FXa Inhibition and Coagulation Changes During DVT Prophylaxis by Enoxaparin Over the Course of a 15-Day Follow-Up in Septic Patients

The objective of our study was to examine the changes in coagulation parameters and inflammatory reaction over the course of 15 days in patients with severe sepsis. We tried to identify mechanisms by which sepsis-induced pathophysiological changes may influence the effectiveness of subcutaneously (SC) administered enoxaparin 40 mg once daily. A total of 16 patients (8 men, 8 women; age 35-83 years) meeting the inclusion criteria of severe sepsis were enrolled in this study. The follow-up was performed on days 1, 2, 3, 6, 9, 12, and 15 of hospitalization at the intensive care unit (ICU). Blood coagulation (activated partial thromboplastin time [aPTT], prothrombin time [PT], fibrinogen, antithrombin (AT), protein C [PC], D-dimer, fragment 1.2 [F1.2], factor Xa [FXa] inhibition) and inflammatory reactants (interleukin 6 [IL-6], C-reactive protein [CRP], orosomucoid, α-1-antitrypsin) were tested. The mean FXa inhibition was 0.17 (±0.17) IU/mL. The arbitrarily established range of FXa inhibition for prophylaxis, 0.2 to 0.4 IU/mL, was reached in 22 cases (20%), while in 74 cases (68%), it was below and in 13 cases (12%) above the aforementioned range. Factor Xa inhibition positively correlated with AT (r = .42; P < .001) and PC (r = .45; P < .001) activities. A negative correlation was found between the FXa inhibition and α-1-antitrypsin concentrations (r = —.33; P = .01) but only in the subgroup with α-1-antitrypsin concentrations ≥2.2 g/L. We confirmed that in most patients with sepsis, the prophylaxis with enoxaparin did not lead to the required FXa inhibition. The inhibition of FXa by enoxaparin depends mainly on the AT and PC activities.

Download Full-text

Serum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis

Scientific Reports ◽

10.1038/s41598-021-86064-x ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Anne-Christine Bay-Jensen ◽

Asger Bihlet ◽

Inger Byrjalsen ◽

Jeppe Ragnar Andersen ◽

Bente Juhl Riis ◽

...

Keyword(s):

Phase Iii ◽

Response To Treatment ◽

C Reactive Protein ◽

Two Phase ◽

Knee Oa ◽

Reactive Protein ◽

Inflammatory Phenotype ◽

The Mean ◽

Using Data

AbstractThe heterogeneous nature of osteoarthritis (OA) and the need to subtype patients is widely accepted in the field. The biomarker CRPM, a metabolite of C-reactive protein (CRP), is released to the circulation during inflammation. Blood CRPM levels have shown to be associated with disease activity and response to treatment in rheumatoid arthritis (RA). We investigated the level of blood CRPM in OA compared to RA using data from two phase III knee OA and two RA studies (N = 1591). Moreover, the association between CRPM levels and radiographic progression was investigated. The mean CRPM levels were significantly lower in OA (8.5 [95% CI 8.3–8.8] ng/mL, n = 781) compared to the RA patients (12.8 [9.5–16.0] ng/mL, n = 60); however, a significant subset of OA patients (31%) had CRPM levels (≥ 9 ng/mL) comparable to RA. Furthermore, OA patients (n = 152) with CRPM levels ≥ 9 ng/mL were more likely to develop contra-lateral knee OA assessed by X-ray over a two-year follow-up period with an odds ratio of 2.2 [1.0–4.7]. These data suggest that CRPM is a blood-based biochemical marker for early identification OA patients with an inflammatory phenotype.

Download Full-text

Pre- and post-treatment levels of serum high-sensitivity C-reactive protein in patients with lesions of endodontic origin: A clinical pilot study

Asian Journal of Oral Health and Allied Sciences ◽

10.25259/ajohas_1_2020 ◽

2020 ◽

Vol 10 ◽

pp. 2 ◽

Cited By ~ 1

Author(s):

Rhythm Bains ◽

Aseem P. Tikku ◽

Wahid Ali ◽

Promila Verma ◽

Pragya Pandey

Keyword(s):

High Sensitivity ◽

Time Frame ◽

Post Treatment ◽

C Reactive Protein ◽

Reactive Protein ◽

Effect Of Treatment ◽

The Mean ◽

Hs Crp ◽

The Impact

Objective: The objective of the study was to evaluate the impact of lesions of endodontic origin (LEO) and their treatment on the patients’ serum high-sensitivity C-reactive protein (hs-CRP) levels. Materials and Methods: A total of 20 healthy patients with radiographic evidence of LEO in at least one tooth were recruited for the study, of which 11 were finally evaluated. Before initiating the endodontic treatment, 10 ml of patient’s venous was taken from the antecubital vein to assess the pre-operative serum hs-CRP levels (T0). Canals were prepared with K-files till a suitable size and irrigated with 2.5% sodium hypochlorite. At the subsequent appointment after 1 week, teeth were obturated. The patients were then recalled 30 days after the completion of endodontic therapy. Again blood samples will be taken at time-frame T1 to assess the serum hs- CRP levels. The change in pre- and post-treatment values for T0 and T1 was statistically evaluated to assess the effect of treatment on serum hs-CRP levels. Results: The mean CRP (mg/L) at T0 ± SD (Range) at baseline was 6.18 ± 3.72 (0.96–11.02) and the mean CRP at T1 ± SD (Range) was 3.92 ± 3.59 (1.108–11.04) and mean change in CRP ± SD (Range) after 30 days follow-up was −2.26 ± 3.04 (−8.26–1.16). Significance of change in CRP levels (Paired t-test) was t = 2.458; P = 0.034. Conclusion: The results of the present study indicate that root canal treatment reduced the levels of hs-CRP in the serum of the patients having LEO. Timely diagnosis and treatment of these lesions may have some contribution in reducing systemic inflammatory burden.

Download Full-text

What Is the Interaction between Urine C-Reactive Protein, Prostatic Inflammation, and Doxazosin Treatment in Patients with Benign Prostatic Hyperplasia? A Pilot Study

Urologia Internationalis ◽

10.1159/000518474 ◽

2021 ◽

pp. 1-5

Author(s):

Ahmet Asfuroglu ◽

Melih Balci ◽

Yilmaz Aslan ◽

Cagdas Senel ◽

Ozer Guzel ◽

...

Keyword(s):

International Prostate Symptom Score ◽

Prostatic Hyperplasia ◽

Urinary Flow ◽

C Reactive Protein ◽

Alpha Blocker ◽

Reactive Protein ◽

The Mean ◽

Maximum Urinary Flow ◽

First Admission

Introduction: It was aimed to show the relationship between benign prostatic hyperplasia and inflammation by measuring urinary C-reactive protein values before and after alpha-blocker treatment. Methods: A total of 71 patients with a total prostate-specific antigen <3.5 ng/mL, International Prostate Symptom Score >7, and maximum urinary flow rate <15 mL/s were included in the study. Doxazosin 4 mg p.o. once daily was started orally as an alpha-blocker treatment. Serum and urine C-reactive protein values, International Prostate Symptom Score, maximum urinary flow rate, and the post-void residual volume of patients were recorded at the first admission and in the first month of alpha-blocker treatment. Results: The mean age of the patients was 59.2 ± 7.5 years. The mean serum C-reactive protein values of the patients at the first admission and follow-up were 2.62 ± 1.8 (range, 0–5) mg/L and 2.83 ± 1.6 (0–6) mg/L, respectively. The mean urine C-reactive protein values of the patients at the first admission and follow-up were 0.45 ± 0.11 (range, 0.28–0.99) mg/L and 0.14 ± 0.04 (range, 0.79–0.328) mg/L, respectively, which was statistically significantly different. In the subgroup analysis, the urine C-reactive protein level change was more prominent in severely symptomatic patients than in moderately symptomatic patients. Conclusion: Our results showed that C-reactive protein was detectable in urine, alpha-blocker treatment significantly reduced urine C-reactive protein levels, and the decrease was more prominent in severely symptomatic patients.

Download Full-text

The Effect of Activity and Type of Rheumatoid Arthritis on the Flexible Implant Arthroplasty of the Metacarpophalangeal Joint

Journal of Hand Surgery (European Volume) ◽

10.1054/jhsb.2001.0704 ◽

2002 ◽

Vol 27 (2) ◽

pp. 180-183 ◽

Cited By ~ 11

Author(s):

H. ISHIKAWA ◽

A. MURASAWA ◽

T. HANYU

Keyword(s):

Rheumatoid Arthritis ◽

Retrospective Study ◽

Metacarpophalangeal Joint ◽

C Reactive Protein ◽

Reactive Protein ◽

Systemic Factors ◽

Postoperative Serum ◽

The Mean ◽

Clinical And Radiological Results

A retrospective study was performed on 184 Swanson flexible implant arthroplasties of the metacarpophalangeal joint in 75 hands of 64 patients with rheumatoid arthritis, to investigate the influence of systemic factors on the clinical and radiological results. The mean follow-up period was 6 years. The postoperative serum C-reactive protein level was found to affect postoperative pain, and there was a larger extension lag and more subsidence of the implant in those with the mutilating type of the disease.

Download Full-text

Short Term Effects of Mild Severity COVID-19 on Left Ventricular Functions

10.21203/rs.3.rs-869751/v1 ◽

2021 ◽

Author(s):

Osman Bektaş ◽

Ahmet Karagöz ◽

Feyza Nur Topçu Yenerçağ ◽

Seçkin Dereli ◽

Celali Kurt ◽

...

Keyword(s):

Speckle Tracking Echocardiography ◽

Left Ventricular ◽

Long Term Effects ◽

C Reactive Protein ◽

Short Term ◽

Reactive Protein ◽

The Mean ◽

And Gender

Abstract Purpose: We aimed to evaluate long term effects of COVID-19 disease on left ventricular function using speckle tracking echocardiography. Methods: In our study, 96 non-hospitalized patients who were diagnosed with COVID-19 disease in our center between 15 August 2020 and 01 September 2020 and 96 age and gender matched control subjects were included.Results:The mean follow up duration was 137 ± 7 days. White blood cell, neutrophile and lymphocyte were significantly lower and C-reactive protein (CRP) and neutrophil to lymphocyte ratio (NLR) were significantly higher in the COVID-19 group. (6.6 ± 2.8 vs. 24.4 ± 21.8, p <0.001 and 4.1 ± 2.5 vs. 7.1 ± 4, p <0.001, respectively). LV-GLS and LV-GCS were significantly lower in the COVID-19 group. (-20.1 ± 3.1 vs -15.9 ± 2, p <0.001 and -29.3 ± 2.1 vs -26.3 ± 2.1, p <0.001, respectively). LV-GLS and LV-GCS were found to be negatively correlated with CRP (rs = -0.515, p <0.001 and rs = 0.-466, p <0.001, respectively) and NLR (rs = -0.494, p <0.001 and rs = -434, p <0.001, respectively). Conclusion: Deteriorating effects of COVID-19 disease on both LV-GCS and LV-GLS can be seen even in the short term. These detrimental effects seem to be associated with CRP levels and NLR measured in the course of active infection.

Download Full-text

A CLINICAL STUDY TO EVALUATE THE EFFICACY OF SAINDHAVADI TAILA MATRA VASTI IN THE MANAGEMENT OF AMAVATA W.S.R. RHEUMATOID ARTHRITIS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i12.20647 ◽

2017 ◽

Vol 10 (12) ◽

pp. 435

Author(s):

Archana Negi ◽

Punita Pandey ◽

Bhupinder Singh

Keyword(s):

Rheumatoid Arthritis ◽

Clinical Study ◽

Biochemical Parameters ◽

Symptomatic Relief ◽

C Reactive Protein ◽

Foot Pressure ◽

Once Daily ◽

Functional Parameters ◽

Reactive Protein ◽

The Mean

Objective: The objective of the study is to find the efficacy of Saindhavadi Taila Matra Vasti in the management of Amavata (rheumatoid arthritis [RA]).Methods: For the present clinical study 15 patients of Amavata (RA) were registered from the Outpatient Department, PG Department of Kayachikitsa, Rishikul Campus, Haridwar. Saindhavadi Taila Matra Vasti was given 60 ml once daily for 8 days, followed by an interval of 7 days. Again Vasti was given once daily for 8 days followed by gap of 7 days. Same cycle was repeated next month. Assessment of the patients was done on the basis of subjective, objective, and functional parameters at the interval of 15 days.Results: Statistically significant result was found in subjective parameters such as pain intensity, Sandhishotha, Gaurav, Apaka (p<0.01 in each), Jwara, Aruchi, and Utsahahani (p<0.05 in each). Statistically non-significant result was found in all the functional parameters (p>0.05), that is, in grip strength, foot pressure, and goniometry. In biochemical parameters, statistically significant result was found in erythrocyte sedimentation rate only (p<0.05). Although non-significant result was found in other biochemical parameters such as hemoglobin, RA factor, and C-reactive protein (CRP) concentration, the mean scores of RA factor and CRP were reduced from 48.7 IU/ml and 10.4 mg/L before treatment to 25.8 IU/ml, 8.2 mg/L after treatment, respectively.Conclusion: In the clinical study, patients got symptomatic relief in many of the complaints but no significant result was found in functional parameters and most of the biochemical parameters. Thus, it can be concluded that Saindhavadi Taila Matra Vasti alone is effective in mild-to-moderate cases of Amavata (RA) and in severe cases it can be used along with oral Ayurvedic formulations for better results.

Download Full-text

Ceruloplasmin is a Better Predictor of the Long-Term Prognosis Compared with Fibrinogen, CRP, and IL-6 in Patients with Severe Unstable Angina

Angiology ◽

10.1177/0003319708314249 ◽

2008 ◽

Vol 60 (1) ◽

pp. 50-59 ◽

Cited By ~ 8

Author(s):

Antonios Ziakas ◽

Stavros Gavrilidis ◽

Efthimia Souliou ◽

George Giannoglou ◽

Ioannis Stiliadis ◽

...

Keyword(s):

Unstable Angina ◽

Cardiovascular Events ◽

Time Course ◽

C Reactive Protein ◽

Mean Values ◽

Reactive Protein ◽

The Mean ◽

Long Term Prognosis

Background. We investigated the time course and prognostic value of fibrinogen (Fib), C-reactive protein (CRP), interleukin-6 (IL-6), and ceruloplasmin (CP) in patients with severe unstable angina. Methods. All 4 substances were measured on admission and after 6, 12, 24, 48, and 72 hours, and after 7 days and 6 months in 40 patients with Braunwald's classification class IIIB unstable angina. Results. All recorded substances increased significantly; 15 patients had cardiovascular events during hospitalization and 11 patients during follow-up. The time course and the mean values of Fib, CRP, and IL-6 were similar in patients with and without complications both during hospitalization and follow-up. However, CP levels from 6 hours until 6 months were significantly higher in patients with complications during follow-up ( P < .05). Conclusions. Fib, CRP, IL-6, and CP levels alter in patients with severe unstable angina. However, only CP levels were related to 12-month follow-up prognosis.

Download Full-text

COMPARATIVE ANALYSIS OF MAIN CLINICAL MANIFESTATIONS IN MALES AND FEMALES WITH EARLY AXIAL SPONDYLOARTHRITIS

Rheumatology Science and Practice ◽

10.14412/1995-4484-2019-440-444 ◽

2019 ◽

Vol 57 (4) ◽

pp. 440-444

Author(s):

D. G. Rumyantseva ◽

T. V. Dubinina ◽

A. B. Demina ◽

A. V. Smirnov ◽

Sh. Erdes

Keyword(s):

Disease Duration ◽

Axial Spondyloarthritis ◽

Clinical Manifestations ◽

Hla B27 ◽

C Reactive Protein ◽

Radiological Progression ◽

Reactive Protein ◽

Males And Females ◽

The Mean

Currently, there have been a small number of works on differences between males and females with axial spondyloarthritis (axSpA) and there have been no studies estimating a gender difference in radiographic sacroiliitis progression in axSpA.Objective: to compare the main clinical manifestations of sacroiliitis and its radiological progression in axSpA in men and women over time during a 2-year follow-up period.Subjects and methods. The investigation was conducted using the Moscow cohort from the early SpondyloArthritis (CoRSAr) study, which currently consisted of 175 patients. The analysis included 68 patients followed up for ≥2 years. Their mean age at the time of inclusion in the cohort was 28.5±5.8 years; the mean disease duration was 24.1±15.4 months. 92.6% of patients were HLA-B27-positive.Results and discussion. Among the 68 patients followed up over 2 years, there were 33 (48.5%) men and 35 (51.5%) women. At baseline, the females were older than the males (p<0.01), while the disease duration was the same and averaged about 2 years. Among the males, there were more patients with ankylosing spondylitis (AS) than those among the females (75.5 and 42.8%, respectively; p<0.05), and the men had a higher total score of radiological sacroiliitis (tsrSI) than the women. The level of C-reactive protein (CRP) was also higher in the men than in the women (12.8 and 4.3 mg/l, respectively; p<0.05). Two years later, AS was present in 90.9% of the males and in 60.0% of the females (p<0.05).Conclusion. Women fall ill with axSpA later than men, and the latter are more frequently observed to have HLA-B27, higher tsrSI and elevated CRP levels. Progression from non-radiological axSpa to AS was more common in men.

Download Full-text

N-terminal brain natriuretic propeptide levels correlate with procalcitonin and C-reactive protein levels in septic patients

Cellular & Molecular Biology Letters ◽

10.2478/s11658-006-0062-y ◽

2007 ◽

Vol 12 (2) ◽

Cited By ~ 12

Author(s):

Mariusz Piechota ◽

Maciej Banach ◽

Robert Irzmański ◽

Małgorzata Misztal ◽

Jacek Rysz ◽

...

Keyword(s):

Severe Sepsis ◽

Plasma Concentrations ◽

University Hospital ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

The Mean ◽

A Prospective Study ◽

Medical University ◽

The Relationship

AbstractThe aim of this study was to find the relationship between N-terminal brain natriuretic propeptide (NT-proBNP), procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations in septic patients. This was a prospective study, performed at Medical University Hospital No. 5 in łódź. Twenty patients with sepsis and severe sepsis were included in the study. N-terminal brain natriuretic propeptide, procalcitonin and C-reactive protein concentrations, and survival were evaluated. In the whole studied group (128 measurements), the mean NT-proBNP, procalcitonin and C-reactive protein concentrations were, respectively: 140.80±84.65 pg/ml, 22.32±97.41 ng/ml, 128.51±79.05 mg/l. The correlations for the NT-proBNP level and procalcitonin and C-reactive protein levels were 0.3273 (p<0.001) and 0.4134 (p<0.001), respectively. NT-proBNP levels correlate with PCT and CRP levels in septic patients. In the survivor subgroup, the mean NT-proBNP plasma concentrations were significantly lower than in the non-survivor subgroup.

Download Full-text

Septic Arthritis of the Pediatric Shoulder: From Infancy to Adolescence

International Journal of Pediatrics ◽

10.1155/2016/3086019 ◽

2016 ◽

Vol 2016 ◽

pp. 1-4

Author(s):

Justin W. Walker ◽

William L. Hennrikus

Keyword(s):

Septic Arthritis ◽

Glenohumeral Joint ◽

Pediatric Population ◽

C Reactive Protein ◽

Orthopaedic Department ◽

Reactive Protein ◽

Erythrocyte Sedimentation ◽

Irrigation And Debridement ◽

The Mean

Background. Septic arthritis of the glenohumeral joint in the pediatric population (<18 yo) is not commonly described in the literature. There is a corresponding paucity of information regarding its presentation and treatment.Methods. An IRB approved review of patients treated with irrigation and debridement by the Orthopaedic Department was completed. This retrospective study includes four patients, presenting from 2005 to 2015, with septic arthritis of the shoulder.Results. The mean age (Mage) at presentation was 5 years, with a range of 1 month to 15 years. Patients presented on average after 7 days with pain and a mean temperature of 39°C, erythrocyte sedimentation rate of 66 mm/hr, a C-reactive protein level of 11.17 g/dL, and a white blood cell count of 20.2 × 103/mcL.Staphylococcus aureus,Candida albicans, andPseudomonas aeruginosawere cultured from the wounds. All cases were treated operatively with irrigation and debridement and with antimicrobial therapy. Patients received antibiotics for an average of 6 weeks.Conclusion. Septic arthritis of the shoulder occurs in all pediatric ages. Successful treatment of septic arthritis of the shoulder was accomplished in four cases without division of the biceps sheath, with an average follow-up of 8 months.

Download Full-text