New Chromone and Triglyceride from Cucumis melo Seeds

Re-investigation of the MeOH extract of the seeds of Cucumis melo L. var. reticulatus (Cucurbitaceae) led to the isolation of a new chromone derivative (5,7-dihydroxy-2-[2-(3-methoxy-4-hydroxyphenyl)ethyl]chromone (5) and a triglyceride (1,3-di-(6 Z,9 Z)-docosa-6,9-dienoyl-2-(6 Z) hexacos-6-enoylglycerol (1), together with three known compounds; α-spinasterol (2), stigmasta-7,22,25-trien-3-ol (3), and D:B-friedoolean-5-ene-3-β-ol (4), are reported from this species for the first time. Their structures were determined by extensive 1D (1H, 13C, and DEPT) and 2D (1H-1H COSY, HMQC, and HMBC) NMR and mass spectral measurements. Compound 5 displayed significant cytotoxic activity against L5178Y cells, with an ED50 of 5 μM. The MeOH extract and 5 showed antioxidant activity using the DPPH assay.

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In-vitro antioxidant, anti-inflammatory and cytotoxic activity of Cucumis melo L. of ethanolic extract

Biomedicine ◽

10.51248/.v41i2.1054 ◽

2021 ◽

Vol 41 (2) ◽

pp. 439-442

Author(s):

G. Malathi ◽

J. Vadivelu

Keyword(s):

Antioxidant Activity ◽

Cytotoxic Activity ◽

Cucumis Melo ◽

Protein Denaturation ◽

Ethanolic Extract ◽

Cytotoxic Activities ◽

Dpph Method ◽

Anti Inflammatory ◽

Cucumis Melo L

Introduction and Aim: Cucumis melo L. commonly known as wild melon (in English) belongs to the family Cucurbitaceae and well distributed in rural areas. Cucumis melo L. is a annual climbing or perennial herb, distributed almost throughout India and neighbouring countries. Nowadays food wastes are a major concern. On the other hand, the demand for natural valuable compounds to human health is increasing. These by-products contain phytochemical compounds with great nutritional and functional potentials. The fruits of this plant possess the abortifacient property and have antitussive, antioxidant, digestive, cytotoxic and anti-inflammatory properties. Materials and Methods: The ethanolic extract was used to determine the antioxidant scavenging activity using DPPH method, protein denaturation for anti inflammatory studies, as well as in vitro cytotoxic activity by brine shrimp lethal assay (BSLA). Results: The results obtained indicated highest antioxidant activity as compared to DPPH methods. The protein denaturation test showed the ethanolic extracts of Cucumis melo L. had effective anti-inflammatory activity. Extracts of Cucumis melo L. also registered potential cytotoxic activities by BSLA. This study provides the basis for further investigation of Cucumis melo L. for potential identification of novel bioactive compounds with therapeutic properties. Conclusion: The presence of phytoconstituents such as flavonoids, terpenoids, alkaloids, may indeed assist to the antioxidant activity of fruit extract. That this next thing that must be done will be to conduct in vivo experiments and discern the histopathological mechanism.

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Antioxidant activity of melon fruit (Cucumis melo L. ‘GMP’) ethanolic extract

10.1063/5.0015748 ◽

2020 ◽

Author(s):

Muhammad Zulfikar ◽

Faiza Senja Widya ◽

Wiko Arif Wibowo ◽

Budi Setiadi Daryono ◽

Slamet Widiyanto

Keyword(s):

Antioxidant Activity ◽

Cucumis Melo ◽

Ethanolic Extract ◽

Cucumis Melo L ◽

Melon Fruit

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Chemical Constituents of the Roots and Rhizomes of Saposhnikovia divaricata and their Cytotoxic Activity

Natural Product Communications ◽

10.1177/1934578x1701200229 ◽

2017 ◽

Vol 12 (2) ◽

pp. 1934578X1701200 ◽

Cited By ~ 2

Author(s):

Akihito Yokosuka ◽

Satoru Tatsuno ◽

Takuma Komine ◽

Yoshihiro Mimaki

Keyword(s):

Cytotoxic Activity ◽

Apoptotic Cell ◽

Chemical Constituents ◽

Leukemia Cells ◽

Caspase 9 ◽

Meoh Extract ◽

Apoptotic Pathway ◽

Phytochemical Investigation ◽

Saposhnikovia Divaricata ◽

First Time

Phytochemical investigation of the MeOH extract of the roots and rhizomes of Saposhnikovia divaricata (Umbelliferae) resulted in the isolation of six chromons (1-6) and five polyacetylene derivatives (7-11). Compounds 9 and 11 were isolated from S. divaricate for the first time. The chromon derivatives (1-6) were evaluated for their cytotoxic activity against HL-60 human promyelocytic leukemia cells. Compound 1 (3′- O-angeloylhamaudol) showed the most potent cytotoxic activity with an IC50 value of 4.41 μM and was found to induce apoptotic cell death in HL-60 cells. The loss of mitochondrial membrane potential, release of cytochrome c into the cytoplasm, and activation of caspase-9 in the 1-treated HL-60 cells suggests that 1 induces apoptosis through the mitochondrial-dependent apoptotic pathway.

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Cytotoxic Sesquiterpene Lactones of Egyptian Tanacetum santolinoides

Natural Product Communications ◽

10.1177/1934578x0700200801 ◽

2007 ◽

Vol 2 (8) ◽

pp. 1934578X0700200 ◽

Cited By ~ 2

Author(s):

Diaa T. A. Youssef ◽

Mahmoud A. Ramadan ◽

Sabrin R. M. Ibrahim ◽

Jihan M. Badr

Keyword(s):

Cytotoxic Activity ◽

Brine Shrimp ◽

Nmr Spectra ◽

Methanolic Extract ◽

Soluble Fraction ◽

Sesquiterpene Lactones ◽

Natural Source ◽

Mass Spectral ◽

Aerial Parts ◽

First Time

The chloroform soluble fraction of the methanolic extract of the aerial parts of Tanacetum santolinoides afforded six sesquiterpene lactones. Tanacetolide A (1) was isolated for the first time from a natural source, in addition to five known sesquiterpene lactones. The structures were established on the basis of extensive studies of their 1D and 2D (1H-1H COSY, HMQC, HMBC, HOHAHA and NOESY) NMR spectra and FAB mass spectral determinations. The compounds showed good cytotoxic activity when tested using the brine shrimp bioassay.

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KARAKTERISTIK PERMEN JELLY TIMUN SURI (Cucumis melo L.) DENGAN PENAMBAHAN SORBITOL DAN EKSTRAK KUNYIT (Curcuma domestika Val.)

Jurnal Gizi dan Pangan ◽

10.25182/jgp.2010.5.2.78-86 ◽

2010 ◽

Vol 5 (2) ◽

pp. 78 ◽

Cited By ~ 1

Author(s):

Merynda Indriyani Syafutri ◽

Eka Lidiasari ◽

Hendra Indawan

Keyword(s):

Antioxidant Activity ◽

Water Content ◽

Cucumis Melo ◽

Total Sugar ◽

Font Size ◽

Chemical Laboratory ◽

Randomized Design ◽

S Factor ◽

Agricultural Faculty ◽

Cucumis Melo L

The objective of this research was to determine the chemical and organoleptic characteristics of Cucumis melo L. jelly candies with the addition of sorbitol and Curcuma domestika Val. extract. This research was conducted in the Chemical Laboratory of Agricultural, Department of Agricultural Technology, Agricultural Faculty, Sriwijaya University, Indralaya, from January 2010 to June 2010.This research used a Factorial Completely Randomized Design with two treatments and three replications for each treatment. S factor was the addition of sorbitol concentration (9%, 16% and 23%) and E was the concentration factor addition of Curcuma domestika Val. extract (5%, 7% and 9%). The results showed that the addition of sorbitol concentration had significant effect on the water content, pH, total sugar and antioxidant activity of Cucumis melo L. jelly candies. The addition of Curcuma domestika Val. extract had significant effect on the water content and antioxidant activity of Cucumis melo L. jelly candies. Interaction addition of sorbitol and Curcuma domestika Val. extract had significant effect on the antioxidant activity of jelly candies.S2E2 treatment (sorbitol 20% and 7.5% Curcuma domestika Val. extract) was the best treatment with chemical characteristics (water content 36.48%, ash content 3.01%, pH 5.03, total sugar 37.00% and the antioxidant activity 27.09%), and sensory characteristics by scoring preferences (color 3.08, texture 2.88, odour 3.08 and taste 2.88).

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New 2-(2-Phenylethyl)chromone Derivatives from the Seeds of Cucumis melo L var. reticulatus

Natural Product Communications ◽

10.1177/1934578x1000500313 ◽

2010 ◽

Vol 5 (3) ◽

pp. 1934578X1000500 ◽

Cited By ~ 2

Author(s):

Sabrin R. M. Ibrahim

Keyword(s):

Antimicrobial Activity ◽

Cytotoxic Activity ◽

Brine Shrimp ◽

Cucumis Melo ◽

Spectroscopic Data ◽

Methanolic Extract ◽

2D Nmr ◽

Chromone Derivatives ◽

Methanolic Extracts ◽

Cucumis Melo L

Chemical investigation of the methanolic extract of the seeds of Cucumis melo L. var. reticulatus (Cucurbitaceae) afforded three new chromone derivatives; 5,7-dihydroxy-2-[2-(4-hydroxyphenyl)ethyl]chromone 3, 5,7-dihydroxy-2-[2-(3,4-dihydroxyphenyl)ethyl]chromone 4, and 7-glucosyloxy-5-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]chromone 6, together with three known compounds; β-amyrin 1, β-sitosterol 2, and β-sitosterol-3- O-β-glucopyranoside 5. Their structures were established by UV, IR, 1D and 2D NMR, in addition to mass spectroscopic data and comparison with literature data. The n-hexane and methanolic extracts were evaluated for their antimicrobial activity, as well as cytotoxic activity using the brine shrimp bioassay.

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A comparative study of bioactive compounds, antioxidant activity and phenolic compounds of melon ( Cucumis melo L.) slices dehydrated by oven, microwave and infrared systems

Journal of Food Processing and Preservation ◽

10.1111/jfpp.15605 ◽

2021 ◽

Author(s):

Isam A. Mohamed Ahmed ◽

Fahad Al Juhaimi ◽

Mehmet Musa Özcan ◽

Nurhan Uslu ◽

Elfadıl E Babiker ◽

...

Keyword(s):

Antioxidant Activity ◽

Phenolic Compounds ◽

Comparative Study ◽

Bioactive Compounds ◽

Cucumis Melo ◽

Cucumis Melo L

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Determination of Volatile Constituents of Cucumis melo L. var. aegyptiacus cv. Ismailawi Fruits and Evaluation of Its Cytotoxic Activity

Journal of Advanced Pharmacy Research ◽

10.21608/aprh.2019.18355.1091 ◽

2020 ◽

Vol 0 (0) ◽

pp. 0-0

Author(s):

Nagwan Gabr ◽

Suzan Mina ◽

Jaky Talat ◽

Sherifa Fahmy

Keyword(s):

Cytotoxic Activity ◽

Cucumis Melo ◽

Volatile Constituents ◽

Cucumis Melo L

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In vitro antioxidant activity and gastroprotective effect of ethanolic extract from Cucumis melo L. var. inodorus fruit on ethanol-induced gastric ulcer in rats

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v10i5-s.4529 ◽

2020 ◽

Vol 10 (5-s) ◽

pp. 302-307

Author(s):

Amel Bouaziz ◽

Assia Bentahar ◽

Saliha Djidel ◽

Saliha Dahamna ◽

Seddik Khennouf

Keyword(s):

Antioxidant Activity ◽

Gastric Ulcer ◽

Hydroxyl Radical ◽

Cucumis Melo ◽

Radical Scavenging ◽

Ethanolic Extract ◽

Dry Extract ◽

Cucumis Melo L ◽

In Vitro Antioxidant Activity

The aim of this study was to estimate the content of polyphenols, flavonoids and tannins and to evaluate the antioxidant property and the antiulcer activity of the ethanolic extract of melon (Cucumis melo L. var. inodorus) pulp on ethanol-induced gastric ulcers in rats. Ferric reducing power and hydroxyl radical scavenging tests were applied to evaluate the in vitro antioxidant activity. The polyphenolic and flavonoids contents of melon extract were found to be 56.5 ± 2.49 mg GAE/g of dry extract and 0.43 ± 0.09 mg QE/ g of dry extract, respectively. Whereas the tannins content was 48. 30 ± 0. 9 mg ETA/ g of dry extract. Melon pulp extract exhibited a good reducing potential with an EC50 of 4.23 ± 0.08 mg/ml and high hydroxyl radical scavenging activity with IC50 of 1.83± 0.09 mg/ml. Oral administration of the melon pulp extract at doses of 200 and 600 mg/kg to rats reduced gastric mucosal lesions dose-dependently with percentage protection of 56.56 and 93.79% compared to omeprazole (95.92 %) as reference drug. These results showed that the melon pulp extract had a good antioxidant activity and gastroprotective potential suggesting it use as an adjuvant in the treatment of gastric ulcer. Keywords: Cucumis melo var. inodorus, Polyphenols, Flavonoids, Tannins, Ulcer, Rat.

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An Evaluation of the Antioxidant Activity of a Methanolic Extract of Cucumis melo L. Fruit (F1 Hybrid)

Separations ◽

10.3390/separations8080123 ◽

2021 ◽

Vol 8 (8) ◽

pp. 123

Author(s):

R. S. Rajasree ◽

Sibi P. Ittiyavirah ◽

Punnoth Poonkuzhi Naseef ◽

Mohamed Saheer Kuruniyan ◽

G. S. Anisree ◽

...

Keyword(s):

Nitric Oxide ◽

Antioxidant Activity ◽

Cucumis Melo ◽

Methanolic Extract ◽

Antioxidant Activities ◽

Reducing Power ◽

Total Antioxidant Activity ◽

F1 Hybrid ◽

Total Antioxidant ◽

Cucumis Melo L

Cucumis melo L. (C. melo) is a fruit with many medicinal properties and is consumed in various countries. It is utilised for chronic eczema and to treat minor burns and scrapes. The present study was conducted to evaluate the antioxidant activity of a methanolic extract of Cucumis melo Linn (MECM). A coarse powder prepared from the fruit and seeds was extracted with methanol (absolute) by a hot continuous percolation process in accordance with the standard protocols. All the extracts were estimated for potential antioxidant activities with tests such as an estimation of total antioxidant activity, hydroxyl radical and nitric oxide scavenging activity and reducing power ability. The qualitative analysis of the methanolic extract of C. melo fruit showed the presence of various phytochemical constituents such as carbohydrates, alkaloids, sterols, phenolic compounds, terpenes and flavonoids. The total antioxidant activity of concentrations of 50, 100 and 200 µg were tested and observed to be 3.3 ± 0.1732, 6.867 ± 0.5457 and 13.63 ± 0.8295 µg of ascorbic acid, respectively. The results also showed significant nitric oxide and DPPH scavenging activities as well as a reducing power activity of MECM. Thus, our results suggest that MECM may serve as a putative source of natural antioxidants for therapeutic and nutraceutical applications.

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