Synovial Sarcoma Mimicking Pleomorphic Hyalinizing Angiectatic Tumor of Soft Parts: A Case Report

2017 ◽  
Vol 26 (1) ◽  
pp. 73-77
Author(s):  
Neha Gupta ◽  
Samuel Kenan ◽  
Leonard B. Kahn
Keyword(s):  
Synovial Sarcoma ◽  
Fluorescent In Situ Hybridization ◽  
Spindle Cell ◽  
Low Grade ◽  
Unique Case ◽  
Gene Translocation ◽  
High Grade Sarcoma ◽  
Pleomorphic Hyalinizing Angiectatic Tumor ◽  
Histologic Types

Synovial sarcoma is a high-grade sarcoma commonly affecting young adults. The sites of involvement include soft tissue near joints, lung, pleura, mediastinum, larynx, kidney, and buttocks. Histologic types include monophasic, biphasic, and undifferentiated. We report a unique case of synovial sarcoma with low-grade histologic features mimicking pleomorphic hyalinizing angiectatic tumor (PHAT) with indolent behavior for a period of 10 years. The tumor showed angiectatic blood vessels with fibrinous cuffing, hypocellular and hypercellular spindle cell areas with rare mitoses, and focal atypia in a myxoid background. TLE1 was positive with SYT gene translocation detected on fluorescent in situ hybridization. Cases of myxoinflammatory fibroblastic sarcoma and myxofibrosarcoma have been reported as exhibiting histologic features of PHAT. However, to the best of our knowledge, cases of synovial sarcoma mimicking PHAT have not been reported.

Primary Pleural Synovial Sarcoma

2003 ◽  
Vol 127 (1) ◽  
pp. 85-90 ◽  
Author(s):  
Siok Bian Ng ◽  
Qasim Ahmed ◽  
Sim Leng Tien ◽  
Christina Sivaswaren ◽  
Lai Ching Lau
Keyword(s):  
Young Adults ◽  
In Situ Hybridization ◽  
Soft Tissue ◽  
Synovial Sarcoma ◽  
Fluorescent In Situ Hybridization ◽  
Soft Tissue Tumor ◽  
Differential Diagnoses ◽  
Positive Staining ◽  
Rare Occurrence

Abstract Synovial sarcoma (SS) is an uncommon soft tissue tumor that occurs primarily in the extremities of young adults, especially in the periarticular region. In this report, we describe the rare occurrence of primary SS of the pleura in a 15-year-old boy. Histologically, the tumor demonstrated monophasic morphologic findings and showed positive staining with vimentin and Bcl-2 and focally for cytokeratin CK7. Fluorescent in situ hybridization identified t(X;18) translocation. The patient developed recurrences 20 months following resection of the tumor. The literature on this uncommon entity is reviewed, and its histogenesis, differential diagnoses, and cytologic features are also discussed.

scholarly journals Fluorescent In Situ Hybridization 1p/19q Deletion/Imbalance Analysis of Low-Grade and Atypical Meningiomas

2010 ◽  
Vol 50 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Toru NAGASAKA ◽  
Masaharu GUNJI ◽  
Noboru HOSOKAI ◽  
Kumiko HAYASHI ◽  
Masahiko FUJINO ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Fluorescent In Situ Hybridization ◽  
Low Grade ◽  
Atypical Meningiomas

Benign Fibromyxoid Lesion of the Breast: A Distinct Entity From Benign Spindle Cell Tumors of the Mammary Stroma?

2018 ◽  
Vol 26 (6) ◽  
pp. 488-493 ◽  
Author(s):  
Christopher J. Schwartz ◽  
Cynthia A. Schandl ◽  
Jennifer Morse ◽  
Jonathan Ralston ◽  
Amy Rapkiewicz ◽  
...  
Keyword(s):  
Fluorescent In Situ Hybridization ◽  
Gene Rearrangement ◽  
Spindle Cell ◽  
Smooth Muscle Actin ◽  
Distinct Entity ◽  
Myxoid Stroma ◽  
Spindle Cells ◽  
Spindle Cell Proliferation ◽  
Rb Gene

Myxoid lesions of the breast can be diagnostically challenging entities. We report 4 cases of CD34+ fibromyxoid lesion that have been previously diagnosed as “benign myxoid lesion,” “nodular mucinosis,” or “mammary myofibroblastoma, myxoid type” on the basis of CD34-positivity. The lesions were microscopically well circumscribed and composed of a paucicellular spindle cell proliferation in a background of myxoid stroma. No epithelial component was identified. The spindle cells showed immunohistochemical reactivity for CD34 and smooth muscle actin. Based on morphologic and immunohistochemical similarities between these cases and myxoid myofibroblastoma, we compared 4 myxoid lesions with cases of typical myofibroblastoma, utilizing retinoblastoma (Rb) antibody and fluorescent in situ hybridization for 13q14 gene rearrangement (encoding the Rb gene). The myxoid lesions showed retention of Rb protein by immunohistochemistry, whereas Rb expression was lost in cases of myofibroblastoma. We identified loss of 13q14 in 3 of 4 cases of myofibroblastoma. Notably, 13q14 gene rearrangement was not observed in any of the myxoid lesions. Our data show that there is at least a subset of CD34+ fibromyxoid lesions that, despite overlapping morphologic and immunohistochemical phenotype and proposed common histogenesis with myofibroblastomas, is genetically distinct from the latter based on Rb analysis.

Primary Intravascular Synovial Sarcoma: Case Report

2012 ◽  
Vol 15 (5) ◽  
pp. 297 ◽  
Author(s):  
Osman Nuri Tuncer ◽  
Ozan Erbasan ◽  
İlhan Golbasi
Keyword(s):  
Synovial Sarcoma ◽  
Spindle Cell ◽  
English Literature ◽  
Superior Vena ◽  
Vena Cava ◽  
Soft Tissue Sarcomas ◽  
Chromosomal Translocation ◽  
Cell Tumor ◽  
The Right

Synovial sarcoma (SS), a mesenchymal spindle cell tumor, displays variable epithelial differentiation, including glandular formation, and features a specific chromosomal translocation, t(X;18)(p11;q11). SS accounts for 5% to 10% of soft-tissue sarcomas. These tumors occur mostly in the joints, especially near the knee, but they also occur in other locations. Primary intravascular SS (IVSS) are extremely rare; only 6 well-documented cases have been reported in the English literature. We describe a new case of primary IVSS of the superior vena cava (SVC) in a 16-year-old boy. A transthoracic echocardiogram confirmed a large (4.8 ◊ 4.6 cm) circumscribed mass filling the right atrium, as well as a moderate pericardial effusion. The mass extended from the SVC to the tricuspid valve but did not prevent valve coaptation. Surgery via a transatrial approach revealed a huge mass (8 to 12 cm) attached to the SVC via a 5-mm pedicle. The tumor was excised, and the patient experienced an uneventful postoperative course. Fluorescence in situ hybridization analysis revealed the presence of the SS-specific translocation.

Cytologic and Histologic Features of Pleomorphic Undifferentiated Sarcoma Arising in a Hybrid Hemosiderotic Fibrolipomatous Tumor and Pleomorphic Hyalinizing Angiectatic Tumor: Report of an Unusual Case with a Literature Review

2015 ◽  
Vol 59 (6) ◽  
pp. 493-497 ◽  
Author(s):  
Elizabeth Morency ◽  
William Laskin ◽  
Xiaoqi Lin
Keyword(s):  
Unusual Case ◽  
Surgical Excision ◽  
Excisional Biopsy ◽  
Metastatic Potential ◽  
Low Grade ◽  
Undifferentiated Sarcoma ◽  
High Grade Sarcoma ◽  
Pleomorphic Hyalinizing Angiectatic Tumor ◽  
Mitotic Figures ◽  
Vacuolated Cytoplasm

Background: Pleomorphic hyalinizing angiectatic tumor (PHAT) and hemosiderotic fibrolipomatous tumor (HFLT) are low-grade neoplasms that share clinicopathologic features and recurring translocation t(1;10)(p22;q24) involving the TGFBR3 and MGEA5 genes. Coexistence of these tumors with a high-grade sarcoma is exceedingly rare and the cytologic features have not been widely described in the literature. Case: A 55-year-old female presented with a soft tissue tumor on the dorsum of the foot. Cytologic smears and corresponding core biopsies were composed of a population of markedly pleomorphic spindle cells seen singly and in loose clusters within a myxofibrous matrix and infiltrating fat, with coarse chromatin, prominent nucleoli, irregular nuclear contours and delicate to vacuolated cytoplasm. Intracytoplasmic hemosiderin granules and rare intranuclear cytoplasmic pseudoinclusions were identified. The histologic features of the excisional biopsy mirrored those of the cytologic preparations, but also demonstrated cellular foci of higher-grade sarcoma composed of markedly pleomorphic tumor cells with large vesicular nuclei and prominent nucleoli, exhibiting a mitotic index of 12 mitotic figures per 10 high-powered fields. Conclusion: While HFLT/PHAT generally can be managed by wide local excision, it is important to be aware of their capacity to harbor higher-grade lesions with metastatic potential which may require more radical surgical excision.

scholarly journals Diagnostic value comparison of CellDetect, fluorescent in situ hybridization (FISH), and cytology in urothelial carcinoma

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Donghao Shang ◽  
Yuting Liu ◽  
Xiuhong Xu ◽  
Zhenghao Chen ◽  
Daye Wang
Keyword(s):  
Bladder Cancer ◽  
In Situ Hybridization ◽  
Fluorescent In Situ Hybridization ◽  
Urine Cytology ◽  
Low Grade ◽  
High Grade ◽  
Muscle Invasive Bladder Cancer ◽  
Significant Difference ◽  
Muscle Invasive

Abstract Background To evaluate the clinical effectiveness of a novel CellDetect staining technique, compared with fluorescent in situ hybridization (FISH), and urine cytology, in the diagnosis of urothelial carcinoma (UC). Methods A total of 264 patients with suspicious UC were enrolled in this study. All tissue specimens were collected by biopsy or surgery. Urine specimen was obtained for examinations prior to the surgical procedure. CellDetect staining was carried out with CellDetect kit, and FISH was performed with UroVysion detection kit, according to the manufacturer’s instructions. For urine cytology, all specimens were centrifuged using the cytospin method, and the slides were stained by standard Papanicolaou stain. Results In this study, there were 128 cases of UC and 136 cases of non-UC, with no significant difference in gender and age between the two groups. Results for sensitivity of CellDetect, FISH, and urine cytology were 82.8%, 83.6%, and 39.8%, respectively. The specificity of the three techniques were 88.2%, 90.4%, and 86.0%, respectively. The sensitivity of CellDetect and FISH are significantly superior compared to the conventional urine cytology; however, there was no significant difference in specificity among three staining techniques. In addition, the sensitivity of CellDetect in lower urinary tract UC, upper urinary tract UC, non-muscle-invasive bladder cancer (NMIBC), and muscle-invasive bladder cancer (MIBC) were 83.3%, 81.8%, 83.5%, and 72.0%, respectively. The screening ability of CellDetect has no correlation with tumor location and the tumor stage. The sensitivity of CellDetect in low-grade UC and high-grade UC were 51.6 and 92.8%. Thus, screening ability of CellDetect in high-grade UC is significantly superior compared to that in low-grade UC. Conclusions CellDetect and FISH show equal value in diagnosing UC, both are superior to conventional urine cytology. Compared to FISH, CellDetect is cost effective, easy to operate, with extensive clinical application value to monitor recurrence of UC, and to screen indetectable UC.

Primary intracranial dural-based synovial sarcoma with an unusual SYT fluorescence in situ hybridization pattern

2008 ◽  
Vol 109 (5) ◽  
pp. 897-903 ◽  
Author(s):  
Craig Horbinski ◽  
Kathleen Cieply ◽  
Ghassan K. Bejjani ◽  
Kathryn McFadden
Keyword(s):  
Differential Diagnosis ◽  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Synovial Sarcoma ◽  
Spindle Cell ◽  
Second Primary ◽  
Hybridization Pattern ◽  
Molecular Studies

The authors present the case of an elderly man with a primary dural-based intracranial synovial sarcoma. Histological and immunohistochemical profiles of the lesion were diagnostic for a synovial sarcoma, and molecular studies using fluorescence in situ hybridization were compatible with a synovial sarcoma. A wide array of spindle cell neoplasms has been described as originating in the dura. To the authors' knowledge, however, this is only the second primary durabased intracranial synovial sarcoma ever reported, emphasizing the importance of a broad differential diagnosis when encountering spindle cell lesions of the meninges.

Mullerian adenosarcoma with sarcomatous overgrowth of the cervix presenting as cervical polyp: a case report and review of the literature

2004 ◽  
Vol 14 (5) ◽  
pp. 1024-1029 ◽  
Author(s):  
H. M. Park ◽  
M. H. Park ◽  
Y. J. Kim ◽  
S. H. Chun ◽  
J. J. Ahn ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Uterine Cervix ◽  
Spindle Cell ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Low Grade ◽  
Cervical Mass ◽  
Spindle Cell Proliferation ◽  
High Grade Sarcoma ◽  
Cervical Polyp

An aggressive variant of adenosarcoma, mullerian adenosarcoma with sarcomatous overgrowth (MASO) in the cervix is extremely rare. This variant contains obvious, high-grade sarcoma in addition to a low-grade form. In this report, we describe a case of MASO of the uterine cervix and review the clinical and pathological features of these tumors. The patient was a 37-year-old woman with a cervical polypoid mass, which was morphologically considered as a benign endocervical polyp. Microscopically, polypoid cervical mass showed diffuse and dense malignant spindle cell proliferation around the benign endocervical glands and also an area of markedly anaplastic and pleomorphic spindle cell proliferation, so called, sarcomatous overgrowth. Total abdominal hysterectomy and bilateral salpingo-oophorectomy with pelvic lymph node dissection were performed. The patient has been followed-up and neither chemotherapy nor other adjuvant therapies have been administered. At present, she has been clinically free of disease for 9 months since she received surgery. It is extremely rare that MASO of the uterine cervix is presented in premenopausal woman. Gynecologists and pathologists should be aware of the difficulties associated with a delay in the diagnosis of MASO when the tumor is present as a benign looking cervical polyp.

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