Congenital Myoepithelial Carcinoma of Soft Tissue Associated With Cystic Myoepithelioma

Myoepithelial neoplasms of soft tissue represent a heterogeneous group of lesions, encompassing both benign entities as myoepithelioma (ME) and highly aggressive tumors as myoepithelial carcinoma (MEC). We describe a case of pediatric soft tissue MEC with peculiar features that may lead to misdiagnosis: congenital onset and presence of a benign component with predominant cystic structure. Few cases of congenital MEC have been reported, but the coexistence of MEC with ME is even more rare, accounting for less than 1% of myoepithelial tumors. Moreover, an extensive cystic appearance had never been described in either ME or MEC of soft tissue. Despite several predictors of poor prognosis, the patient has been showing a favorable clinical course since the administration of ICpE (ifosfamide, cisplatin, and etoposide) chemotherapy. This report provides valuable information in the differential diagnosis of cystic congenital tumors and supports a possible efficacy of adjuvant combined treatment for patients with localized disease after surgery.

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Myolipoma of Mesentery: A Case Report

Case Reports in Pathology ◽

10.1155/2013/823823 ◽

2013 ◽

Vol 2013 ◽

pp. 1-4 ◽

Cited By ~ 5

Author(s):

Hyun Sung Kim ◽

Suk Kim ◽

Kyungbin Kim ◽

Kyung Un Choi ◽

Joo Youn Kim

Keyword(s):

Differential Diagnosis ◽

Adipose Tissue ◽

Soft Tissue ◽

Clinical Course ◽

Correct Diagnosis ◽

Soft Tissue Tumors ◽

Pelvic Cavity ◽

Mature Adipose Tissue ◽

Large Size ◽

Deep Location

Myolipomas are very rare benign lipomatous soft tissue tumors which are usually located in retroperitoneum, abdominal and pelvic cavity, and the abdominal wall. They can be diagnosed histologically by the presence of irregularly admixed mature adipose tissue and smooth muscle fibers. The correct diagnosis of myolipoma is important, because it should be considered in the differential diagnosis of fat-containing lesions of the soft tissue and should follow a benign clinical course despite its frequently large size and deep location. We report here a case of myolipoma arising in the mesentery of the jejunum.

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The many facets of disseminated parenchymal brain cysticercosis: A differential diagnosis with important therapeutic implications

PLoS Neglected Tropical Diseases ◽

10.1371/journal.pntd.0009883 ◽

2021 ◽

Vol 15 (11) ◽

pp. e0009883

Author(s):

Oscar H. Del Brutto ◽

Hector H. Garcia

Keyword(s):

Immune Response ◽

Nervous System ◽

Differential Diagnosis ◽

Poor Prognosis ◽

Clinical Course ◽

Taenia Solium ◽

Host Immune Response ◽

Anatomical Location ◽

Therapeutic Implications ◽

The Many

Neurocysticercosis (NCC), the infection of the nervous system by the cystic larvae of Taenia solium, is a highly pleomorphic disease because of differences in the number and anatomical location of lesions, the viability of parasites, and the severity of the host immune response. Most patients with parenchymal brain NCC present with few lesions and a relatively benign clinical course, but massive forms of parenchymal NCC can carry a poor prognosis if not well recognized and inappropriately managed. We present the main presentations of massive parenchymal NCC and their differential characteristics.

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Primary Breast Sarcoma

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v19i3.45878 ◽

2020 ◽

Vol 19 (3) ◽

pp. 579-581

Author(s):

Mansharan Kaur CS

Keyword(s):

Soft Tissue ◽

Poor Prognosis ◽

Medical Science ◽

Soft Tissue Sarcomas ◽

Heterogeneous Group ◽

Chinese Woman ◽

High Rate ◽

Breast Sarcoma

Breast sarcomas are an extremely rare and heterogeneous group of malignancies derived fromnon-epithelial elements of the gland constituting less than 1% of total breast malignanciesand less than 5% of all soft tissue sarcomas. It can be divided into two categories: de novodevelopment (primary) or secondary. These tumors are important as they have a high rate ofrecurrence and poor prognosis. In addition it is important to differentiate these tumors frombreast carcinoma as the treatment differs in these two entities. We present a case of primarybreast sarcoma in a 46 year old nulliparous Chinese woman. Bangladesh Journal of Medical Science Vol.19(3) 2020 p.579-581

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Expression of fibroblast growth factor receptor1 (FGFR) in soft tissue sarcomas is associated with poor prognosis regardless of tumour subtypes

10.26226/morressier.5b4709896f4cb30010952084 ◽

2018 ◽

Author(s):

Jeong-Hwa Kwon

Keyword(s):

Growth Factor ◽

Soft Tissue ◽

Fibroblast Growth Factor ◽

Poor Prognosis ◽

Soft Tissue Sarcomas ◽

Fibroblast Growth

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Integrative Clustering Reveals a Novel Subtype of Soft Tissue Sarcoma With Poor Prognosis

Frontiers in Genetics ◽

10.3389/fgene.2020.00069 ◽

2020 ◽

Vol 11 ◽

Author(s):

Zhenhua Zhu ◽

Zheng Jin ◽

Haibo Zhang ◽

Mei Zhang ◽

Dahui Sun

Keyword(s):

Soft Tissue ◽

Soft Tissue Sarcoma ◽

Poor Prognosis

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An Eschar-like souvenir from a journey to Colombia: Ecthyma gangrenosum as a differential diagnosis of tropical diseases in immunocompromised patients – a case report

BMC Infectious Diseases ◽

10.1186/s12879-021-05998-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Gabriela M. Wiedemann ◽

Jochen Schneider ◽

Mareike Verbeek ◽

Björn Konukiewitz ◽

Christoph D. Spinner ◽

...

Keyword(s):

Pseudomonas Aeruginosa ◽

Differential Diagnosis ◽

Antibiotic Treatment ◽

Partial Remission ◽

Combined Treatment ◽

Lymphocytic Leukemia ◽

Entire Body ◽

Tropical Diseases ◽

Ecthyma Gangrenosum ◽

Skin Ulcers

Abstract Background Ecthyma gangrenosum (EG) is a cutaneous infectious disease characterized by eschar-like skin ulcers typically caused by Pseudomonas aeruginosa. Here, we report a case of relapsing EG in a patient who had returned from a trip to Colombia, thus establishing EG as an important differential diagnosis of tropical diseases, and demonstrating that even long-term antibiotic treatment can result in only partial remission of EG. Case presentation A 77-year-old man with underlying chronic lymphocytic leukemia (CLL) on ibrutinib treatment was admitted because of a superinfected mosquito bite on the left ear and multiple partially necrotic skin lesions disseminated all over the entire body five days after returning from a trip to Colombia. The initial clinical suspicion of a tropical disease (leishmaniosis, systemic mycosis, or others) could not be confirmed. During the diagnostic workup, microbiological cultures of the skin biopsies and bronchoalveolar lavage revealed Pseudomonas aeruginosa, leading to a diagnosis of EG. Initial antibiotic treatment resulted in partial remission. However, the patient had to be re-admitted due to a relapse 3–4 weeks after the first episode. Finally, the patient was successfully treated with a combined approach consisting of antibiotics, recurrent surgical incisions, and administration of immunoglobulins. Conclusions In conclusion, EG should be considered as a differential diagnosis in immunosuppressed patients presenting with eschar-like skin ulcers. A combined treatment approach seems to be the best choice to achieve clinical cure and avoid relapse.

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Lipschütz Ulcer: An Unusual Diagnosis that Should Not be Neglected

Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics ◽

10.1055/s-0041-1729147 ◽

2021 ◽

Vol 43 (05) ◽

pp. 414-416

Author(s):

Daniela Alexandra Gonçalves Pereira ◽

Eliana Patrícia Pereira Teixeira ◽

Ana Cláudia Martins Lopes ◽

Ricardo José Pina Sarmento ◽

Ana Paula Calado Lopes

Keyword(s):

Emergency Department ◽

Differential Diagnosis ◽

Clinical Course ◽

Malignant Tumors ◽

Sudden Onset ◽

Drug Reactions ◽

Genital Ulceration ◽

Sexually Transmitted ◽

Inflammatory Processes ◽

Genital Ulcers

AbstractThe diagnosis of genital ulcers remains a challenge in clinical practice. Lipschütz ulcer is a non-sexually transmitted rare and, probably, underdiagnosed condition, characterized by the sudden onset of vulvar edema along with painful necrotic ulcerations. Despite its unknown incidence, this seems to be an uncommon entity, with sparse cases reported in the literature. We report the case of an 11-year-old girl who presented at the emergency department with vulvar ulcers. She denied any sexual intercourse. The investigation excluded sexually transmitted infections, so, knowledge of different etiologies of non-venereal ulcers became essential. The differential diagnoses are extensive and include inflammatory processes, drug reactions, trauma, and malignant tumors. Lipschütz ulcer is a diagnosis of exclusion. With the presentation of this case report, the authors aim to describe the etiology, clinical course, and outcomes of this rare disease, to allow differential diagnosis of genital ulceration.

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Superficial CD34-Positive Fibroblastic Tumor

International Journal of Surgical Pathology ◽

10.1177/1066896920938133 ◽

2020 ◽

Vol 28 (8) ◽

pp. 879-881

Author(s):

Oliver Foot ◽

Magnus Hallin ◽

Silvia Bagué ◽

Robin L. Jones ◽

Khin Thway

Keyword(s):

Soft Tissue ◽

Soft Tissue Tumors ◽

Good Prognosis ◽

Differential Diagnoses ◽

Clinical Context ◽

Aggressive Tumors

Superficial CD34-positive fibroblastic tumor (SCPFT) is a recently described entity that, despite significant pleomorphism, carries a good prognosis. We briefly describe this tumor and its principal differential diagnoses. Recognition of SCPFTs, including the clinical context in which they arise, is important to avoid confusion with other pleomorphic soft tissue tumors, particularly neoplasms in the group of pleomorphic sarcomas, which are typically aggressive tumors that could lead to unnecessary overtreatment.

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