scholarly journals An Optical-Fiber-Based Smart Textile (Smart Socks) to Manage Biomechanical Risk Factors Associated With Diabetic Foot Amputation

2017 ◽  
Vol 11 (4) ◽  
pp. 668-677 ◽  
Author(s):  
Bijan Najafi ◽  
Hooman Mohseni ◽  
Gurtej S. Grewal ◽  
Talal K. Talal ◽  
Robert A. Menzies ◽  
...  
Keyword(s):  
Fiber Optics ◽  
Peak Pressure ◽  
Pressure Profile ◽  
Joint Angles ◽  
Factors Associated ◽  
Optical Wavelength ◽  
Smart Textile ◽  
Flexible Fiber ◽  
Gold Standards

Objective: This study aimed to validate a smart-textile based on fiber-optics for simultaneous measurement of plantar temperature, pressure, and joint angles in patients with diabetic peripheral neuropathy (DPN). Methods: After in-vitro validation in the laboratory, 33 eligible subjects with DPN were recruited (age: 58 ± 8 years, BMI: 31.5 ± 8 kg/m2) for assessing plantar pressure and temperature during habitual gait-speed in a clinical-setting. All participants were asked to walk at their habitual speed while wearing a pair of sensorized socks made from highly flexible fiber optics (SmartSox). An algorithm was designed to estimate temperature, pressure, and toe range of motion from optical wavelength generated from SmartSox. To validate the device, results from thermal stress response (TSR) using thermography and peak pressure measured by computerized pressure insoles (F-Scan) were used as gold standards. Results: In laboratory and under controlled conditions, the agreements for parameters of interest were excellent ( r > .98, P = .000), and no noticeable cross-talks between measurements of temperature, angle, and pressure were observed. During clinical data acquisition, a significant correlation was found for pressure profile under different anatomical regions of interest between SmartSox and F-Scan ( r = .67, P < .050) as well as between thermography and SmartSox ( r = .55, P < .050). Conclusion: This study demonstrates the validity of an innovative smart textile for assessing simultaneously the key parameters associated with risk of foot ulcers in patients with DPN. It may empower clinicians to objectively stratify foot risk and provide timely care. Another study is warranted to validate its clinical application in preventing limb threating problems in patients with DPN.

PAPER PHYSICS. The web structure in relation to the furnish composition and shoe press pulse profiles during wet pressing

2012 ◽  
Vol 27 (4) ◽  
pp. 798-805 ◽  
Author(s):  
Collin Hii ◽  
Øyvind W. Gregersen ◽  
Gary Chinga-Carrasco ◽  
Øyvind Eriksen ◽  
Kai Toven
Keyword(s):  
Porous Structure ◽  
Peak Pressure ◽  
Pulse Length ◽  
Pressure Profile ◽  
Steam Consumption ◽  
Web Structure ◽  
Wet Pressing ◽  
Solids Content ◽  
In The Beginning ◽  
The Web

Abstract This study shows that wet-pressing TMP and DIP with a shoe press pulse may yield similar afterpress solids, provided that an adequate shoe pulse length with similar pressure profile is applied. A wet web with more porous structure in the sheet dewatering (felt) layer seems to contribute to the increased dewatering during wet pressing. In addition, a shoe press pulse with high peak pressure at the end yields higher solids content after wet-pressing and higher bulk compared to a pulse with a peak pressure in the beginning. The increased dewatering during wet-pressing implies a reduction of steam consumption in the dryer.

An In-Vitro Investigation into the Cement Pressurization Achieved During Insertion of Four Different Femoral Stems

2005 ◽  
Vol 219 (6) ◽  
pp. 407-413 ◽  
Author(s):  
C Gozzard ◽  
S Gheduzzi ◽  
A W Miles ◽  
I D Learmonth
Keyword(s):  
Revision Surgery ◽  
In Vitro Study ◽  
The Other ◽  
Stem Volume ◽  
Factors Associated ◽  
In Vitro Investigation ◽  
Femoral Stems ◽  
Stem Shape ◽  
Distal Stem

Adequate cement pressurization during stem insertion improves the interdigitation of cement into bone. This increases the strength of the cement-bone interface, thus contributing to the reduction of the incidence of aseptic loosening, the commonest cause of revision surgery. This in-vitro study compared the cement pressurization achieved during insertion of four different stems of equivalent sizes: the Elite Plus (DePuy, UK), C-Stem (DePuy, UK), Exeter (Stryker, USA), and CPS-Plus (Plus Orthopedics, Switzerland). The maximum pressures attained at the time of stem insertion were recorded at proximal, mid and distal stem levels. The Elite Plus generated significantly higher distal pressures than the other stems. The CPS-Plus generated significantly greater proximal cement pressures than the Elite Plus, C-Stem, and Exeter prostheses. The triple taper of the C-Stem increased the cement pressurization medial to the stem. The stem shape and the presence or absence of a proximal stem centralizer affect cement pressurization. The presence of a proximal stem centralizer, a large stem volume, and a lateral-medial taper are all factors associated with increased cement pressurization during stem insertion.

scholarly journals In vitro study of trileaflet polytetrafluoroethylene conduit and its valve-in-valve transformation

2020 ◽  
Vol 30 (3) ◽  
pp. 408-416 ◽  
Author(s):  
Te-I Chang ◽  
Kang-Hong Hsu ◽  
Chi-Wen Luo ◽  
Jen-Hong Yen ◽  
Po-Chien Lu ◽  
...  
Keyword(s):  
Pressure Gradient ◽  
Stent Graft ◽  
Peak Pressure ◽  
Circulatory System ◽  
Valve Design ◽  
Mock Circulatory System ◽  
Valved Conduit ◽  
Valve In Valve ◽  
In Vitro Performance

Abstract OBJECTIVES Handmade trileaflet expanded polytetrafluoroethylene valved conduit developed using the flip-over method has been tailored for pulmonary valve reconstruction with satisfactory outcomes. We investigated the in vitro performance of the valve design in a mock circulatory system with various conduit sizes. In our study, the design was transformed into a transcatheter stent graft system which could fit in original valved conduits in a valve-in-valve fashion. METHODS Five different sizes of valved polytetrafluoroethylene vascular grafts (16, 18, 20, 22 and 24 mm) were mounted onto a mock circulatory system with a prism window for direct leaflets motion observation. Transvalvular pressure gradients were recorded using pressure transducers. Mean and instant flows were determined via a rotameter and a flowmeter. Similar flip-over trileaflet valve design was then carried out in 3 available stent graft sizes (23, 26 and 28.5 mm, Gore aortic extender), which were deployed inside the valved conduits. RESULTS Peak pressure gradient across 5 different sized graft valves, in their appropriate flow setting (2.0, 2.5 and 5.0 l/min), ranged from 4.7 to 13.2 mmHg. No significant valve regurgitation was noted (regurgitant fraction: 1.6–4.9%) in all valve sizes and combinations. Three sizes of the trileaflet-valved stent grafts were implanted in the 4 sizes of valved conduits except for the 16-mm conduit. Peak pressure gradient increase after valved-stent graft-in-valved-conduit setting was &lt;10 mmHg in all 4 conduits. CONCLUSIONS The study showed excellent in vitro performance of trileaflet polytetrafluoroethylene valved conduits. Its valved stent graft transformation provided data which may serve as a reference for transcatheter valve-in-valve research in the future.

Factors associated with errors in the heparin dose response test: recommendations to improve individualized heparin management in cardiopulmonary bypass

Perfusion ◽  
2020 ◽  
pp. 026765912095297
Author(s):  
Min-Ho Lee ◽  
William Riley
Keyword(s):  
Cardiopulmonary Bypass ◽  
Dose Response ◽  
Clotting Time ◽  
Critical Aspect ◽  
Heparin Dose ◽  
Factors Associated ◽  
Heparin Concentration ◽  
Activated Clotting Time

Background: A critical aspect of cardiopulmonary bypass (CPB) is to achieve full anticoagulation to prevent thrombosis and consumptive coagulation without using excessive amount of heparin. This can be achieved with heparin dose response (HDR) test in vitro to calculate an individualized heparin bolus to reach a target activated clotting time (ACT) and heparin concentration. However, we often observe that the measured ACT (mACT) with the calculated heparin bolus gives significant errors, both positive (mACT is higher than expected) and negative (mACT is lower), from expected ACT (eACT). Methods: We performed a retrospective study of 250 patients who underwent cardiac surgery to attain an error distribution of the mACT from eACT with calculated heparin bolus. In addition, it is aimed to identify possible patterns of baseline ACT (bACT), calculated heparin concentration (CHC) and HDR slope that are associated with the significant positive and negative errors. Results: We found that individualized heparin bolus by HDR test is consistently underestimated while it gave a significant number of positive and negative errors. Further analysis indicates that significant negative errors correlate with high bACT and slope and low CHC while significant positive errors with low bACT and slope and high CHC. Conclusion: The mACT can be substantially different from eACT. The accuracy of the HDR test appears to be dependent upon bACT, slope, and CHC. Based on our analysis, we provide several recommendations and a flow chart to improve the quality of individualized heparin management on CPB.

scholarly journals Factors associated with early in vitro fertilization treatment discontinuation

2019 ◽  
Vol 112 (1) ◽  
pp. 105-111 ◽  
Author(s):  
Bronwyn S. Bedrick ◽  
Kelsey Anderson ◽  
Darcy E. Broughton ◽  
Barton Hamilton ◽  
Emily S. Jungheim
Keyword(s):  
In Vitro Fertilization ◽  
Treatment Discontinuation ◽  
Vitro Fertilization ◽  
Factors Associated

scholarly journals XCHD Inhibits C6 Cell Growth Primarily via the p53/Caspase Pathway

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Huiling Yu ◽  
Qinnuan Sun ◽  
Fen Yun ◽  
Xiaoyan Xu ◽  
Feng Ding ◽  
...  
Keyword(s):  
Cell Growth ◽  
Caspase 3 ◽  
Mrna Level ◽  
Time Effect ◽  
Caspase 8 ◽  
C6 Cells ◽  
Western Blots ◽  
Factors Associated ◽  
Caspase Pathway

The effects of XCHD on the proliferation of C6 cells and on factors associated with the microRNA-34a (miR-34a)/p53/caspase-3 signaling pathway in vitro were investigated. Methods. XCHD was purchased too much to complete the study. CCK-8 assay was used to measure the XCHD concentration, and qPCR was used to quantify miR-34a expression at the mRNA level. Apoptosis was assessed using TUNEL. Western blots were used to determine the p53, caspase-3, caspase-8, and Bcl-2 expression levels. Results. The optimal XCHD concentration and time effect for C6 cells were observed after 36 h of exposure to a concentration of 100 µg/ml XCHD. miR-34a expression increased 8 and 12 h after the addition of XCHD. The presence of XCHD decreased Bcl-2 expression but increased p53, cleaved caspase-3, Bax, and caspase-8 expression. When p53 was inhibited, miR-34a expression was unaffected by the addition of XCHD, Bcl-2 expression was low, and cleaved caspase-3, Bax, and caspase-8 expression increased. The inhibition of p53 promoted C6 cell growth when compared with C6 cells exposed to XCHD and with no inhibition of p53. Conclusions. XCHD inhibits C6 cell growth which was influenced by the p53/caspase pathway.

Factors Associated With Second-Trimester Pregnancy Loss in Women With Normal Uterine Anatomy Undergoing In Vitro Fertilization

2015 ◽  
Vol 125 (3) ◽  
pp. 621-627 ◽  
Author(s):  
Leah Hawkins Bressler ◽  
Katharine F. Correia ◽  
Serene S. Srouji ◽  
Mark D. Hornstein ◽  
Stacey A. Missmer
Keyword(s):  
In Vitro Fertilization ◽  
Pregnancy Loss ◽  
Second Trimester ◽  
Vitro Fertilization ◽  
Factors Associated ◽  
Trimester Pregnancy ◽  
Second Trimester Pregnancy

scholarly journals Risk factors associated with the antimicrobial resistance of Staphylococcus aureus isolated from bovine mastitis

2014 ◽  
Vol 34 (10) ◽  
pp. 947-952 ◽  
Author(s):  
Daniele C. Beuron ◽  
Cristina S. Cortinhas ◽  
Bruno G. Botaro ◽  
Susana N. Macedo ◽  
Juliano L. Gonçalves ◽  
...  
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Antimicrobial Resistance ◽  
Antimicrobial Susceptibility ◽  
Management Practices ◽  
Bovine Mastitis ◽  
Factors Associated ◽  
Milk Samples ◽  
Treatment Procedures

The objective of this study was to evaluate herd management practices and mastitis treatment procedures as risk factors associated with Staphylococcus aureus antimicrobial resistance. For this study, 13 herds were selected to participate in the study to evaluate the association between their management practices and mastitis treatment procedures and in vitro antimicrobial susceptibility. A total of 1069 composite milk samples were collected aseptically from the selected cows in four different periods over two years. The samples were used for microbiological culturing of S. aureus isolates and evaluation of their antimicrobial susceptibility. A total of 756 samples (70.7%) were culture-positive, and S. aureus comprised 27.77% (n=210) of the isolates. The S. aureus isolates were tested using the disk-diffusion susceptibility assay with the following antimicrobials: ampicillin 10mg; clindamycin 2μg; penicillin 1mg; ceftiofur 30μg; gentamicin 10mg; sulfa-trimethoprim 25μg; enrofloxacin 5μg; sulfonamide 300μg; tetracycline 30μg; oxacillin 1mg; cephalothin 30μg and erythromycin 5μg. The variables that were significantly associated with S. aureus resistance were as follows: the treatment of clinical mastitis for ampicillin (OR=2.18), dry cow treatment for enrofloxacin (OR=2.11) and not sending milk samples for microbiological culture and susceptibility tests, for ampicillin (OR=2.57) and penicillin (OR=4.69). In conclusion, the identification of risk factors for S. aureus resistance against various mastitis antimicrobials is an important information that may help in practical recommendations for prudent use of antimicrobial in milk production.

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