scholarly journals Myostatin serum concentration as an indicator for deviated muscle metabolism in severe burn injuries

2018 ◽  
Vol 108 (4) ◽  
pp. 297-304 ◽  
Author(s):  
C. Wallner ◽  
J. M. Wagner ◽  
S. Dittfeld ◽  
M. Drysch ◽  
M. Lehnhardt ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Serum Concentration ◽  
Surface Area ◽  
Body Surface ◽  
Burn Injury ◽  
Total Body Surface Area ◽  
Muscle Metabolism ◽  
Burn Injuries ◽  
Total Body

Introduction: Patients experiencing thermal injuries with an extent of over 20% of total body surface area suffer from systemic catabolic disease. The thermal trauma-induced loss of muscle mass causes a higher incidence for comorbidities and subsequently a higher mortality. In this study, we aimed to investigate the role of myostatin in the interplay with follistatin during muscle cachexia. Methods: Patients with burn injuries (>10% total body surface area) between the ages of 18 and 75 were prospectively included within the first 48 h after trauma to determine deviations of parameters connected to muscle catabolism. In the chronic state of burn injury (9–12 months after trauma), we re-evaluated myostatin and follistatin concentrations as well as muscle strength of the non-dominant forearm. Results: We were able to show a time-dependent alteration (9–12 months after burn injury) of myostatin with an initial decrease ( p < 0.001) and long-term increase ( p < 0.001) after thermal injury in blood serum. For follistatin, a reciprocal correlation was observed ( r = −0.707, p = 0.001). Accordingly, muscle strength of the non-dominant hand and forearm was significantly decreased 9–12 months after injury in post-burn patients compared with healthy patients with a significant correlation to myostatin levels ( r = −0.899, p < 0.001). In addition, initial myostatin serum concentration was predictive for long-term muscle strength impairment. Conclusion: With regard to the muscle metabolism after thermal trauma, our data suggest an acute anabolic response, presumably to spare muscle mass, which is converted to catabolic conditions accompanied by muscle strength reduction in the chronic phase. Myostatin plays a crucial role in this orchestration and initial myostatin concentration may predict the long-term muscle strength.

Burns and Electrical Injuries

2019 ◽  
pp. 409-414
Author(s):  
Brandon T. Nokes ◽  
Ayan Sen
Keyword(s):  
Critical Care ◽  
Surface Area ◽  
Body Surface ◽  
Burn Injury ◽  
Total Body Surface Area ◽  
Burn Injuries ◽  
Burn Severity ◽  
Thermal Burn ◽  
Total Body ◽  
Electrical Injuries

Burn injuries may cause morbidity and death, and patients may have widely variable presentations and outcomes. This chapter focuses on the critical care aspects of burn injury and management issues of burn and electrical injuries. Burns are classified according to the amount of total body surface area (TBSA) affected, the depth of burn, and the type of exposure associated with the burn. More specifically, burns can be chemical, electrical, or thermal. Burn severity is determined by the depth of involvement.

Prevalence of Psychiatric Disorders in Burn Patients in a Tertiary Care Hospital

2021 ◽  
Vol 15 (11) ◽  
pp. 3389-3391
Author(s):  
Imran Khan ◽  
Taimur Khan ◽  
Shakil Asif ◽  
Syed Azhar Ali Kazmi ◽  
Subhan Ullah ◽  
...  
Keyword(s):  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Total Body Surface Area ◽  
Burn Injuries ◽  
Care Hospital ◽  
Burn Patients ◽  
Total Body

Background and Aim: Burn injuries patients generally suffer from various psychological and mental disorders especially in lower socio-economic groups. It can adversely affect their wellbeing and health. Proper consultation and clinical diagnosis need to be carried out on burns injuries patients from the early critical phase to rehabilitation phase recovery. The current study's aim was to determine the prevalence of psychiatric disorders in burn patients in a tertiary care hospital. Materials and Methods: This cross-sectional study was conducted on 82 attempted burn suicides, adult patients in Khattak Medical Center Peshawar, Khyber Teaching Hospital Peshawar and Divisional Headquarter hospital, Mirpur AJK for duration of six months from June 2020 to December 2020. All the patients admitted with suicides burns were of either gender and had ages above 15 years. The convenience technique was used for sampling. The patients’ demographic details such as psychiatric illness, self-immolation act motivation, burn injury depth, burn total body surface area, inhalation injury, hospitalization duration, and mortality was recorded on pre-designed proforma. Data analysis was carried out with SPSS version 20. Results: The mean age of all 82 patients was 28.9±5.2 with an age range of 14 to 55 years. Of the total, 66 (80.5%) were female while 16 (19.5%) were male. In this study, the most frequent suicidal attempt was made by the marital conflicted patients 50 (61%) followed by love affair failure 8 (9.7%). An overall mean of 53.6±19.6 was observed for total body surface area affected with a range of 15-100%. The hospital duration mean was 8.2±5.9 with a range of 1-38 days. Young, married, and rural area illiterate housewives were the most common self-inflicted/suicide burn injuries. The prime cause of such injuries was getting married. The mortality rate was found at 82.3%. Conclusion: Our study concluded that patient’s well-being and mental health could be severely affected by burn injuries. Prevalent depression was noted among severe burn injuries patients. Depression related to deformity could be prevented with early grafting, wound management, proper splinting, coping ability, intense physiotherapy, and long-term rehabilitation. Keywords: Burn; Depressed mood, Psychiatric morbidity, Posttraumatic stress disorder

Assessment of burn surface area

2019 ◽  
pp. 67-76
Author(s):  
Rowan Pritchard-Jones ◽  
Kayvan Shokrollahi
Keyword(s):  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Gold Standard ◽  
Burn Injury ◽  
Total Body Surface Area ◽  
Injured Patient ◽  
Crucial Step ◽  
Total Body

Assessment of total body surface area of a burn injured patient is a crucial step in managing burn injury. The chapter describes a number of techniques from using the size of the patient’s palm as an estimate of 1% to the gold standard Lund and Browder Chart. Key caveats are explained, copies of the charts included as well as the use of the CE certified app Mersey Burns.

scholarly journals Prevalence and associated predictors for patients developing chronic neuropathic pain following burns

2020 ◽  
Vol 8 ◽  
Author(s):  
Kevin M Klifto ◽  
A Lee Dellon ◽  
C Scott Hultman
Keyword(s):  
Mechanical Ventilation ◽  
Neuropathic Pain ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Burn Injury ◽  
Total Body Surface Area ◽  
Chronic Neuropathic Pain ◽  
Burn Center ◽  
Total Body

Abstract Background Chronic pain, unrelated to the burn itself, can manifest as a long-term complication in patients sustaining burn injuries. The purpose of this study was to determine the prevalence of chronic neuropathic pain (CNP) and compare burn characteristics between patients who developed CNP and patients without CNP who were treated at a burn center. Methods A single-center, retrospective analysis of 1880 patients admitted to the adult burn center was performed from 1 January 2014 to 1 January 2019. Patients included were over the age of 15 years, sustained a burn injury and were admitted to the burn center. CNP was diagnosed clinically following burn injury. Patients were excluded from the definition of CNP if their pain was due to an underlying illness or medication. Comparisons between patients admitted to the burn center with no pain and patients admitted to the burn center who developed CNP were performed. Results One hundred and thirteen of the 1880 burn patients developed CNP as a direct result of burn injury over 5 years with a prevalence of 6.01%. Patients who developed CNP were a significantly older median age (54 years vs. 46 years, p = 0.002), abused alcohol (29% vs. 8%, p &lt; 0.001), abused substances (31% vs. 9%, p &lt; 0.001), were current daily smokers (73% vs. 33%, p &lt; 0.001), suffered more full-thickness burns (58% vs. 43%, p &lt; 0.001), greater median percent of total body surface area (%TBSA) burns (6 vs. 3.5, p &lt; 0.001), were more often intubated on mechanical ventilation (33% vs. 14%, p &lt; 0.001), greater median number of surgeries (2 vs. 0, p &lt; 0.001) and longer median hospital length of stay (LOS) (10 days vs. 3 days, p &lt; 0.001), compared to those who did not develop CNP, respectively. Median patient follow-up was 27 months. Conclusions The prevalence of CNP over 5 years was 6.01% in the burn center. Older ages, alcohol abuse, substance abuse, current daily smoking, greater percent of total body surface area (%TBSA) burns, third degree burns, being intubated on mechanical ventilation, having more surgeries and longer hospital LOS were associated with developing CNP following burn injury, compared to patients who did not develop CNP following burn injury.

scholarly journals The epidemiology of burn injury among children during COVID-19 19 pandemic and WFH policy in Malang, East Java, Indonesia

2021 ◽  
Vol 10 (4) ◽  
pp. 744
Author(s):  
Herman Yosef Limpat Wihastyoko ◽  
Arviansyah Arviansyah ◽  
Erdo Puncak Sidarta
Keyword(s):  
Comparative Analysis ◽  
Body Surface ◽  
Clinical Characteristics ◽  
Burn Injury ◽  
Total Body Surface Area ◽  
Burn Injuries ◽  
Work From Home ◽  
Injury Group ◽  
Significant Difference ◽  
Total Body

Work from home (WFH) mandate is one of the major changes known during this pandemic, aimed as a preventive way to mitigate the spread of the COVID-19 virus. This study aimed to observe the characteristics of pediatric burn injury during COVID-19 pandemic and WFH mandate's impact on pediatric burn injury admission at some Hospital burn centers in Malang. Every patient’s age, gender, clinical characteristics, parent's background, and other variables such as the possession of siblings, response time using our burn registry form, and comparative analysis of the incident in WFH housewife mother were assessed. The majority were in the group age of under five years old group age (70%) with a mean of 5.5 years. The most frequent part of the burn injured is extremity 36.7%, and hot liquid dominates as the cause of the injury 73.3% with the total body surface area of burn injury group &gt;10% is the most common 56.7%. The burn injury incident happened more frequently in mothers with children less than two in both groups. This study showed that the increase in increasement of the pediatric burn injury during COVID-19 pandemic between housewife mother and WFH mother has no significant difference also showed that parent especially mother unable to supervise the children during WFH. Strategies to mitigate pediatric burn injuries during WFH should be thoughtfully implemented.

scholarly journals Recovery from an Eighty-Percent Total Body Surface Area Burn Injury Sustained at Work

2012 ◽  
Vol 63 (2) ◽  
pp. 223-226
Author(s):  
Helga Hahn
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Initial Treatment ◽  
Burn Injury ◽  
Total Body Surface Area ◽  
Hot Water ◽  
Total Body

Recovery from an Eighty-Percent Total Body Surface Area Burn Injury Sustained at WorkThis article presents a case of severe burn injury at work involving 80 % of body surface area and patient treatment and rehabilitation, which resulted in preserved working ability. The worker was injured by hot water and steam. After initial treatment in the intensive care unit, he underwent comprehensive clinical and outpatient rehabilitation that took 92 weeks, after which he returned to work. His working disability was 100 % after the initial treatment in the intensive care unit, but rehabilitation improved it to 50 %. It should always be kept in mind that even patients with serious or life-threatening injuries can be reintegrated into the workforce if patients, physicians, occupational physicians, and employers all work together.

NON-ACCIDENTAL BURN INJURIES IN ADULTS ADMITTED AT MANKWENG BURNS UNIT

2020 ◽  
Vol 3 (9) ◽  
Author(s):  
Salathiel Zhou Mzezewa ◽  
Livhuwani Makhuvha
Keyword(s):  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Total Body Surface Area ◽  
Public Health Problem ◽  
Intimate Partner ◽  
Burn Injuries ◽  
Traditional Beliefs ◽  
Causative Agents ◽  
Total Body

Abstract IntroductionBurns are a serious public health problem responsible for mortality and morbidity such as infection, contractures, and psycho-social disability.Aims and ObjectivesTo obtain information on non-accidental burn injuries admitted to our burns unit.To record the outcome.MethodsAll patients with a history of non-accidental burn injuries from January 2019 to August 2020 were prospectively included in this study. A data collection tool was created which consisted of data on age, gender, causative agents of burns, mechanism/circumstances that led to injury, total body surface area (TBSA) involved, and the patient’s outcome. ResultsWe admitted 38 patients. 22 males and 16 females. The mechanisms were intimate partner related violence 21, religious and traditional beliefs 5, self-inflicted 3, mob assault 1, robbery 2, alcohol-related conflicts 3, unclear mechanisms 3. The causative agents were scald 20, open flame 15 and chemical burns 3. The median age was 35,63(19-64) years. The median total body surface area was 24,4 (3-80) %. Mortality was 11(29%). ConclusionBurn injuries as a result of intimate partner-related violence were the leading reason for admission at 55,26%. Mortality was highest among those admitted following religious and traditional beliefs burns. The mortality was 29%.

511 Point-of-care 3-dimensional Body Mapping for Determining Total Body Surface Area in Severely Burned Patients

2020 ◽  
Vol 41 (Supplement_1) ◽  
pp. S92-S93
Author(s):  
Julia Loegering ◽  
Kevin Webb ◽  
Jesse Ahlquist ◽  
Kevin Krause ◽  
Karen Xu ◽  
...  
Keyword(s):  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Gold Standard ◽  
Burn Injury ◽  
Point Of Care ◽  
Total Body Surface Area ◽  
Body Mapping ◽  
Burn Care ◽  
Total Body

Abstract Introduction With severe burn injury, there is systemic fluid loss due to inflammatory responses in damaged tissue, leading to disruption of cellular processes. Patient fluid levels are restored with the calculation of total body surface area (TBSA). Clinically used TBSA equations are often outdated and inaccurate with error up to 20%, resulting in misinformed treatment and subsequent sequelae including prolonged hospital length of stay and increased mortality. Our objective, therefore, was to create a point-of-care (POC) system employing 3D imaging technology to accurately calculate TBSA for all patient population varieties. Methods Our team employed an iPad attachable, infrared scanner to create 3D models of the human body. From these models, TBSA can be extrapolated using scan processing software. Subject scans were collected on our device and on a gold standard scanner for comparison of TBSA output. Clinical testing on burn patients is occurring at present to establish scanning precision of TBSA in the burn care environment. Results Non-clinical verification tests of the 3D scanned TBSA revealed a 4.05% error when compared to the gold standard, and precision error of 3.8%. Additionally, we introduced the device into the burn unit for preliminary testing with a physician user and non-patient subjects. The subjects were scanned in a prone position to mimic burn care workflow. Clinician scanning error was 1.41% when compared to the gold standard scan of the same subject. Clinical precision study results are on-going in collection. Conclusions Our device introduces an improved method of TBSA estimation to assist clinicians in making accurate burn care decisions and further precision medicine with greater anthropomteric data, notably for children. This device is one of the first POC-3D scanning technologies to be used in a burn setting and may also be employed at outlying medical facilities. Destructive wildfires and combat burn injuries highlight the need for such a device to standardize the triage of burn victims with and away from experienced medical staff. Applicability of Research to Practice 3D body mapping points to an enhanced method of TBSA calculation and minimally disruptive to the burn workflow. Future developments of 3D scanning include deep learning algorithms to identify and better assess burned surface area. Additionally, further automation of TBSA scan processing to reduce user error in calculation and improve burn injury outcomes.

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