean age of 30.9 years (range 18–64). In 182 participants with results available, anal HPV infection was common with 169 (93%) with ≥1 type, 132 (73%) with ≥1 nine-valent vaccine types, and 66 (36%) with HPV 16. Participants in the US had a higher prevalence of HPV 16 (56%, p = 0.004) and HPV 6 (69%, p < 0.001) compared to the other regions. Stimulant drug use was significantly associated with HPV 6 detection. Anal HPV is highly prevalent in this population of MSM and TW sampled from four countries, with HPV 16 the most commonly detected type. The nine-valent HPV vaccine has the potential to provide significant protection if given prior to exposure.

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Incidence and Clearance of Anal Human Papillomavirus (HPV)-16 and HPV-18 Infection, and Their Determinants, Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men in France

The Journal of Infectious Diseases ◽

10.1093/infdis/jiz623 ◽

2019 ◽

Vol 221 (9) ◽

pp. 1488-1493 ◽

Cited By ~ 1

Author(s):

Catharina J Alberts ◽

Isabelle Heard ◽

Ana Canestri ◽

Lucie Marchand ◽

Jean-François Fléjou ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Human Papillomavirus ◽

Hpv Infection ◽

High Grade ◽

Hpv 16 ◽

Human Papillomavirus 16 ◽

Immunodeficiency Virus ◽

Adjusted Incidence Rate ◽

Sex With Men ◽

Hpv 18

Abstract Background Prospective data on the natural history of anal human papillomavirus (HPV) infection are scarce in human immunodeficiency virus (HIV)-infected men who have sex with men (MSM). Methods We analyzed incidence and clearance of HPV-16 and HPV-18 in a French cohort of HIV-infected MSM, aged ≥35 years, followed-up annually (n = 438, 2014–2018). Results Human papillomavirus-16 and HPV-18 incidence were similar (~10% incident infections at 24 months). Human papillomavirus-16 incidence was higher among high-grade versus no lesion at baseline (adjusted incidence rate ratio = 3.0; 95% confidence interval, 1.07–8.18). Human papillomavirus-16 cleared significantly slower than HPV-18 (32% versus 54% by 24 months). Conclusions In conclusion, anal HPV-16 is more persistent than HPV-18, and its incidence correlates with a prior detection of high-grade lesions.

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Anal Human Papillomavirus Infection among MSM Attending University in China: Implications for Vaccination

Vaccines ◽

10.3390/vaccines8020175 ◽

2020 ◽

Vol 8 (2) ◽

pp. 175

Author(s):

Song Fan ◽

Peiyang Li ◽

Lin Ouyang ◽

Tanwei Yuan ◽

Hui Gong ◽

...

Keyword(s):

Human Papillomavirus ◽

Sexual Behaviors ◽

Hpv Vaccination ◽

Northern China ◽

Hpv Infection ◽

High Risk Population ◽

Online Questionnaire ◽

Vaccination Programs ◽

Papillomavirus Infection ◽

Sex With Men

Men who have sex with men (MSM) attending university are a high-risk population for human papillomavirus (HPV) infection and are a neglected population of HPV vaccination programs in China. To provide evidence for HPV vaccination policies, we conducted this study to examine the prevalence and factors associated with anal HPV infection among MSM attending university in China. A self-administered online questionnaire was conducted to collect information on social demographics and sexual behaviors. A self-collected rectal swab specimen was collected to test for 37 HPV types. A total of 426 participants were tested for HPV. The median age was 20 years. HPV prevalence was 37.5% for any type, 29.8% for nine-valent vaccine types, 24.6% for four-valent vaccine types, 11.5% for HPV-16/18, and 15.7% for HPV-6/11. Men enrolled in a technical diploma, living in Northern China, having more than two sex partners, being bottom or versatile in anal sex, and having a human immunodeficiency virus (HIV) testing history were more likely to have positive anal HPV of any type. Our study found a high prevalence of anal HPV infection among MSM attending university in China, with HPV vaccine-preventable types being the most popular types in this group. Thus, our findings highlight the urgency of promoting HPV vaccination among teenage MSM.

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Sexual positioning practices and anal human papillomavirus infection among young men who have sex with men and transgender women — Chicago, Illinois, 2016–2018

Sexually Transmitted Diseases ◽

10.1097/olq.0000000000001433 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Ethan Morgan ◽

Elissa Meites ◽

Lauri E. Markowitz ◽

Casey D. Xavier Hall ◽

Troy D. Querec ◽

...

Keyword(s):

Human Papillomavirus ◽

Young Men ◽

Transgender Women ◽

Human Papillomavirus Infection ◽

Papillomavirus Infection ◽

Sex With Men

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Providing Unique Support for Health Study Among Young Black and Latinx Men Who Have Sex With Men and Young Black and Latinx Transgender Women Living in 3 Urban Cities in the United States: Protocol for a Coach-Based Mobile-Enhanced Randomized Control Trial

JMIR Research Protocols ◽

10.2196/17269 ◽

2020 ◽

Vol 9 (9) ◽

pp. e17269

Author(s):

Renata Arrington-Sanders ◽

Kimberly Hailey-Fair ◽

Andrea Wirtz ◽

Travis Cos ◽

Noya Galai ◽

...

Keyword(s):

United States ◽

Qualitative Research ◽

Substance Use ◽

The United States ◽

Transgender Women ◽

Washington Dc ◽

Seed Selection ◽

Sex With Men ◽

Living With Hiv ◽

Hiv 1

Background The US National HIV/AIDS Strategy 2020 calls for increasing access to care, improving outcomes of people living with HIV, and targeting biomedical prevention efforts, including access to pre-exposure prophylaxis (PrEP) in communities where HIV is most heavily concentrated. The cities of Baltimore, Maryland (MD); Washington, DC; and Philadelphia, Pennsylvania (PA) are disproportionately burdened by high rates of new cases of HIV infection, with high prevalence among young Black and Latinx men who have sex with men (YBLMSM) and young Black and Latinx transgender women (YBLTW) aged 15-24 years. Objective This study aims (1) to identify and recruit YBLMSM and YBLTW who are at risk or living with HIV in Baltimore, MD; Philadelphia, PA; and Washington, DC, using respondent-driven sampling (RDS) with targeted seed selection, and (2) to assess the efficacy of a coach-based mobile-enhanced intervention (MEI) compared with standard of care (SOC) to increase successful engagement and retention into HIV, PrEP, and substance use treatment care across the HIV care and prevention continua in 3 Mid-Atlantic cities. This paper describes the protocol and progress as of October 20, 2019. Methods This study uses a multiphase mixed methods design. The first phase is a formative, qualitative research with focus group discussions and key informant interviews. The second phase consists of evaluating the ability of RDS with targeted seed selection. The third phase includes 2 embedded randomized controlled trials (RCTs), where participants complete a baseline sociobehavioral survey, rapid HIV testing, and eligible youth enroll in parallel status-dependent RCTs that randomize the participant to 1 of 2 study arms: MEI with coach or SOC. Participants are asked to complete a web-based survey and provide biologic specimens—HIV-1 RNA (viral load) or HIV-1 antibody test and urine drug screen—at baseline and at 3, 6, and 12 months, and an exit interview at 18 months. Results A formative qualitative research was conducted in February 2017 and May 2018, and this led to further refinement of recruitment and study methods. Aim 1 recruitment began in September 2017 with subsequent enrollment into the RCTs. Recruitment is ongoing with 520 participants screened and 402 (77.3%) enrolled in aim 1 by October 2020. Of these, 159 are enrolled in the 2 randomized trials: 36 (22.6%) HIV-positive not virally suppressed (aim 2) and 123 (77.4%) high-risk HIV-negative (aim 3). Conclusions This study has the potential to significantly impact the medical and substance use services provided to YBLMSM and YBLTW in the United States by providing rigorous scientific evidence outlining approaches and strategies that improve the uptake and engagement of YBLMSM and YBLTW in the HIV treatment and prevention continuum. Trial Registration ClinicalTrials.gov NCT03194477; https://clinicaltrials.gov/ct2/show/NCT03194477 International Registered Report Identifier (IRRID) DERR1-10.2196/17269

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Providing Unique Support for Health Study Among Young Black and Latinx Men Who Have Sex With Men and Young Black and Latinx Transgender Women Living in 3 Urban Cities in the United States: Protocol for a Coach-Based Mobile-Enhanced Randomized Control Trial (Preprint)

10.2196/preprints.17269 ◽

2019 ◽

Author(s):

Renata Arrington-Sanders ◽

Kimberly Hailey-Fair ◽

Andrea Wirtz ◽

Travis Cos ◽

Noya Galai ◽

...

Keyword(s):

United States ◽

Qualitative Research ◽

Substance Use ◽

The United States ◽

Transgender Women ◽

Washington Dc ◽

Seed Selection ◽

Sex With Men ◽

Living With Hiv ◽

Hiv 1

BACKGROUND The US National HIV/AIDS Strategy 2020 calls for increasing access to care, improving outcomes of people living with HIV, and targeting biomedical prevention efforts, including access to pre-exposure prophylaxis (PrEP) in communities where HIV is most heavily concentrated. The cities of Baltimore, Maryland (MD); Washington, DC; and Philadelphia, Pennsylvania (PA) are disproportionately burdened by high rates of new cases of HIV infection, with high prevalence among young Black and Latinx men who have sex with men (YBLMSM) and young Black and Latinx transgender women (YBLTW) aged 15-24 years. OBJECTIVE This study aims (1) to identify and recruit YBLMSM and YBLTW who are at risk or living with HIV in Baltimore, MD; Philadelphia, PA; and Washington, DC, using respondent-driven sampling (RDS) with targeted seed selection, and (2) to assess the efficacy of a coach-based mobile-enhanced intervention (MEI) compared with standard of care (SOC) to increase successful engagement and retention into HIV, PrEP, and substance use treatment care across the HIV care and prevention continua in 3 Mid-Atlantic cities. This paper describes the protocol and progress as of October 20, 2019. METHODS This study uses a multiphase mixed methods design. The first phase is a formative, qualitative research with focus group discussions and key informant interviews. The second phase consists of evaluating the ability of RDS with targeted seed selection. The third phase includes 2 embedded randomized controlled trials (RCTs), where participants complete a baseline sociobehavioral survey, rapid HIV testing, and eligible youth enroll in parallel status-dependent RCTs that randomize the participant to 1 of 2 study arms: MEI with coach or SOC. Participants are asked to complete a web-based survey and provide biologic specimens—HIV-1 RNA (viral load) or HIV-1 antibody test and urine drug screen—at baseline and at 3, 6, and 12 months, and an exit interview at 18 months. RESULTS A formative qualitative research was conducted in February 2017 and May 2018, and this led to further refinement of recruitment and study methods. Aim 1 recruitment began in September 2017 with subsequent enrollment into the RCTs. Recruitment is ongoing with 520 participants screened and 402 (77.3%) enrolled in aim 1 by October 2020. Of these, 159 are enrolled in the 2 randomized trials: 36 (22.6%) HIV-positive not virally suppressed (aim 2) and 123 (77.4%) high-risk HIV-negative (aim 3). CONCLUSIONS This study has the potential to significantly impact the medical and substance use services provided to YBLMSM and YBLTW in the United States by providing rigorous scientific evidence outlining approaches and strategies that improve the uptake and engagement of YBLMSM and YBLTW in the HIV treatment and prevention continuum. CLINICALTRIAL ClinicalTrials.gov NCT03194477; https://clinicaltrials.gov/ct2/show/NCT03194477 INTERNATIONAL REGISTERED REPORT DERR1-10.2196/17269

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Traditional Chinese Medicine Combined with Routine Nursing on Patients with Cervical Human Papillomavirus Infection

Tobacco Regulatory Science ◽

10.18001/trs.7.6.115 ◽

2021 ◽

Vol 7 (6) ◽

pp. 6415-6421

Author(s):

Jing Ye ◽

Hui Cheng

Keyword(s):

Human Papillomavirus ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Infection Rate ◽

Hpv Infection ◽

Common Disease ◽

Postoperative Rehabilitation ◽

Human Papillomavirus Infection ◽

Papillomavirus Infection ◽

Cervical Human Papillomavirus

Cervical papillomavirus infection is a common disease in women. The risk of permanent infection is the main reason for cervical HPV and its advanced acanthosis. The last time, the incidence rate of cervical papillomavirus is only different from that of malignant tumor women. The trend of young tumors is more and more obvious. Therefore, the treatment of parasitic lesions is very important to prevent or reduce the occurrence of cervical HPV. This paper aims to study the effect of traditional Chinese medicine combined with routine nursing on patients with cervical human papillomavirus infection. The application of traditional Chinese medicine therapy to promote the postoperative rehabilitation of patients with cervical human papillomavirus infection has significant effect, which is of great significance for clinicians in the future work. In this paper, through the introduction of traditional Chinese medicine and traditional Chinese medicine oral and external use combined with routine nursing methods, through the follow-up experimental investigation method to study the cervical human papillomavirus infection rate and the effect of cervical human papillomavirus infection patients after operation, it is proved that the effect of traditional Chinese medicine oral and external use combined with routine nursing on cervical human papillomavirus infection patients is better. The results show that 54% of the cervical HPV infection rate makes people pay more and more attention to cervical HPV. The infection investigation and genotyping can effectively judge the prognosis of patients, which has extremely important clinical significance.

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Correction:Incidence and duration of type-specific human papillomavirus infection in high-risk HPV-naïve women: results from the control arm of a phase II HPV-16/18 vaccine trial

BMJ Open ◽

10.1136/bmjopen-2016-011371corr1 ◽

2016 ◽

Vol 6 (9) ◽

pp. e011371corr1

Keyword(s):

Human Papillomavirus ◽

High Risk ◽

Phase Ii ◽

Vaccine Trial ◽

Hpv 16 ◽

Human Papillomavirus Infection ◽

Papillomavirus Infection ◽

High Risk Hpv

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Risk Factors for Subsequent Cervicovaginal Human Papillomavirus (HPV) Infection and the Protective Role of Antibodies to HPV‐16 Virus‐Like Particles

The Journal of Infectious Diseases ◽

10.1086/342972 ◽

2002 ◽

Vol 186 (6) ◽

pp. 737-742 ◽

Cited By ~ 114

Author(s):

Gloria Y. F. Ho ◽

Yevgeniy Studentsov ◽

Charles B. Hall ◽

Robert Bierman ◽

Leah Beardsley ◽

...

Keyword(s):

Risk Factors ◽

Human Papillomavirus ◽

Hpv Infection ◽

Protective Role ◽

Hpv 16 ◽

Virus Like Particles

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High Human Papillomavirus Vaccine Acceptability and Cost-Effectiveness of the Chinese 2-Valent Vaccine Among Men Who Have Sex With Men: A Cross-Sectional Study in Shenyang, China

Frontiers in Medicine ◽

10.3389/fmed.2021.763564 ◽

2021 ◽

Vol 8 ◽

Author(s):

Ze-Hao Ye ◽

Zhao-Zhen Liu ◽

Si-Tong Cui ◽

Zhen-Xing Chu ◽

Yong-Jun Jiang ◽

...

Keyword(s):

Human Papillomavirus ◽

Cost Effectiveness ◽

Hpv Vaccine ◽

Online Survey ◽

Cost Effective ◽

Hpv Infection ◽

Human Papillomavirus Vaccine ◽

Vaccine Acceptability ◽

Cross Sectional ◽

Sex With Men

Background: Despite the insupportable burden caused by the human papillomavirus (HPV) and high vaccine acceptability, vaccination programs are not currently available for men who have sex with men (MSM). We aimed to assess HPV infection by examining the willingness for vaccination among MSM and cost-effectiveness of the Chinese 2-valent HPV vaccine.Methods: We recruited MSM in Shenyang, China between July and December 2020 to conduct anal HPV testing and an online survey regarding HPV-related knowledge and vaccine acceptability. We performed a cost-effectiveness analysis to evaluate the incremental cost-effectiveness ratios (ICERs) of the Chinese 2-valent HPV vaccine.Results: A total of 234 participants completed the online survey; of those, 203 were successfully tested for HPV. The median age was 30 years [interquartile range (IQR): 23–38 years]. Most participants had at least undergraduate education (136/234, 58.1%). The acceptability rate for the free HPV vaccine was 57.7% (135/234). The prevalence of HPV types 16 and 18 was 14.9% (18/121) and 26.8% (22/82) in the willing and unwilling to vaccinate groups, respectively (P > 0.05). The prevalence of high-risk HPV among participants aged <30 and ≥50 years was 48.6 and 38.9%, respectively. Using the Chinese per capita gross domestic product (GDP) as a threshold, the Chinese 2-valent HPV vaccine would be a “very cost-effective” strategy, with an ICER value of USD 4,411. This evidence showed that the Chinese 2-valent HPV vaccine was more cost-effective than other imported vaccines.Conclusions: Targeted strategies should be utilized in MSM with different rates of vaccine acceptability. A pilot HPV vaccination program based on the Chinese 2-valent HPV vaccine for MSM is urgently warranted to reduce the burden of HPV and anal cancer.

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