Emergence of fowl aviadenovirus C-4 in a backyard chicken flock in California

2021 ◽  
pp. 104063872110199
Author(s):  
Aslı Mete ◽  
Anibal G. Armien ◽  
Daniel Rejmanek ◽  
Meghan Mott ◽  
Beate M. Crossley
Keyword(s):  
Total Mortality ◽  
The United States ◽  
Hepatic Necrosis ◽  
Liver Sample ◽  
Hydropericardium Syndrome ◽  
Inclusion Body Hepatitis ◽  
Good Body Condition ◽  
Mixed Flock ◽  
Backyard Chicken ◽  
Body Condition Scores

Fowl aviadenovirus (FAdV) species D and E are associated with inclusion body hepatitis (IBH); species C, serotype 4 (hereafter, FAdV4) is associated with hepatitis–hydropericardium syndrome (HHS) in young chickens. Outbreaks of HHS have led to significant losses in the poultry industry in several countries, predominantly in China. In April 2020, FAdV4 was detected in a remote backyard flock in California. In a mixed flock of chickens of various breeds and ages (6 mo to 2 y old), 7 of 30 were found dead within a week without premonitory signs. One additional bird died after the flock was relocated to fresh pasture, bringing the total mortality to 8 of 30 (27%). Postmortem examination of 3 birds revealed good body condition scores and active laying. One chicken had subtle hemorrhages throughout the liver, and the other 2 had diffusely dark mahogany livers. On histopathology, 2 chickens had hepatic necrosis with hepatocytes containing large, mostly basophilic, intranuclear inclusion bodies, identified by electron microscopy as 82.2-nm diameter adenoviral particles. Virus isolation and genomic sequencing performed on a liver sample revealed strains with 99.9% homology to FAdV4 isolates reported from China. To our knowledge, FAdV4 has not been reported in the United States to date. Furthermore, the chickens affected here were all adults and exhibited a variation of serotype 4 disease in which IBH was present but not hydropericardium.

scholarly journals Dietary patterns related to total mortality and cancer mortality in the United States

2021 ◽  
Author(s):  
Marcela R. Entwistle ◽  
Donald Schweizer ◽  
Ricardo Cisneros
Keyword(s):  
United States ◽  
Dietary Patterns ◽  
Cancer Mortality ◽  
Cox Regression ◽  
Total Mortality ◽  
Principal Component ◽  
The United States ◽  
Red Meat ◽  
Increased Risk ◽  
All Cause Mortality

Abstract Purpose This study investigated the association between dietary patterns, total mortality, and cancer mortality in the United States. Methods We identified the four major dietary patterns at baseline from 13,466 participants of the NHANES III cohort using principal component analysis (PCA). Dietary patterns were categorized into ‘prudent’ (fruits and vegetables), ‘western’ (red meat, sweets, pastries, oils), ‘traditional’ (red meat, legumes, potatoes, bread), and ‘fish and alcohol’. We estimated hazard ratios for total mortality, and cancer mortality using Cox regression models. Results A total of 4,963 deaths were documented after a mean follow-up of 19.59 years. Higher adherence to the ‘prudent’ pattern was associated with the lowest risk of total mortality (5th vs. 1st quintile HR 0.90, 95% CI 0.82–0.98), with evidence that all-cause mortality decreased as consumption of the pattern increased. No evidence was found that the ‘prudent’ pattern reduced cancer mortality. The ‘western’ and the ‘traditional’ patterns were associated with up to 22% and 16% increased risk for total mortality (5th vs. 1st quintile HR 1.22, 95% CI 1.11–1.34; and 5th vs. 1st quintile HR 1.16, 95% CI 1.06–1.27, respectively), and up to 33% and 15% increased risk for cancer mortality (5th vs. 1st quintile HR 1.33, 95% CI 1.10–1.62; and 5th vs. 1st quintile HR 1.15, 95% CI 1.06–1.24, respectively). The associations between adherence to the ‘fish and alcohol’ pattern and total mortality, and cancer mortality were not statistically significant. Conclusion Higher adherence to the ‘prudent’ diet decreased the risk of all-cause mortality but did not affect cancer mortality. Greater adherence to the ‘western’ and ‘traditional’ diet increased the risk of total mortality and mortality due to cancer.

scholarly journals Perspective: Characterization of Dietary Supplements Containing Calcium and Magnesium and Their Respective Ratio—Is a Rising Ratio a Cause for Concern?

2020 ◽  
Author(s):  
Rebecca B Costello ◽  
Andrea Rosanoff ◽  
Qi Dai ◽  
Leila G Saldanha ◽  
Nancy A Potischman
Keyword(s):  
Dietary Supplements ◽  
Total Mortality ◽  
The United States ◽  
Multiple Chronic Conditions ◽  
Range Data ◽  
Increased Risk ◽  
High Calcium ◽  
Liquid Products ◽  
Calcium And Magnesium ◽  
Ratio Range

ABSTRACT Low magnesium intakes coupled with high calcium intakes and high calcium-to-magnesium (Ca:Mg) intake ratios have been associated with increased risk for multiple chronic conditions such as cardiovascular disease and metabolic syndrome, as well as some cancers (colorectal, prostate, esophageal), and total mortality. A high dietary Ca:Mg ratio (>2.60) may affect body magnesium status while, on the other hand, high intakes of magnesium could adversely impact individuals with an exceedingly low dietary Ca:Mg ratio (<1.70). Thus, a Ca:Mg ratio range of 1.70–2.60 (weight to weight) has been proposed as an optimum range. Data from NHANES surveys have shown the mean Ca:Mg intake ratio from foods alone for US adults has been >3.00 since 2000. One-third of Americans consume a magnesium supplement with a mean dose of 146 mg/d, and 35% of Americans consume a calcium supplement with a mean dose of 479 mg/d. Our review of Ca:Mg ratios in dietary supplements sold in the United States and listed in NIH's Dietary Supplement Label Database (DSLD) found a mean ratio of 2.90 across all calcium- and magnesium-containing products, with differences by product form. The ratios ranged from a low of 0.10 in liquid products to a high of 48.5 in powder products. Thirty-one percent of products fell below, 40.5% fell within, and 28.3% fell above the ratio range of 1.70–2.60. Our findings of calculated Ca:Mg ratios from dietary supplements coupled with food-intake data suggest that, in individuals with high calcium intakes from diet and/or supplements, magnesium supplementation may be warranted to establish a more favorable dietary Ca:Mg ratio in their total diet. Additional research may provide greater insight into whether the Ca:Mg ratio is a biomarker of interest for moderating chronic disease and which population groups may derive benefit from moderating that ratio.

scholarly journals Comprehensive Report of the Caseload of Donkeys and Mules Presented to a Veterinary Medical Teaching Hospital over a Ten-Year Period

Animals ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. 413
Author(s):  
Lais R. R. Costa ◽  
Monica Aleman ◽  
Eric Davis
Keyword(s):  
United States ◽  
Body Condition ◽  
Teaching Hospital ◽  
The United States ◽  
The Body ◽  
Medical Teaching ◽  
Preventative Health ◽  
The University ◽  
Good Standard ◽  
Body Condition Scores

Comprehensive reports of the caseload of donkeys and mules in veterinary hospitals in the United States are lacking. We compiled the information of the caseload of donkeys and mules at the Veterinary Medical Teaching Hospital at the University of California, Davis for a ten-year period, from 2008 to 2017. The overall equid caseload was 94,147, of which 996 (1.06%) were donkeys and mules. Most of the neonates seen were mules. Most miniature donkeys were between 2 and 10 years of age, and standard donkeys and mules were 10 to 20 years old. The body condition scores were predominantly high, especially in donkeys. Most miniature and standard donkeys resided in sanctuary and rescue farms and their use was not stated. Most mules were used for riding, packing or driving. Medical complaints represented 62% of the total visits and wellness visits represented 38% of total visits. The donkeys and mules in the case population described here received a good standard of veterinary care with regular vaccinations, deworming, routine dental care, and treatment of ailments. Our study is the first report of the life expectancy, use, body condition, preventative health and veterinary medical care of a population of donkeys and mules in the western United States.

scholarly journals Characterization of fowl adenoviruses associated with hydropericardium syndrome and inclusion body hepatitis in broiler chickens

VirusDisease ◽  
2013 ◽  
Vol 25 (1) ◽  
pp. 114-119 ◽  
Author(s):  
Dinesh Mittal ◽  
Naresh Jindal ◽  
Ashok Kumar Tiwari ◽  
Raj Singh Khokhar
Keyword(s):  
Inclusion Body ◽  
Broiler Chickens ◽  
Hydropericardium Syndrome ◽  
Inclusion Body Hepatitis

In praise of anesthesia: Two case studies of pain and suffering during major surgical procedures with and without anesthesia in the United States Civil War-1861–65

2013 ◽  
Vol 4 (4) ◽  
pp. 243-246 ◽  
Author(s):  
Maurice S. Albin
Keyword(s):  
United States ◽  
Civil War ◽  
Surgical Procedures ◽  
Mexican American ◽  
Total Mortality ◽  
The United States ◽  
Field Hospital ◽  
First Case ◽  
Surgical Pain ◽  
Open Drop

AbstractBackgroundThe United States Civil War (1861–1865) pitted the more populous industrialized North (Union) against the mainly agricultural slaveholding South (Confederacy). This conflict cost an enormous number of lives, with recent estimates mentioning a total mortality greater than 700,000 combatants [1]. Although sulfuric ether (ETH) and chloroform (CHL) were available since Morton’s use of the former in 1846 and the employment of the latter in 1847, and even though inhalational agents were used in Crimean war (1853–1856) and the Mexican-American War (1846–1848), the United States Civil War gave military surgeons on both sides the opportunity to experience the use of these two agents because of the large number of casualties.MethodsResearch of historic archives illustrates the dramatic control of surgical pain made possible with introduction of two general anesthetic and analgesic drugs in 1846 and 1847.ResultsAn appreciation of the importance of anesthesia during surgical procedures can be noted in the poignant and at times hair raising cases of two left arm amputations carried out under appalling circumstances during the United States Civil War. In the first-case the amputation was delayed for nearly five days after the wounding of Private Winchell who served in an elite sharpshooter brigade and was captured by the Confederate Army during battle. The amputation was performed without anesthesia and the voice of the Private himself narrates his dreadful experience. The postoperative course was incredible as he received no analgesia and survived a delirious comatose state lying on the ground in the intense summer heat.Thomas Jonathan “Stonewall” Jackson was a famous ascetic Confederate General who helped defeat the Union forces at the Battle of Chancellorsville on May 2, 1863. In the ensuing near-darkness, Jackson was fired upon by his own friendly troops where he suffered multiple gunshot wounds on his right hand as well as a ball in the upper humerus of the left arm similar to that of Private Winchell. Transported to a field hospital about thirty miles away, the evacuation was carried out under artillery fire and the General dropped from the stretcher at least twice before arriving at the field hospital. There, a team of surgeons operated on “Stonewall”, using open drop chloroform, the surgery taking 50 min, anesthesia times of one hour with General Jackson awake and speaking with clarity shortly after the termination of the anesthesia. A brief explanation of the use of anesthetics in the military environment during the Crimean, Mexican American and the United States Civil War is also presented.Conclusion and implicationsTwo case stories illustrate the profound improvement in surgical pain made possible with ether and chloroform only 160 years ago. Surgeons and patients nowadays have no ideas what these most important improvements in modern medicine means, unless “reliving” the true hell of pain surgery was before ether and chloroform.

scholarly journals Molecular and Pathotypic Characterization of Fowl Adenovirus Associated with Inclusion Body Hepatitis in Indian Chickens

2020 ◽  
Author(s):  
Dasharath B. Shinde ◽  
Anil L Thormoth ◽  
Santosh S. Koratkar ◽  
Neeti Sharma ◽  
Ashok Rajguru ◽  
...  
Keyword(s):  
Inclusion Body ◽  
Broiler Chickens ◽  
Emerging Diseases ◽  
Enzyme Analysis ◽  
Restriction Enzyme Analysis ◽  
Hydropericardium Syndrome ◽  
Inclusion Body Hepatitis ◽  
Infective Dose ◽  
Pathogenic Analysis

Abstract Inclusion body hepatitis (IBH) is a disease of chickens characterized by acute mortality with severe anemia caused by fowl adenoviruses (FAdV). IBH is one of the most important re-emerging diseases world-wide. In India earlier IBH/ Hydropericardium Syndrome (HPS) outbreaks were mainly due to FAdV) type 4; however, in recent outbreaks, other serotypes are involved, despite regular vaccination in breeders and young chicks. The aim of the present study was isolation and molecular characterization of FAdV associated with IBH in India. A total of 193 liver samples of IBH suspected broiler chickens were collected from different regions of India. Liver samples were initially screened by histopathology and further, a total of 127 samples which microscopically showed basophilic, intra-nuclear inclusion bodies were processed for FAdV detection. A total of 69 samples were found to be positive for Hexon gene in PCR, of which 28 were sequenced. These samples showed more than 94% sequence homology with FAdV2 and 97% with FAdV11, which was confirmed by Restriction Enzyme Analysis (REA). Tissue Culture Infective Dose 50 (TCID50) and Egg Infective Dose50 (EID50) titer of isolated FAdV was found to be 106.5/ml. Pathogenicity study in SPF chicks showed 100% mortality up to Post Infection Day (PID)-6. These findings conclude that the prevalence of FAdV-11 is currently causing IBH outbreaks India. However, further genetic and pathogenic analysis of FAdV is required, which would provide useful information for the development of the efficient commercial IBH vaccine.

scholarly journals Teenage Driving, Mortality, and Risky Behaviors

2021 ◽  
Vol 3 (4) ◽  
pp. 523-539
Author(s):  
Jason Huh ◽  
Julian Reif
Keyword(s):  
United States ◽  
Sex Differences ◽  
Motor Vehicle ◽  
Regression Discontinuity ◽  
Total Mortality ◽  
Risky Behaviors ◽  
The United States ◽  
Regression Discontinuity Design ◽  
Drug Overdoses ◽  
Poisoning Deaths

We investigate the effect of teenage driving on mortality and risky behaviors in the United States using a regression discontinuity design. We estimate that total mortality rises by 5.84 deaths per 100,000 (15 percent) at the minimum legal driving age cutoff, driven by an increase in motor vehicle fatalities of 4.92 deaths per 100,000 (44 percent). We also find that poisoning deaths, which are caused primarily by drug overdoses, rise by 0.31 deaths per 100,000 (29 percent) at the cutoff and that this effect is concentrated among females. Our findings show that teenage driving contributes to sex differences in risky drug use behaviors. (JEL I12, J13, J16, R41)

Blood troponin levels in acute cardiac events depends on space weather activity components (a correlative study)

2018 ◽  
Vol 29 (3) ◽  
pp. 257-263
Author(s):  
Eliiyahu Stoupel ◽  
Richardas Radishauskas ◽  
Gailute Bernotiene ◽  
Abdonas Tamoshiunas ◽  
Daiva Virvichiute
Keyword(s):  
Space Weather ◽  
Troponin I ◽  
Troponin T ◽  
Pearson Correlation ◽  
Total Mortality ◽  
Cosmic Ray ◽  
The United States ◽  
Biological Data ◽  
Blood Levels ◽  
Coronary Syndrome

Abstract Background: Many biological processes are influenced by space weather activity components such as solar activity (SA), geomagnetic activity (GMA) and cosmic ray activity (CRA). Examples are total mortality, acute myocardial infarction (AMI), stroke (cerebrovascular accident), sudden cardiac death, some congenital maladies (congenital heart disease and Down syndrome), many events in neonatology, ophtalmology, blood pressure regulation, blood coagulation, inflammation, etc. The aim of this study was to check if the level of blood troponins (Tns) – markers of myocardial damage and recognized components of modern description of AMI – is connected with the mentioned space weather parameters. Methods: Patients admitted to a 3000-bed tertiary university hospital in Kaunas, Lithuania, with suspected AMI were the object of the study. Data for the time between 2008 and 2013 – 72 consecutive months – were studied. Of the patients, 1896 (1398 male, 498 female) had elevated troponin I (Tn I) or troponin T (Tn T, sensitive Tn) levels. Normal values were 0.00–0.03 ng/mL for Tn I and 0.00–14.00 ng/mL for Tn T. Monthly means and standard deviation of Tn I and Tn T were compared with monthly markers of SA, GMA and CRA. Pearson correlation coefficients and their probabilities were established (in addition to the consecutive graphs of both comparing physical and biological data). The cosmophysical data came from space service institutions in the United States, Russia and Finland. Results: AMI was diagnosed in 1188 patients (62.66%), and intermediate coronary syndrome in 698 patients (36.81%). There were significant links of the Tn blood levels with four SA indices and CRA (neutron activity in imp/min); there was no significant correlation with GMA indices Ap and Cp (p=0.27 and p=0.235). Tn T levels significantly correlated with the GMA indices and not with the SA and CRA levels (Ap: r=0.77, p=0.0021; Cp: r=0.729, p=0.0047). Conclusions: First, the monthly level of blood Tn I in ACS is significantly correlated with the indices of SA (inverse) and with CRA (neutron); second, no significant correlation with the GMA indices was found; and third, the Tn T levels showed significant links with the GMA indices and none with SA and CRA (neutron).

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