Epidemiology of Sebaceous Carcinoma in Alberta, Canada, from 1988 to 2007

2012 ◽  
Vol 16 (6) ◽  
pp. 417-423 ◽  
Author(s):  
Paul Kuzel ◽  
Andrei I. Metelitsa ◽  
Douglas C. Dover ◽  
Thomas G. Salopek

Background: The epidemiology of sebaceous carcinoma (SC) has not previously been examined in a Canadian population. Objective: To determine the epidemiologic trends of SC in Alberta, Canada, from 1988 to 2007. Methods: This study was a population-based, retrospective, epidemiologic analysis of SC in Alberta over a 20-year span. Results: Over the study period, the age-standardized SC incidence increased from 0.22 per 100,000 to 0.65 per 100,000. Sebaceous carcinoma is a cancer that predominantly affects the elderly (over 85% of cases were in persons 60 years or older). Interestingly, the face (37.7% of cases), not the eyelids (26.2% of cases), was the most frequently affected site overall. Gender-specific trends reflected a slight male predominance (1.4:1) and significant differences in anatomic distribution between the sexes. Conclusion: For unexplained reasons, there has been a threefold increase in SC incidence in Alberta over the last two decades. In addition, there are significant gender-specific differences in the anatomic distribution of SC. Contexte: L'épidémiologie du carcinome sébacé (CS) n'a jamais fait l'objet d'étude au Canada. Objectif: L'étude visait à déterminer les tendances épidémiologiques du CS en Alberta, au Canada, de 1988 à 2007. Méthodes: Il s'agit d'une analyse épidémiologique, rétrospective, fondée sur la population, du CS, en Alberta, sur une période de 20 ans. Résultats: Au cours de la période à l'étude, l'incidence du CS normalisée selon l'âge est passée de 0.22 pour 100,000 à 0.65 pour 100,000. Le carcinome sébacé est un cancer qui touche surtout les personnes âgées (plus de 85% des cas se comptaient parmi les personnes de 60 ans et plus). Point intéressant, la région le plus souvent touchée, dans l'ensemble, était la face (37.7% des cas), et non les paupières (26.2% des cas). Les tendances propres à chaque sexe ont révélé une fréquence légèrement plus élevée chez les hommes que chez les femmes (1.4/1) et des différences importantes entre les sexes quant à la répartition anatomique du siège des lésions. Conclusion: Pour des raisons inconnues, l'incidence du CS a triplé en Alberta au cours des deux dernières décennies. De plus, il existe des différences importantes entre les sexes quant à la répartition anatomique du CS.

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Wolfgang Hermann ◽  
Lorenz Risch ◽  
Chris Grebhardt ◽  
Urs E. Nydegger ◽  
Benjamin Sakem ◽  
...  

AbstractObjectivesMean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) possess diagnostic and prognostic capabilities in a variety of diseases. We aimed to establish reference intervals (RI) for platelet indices (PI) in seniors.MethodsWe established direct and indirect RI for MPV, PDW, and PCT in selected reference individuals aged 60 years and older. Abnormal PI were assessed in a population-based setting in the Principality of Liechtenstein, where 37.7% of the whole nation’s population aged 60 years and older had PI determined by hematology analyzers from Sysmex (Horgen, Switzerland).ResultsAmong 689 female and 542 male participants, MPV and PDW did not exhibit age- and gender-specific differences, whereas PCT in females also displayed no age-specific differences. Age- and sex-independent RI were 9.3–12.5 fl for MPV and 10.1–16.7% for PDW, whereas the age-independent RI for PCT in women was 0.18–0.37. In males, age-specific RI for PCT were 0.16–0.30 (age 60–69), 0.15–0.33 (age 70–79), and 0.14–0.33 (age 80 and older). The population-based frequency of abnormal PI results was 0.8% (MPV), 1.1% (PDW), and 24.4% (PCT).ConclusionsApplying novel RI for PI reveals that only approximately 1% of patients exhibit abnormal MPV and PDW. Abnormal PCT is observed much more frequently.


2018 ◽  
Vol 35 (01) ◽  
pp. 009-016 ◽  
Author(s):  
Kristofer Schramm ◽  
Paul Rochon

AbstractIn the past 20 years, peripheral artery disease (PAD) has been increasingly recognized as a significant cause of morbidity and mortality in the United States. PAD has traditionally been identified as a male-dominant disease; however, recent population trends and studies in PAD suggest that women are affected at least as often as men. Women comprise a larger population of the elderly than men, as well as an increasing proportion of patients with PAD. Much of the existing research on PAD has focused on whole populations, and gender-specific data on PAD is sparse. This review focuses on gender-specific differences in presentation, management, and outcomes of PAD intervention that are important considerations for the interventional radiologist.


2005 ◽  
Vol 113 (S 1) ◽  
Author(s):  
C Riese ◽  
F Streckfuss ◽  
U Schweizer ◽  
J Köhrle ◽  
L Schomburg

2006 ◽  
Vol 54 (S 1) ◽  
Author(s):  
M Bauer ◽  
G Mitterer ◽  
W Dietl ◽  
K Trescher ◽  
E Wolner ◽  
...  

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