Altered anterior default mode network dynamics in progressive multiple sclerosis

Background: Modifications in brain function remain relatively unexplored in progressive multiple sclerosis (PMS), despite their potential to provide new insights into the pathophysiology of the disease at this stage. Objectives: To characterize the dynamics of functional networks at rest in patients with PMS, and the relation with clinical disability. Methods: Thirty-two patients with PMS underwent clinical and cognitive assessment. The dynamic properties of functional networks, retrieved from transient brain activity, were obtained from patients and 25 healthy controls (HCs). Sixteen HCs and 19 patients underwent a 1-year follow-up (FU) clinical and imaging assessment. Differences in the dynamic metrics between groups, their longitudinal changes, and the correlation with clinical disability were explored. Results: PMS patients, compared to HCs, showed a reduced dynamic functional activation of the anterior default mode network (aDMN) and a decrease in its opposite-signed co-activation with the executive control network (ECN), at baseline and FU. Processing speed and visuo-spatial memory negatively correlated to aDMN dynamic activity. The anti-couplings between aDMN and auditory/sensory-motor network, temporal-pole/amygdala, or salience networks were differently associated with separate cognitive domains. Conclusion: Patients with PMS presented an altered aDMN functional recruitment and anti-correlation with ECN. The aDMN dynamic functional activity and interaction with other networks explained cognitive disability.

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Functional network dynamics in progressive multiple sclerosis

10.1101/2020.11.26.20238923 ◽

2020 ◽

Author(s):

Giulia Bommarito ◽

Anjali Tarun ◽

Younes Farouj ◽

Maria Giulia Preti ◽

Maria Petracca ◽

...

Keyword(s):

Multiple Sclerosis ◽

Large Scale ◽

Dynamic Properties ◽

Progressive Multiple Sclerosis ◽

Default Mode ◽

Functional Reorganization ◽

Functional Dynamics ◽

One Year ◽

Progressive Stage

AbstractFunctional reorganization at the progressive stage of multiple sclerosis has received limited attention, despite the fact that functional changes are known to occur. Characterizing large-scale network dynamics at rest has the potential to provide new insights into the complexity of such functional alterations. In this case-control study, we explored the dynamic properties of large-scale functional networks during rest in 25 healthy controls and 32 patients with progressive multiple sclerosis, using the innovation-driven co-activation patterns. Thirty-five subjects also underwent a one-year follow-up examination. Partial least squares correlation analysis was applied to explore the relationship between functional dynamics and clinical disability. We observed a reduced dynamic engagement of the anterior default mode network and its coupling with the executive-control network in patients with progressive multiple sclerosis compared to controls, at baseline and follow-up. The global and motor disabilities were related to functional dynamics of subcortical, sensory-motor and posterior default mode network, while the cognitive disability was associated to the altered dynamics of anterior default mode, visual and temporal networks. These findings reveal that the anterior default mode functional recruitment and its interaction with other networks play a major role in the functional reorganization occurring during the progressive stage of multiple sclerosis. Also, the dynamic properties of large-scale functional networks are steady over one year and unveil the intricate relationship between brain function and clinical disability.

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Patterns of Brain Activity Supporting Autobiographical Memory, Prospection, and Theory of Mind, and Their Relationship to the Default Mode Network

Journal of Cognitive Neuroscience ◽

10.1162/jocn.2009.21282 ◽

2010 ◽

Vol 22 (6) ◽

pp. 1112-1123 ◽

Cited By ~ 511

Author(s):

R. Nathan Spreng ◽

Cheryl L. Grady

Keyword(s):

Theory Of Mind ◽

Default Mode Network ◽

Brain Activity ◽

Brain Structures ◽

Neural Activation ◽

Default Mode ◽

Cognitive Behaviors ◽

Core Set ◽

Multiple Processes ◽

Human Feature

The ability to rise above the present environment and reflect upon the past, the future, and the minds of others is a fundamentally defining human feature. It has been proposed that these three self-referential processes involve a highly interconnected core set of brain structures known as the default mode network (DMN). The DMN appears to be active when individuals are engaged in stimulus-independent thought. This network is a likely candidate for supporting multiple processes, but this idea has not been tested directly. We used fMRI to examine brain activity during autobiographical remembering, prospection, and theory-of-mind reasoning. Using multivariate analyses, we found a common pattern of neural activation underlying all three processes in the DMN. In addition, autobiographical remembering and prospection engaged midline DMN structures to a greater degree and theory-of-mind reasoning engaged lateral DMN areas. A functional connectivity analysis revealed that activity of a critical node in the DMN, medial prefrontal cortex, was correlated with activity in other regions in the DMN during all three tasks. We conclude that the DMN supports common aspects of these cognitive behaviors involved in simulating an internalized experience.

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Exploring Dynamic Brain Functional Networks Using Continuous “State-Related” Functional MRI

BioMed Research International ◽

10.1155/2015/824710 ◽

2015 ◽

Vol 2015 ◽

pp. 1-8 ◽

Cited By ~ 4

Author(s):

Xun Li ◽

Yu-Feng Zang ◽

Han Zhang

Keyword(s):

Executive Control ◽

Force Feedback ◽

Functional Network ◽

External Information ◽

Functional Networks ◽

Default Mode ◽

Sensorimotor Network ◽

Motor Network ◽

Continuous State ◽

Related Mode

We applied a “temporal decomposition” method, which decomposed a single brain functional network into several “modes”; each of them dominated a short temporal period, on a continuous, “state-” related, “finger-force feedback” functional magnetic resonance imaging experiment. With the hypothesis that attention and internal/external information processing interaction could be manipulated by different (real and sham) feedback conditions, we investigated functional network dynamics of the “default mode,” “executive control,” and sensorimotor networks. They were decomposed into several modes. During real feedback, the occurrence of “default mode-executive control competition-related” mode was higher than that during sham feedback (P=0.0003); the “default mode-visual facilitation-related” mode more frequently appeared during sham than real feedback (P=0.0004). However, the dynamics of the sensorimotor network did not change significantly between two conditions (P>0.05). Our results indicated that the visual-guided motor feedback involves higher cognitive functional networks rather than primary motor network. The dynamics monitoring of inner and outside environment and multisensory integration could be the mechanisms. This study is an extension of our previous region-specific and static-styled study of our brain functional architecture.

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Hyperconnectivity of the Default Mode Network is Linked to Cognitive Disability in Multiorgan Dysfunction Syndrome

Archives of Physical Medicine and Rehabilitation ◽

10.1016/j.apmr.2019.08.241 ◽

2019 ◽

Vol 100 (10) ◽

pp. e83

Author(s):

Juan Carlos Arango-Lasprilla ◽

Antonio Jiménez-Marín ◽

Diego Rivera ◽

Ibai Diez ◽

Fermin Labayen ◽

...

Keyword(s):

Default Mode Network ◽

Cognitive Disability ◽

Multiorgan Dysfunction ◽

Default Mode ◽

Multiorgan Dysfunction Syndrome

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Spontaneous Brain Activity in the Default Mode Network Is Sensitive to Different Resting-State Conditions with Limited Cognitive Load

PLoS ONE ◽

10.1371/journal.pone.0005743 ◽

2009 ◽

Vol 4 (5) ◽

pp. e5743 ◽

Cited By ~ 212

Author(s):

Chaogan Yan ◽

Dongqiang Liu ◽

Yong He ◽

Qihong Zou ◽

Chaozhe Zhu ◽

...

Keyword(s):

Cognitive Load ◽

Default Mode Network ◽

Resting State ◽

Brain Activity ◽

Default Mode ◽

Spontaneous Brain Activity

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Temporal circuit of macroscale dynamic brain activity supports human consciousness

Science Advances ◽

10.1126/sciadv.aaz0087 ◽

2020 ◽

Vol 6 (11) ◽

pp. eaaz0087 ◽

Cited By ~ 11

Author(s):

Zirui Huang ◽

Jun Zhang ◽

Jinsong Wu ◽

George A. Mashour ◽

Anthony G. Hudetz

Keyword(s):

Default Mode Network ◽

Functional Role ◽

Brain Activity ◽

Human Consciousness ◽

Attention Network ◽

Attention Networks ◽

Default Mode ◽

Dorsal Attention Network ◽

Brain States

The ongoing stream of human consciousness relies on two distinct cortical systems, the default mode network and the dorsal attention network, which alternate their activity in an anticorrelated manner. We examined how the two systems are regulated in the conscious brain and how they are disrupted when consciousness is diminished. We provide evidence for a “temporal circuit” characterized by a set of trajectories along which dynamic brain activity occurs. We demonstrate that the transitions between default mode and dorsal attention networks are embedded in this temporal circuit, in which a balanced reciprocal accessibility of brain states is characteristic of consciousness. Conversely, isolation of the default mode and dorsal attention networks from the temporal circuit is associated with unresponsiveness of diverse etiologies. These findings advance the foundational understanding of the functional role of anticorrelated systems in consciousness.

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The Functional Convergence and Heterogeneity of Social, Episodic, and Self-Referential Thought in the Default Mode Network

Cerebral Cortex ◽

10.1093/cercor/bhaa166 ◽

2020 ◽

Vol 30 (11) ◽

pp. 5915-5929 ◽

Cited By ~ 1

Author(s):

Tanya Wen ◽

Daniel J Mitchell ◽

John Duncan

Keyword(s):

Default Mode Network ◽

Medial Temporal Lobe ◽

Brain Activity ◽

Activity Patterns ◽

Univariate Analysis ◽

Moral Dilemmas ◽

Default Mode ◽

Multiple Components ◽

Common Activity ◽

Rest Condition

Abstract The default mode network (DMN) is engaged in a variety of cognitive settings, including social, semantic, temporal, spatial, and self-related tasks. Andrews-Hanna et al. (2010; Andrews-Hanna 2012) proposed that the DMN consists of three distinct functional–anatomical subsystems—a dorsal medial prefrontal cortex (dMPFC) subsystem that supports social cognition; a medial temporal lobe (MTL) subsystem that contributes to memory-based scene construction; and a set of midline core hubs that are especially involved in processing self-referential information. We examined activity in the DMN subsystems during six different tasks: 1) theory of mind, 2) moral dilemmas, 3) autobiographical memory, 4) spatial navigation, 5) self/other adjective judgment, and 6) a rest condition. At a broad level, we observed similar whole-brain activity maps for the six contrasts, and some response to every contrast in each of the three subsystems. In more detail, both univariate analysis and multivariate activity patterns showed partial functional separation, especially between dMPFC and MTL subsystems, though with less support for common activity across the midline core. Integrating social, spatial, self-related, and other aspects of a cognitive situation or episode, multiple components of the DMN may work closely together to provide the broad context for current mental activity.

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