Effect of Assay Methodology on the Prediction of Lithiumc Maintenance Dosage

DICP ◽  
1989 ◽  
Vol 23 (5) ◽  
pp. 372-375 ◽  
Author(s):  
Shyam D. Karki ◽  
Stanley W. Carson ◽  
J.M.C. Holden
Keyword(s):  
Spectrophotometric Method ◽  
Analytical Method ◽  
Slow Release ◽  
Test Dose ◽  
Lithium Carbonate ◽  
Test Methods ◽  
Decimal Place ◽  
Maintenance Dosage ◽  
Clinically Significant ◽  
Bipolar Patients

Test dose methods have been used to predict the maintenance dosage of lithium carbonate tablets in bipolar patients. These methods require a lithium analytical method that is accurate to the second decimal place. Successful use of these test methods has employed the atomic absorption spectrophotometric method, yet many hospitals use a flame spectrophotometric method. We evaluated a two-point method to predict lithium maintenance dosages of slow-release lithium carbonate tablets in 20 bipolar patients using both assay methodologies. No clinically significant differences were found between the two sets of predictions, suggesting that either assay methodology has requisite sensitivity and accuracy for use in test dose predictions of lithium maintenance dosages.

scholarly journals Oxcarbazepine: validation and application of an analytical method

2010 ◽  
Vol 46 (2) ◽  
pp. 265-272 ◽  
Author(s):  
Paula Cristina Rezende Enéas ◽  
Renata Barbosa de Oliveira ◽  
Gerson Antônio Pianetti
Keyword(s):  
Spectrophotometric Method ◽  
Analytical Method ◽  
Disintegration Time ◽  
International Conference ◽  
Pharmacopoeial Monograph ◽  
Development And Validation ◽  
Excipient Compatibility

Oxcarbazepine (OXC) is an important anticonvulsant and mood stabilizing drug. A pharmacopoeial monograph for OXC is not yet available and therefore the development and validation of a new analytical method for quantification of this drug is essential. In the present study, a UV spectrophotometric method for the determination of OXC was developed. The various parameters, such as linearity, precision, accuracy and specificity, were studied according to International Conference on Harmonization Guidelines. Batches of 150 mg OXC capsules were prepared and analyzed using the validated UV method. The formulations were also evaluated for parameters including drug-excipient compatibility, flowability, uniformity of weight, disintegration time, assay, uniformity of content and the amount of drug dissolved during the first hour.

scholarly journals The Liquid and Plastic Limit Data Treated System Based on VC++

2013 ◽  
Vol 347-350 ◽  
pp. 3039-3043
Author(s):  
Xiao Dong Zhang ◽  
Jian Qiao Li ◽  
Rui Yang Shi ◽  
Meng Zou ◽  
Yang Wang ◽  
...  
Keyword(s):  
Analytical Method ◽  
High Efficiency ◽  
Object Oriented ◽  
Test Methods ◽  
Visual Programming ◽  
Soil Test ◽  
Graphic Method ◽  
Plastic Limit ◽  
Combined Test ◽  
Nested Structure

According to two standards for soil test methods with liquid and plastic limit combined test, a liquid and plastic limit data treated system was developed using object-oriented visual programming Microsoft Visual C++6.0 based on analytical method. The flow char indicated that programs of the system used select structure and its nested structure as main its algorithm. Contrasted with manual graphic method, the liquid and plastic limit data treated system had high efficiency and reliable accuracy.

Single Dose Pharmacokinetic Study of Lithium in Taiwanese/Chinese Bipolar Patients

1998 ◽  
Vol 32 (1) ◽  
pp. 133-136 ◽  
Author(s):  
Ching-Fa Lee ◽  
Yong-Yi Yang ◽  
Oliver Yoa-Pu Hu
Keyword(s):  
Single Dose ◽  
Racial Differences ◽  
Half Life ◽  
Lithium Carbonate ◽  
Pharmacokinetic Analysis ◽  
Pharmacokinetic Parameters ◽  
Overnight Fasting ◽  
Ethnic Comparisons ◽  
Bipolar Patients ◽  
Kinetics Of

Objective: The purpose of this study is to investigate the single dose pharmaco-kinetics of lithium in Taiwanese/Chinese bipolar patients for future interracial comparisons. Method: Eight bipolar patients took 900 mg of lithium carbonate after overnight fasting. Blood samples of 5 mL were taken after 15 min, 30 min, 45 min, 1 h, 2 h, 3 h, 4 h, 7 h, 9 h, 15 h, 25 h and 31 h after dosing. The computer programs CSTRIP and PCNONLIN were used for pharmacokinetic analysis. Results: The pharmacokinetic parameters obtained were as follows: Cmax, 0.970 ± 0.170 (SD) mmoi/L; Tmax, 1.59 ± 0.78 h; AUC31h = 548.9 ± 135.4 mmol.m/L; AUC = 722.6 ± 262.7 mmol.m/L; β-half-life = 16.3 ± 7.18 h; K-half-life = 0.613 ± 0.442 h; CIoral = 1.13 ± 0.39 mL/min/kg; Vd/F = 1.43 ± 0.387 L/kg. Most of the pharmacokinetic parameters were within the ranges reported in investigations of Caucasian subjects. Conclusions: This study showed that racial differences in lithium pharmacokinetics might not exist. We suggest that methodological designs, including method of blood sampling, measurement of lithium, and pharmacokinetic and statistical calculations, be standardised if future cross-ethnic comparisons are to be conducted.

scholarly journals Comparison of the Robustness of Spectrophotometric Method and High-Performance Liquid Chromatographic Method for the Determination of Pioglitazone in Solid Dosage Form

2021 ◽  
pp. 37-45
Author(s):  
Sara Zahid ◽  
Fatima Zahid ◽  
Asma Ahmed ◽  
Waqas Safir
Keyword(s):  
Spectrophotometric Method ◽  
Analytical Method ◽  
High Performance ◽  
Dosage Form ◽  
Raw Materials ◽  
High Performance Liquid Chromatographic ◽  
Hplc Method ◽  
The Body ◽  
Solid Dosage Form ◽  
Solid Dosage

Pioglitazone is a drug that reduces the amount of glucose (sugar) in the blood. It is included in the class of anti-diabetic drugs called “thiazolidinedione” that are used in the treatment of type II diabetes. It attaches to the peroxisomes proliferated- activated receptor gamma (PPARϒ) on tissues throughout the body and causes the cells to become more sensitive to insulin. As a result, more glucose is removed from the blood.The aim of the study is more precisely to find out the better analytical method for the quantitative measurement of the content of pioglitazone in commercially available drugs using two analytical methods i-e Spectrophotometric method and HPLC method.The analytical method for the pioglitazone hydrochloride was developed by HPLC, and then validated the method according to compendial requirements. Pioglitazone in various Dowglit and Gliden tablets was determined by this developed methodPrecision, Accuracy and stability of Pioglitazone was checked which came out to be100.40% and 100.19% respectively. The analysis of pioglitazone hydrochloride in solid dosage form using the HPLC method shows the results are more sensitive, accurate, validated and economical and can be easily applied to raw materials and finished goods compared to the Spectrophotometer method.

scholarly journals Analytical Method Validation of Azadirachtin Extracted From Azadirachta Indica

2017 ◽  
Vol 2 (04) ◽  
pp. 99-106
Author(s):  
Syed Imran Ul Haq ◽  
Tribhuvan Singh ◽  
Shaik Mohammed Salman ◽  
Afifa Namreen ◽  
Anas Rasheed
Keyword(s):  
Regression Analysis ◽  
Statistical Analysis ◽  
Azadirachta Indica ◽  
Spectrophotometric Method ◽  
Drug Concentration ◽  
Analytical Method ◽  
Distilled Water ◽  
Analytical Method Validation ◽  
Accuracy And Precision

A simple UV spectrophotometric method for the determination of Azadirachtin is developed exhibiting maximum absorbance using distilled water at 542nm.The present study is based on the detection of sample drug concentration using dichloro methane as diluent. All the conditions required were optimized. Statistical analysis was carried out and results of which were satisfactory. The optical characteristics such as absorption maxima, regression analysis and correlation coefficient are obtained. Recovery studies were close to 100% that indicate the accuracy and precision of proposed method and the non-interference of the formulation excipients. All the valid parameters are summarized.

Effect of Boiling on Carotenoids content of Pumpkin available in Damascus, Syria

2021 ◽  
pp. 5642-5646
Author(s):  
Hala Juha ◽  
Fida Amali
Keyword(s):  
Linear Regression ◽  
Correlation Coefficient ◽  
Spectrophotometric Method ◽  
Analytical Method ◽  
Beta Carotene ◽  
Local Market ◽  
Beer's Law ◽  
Beer’S Law ◽  
Standard Solution ◽  
Regression Correlation

The carotenoids contents of pumpkin were determined in this study by spectrophotometric method. This method was applied on beta-carotene as standard solution as well as samples. The absorption were determined at λmax 454 nm, the analytical method was validated by evaluating linearity, precision, accuracy, LODs, and LOQs of the analyts. Beer’s law is obeyed over the concentration of (0.3-9) µg/ml with a linear regression correlation coefficient of 0.9986, and recovery in range from 98.5-102.2%. After the validation was performed using standard solution, the method then was applied on samples of pumpkin available in local market in Syria after extraction the carotenoids by using Acetone/ Dichloromethane 70/30 .The results ranged between 216.46 - 80.56 µg/g. During boiling for pumpkin, the level of carotenoid reduced between 0.45-13.26 %, 0.18 – 23.07%, 17.3-40.54%, 22.65-51.73%, 14.91_55.82% and 26.16 – 72.56%, for 5, 10, 15, 30, 45 and 60 min respectively. According to the obtained result results, it is concluded that the boiling reduced carotenoid at different rates.

Analytical Method Development and Validation of Prucalopride Succinate in Bulk and Formulation by UV-Visible Spectrophotometry

2021 ◽  
pp. 4189-4191
Author(s):  
A.C. Bhosale ◽  
V.C. Bhagat ◽  
V. V Kunjir ◽  
D.P. Kardile ◽  
R.V. Shete
Keyword(s):  
Quantitative Determination ◽  
Spectrophotometric Method ◽  
Analytical Method ◽  
Method Development ◽  
Routine Analysis ◽  
Ich Guidelines ◽  
Method Development And Validation ◽  
Uv Visible ◽  
Development And Validation

Purpose: Analytical method development and validation for the quantitative determination of Prucalopride succinate in bulk and tablet formulation which plays major role in the development and manufacture of pharmaceuticals. Methods: In the present work a simple, rapid and reproducible UV-Visible Spectrophotometric method was developed and validated according to ICH guidelines. Results and Conclusions: The parameters linearity, specificity, precision, accuracy, and robustness were studied. The wavelength 243nm was selected for the estimation of drug using methanol as a solvent. The drug obeys Beer-lambert’s law over the concentration range 2-10μg/ml. The accuracy of the method was assessed by recovery studies and was found between 97.2- 98.3 %. The method was successfully applied for routine analysis of Prucalopride succinate in bulk and formulation.

Altered platelet monoamine oxidase activity in affective disorders

1979 ◽  
Vol 9 (4) ◽  
pp. 729-736 ◽  
Author(s):  
John Mann
Keyword(s):  
Affective Disorders ◽  
Lithium Carbonate ◽  
Depressive Illness ◽  
Reactive Depression ◽  
Platelet Mao ◽  
Genetic Mechanisms ◽  
Mao Activity ◽  
Platelet Mao Activity ◽  
Platelet Monoamine Oxidase ◽  
Bipolar Patients

SYNOPSISPlatelet MAO activity was found to be elevated in primary depressive illness, and the severity to correlate positively with MAO activity. The reactive depression subgroup's mean platelet MAO activity was not significantly different from that of the controls. The endogenous group's unipolar and bipolar subgroups had significantly different platelet MAO activity, respectively high and low. The differences in MAO activity between unipolar and bipolar patients appeared to persist in the well state, but not after lithium carbonate therapy. These differences in MAO activity were apparent with the substrate tyramine but not with benzylamine. Altered MAO activity in patients with affective disorders may be determined through genetic mechanisms.

scholarly journals Development and Validation of a Spectrophotometric Method for Quantification and Dissolution Studies of Glimepiride in Tablets

2012 ◽  
Vol 9 (2) ◽  
pp. 993-998
Author(s):  
Madhusudhanareddy Induri ◽  
Bhagavan Raju M. ◽  
Rajendra Prasad Y. ◽  
Pavankumar Reddy K.
Keyword(s):  
Quantitative Determination ◽  
Spectrophotometric Method ◽  
Analytical Method ◽  
Limit Of Detection ◽  
Pharmaceutical Formulations ◽  
Spectrophotometric Methods ◽  
Dissolution Studies ◽  
Limit Of Quantitation ◽  
Development And Validation

The objective of present study was to develop and validate an analytical method for quantitative determination and dissolution studies of glimepiride in tablets. The glimepiride shows absorption maxima at 225 nm and obeyed Beer's law in the range of 6.0 – 14.0 µg/mL. The limit of detection and limit of quantitation were 0.06, and 0.17 µg/mL respectively. Percentage recovery of glimepiride for the proposed method ranged from 99.32 to 100.98% indicating no interference of the tablet excipients. It was concluded that the proposed method is simple, easy to apply, economical and used as an alternative to the existing spectrophotometric and non-spectrophotometric methods for the routine analysis of glimepiride in pharmaceutical formulations andin vitrodissolution studies.

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