scholarly journals A Phytochemical Investigation of Zanthoxylum setulosum

2011 ◽  
Vol 6 (12) ◽  
pp. 1934578X1100601 ◽  
Author(s):  
Tameka M. Walker ◽  
Bernhard Vogler ◽  
Debra M. Moriarity ◽  
William A. Haber ◽  
William N. Setzer
Keyword(s):  
Costa Rica ◽  
Bark Extract ◽  
Spectroscopic Techniques ◽  
First Report ◽  
H Nmr ◽  
Phytochemical Investigation ◽  
Phytochemical Studies ◽  
Mcf 7 ◽  
C Nmr

The crude bark extract of Zanthoxylum setulosum from Monteverde, Costa Rica was notably cytotoxic (100% kill at 100 μg/mL) to MCF-7, MDA-MB-231, and MDA-MB-468 cells in vitro. Phytochemical studies of the bark extract revealed the triterpenoid lupeol, the lignan sesamin, the sesquiterpene sesquichamaenol, and the xanthone lichexanthone. This is the first report of the isolation of sesquichamaenol and lichexanthone from the bark extract of Z. setulosum. All structures were determined using NMR spectroscopic techniques (1H NMR and 13C NMR) and GCMS and by comparison with literature data. Lupeol proved to be the cytotoxic component of Z. setulosum bark.

Morphological and in vitro evaluation of programmed cell death in MCF-7 cells by new organoruthenium(ii) complexes

2017 ◽  
Vol 41 (16) ◽  
pp. 8620-8636 ◽  
Author(s):  
G. Devagi ◽  
F. Reyhaneh ◽  
F. Dallemer ◽  
R. Jayakumar ◽  
P. Kalaivani ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Spectroscopic Techniques ◽  
In Vitro Evaluation ◽  
H Nmr ◽  
Thiosemicarbazone Complexes ◽  
Mcf 7 ◽  
C Nmr

Cyclopentadienyl ruthenium(ii) thiosemicarbazone complexes with the formula [Ru(η5-C5H5)(Ac-tsc)PPh3]·Cl (1), [Ru(η5-C5H5)(Ac-mtsc)PPh3]·Cl (2), [Ru(η5-C5H5)(Ac-etsc)PPh3]·Cl (3) and [Ru(η5-C5H5)(Ac-ptsc)PPh3] (4) were synthesized and characterized by various spectroscopic techniques (1H NMR,13C NMR, IR and UV-vis).

scholarly journals A Phytochemical Investigation of Nectandra membranacea from Monteverde, Costa Rica

2006 ◽  
Vol 1 (6) ◽  
pp. 1934578X0600100 ◽  
Author(s):  
Xiujun Wu ◽  
Bernhard Vogler ◽  
William A. Haber ◽  
William N. Setzer
Keyword(s):  
Costa Rica ◽  
Human Tumor ◽  
Bark Extract ◽  
Chemical Components ◽  
Human Tumor Cell Lines ◽  
Gram Positive Bacteria ◽  
Phytochemical Investigation ◽  
Leaf Essential Oil ◽  
First Time

Bioactivity screening of Nectandra membranacea from Monteverde, Costa Rica, revealed that the crude bark extract has in-vitro cytotoxic activity against the Hep G2 and MDA-MB-231 human tumor cell lines, as well as antimicrobial activity against the Gram-positive bacteria Bacillus cereus and Staphylococcus aureus, and the yeast Candida albicans. Phytochemical investigation of the bark extract has yielded three eudesmane sesquiterpenes, ilicic acid, costic acid, and 3-isocostic acid. These three sesquiterpenes have been isolated from the Lauraceae family for the first time. All the structures have been confirmed using NMR spectroscopic and MS techniques. The leaf essential oil of N. membranacea has been obtained by hydrodistillation and the chemical components have been identified by GC-MS techniques. The oil is dominated by terpenoid hydrocarbons.

scholarly journals Cytotoxic Xanthones from the Leaves of Garcinia Urophylla

2007 ◽  
Vol 2 (3) ◽  
pp. 1934578X0700200 ◽  
Author(s):  
Rozida Mohd Khalid ◽  
Md. Lip Jabit ◽  
Faridah Abas ◽  
Johnson Stanslas ◽  
Khozirah Shaari ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cytotoxic Activities ◽  
Spectroscopic Techniques ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
H Nmr ◽  
Mcf 7 ◽  
C Nmr

Two new xanthones, 7-hydroxydesoxymorellin (1) and isocaledonixanthone D (2), and four known ones, gaudichaudione H, 1,7-dihydroxy-3-methoxy-2-(3-methyl-2-butenyl)xanthone, 1,5-dihydroxy-3-methoxy-2-(3-methyl-2-butenyl)xanthone, and 1,3,7-trihydroxy-2-(3-methyl-2-butenyl)xanthone, as well as lupeol were isolated from the leaves of Garcinia urophylla (Guttiferae). Their structures were determined using a combination of 1D (1H NMR, 13C NMR, DEPT) and 2D (COSY, gHSQC, gHMBC) NMR spectroscopic techniques. Among the isolates, 7-hydroxydesoxymorellin (1), gaudichaudione H, 1,5-dihydroxy-3-methoxy-2-(3-methyl-2-butenyl)xanthone, and 1,3,7-trihydroxy-2-(3-methyl-2-butenyl)xanthone demonstrated cytotoxic activities against breast (MCF-7), prostate (DU-145), and lung (NCI-H460) human cancer cell lines.

scholarly journals Cytotoxic and Antileishmanial Components from the Bark Extract of Ruyschia phylladenia from Monteverde, Costa Rica

2017 ◽  
Vol 12 (1) ◽  
pp. 1934578X1701200 ◽  
Author(s):  
Kelly Marie Steinberg ◽  
Samon Shrestha ◽  
Noura S. Dosoky ◽  
Lianet Monzote ◽  
Abel Piñón ◽  
...  
Keyword(s):  
Costa Rica ◽  
Betulinic Acid ◽  
Human Tumor ◽  
Bark Extract ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Isolation And Identification ◽  
Human Tumor Cell Lines ◽  
Mcf 7

The bark of Ruyschia phylladenia was collected from Monteverde, Costa Rica, and extracted with acetone. Bioactivity-directed chromatographic separation of the crude acetone bark extract of R. phylladenia led to isolation and identification of lupeol, betulinic acid, and isofraxidin. Lupeol and betulinic acid showed in-vitro cytotoxic activity to MCF-7, MDA-MB-231, and 5637 human tumor cell lines. Isofraxidin was not cytotoxic, but did show antileishmanial activity to Leishmania amazonensis promastigotes.

scholarly journals Synthesis, Characterization, and Biological Activity of 4-(2-Hydroxy-5-(aryl-diazenyl)phenyl)-6-(aryl)pyrimidin-2-ols Derivatives

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Chandrashekhar P. Pandhurnekar ◽  
Ekta M. Meshram ◽  
Himani N. Chopde ◽  
Rameshkumar J. Batra
Keyword(s):  
Spectroscopic Techniques ◽  
Pyrimidine Derivatives ◽  
Mass Spectral ◽  
H Nmr ◽  
Antibacterial And Antifungal Activities ◽  
Biological Potency ◽  
Antibacterial And Antifungal ◽  
Anti Fungal ◽  
C Nmr

With the aim of synthesizing new heterocyclic compounds and exploring biological potency, new series of chalcones, that is, 3-(2-hydroxy-5-(aryl-diazenyl)phenyl)-1-(aryl)prop-2-en-1-one and their pyrimidine derivatives, that is, 4-(2-hydroxy-5-(aryl-diazenyl)phenyl)-6-(aryl)pyrimidin-2-ols were synthesized using different aromatic amines and salicylaldehyde as starting moieties. The structures of newly synthesized compounds were confirmed using different spectroscopic techniques such as IR, 1H-NMR, 13C-NMR, and mass spectral analysis, and elemental analysis. The newly synthesized pyrimidines derivatives were screened for their in vitro antibacterial and antifungal activities. It was observed that some of the newly synthesized compounds had shown promising activity against several bacterial and fungal stains. Anti-bacterial activity and anti-fungal activity studies revealed that pyrimidine derivatives consisting of nitro group in their molecular structure possess better activity than their corresponding chalcones.

scholarly journals Isolation, Characterization and Anti-Inflammatory Property ofThevetia Peruviana

2010 ◽  
Vol 7 (4) ◽  
pp. 1584-1590 ◽  
Author(s):  
R. Thilagavathi ◽  
Helen P. Kavitha ◽  
B. R. Venkatraman
Keyword(s):  
Seed Oil ◽  
Bacterial Activity ◽  
H Nmr ◽  
Thevetia Peruviana ◽  
Anti Inflammatory ◽  
Isolated Compound ◽  
Phytochemical Studies ◽  
Inflammatory Character ◽  
C Nmr

Thevetia peruvianaseeds contain glucosides of neriifolin, acetylneriifolin and thevetin. Seed oil distillates ofThevetia peruvianahave been found to contain anti-bacterial activity. In the persent work, the fresh flowers ofThevetia peruvianawas subjected to phytochemical studies. The results of the study showed that the flowers contain quercetin, kaempferol and quercetin-7-o-galactoside. The structure of the isolated compound was characterized by UV,1H NMR and13C NMR spectra. The anti-inflammatory character of the isolated compound was tested byin vitromethod and the results of the study revealed that the isolated compound showed a biphasic property.

scholarly journals Diorganotin(iv) benzyldithiocarbamate complexes: synthesis, characterization, and thermal and cytotoxicity study

2020 ◽  
Vol 18 (1) ◽  
pp. 453-462
Author(s):  
Jerry O. Adeyemi ◽  
Damian C. Onwudiwe ◽  
Nirasha Nundkumar ◽  
Moganavelli Singh
Keyword(s):  
Cell Lines ◽  
Human Tumor ◽  
Complexation Reaction ◽  
Spectroscopic Techniques ◽  
X Ray Diffraction ◽  
Human Tumor Cell Lines ◽  
H Nmr ◽  
Cytotoxicity Studies ◽  
Final Residue ◽  
Mcf 7

AbstractAmmonium benzyldithiocarbamate, represented as NH4L, was prepared and used in the complexation reaction involving three organotin(iv) salts, represented as R2SnCl2 (R = CH3, C4H9, and C6H5). The structures of the synthesized complexes [(CH3)2SnL2] (1), [(C4H9)2SnL2] (2), and [(C6H5)2SnL2] (3) were established using various spectroscopic techniques (Fourier transform infrared spectroscopy, 1H NMR, 13C NMR, and 119Sn NMR) and elemental analysis. Thermal decomposition of the complexes using thermogravimetric analysis under nitrogen showed no definite pathway in the pattern of the complexes even though they are structurally related. X-ray diffraction studies of the final residue showed a common diffraction pattern for the complexes and confirmed SnS as the product of the thermal treatment. Cytotoxicity studies of these complexes against the human tumor cell lines (HeLa and MCF-7) compared favorably with the used standard 5-fluorouracil drug, with complexes 2 and 3 showing very good activity toward the used cell lines.

scholarly journals SYNTHESIS AND STRUCTURAL ELUCIDATION OF AMINO ACETYLENIC AND THIOCARBAMATES DERIVATIVES FOR 2-MERCAPTOBENZOTHIAZOLE AS ANTIMICROBIAL AGENTS

2017 ◽  
Vol 9 (2) ◽  
pp. 192
Author(s):  
Aseel Alsarahni ◽  
Zuhair Muhi Eldeen ◽  
Elham Al-kaissi ◽  
Ibrahim Al- Adham ◽  
Najah Al-muhtaseb
Keyword(s):  
Antimicrobial Activity ◽  
Elemental Analysis ◽  
Antimicrobial Agents ◽  
Diffusion Method ◽  
Benzothiazole Derivatives ◽  
H Nmr ◽  
Ft Ir ◽  
Potential Antimicrobial Activity ◽  
C Nmr

<p><strong>Objective: </strong>To design and synthesize amino acetylenic and thiocarbonate of 2-mercapto-1,3-benthiazoles as potential antimicrobial agents.</p><p><strong>Methods: </strong>A new series of 2-{[4-(t-amino-1-yl) but-2-yn-1-yl] sulfanyl}-1,3-benzothiazole derivatives (AZ1-AZ6), and S-1,3-benzothiazol-2-yl-O-alkyl carbonothioate derivatives were synthesised, with the aim that the target compounds show new and potential antimicrobial activity. The elemental analysis was indicated by the EuroEA elemental analyzer, and biological characterization was via IR, <sup>1</sup>H-NMR, [13]C-NMR, DSC were determined with the aid of Bruker FT-IR and Varian 300 MHz spectrometer using DMSO-d<sub>6</sub> as a solvent.<em> </em><em>In vitro </em>antimicrobial activity, evaluation was done for the synthesised compounds, by agar diffusion method and broth dilution test. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were determined. <em></em></p><p><strong>Results: </strong>The IR, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, DSC and elemental analysis were consistent with the assigned structures. Compound of 2-{[4-(4-methylpiperazin-1-yl)but-2-yn-1-yl] sulfanyl}-1,3-benzothiazole (AZ1), 2-{[4-(2-methylpiperidin-1-yl)but-2-yn-1-yl]sulfanyl}-1,3-benzothiazole (AZ2), 2-{[4-(piperidin-1-yl) but-2-yn-1-yl]sulfanyl}-1, 3-benzothiazole (AZ6), S-1,3-benzothiazol-2-yl-O-ethyl carbonothioate (AZ7), and S-1,3-benzothiazol-2-yl-O-(2-methylpropyl) carbonothioate (AZ9) showed the highest antimicrobial activity against <em>Pseudomonas aeruginosa </em>(<em>P. aeruginosa</em>), AZ-9 demonstrated the highest antifungal activity against <em>Candida albicans </em>(<em>C. albicans</em>), with MIC of 31.25 µg/ml.</p><p><strong>Conclusion: </strong>These promising results promoted our interest to investigate other structural analogues for their antimicrobial activity further.</p>

scholarly journals Two New Glycosides from Conyza bonariensis

2010 ◽  
Vol 5 (7) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Aqib Zahoor ◽  
Imran Nafees Siddiqui ◽  
Afsar Khan ◽  
Viqar Uddin Ahmad ◽  
Amir Ahmed ◽  
...  
Keyword(s):  
2D Nmr ◽  
Mass Spectrometric ◽  
Spectroscopic Techniques ◽  
H Nmr ◽  
Alkyl Glycoside ◽  
Conyza Bonariensis ◽  
C Nmr

Studies on Conyza bonariensis (L.) Cronq. led to the isolation of two new glycosides trivially named as erigeside E and F (1–2), along with two new source compounds; benzyl-β-D-glucopyranoside (3) and 2-phenylethyl-β-D-glucopyranoside (4). Compounds 1, 3, and 4 are aromatic glycosides, while compound 2 is an alkyl glycoside. Their structures were elucidated through mass spectrometric, and 1D- and 2D-NMR spectroscopic techniques, including 1H NMR, 13C NMR, HMQC, HSQC and HMBC.

scholarly journals A New Bioactive Steroidal Saponin from Leaves of Furcraea gigantea

2006 ◽  
Vol 61 (9) ◽  
pp. 1153-1157 ◽  
Author(s):  
Bernadete P. da Silva ◽  
José P. Parente
Keyword(s):  
Nmr Spectra ◽  
Capillary Permeability ◽  
Structural Identification ◽  
2D Nmr ◽  
In Vitro Assays ◽  
Steroidal Saponin ◽  
Spectroscopic Techniques ◽  
C Nmr

Abstract A new bidesmosidic furostanol saponin was isolated from leaves of Furcraea gigantea Vent. Its structure was established as 3-[(O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β -D-glucopyranosyl-( 1→3)-O-[O-β -D-glucopyranosyl-(1→3)-β -D-glucopyranosyl-(1→2)-O-β -D-glucopyranosyl- (1→4)-β -D-galactopyranosyl)oxy]-(3β ,5α,15α,22α,25R)-26-(β -D-glucopyranosyloxy)-15,22-dihydroxy- furost-12-one. Its structural identification was performed using detailed analyses of 1H and 13C NMR spectra including 2D NMR spectroscopic techniques (DEPT, COSY, HETCOR and COLOC) and chemical conversions. The steroidal saponin showed no haemolytic effects in the in vitro assays and demonstrated inhibition of the capillary permeability activity.

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