scholarly journals Gastrointestinal and Skin Lesions in Piglets Naturally Infected with Pseudorabies Virus

1995 ◽  
Vol 7 (4) ◽  
pp. 451-455 ◽  
Author(s):  
Kazuhiko Ezura ◽  
Yoshihide Usami ◽  
Kazuhiko Tajima ◽  
Hideo Komaniwa ◽  
Satomi Nagai ◽  
...  
Keyword(s):  
Inclusion Bodies ◽  
Pseudorabies Virus ◽  
Virus Isolation ◽  
Neuronal Degeneration ◽  
Skin Lesions ◽  
The Other ◽  
Submucosal Plexus ◽  
Intranuclear Inclusion ◽  
The Central Nervous System ◽  
Myenteric Plexuses

Pseudorabies virus (PRV) infection was diagnosed in 4 piglets from a litter by immunohistopathologic examination and virus isolation. Three piglets had moderate to severe neuronal degeneration, and PRV antigen was detected in Auerbach's myenteric plexus and Meissner's submucosal plexus of the gastrointestinal tract. One piglet had 2 types of skin lesions. One lesion appeared on the hip and ear and was characterized by ballooning degeneration, necrosis of epithelial cells, and intranuclear inclusion bodies. The other was found on the ear and hematoma-like lesion and was composed of fibrinoid exudation and degenerative connective tissue. PRV antigen was clearly demonstrated in both skin lesions. These results suggested that degeneration of myenteric plexuses might be another characteristic of lesions in PRV-infected pigs and that the virus spreads by interaction between the skin and myenteric plexuses to the central nervous system.

scholarly journals DIGESTIVE AND RESPIRATORY DISORDERS WITH INTRANUCLEAR INCLUSION BODIES IN TWO CALVES

1974 ◽  
Vol 25 (4) ◽  
pp. 5
Author(s):  
Χ. ΠΑΠΑΔΟΠΟΥΛΟΣ ◽  
Ε. ΣΙΜΟΣ
Keyword(s):  
Inclusion Bodies ◽  
The Other ◽  
Capillary Endothelium ◽  
Nuclear Inclusions ◽  
Nuclear Inclusion ◽  
Intranuclear Inclusion ◽  
Respiratory Disorders

The authors give a cytological description of liver and kidneys from two cal ves with digestive and respiratory troubles. Characteristic spherical nuclear inclusions were noticed. In one calf nuclear inclusion were noticed. In the other calf acidophilic nuclear inclusions were found in the kidneys •capillary endothelium especially in the cortex and partial vacuolated degeneration in the myocardial fibres.

Hepatitis and hydropericardium syndrome associated with adenovirus infection in goslings

2010 ◽  
Vol 58 (1) ◽  
pp. 47-58 ◽  
Author(s):  
Éva Ivanics ◽  
Vilmos Palya ◽  
Béla Markos ◽  
Ádám Dán ◽  
Krisztina Ursu ◽  
...  
Keyword(s):  
Inclusion Bodies ◽  
Large Scale ◽  
Genomic Analysis ◽  
The Other ◽  
Acute Disease ◽  
Adenovirus Infection ◽  
Intranuclear Inclusion ◽  
Chain Reaction ◽  
Hydropericardium Syndrome ◽  
Polymerase Chain

Two outbreaks of severe acute disease characterised by hepatitis and hydropericardium were observed in young goslings on large-scale farms in Hungary. Histological examination revealed multifocal necrotic areas and two types of intranuclear inclusion bodies adjacent to necrotic areas in the liver. The most prominent type of inclusion bodies showed strong basophilic staining and completely filled the enlarged nucleus. The other type was eosinophilic and occupied the centre of the nucleus, which had margination of chromatin. In the heart, haemorrhage was associated with multifocal necrosis in the myocardium. The presence of fowl adenovirus DNA in different organs of the naturally infected goslings was detected by polymerase chain reaction (PCR). The virus was isolated, and identified as a goose adenovirus by genomic analysis. This is the first report on the involvement of a goose adenovirus in severe acute disease associated with hepatitis and hydropericardium.

Comparison of methods for the diagnosis of equine herpesvirus type 1 infection

2003 ◽  
Vol 51 (2) ◽  
pp. 153-163 ◽  
Author(s):  
László Szeredi ◽  
V. Pálfi ◽  
T. Molnár
Keyword(s):  
Inclusion Bodies ◽  
Virus Isolation ◽  
Immunohistochemical Method ◽  
Equine Herpesvirus ◽  
Intranuclear Inclusion ◽  
Tissue Samples ◽  
Herpesvirus Type ◽  
Equine Herpesvirus Type ◽  
Equine Herpesvirus Type 1

The objective of the investigations was to study the occurrence of the equine herpesvirus type 1 (EHV-1) infection in aborted equine fetuses and in newborn foals and to compare the sensitivity of virus isolation, immunohistochemistry and histology in 101 cases and of fetal serology in 68 cases in the diagnosis of the infection. Out of the 93 aborted equine fetuses and 8 weak foals, 15 (14.9%) (14 fetuses and 1 foal) proved to be EHV-1 infected by immunohistochemical and 13 (12.9%) by virological investigation. Characteristic microscopic changes were seen in several organs in all cases, while intranuclear inclusion bodies could be found only in 25 (35.2%) of the 71 virus-positive tissue samples. Four (5.9%) cases proved to be positive by fetal serological investigation, but none of these cases showed any EHV-1 specific lesions and in none of these cases could the virus be detected by virus isolation or by immunohistochemistry. According to the results, fetal serology does not seem to be a useful test in virus-positive cases, while the immunohistochemical method seems to be a reliable and a slightly more sensitive method than virus isolation in the diagnosis of EHV-1 infection.

scholarly journals Untersuchungen zur Pathomorphologie und Pathogenese der Aujeszkyschen Krankheit

1967 ◽  
Vol 4 (6) ◽  
pp. 493-512
Author(s):  
V. Bergmann ◽  
C.-H. Becker
Keyword(s):  
Spinal Cord ◽  
Inclusion Bodies ◽  
Pseudorabies Virus ◽  
Spinal Ganglia ◽  
Cns Infection ◽  
Nuclear Changes ◽  
The Central Nervous System ◽  
Spinal Roots ◽  
Cellular Necrosis ◽  
Histopathologic Changes

The histopathologic changes in the spinal ganglia, spinal roots, and spinal cord in 17 piglets following natural or experimental infection with the virus of pseudorabies were characterized by inflammatory mesenchymal and glial infiltrations and cellular necrosis. The lesions in the connective and vascular tissues were often more pronounced than those in neurons. Nuclear changes resembling inclusion bodies were only occasionally demonstrated. This non-specific histopathologic picture was considered to be the result of an increased resistance against the pseudorabies virus. Although the preponderantly diffuse and multicentric localization of the lesions in natural infections may point to a circulatory spread of the infection to the central nervous system, the continuity of lesions in the cord following intramuscular infection substantiates the possibility of the neuronal route of CNS infection in the pig.

Glial intranuclear inclusion bodies in a patient with Alzheimer's disease

2000 ◽  
Vol 99 (6) ◽  
pp. 695-698 ◽  
Author(s):  
J. Al-Maghrabi ◽  
M. Tierney ◽  
L. C. Ang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Inclusion Bodies ◽  
Intranuclear Inclusion

scholarly journals The Role of Axonal Transport in Neurodegenerative Disease Spread: A Meta-Analysis of Experimental and Clinical Poliomyelitis Compares with Amyotrophic Lateral Sclerosis

1991 ◽  
Vol 18 (S3) ◽  
pp. 435-438 ◽  
Author(s):  
Benjamin Rix Brooks
Keyword(s):  
Spinal Cord ◽  
Axonal Transport ◽  
Neuronal Degeneration ◽  
Meta Analysis ◽  
Gender Effects ◽  
The Other ◽  
Disease Spread ◽  
Local Spread ◽  
Other Hand ◽  
Bulbar Onset

ABSTRACT:ALS symptom spread results from local spread of the neuronal degeneration because contiguous areas are more quickly involved than non-contiguous areas. Local spread to contiguous areas of motor neuron dysfunction is faster at the brainstem, cervical and lumbar regions than spread to non-continguous areas. The time for caudal-rostral symptomatic spread of ALS to involve a distant region is a function of the distance of that region from the site of onset. The time for spread to the bulbar region is shorter following arm onset than leg onset. Spread to non-contiguous areas is faster within the spinal cord than from the spinal cord to the bulbar region. These kinetics are consistent with axonal transport of the etiological agent in a manner similar to spread of poliovirus in poliomyelitis patients. Spread from the bulbar region to the spinal cord, on the other hand, occurs faster than symptom spread from the limb region to the bulbar region in limb onset patients. This rapid limb involvement following bulbar onset is more dramatic in males compared with females. Females with leg onset, on the other hand, show more rapid involvement of the opposite leg, either arm or bulbar structures than males. Gender effects may determine the course of ALS depending on the original site of onset.

The influence of lithium on the competence of the ectoderm in Ambystoma mexicanum

Development ◽  
1964 ◽  
Vol 12 (2) ◽  
pp. 317-331
Author(s):  
D. O. E. Gebhardt ◽  
P. D. Nieuwkoop
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Ambystoma Mexicanum ◽  
The Other ◽  
Direct Influence ◽  
Amphibian Embryos ◽  
The Central Nervous System ◽  
The Subject ◽  
Morphogenetic Potential ◽  
Made In

The influence of lithium on the amphibian egg has been the subject of a number of investigations. From the work of Lehmann (1937), Töndury (1938), and Pasteels (1945) it is known that exposure of amphibian embryos to lithium results in a progressive cranio-caudal reduction of the central nervous system and a simultaneous conversion of the presumptive notochord into somites. Whereas these experiments were made with whole embryos, attempts have been made in recent years to localize the lithium effect by transplanting or explanting specific parts of the embryo. Gallera (1949), for instance, concluded from his experiments with transplants containing lithium treated presumptive chorda mesoderm, that lithium had reduced the ‘morphogenetic potential’ of this inductor. Lombard (1952), on the other hand, claimed that the susceptibility of amphibian eggs towards lithium was the result of the ion's direct influence on the ectoderm rather than on the presumptive archenteron roof.

The Co-Ordination of Insect Movements

1957 ◽  
Vol 34 (3) ◽  
pp. 306-333
Author(s):  
G. M. HUGHES
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
The Body ◽  
The Other ◽  
Limb Amputation ◽  
Normal Movement ◽  
Thoracic Ganglia ◽  
Blatta Orientalis ◽  
The Central Nervous System ◽  
Leg Movements

I. The effects of limb amputation and the cutting of commissures on the movements of the cockroach Blatta orientalis have been investigated with the aid of cinematography. Detailed analyses of changes in posture and rhythm of leg movements are given. 2. It is shown that quite marked changes occur following the amputation of a single leg or the cutting of a single commissure between the thoracic ganglia. 3. Changes following the amputation of a single leg are immediate and are such that the support normally provided by the missing leg is taken over by the two remaining legs on that side. Compensatory movements are also found in the contralateral legs. 4. When two legs of opposite sides are amputated it has been confirmed that the diagonal sequence tends to be adopted, but this is not invariably true. Besides alterations in the rhythm which this may involve, there are again adaptive modifications in the movements of the limbs with respect to the body. 5. When both comrnissures between the meso- and metathoracic ganglia are cut, the hind pair of legs fall out of rhythm with the other four legs. The observations on the effects of cutting commissures stress the importance of intersegmental pathways in co-ordination. 6. It is shown that all modifications following the amputation of legs may be related to the altered mechanical conditions. Some of the important factors involved in normal co-ordination are discussed, and it is suggested that the altered movements would be produced by the operation of these factors under the new conditions. It is concluded that the sensory inflow to the central nervous system is of major importance in the co-ordination of normal movement.

On the incubation period in neurolues

1927 ◽  
Vol 23 (10) ◽  
pp. 1046-1050
Author(s):  
E. V. Sukhova
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Incubation Period ◽  
The Other ◽  
Other Hand ◽  
General Number ◽  
The Central Nervous System

Speaking about syphilis lesions of the central nervous system, it is impossible not to note that these lesions are among the most severe diseases of the latter. But, on the other hand, their severity is redeemed to some extent by the specific means of combating them which we have in our hands. In this case, the fight against neurolues is reduced not so much to its treatment as to its prevention. Hence the interest with which the question of the influence of various conditions on the occurrence of syphilitic lesions of the central nervous system has recently begun to be comprehensively discussed and the exact causes which, from the general number of syphilitics, distinguish the group subsequently condemned to neurolues have been sought to be elucidated.

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