Ewing Sarcoma in Older Adults: A Clinicopathologic Study of 50 Cases Occurring in Patients Aged ≥40 Years, With Emphasis on Histologic Mimics

2019 ◽  
Vol 28 (4) ◽  
pp. 352-360 ◽  
Author(s):  
Khadijeh Jahanseir ◽  
Andrew L. Folpe ◽  
Rondell P. Graham ◽  
Caterina Giannini ◽  
Steven I. Robinson ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Older Adult ◽  
Ewing Sarcoma ◽  
Clear Cell ◽  
Age Group ◽  
Clinicopathologic Features ◽  
Round Cell ◽  
Older Adulthood ◽  
Clinicopathologic Study

Objective. We explore the clinicopathologic features of Ewing sarcoma (ES) presenting in older adulthood. Methods. Cases of molecularly confirmed ES arising in patients aged ≥40 years were evaluated. Results. Fifty patients were identified (33 males/17 females; 41-86 years). The majority of tumors (41) arose at extraskeletal sites, while 9 were bone primaries. Twenty-eight cases showed nested architecture, while the remaining cases showed sheet-like growth. Tumor cytology was categorized as conventional (n = 39), crushed (n = 5), clear cell (n = 4), rhabdoid (n = 3), and epithelioid (n = 2). Fifty percent had necrosis, while rosettes were noted in 1 case. Immunostains performed ranged from 1 to 28 (median = 10). Follow-up (n = 43, 1-147 months) revealed 15 patients with metastasis. Conclusion. Although rare, ES should be considered in the differential diagnosis for round cell malignancies in older adult patients. In this cohort, ES is most often extraskeletal, and may show unusual morphologic features, closely simulating more common neoplasms in this age group.

scholarly journals 94 Association between Dual-Task Timed “UP and GO” Test and Occurrence of Falls According to Age Group (Young-Older or Old-Older Adults): A Longitudinal Observation Study

2019 ◽  
Vol 48 (Supplement_4) ◽  
pp. iv18-iv27
Author(s):  
Tsuyoshi Asai ◽  
Kensuke Oshima ◽  
Yoshihiro Fukumoto ◽  
Shogo Misu
Keyword(s):  
Older Adults ◽  
Older Adult ◽  
Dual Task ◽  
Community Dwelling ◽  
Age Group ◽  
Adult Group ◽  
Observation Study ◽  
Timed Up And Go ◽  
Community Dwelling Older Adults

Abstract Aim To elucidate the association between the occurrence of falls and timed “up and go” (TUG) test score in a dual-task condition among community-dwelling older adults by age group. Methods This longitudinal observation study included 987 community-dwelling older adults at baseline. A TUG test (single-TUG) and a TUG test while counting aloud backward from 100 (dual-TUG) were conducted at baseline. The dual-task cost (DTC) value was computed from these results. Data on fall history were obtained using a self-administered questionnaire at the 1-year follow-up. At follow-up, 322 participants had dropped out and six participants had missing data for falls. The final analysis included 658 individuals (follow-up rate: 658/987, 67%) divided into a young-older adult group (aged 60–74 years) and an old-older adult group (aged 75 years or older). Associations between the occurrence of falls and TUG-related values were analyzed by age group using multivariate logistic regression models. Results For old-older adults, there were significant associations between the occurrence of falls and DTC value (odds ratio [OR] 0.981, 95% confidence interval [CI]: 0.963–0.999, p = 0.040) and single-TUG score (OR 1.129, 95% CI: 1.006–1.268, p = 0.039). However, no significant associations were observed for young-older adults. Conclusions Slower single-TUG test score and lower DTC value are associated with the occurrence of falls among old-older adults but not among young-older adults. Dual task assessment is useful for predicting falls in TUG fall assessment for old-older adults.

Clear cell, papillary and chromophobe renal cell carcinoma in patients younger than 20 years old: A clinicopathologic study with follow-up

2012 ◽  
Vol 8 (5) ◽  
pp. 531-534 ◽  
Author(s):  
Jason Wang ◽  
Bahig M. Shehata ◽  
Simone M. Langness ◽  
Gigi K. Davis ◽  
Liang Cheng ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Chromophobe Renal Cell Carcinoma ◽  
Clinicopathologic Study

scholarly journals Case Report: Recurrent Left Posterior Fascicular Ventricular Tachycardia in a Newborn

2021 ◽  
Vol 9 ◽  
Author(s):  
Lu Zhao ◽  
Lin Wu ◽  
Qu-ming Zhao ◽  
Xue-cun Liang
Keyword(s):  
Differential Diagnosis ◽  
Ventricular Tachycardia ◽  
Case Report ◽  
First Year ◽  
Age Group ◽  
Basic Principles ◽  
Left Posterior ◽  
Proper Diagnosis ◽  
First Year Of Life

Left posterior fascicular ventricular tachycardia (LPFVT) is extremely rare in neonates. We described a 17-day-old girl with LPFVT who was initially misdiagnosed as supraventricular tachycardia (SVT). Eventually, she was successfully treated by amiodarone infusion followed by oral amiodarone with propranolol for 9 months, and LPFVT spontaneously resolved after a 1-year follow-up. This case report illustrated the basic principles and caveats in differential diagnosis of LPFVT in the neonatal age group. With proper diagnosis and therapy, neonatal LPFVT might regress in the first year of life.

scholarly journals EWSR1 Rearrangement and CD99 Expression as Diagnostic Biomarkers for Ewing/PNET Sarcomas in a Moroccan Population

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Sara Louati ◽  
Nadia Senhaji ◽  
Laila Chbani ◽  
Sanae Bennis
Keyword(s):  
Differential Diagnosis ◽  
Sensitivity And Specificity ◽  
Ewing Sarcoma ◽  
Primitive Neuroectodermal Tumor ◽  
Neuroectodermal Tumor ◽  
Fish Analysis ◽  
Round Cell ◽  
Diagnostic Biomarkers ◽  
Moroccan Population ◽  
Round Cell Tumors

Ewing sarcoma/primitive neuroectodermal tumor (Ewing/PNET sarcomas or EPS) are a group of round cell tumors. Malignant round cell tumors form a large and diverse group that includes rhabdomyosarcoma, synovial sarcoma, non-Hodgkin’s lymphoma, neuroblastoma, hepatoblastoma, Wilm’s tumor, desmoplastic small round cell tumor, and other morphologically similar entities. Differential diagnosis of Ewing sarcoma/primitive neuroectodermal tumor (Ewing/PNET sarcomas or EPS) is difficult. In addition to morphology and immunohistochemistry (IHC), differential diagnosis of these tumors is based on molecular analysis of the EWSR1 gene rearrangement using fluorescent in situ hybridization (FISH) technique. We investigated the diagnostic value of combined CD99 immunostaining and EWSR1 t(22q12) alteration using a dual-color, break-apart rearrangement probe in forty-one formalin-fixed paraffin-embedded (FFPE) tissue samples from pediatric and adult patients diagnosed with EPS. IHC was performed in all cases using the CD99 antibody and showed a positivity of 92.7% in the enrolled cases (38/41) followed by FISH analysis where 48.8% of the cases (20/41) were rearranged. Sensitivity and specificity for IHC assays were 88% and 58%, respectively. Notably, FISH had a sensitivity of 100% and a specificity of 87%. In addition, CD99 positivity was found to correlate with EWSR1 rearrangement (p<0.05). This report shows that FISH has better sensitivity and specificity than IHC in the Moroccan population, and supports its combination with CD99 immunostaining as diagnostic biomarkers for this rare malignant entity.”

Squamous Carcinoma of the Larynx in Patients Under the Age of 35 Years

1982 ◽  
Vol 90 (4) ◽  
pp. 431-433 ◽  
Author(s):  
Richard K. Newman ◽  
Robert M. Byers
Keyword(s):  
Overall Survival ◽  
Older Adult ◽  
Medical Records ◽  
Survival Rates ◽  
Squamous Carcinoma ◽  
Age Group ◽  
Overall Survival Rate ◽  
Entire Series ◽  
Carcinoma Of The Larynx

Laryngeal carcinoma usually occurs in men between the ages of 50 and 70. In general, epithelial malignancies other than those involving the skin are rare in the young adult. Those squamous carcinomas arising in the lip, tongue, and tonsil appear to have a poorer prognosis than in the older adult. This study is a review of the medical records of 33 patients under the age of 35 years with squamous cell carcinoma of the larynx. The follow-up of the entire series was at least 24 months with an overall survival rate of 81%. These results contrast to five-year survival rates of 79%, 45%, and 14% of the lip, tongue, and tonsil, respectively, in patients from a similar age group.

scholarly journals Spinal Clear Cell Meningioma: Atypical Clinical and Radiological Manifestations

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Mohammad Nasser Alsadiq ◽  
Zainab Shaker Albarbari ◽  
Fatimah Alshakhs ◽  
Muath Ali Alduayji ◽  
Shaymaa Al-Umran ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Magnetic Resonance Image ◽  
Clear Cell ◽  
Histopathological Study ◽  
Rare Form ◽  
Complete Excision ◽  
Motor Weakness ◽  
Clear Cell Meningioma ◽  
Space Occupying Lesion

Meningioma has many subtypes with clear cell meningioma being more aggressive than other variants of meningioma and one of the rarest. We report a case of spinal clear cell meningioma that occurred in a 25-year-old lady who presented with the inability to be in the supine position. A magnetic resonance image showed an intradural mass extending from L1 to L4. Near complete excision was done. The patient had motor weakness postoperatively which improved gradually. A histopathological study showed a clear cell meningioma. In a differential diagnosis of any space-occupying lesion of the spine, clear cell meningioma should be considered though it is a rare form of meningioma due to its potential to recure. An accurate follow-up is warranted.

scholarly journals Reevaluation of Salivary Lymphadenoma

2020 ◽  
Author(s):  
Chunye Zhang ◽  
Ting Gu ◽  
Yuhua Hu ◽  
Jingjing Sun ◽  
Ronghui Xia ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Epithelial Cells ◽  
Mucoepidermoid Carcinoma ◽  
Clinicopathologic Features ◽  
Prognostic Features ◽  
Lymphoid Stroma ◽  
Histologic Evaluation ◽  
Age Range

Context.— Both salivary lymphadenomas (LADs) and Warthin-like mucoepidermoid carcinoma (MEC) contain components of epithelium and lymphoid stroma and their differential diagnosis can be difficult on the basis of morphology alone. Objective.— To clarify whether Warthin-like MEC was diagnosed as a LAD, and to compare their clinicopathologic features. Design.— A total of 16 LAD cases were analyzed for MAML2 rearrangement by using fluorescence in situ hybridization, and the clinical, histologic, immunohistochemical, and prognostic features were compared between MAML2 rearrangement–positive and MAML2 rearrangement–negative groups. Results.— Among the 16 cases investigated, 9 harbored a MAML2 rearrangement and were reclassified as Warthin-like MEC. The remaining 7 cases were classified as LADs with 1 nonsebaceous and 6 sebaceous cases. The patients with Warthin-like MEC had a wider age range (10–75 years) than the patients with LADs (36–68 years). Histologically, 2 of the 9 Warthin-like MECs (22.2%) showed focal invasion, whereas all the LADs had complete capsules. Warthin-like MECs exhibited a diverse epithelial cell morphology, including basaloid, glandular, cuboidal, epidermoid, with mucinous cells, although these cytologic features were seen only focally in some cases. Nonsebaceous LAD was composed of basaloid and glandular epithelial cells predominantly. In sebaceous LAD, the epithelial cells were composed of basaloid and large foamy sebaceous cells. In all cases, the stroma was composed mainly of lymphocytes accompanied by lymphoid follicles, although plasma cell infiltration could be much heavier in Warthin-like MEC. All the patients had a good outcome after a longer follow-up (3∼166 months). Conclusions.— Warthin-like MEC can be misdiagnosed as a LAD owing to overlap in clinicopathologic features of the 2 entities. Careful histologic evaluation and detection of MAML2 rearrangement can facilitate their differential diagnosis.

scholarly journals Paediatric RCC with sarcomatoid variation: a rare entity

2020 ◽  
Vol 26 (1) ◽  
Author(s):  
Anuj Mahajan ◽  
Prashanth Adiga ◽  
Vivek Pai ◽  
Keerthi Raj
Keyword(s):  
Clear Cell ◽  
Histopathological Examination ◽  
Treatment Protocol ◽  
Age Group ◽  
Renal Masses ◽  
Case Presentation ◽  
Long Term Follow Up ◽  
Paediatric Age

Abstract Background Malignant renal masses in paediatric age group are mostly Wilms’ tumour. RCC is very rare in this age group, papillary variant being the most common. Sarcomatoid variation occurs in 5% of adult RCC, while it is extremely rare in children. No treatment protocol exists in the management of paediatric RCC. Case presentation Here, we present a case of 10-year-old female who presented with left flank mass. Radical nephrectomy was done which showed clear cell carcinoma with sarcomatoid variant on histopathological examination. Conclusion RCC with sarcomatoid variation can occur in children. However, further studies and long-term follow-up are needed for formulating a treatment protocol and prognostication factors for the same.

Clear cell sarcoma of the kidney: A clinicopathologic study of 21 patients with long-term follow-up evaluation

1985 ◽  
Vol 16 (12) ◽  
pp. 1219-1230 ◽  
Author(s):  
C. Sotelo-Avila ◽  
F. Gonzalez-Crussi ◽  
S. Sadowinski ◽  
W.M. Gooch ◽  
R. Pena
Keyword(s):  
Clear Cell ◽  
Clear Cell Sarcoma ◽  
Cell Sarcoma ◽  
Clinicopathologic Study ◽  
Long Term Follow Up

Pediatric Non-vestibular Schwannoma

2017 ◽  
Vol 20 (3) ◽  
pp. 232-239 ◽  
Author(s):  
Cory Broehm ◽  
Alyaa Al-Ibraheemi ◽  
Karen J Fritchie
Keyword(s):  
Spindle Cell ◽  
Neurofibromatosis Type ◽  
Mitotic Rate ◽  
Vestibular Schwannomas ◽  
Spindle Cell Sarcoma ◽  
Age Group ◽  
Clinicopathologic Features ◽  
Age Range

While the clinicopathologic features of pediatric vestibular schwannomas, often in the context of neurofibromatosis type 2 (NF2), have been well studied, there is less data regarding the characteristics of pediatric non-vestibular schwannomas (NVS). Additionally, the rate of loss of SMARCB1/INI1 expression in this population has not been systematically evaluated. Our institutional archives were searched for cases of NVS arising in patients 18 years or younger. Clinicopathologic features including SMARCB1/INI1 status were assessed for each case. Twenty-three NVS from 9 males and 13 females (age range, 2 months to 18 years) were identified, and sites included paraspinal (n = 10), head and neck (n = 6), extremities (n = 4), trunk (n = 1), mediastinum (n = 1), and retroperitoneum (n = 1); 22 cases were Antoni A predominant with 6 cases comprising solely Antoni A tissue. The mitotic rate of the tumors ranged from 0 to 10/10 high-power fields (HPFs), and 3 tumors had mitotic rates of ≥4 mitoses/10 HPFs. Two tumors showed plexiform architecture. No NVS showed diffuse atypia, calcifications, microcystic/reticular architecture, epithelioid morphology, pseudoglandular change, neuroblastoma-like features, or necrosis. All tumors tested (23/23) showed retained nuclear expression of SMARCB1/INI1. Follow-up was available in 21 patients (range 1 week to 194 months), and 5 tumors recurred. Pediatric NVS have a relatively homogeneous appearance with a predominance of Antoni A areas. Pathologists should be aware that schwannomas in this age group may be cellular with mitotic rates of ≥4/10 HPFs to avoid misclassification as a spindle cell sarcoma.

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