scholarly journals A New Optical Biflavonoid, (2″R)-2″,3″-Dihydrorobustaflavone 7,4′-Dimethyl Ether, and Other Constituents from Selaginella trichoclada Alsto

2019 ◽  
Vol 14 (12) ◽  
pp. 1934578X1988788
Author(s):  
Peng Yang ◽  
Mei-Long Lu ◽  
Ke Li ◽  
Qun Zhou
Keyword(s):  
Dimethyl Ether ◽  
Spectroscopic Data ◽  
High Performance ◽  
Human Cancer ◽  
Ethanol Extract ◽  
Racemic Compound ◽  
Chiral Phase ◽  
Human Cancer Cell Lines ◽  
First Time ◽  
Mcf 7

A new optical biflavonoid, (2” R)-2″,3″-dihydrorobustaflavone 7,4′-dimethyl ether (1), and 6 known compounds (2-7) were isolated for the first time from the 70% ethanol extract of Selaginella trichoclada Alsto. The structures of the compounds were confirmed by extensive spectroscopic data analyses. Racemic compound 1 was separated by chiral-phase high-performance liquid chromatography, and the absolute configurations of (±)-1 were defined by circular dichroism spectroscopic data. Compound 1 exhibited moderate cytotoxicity against MCF-7, A549, and HepG2 human cancer cell lines.

Cytotoxic Thiophenes from the Root of Echinops grijisii Hance

2009 ◽  
Vol 64 (3-4) ◽  
pp. 193-196 ◽  
Author(s):  
Peng Zhang ◽  
Dong Liang ◽  
Wenrong Jin ◽  
Haibin Qu ◽  
Yiyu Cheng ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Spectroscopic Data ◽  
Human Cancer ◽  
Ethanol Extract ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
First Time

A new thiophene, echinothiophenegenol (1), together with seven known thiophenes was isolated from the crude ethanol extract of roots of Echinops grijisii Hance. The structure of 1 was elucidated on the basis of spectroscopic data. Compounds 2 and 5, isolated from the plant for the first time, and compounds 1 - 7 were tested for their cytotoxicity against two human cancer cell lines, HL60 and K562. The thiophenes showed better activity than the bithiophenes

Cytotoxic constituents of Alocasia macrorrhiza

2017 ◽  
Vol 72 (1-2) ◽  
pp. 21-25 ◽  
Author(s):  
Marwa Elsbaey ◽  
Kadria F.M. Ahmed ◽  
Mahmoud F. Elsebai ◽  
Ahmed Zaghloul ◽  
Mohamed M.A. Amer ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Spectroscopic Data ◽  
Human Cancer ◽  
Indole Alkaloid ◽  
Acid Methyl Ester ◽  
2D Nmr ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Acid Methyl ◽  
First Time

AbstractAn indole alkaloid, 2-(5-hydroxy-1H-indol-3-yl)-2-oxo-acetic acid (1) isolated for the first time from nature, in addition to the nine known compounds 5-hydroxy-1H-indole-3-carboxylic acid methyl ester (2), alocasin B (3), hyrtiosin B (4), α-monopalmitin (5), 1-O-β-D-glucopyranosyl-(2S, 3R, 4E, 8Z)-2-[(2(R)-hydroctadecanoyl) amido]-4,8-octadecadiene-1,3-diol (6), 3-epi-betulinic acid (7), 3-epi-ursolic acid (8),β-sitosterol (9) andβ-sitosterol 3-O-β-D-glucoside (10) were isolated from the rhizomes ofAlocasia macrorrhiza(Araceae). Their structures were elucidated by 1D and 2D NMR spectroscopic data. Of these compounds,6exhibited the strongest cytotoxicity against the four tested human cancer cell lines (IC50of about 10 µM against Hep-2 larynx cancer cells).

scholarly journals Bauhinia variegataLeaf Extracts Exhibit Considerable Antibacterial, Antioxidant, and Anticancer Activities

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Amita Mishra ◽  
Amit Kumar Sharma ◽  
Shashank Kumar ◽  
Ajit K. Saxena ◽  
Abhay K. Pandey
Keyword(s):  
Cell Lines ◽  
Metal Ion ◽  
Human Cancer ◽  
Reducing Power ◽  
Ethanol Extract ◽  
Anticancer Activities ◽  
Leaf Extracts ◽  
Human Cancer Cell Lines ◽  
Polar Extracts ◽  
Mcf 7

The present study reports the phytochemical profiling, antimicrobial, antioxidant, and anticancer activities ofBauhinia variegataleaf extracts. The reducing sugar, anthraquinone, and saponins were observed in polar extracts, while terpenoids and alkaloids were present in nonpolar and ethanol extracts. Total flavonoid contents in various extracts were found in the range of 11–222.67 mg QE/g. In disc diffusion assays, petroleum ether and chloroform fractions exhibited considerable inhibition againstKlebsiella pneumoniae. Several other extracts also showed antibacterial activity against pathogenic strains ofE. coli,Proteusspp. andPseudomonasspp. Minimum bactericidal concentration (MBC) values of potential extracts were found between 3.5 and 28.40 mg/mL. The lowest MBC (3.5 mg/mL) was recorded for ethanol extract againstPseudomonasspp. The antioxidant activity of the extracts was compared with standard antioxidants. Dose dependent response was observed in reducing power of extracts. Polar extracts demonstrated appreciable metal ion chelating activity at lower concentrations (10–40 μg/mL). Many extracts showed significant antioxidant response in beta carotene bleaching assay. AQ fraction ofB. variegatashowed pronounced cytotoxic effect against DU-145, HOP-62, IGR-OV-1, MCF-7, and THP-1 human cancer cell lines with 90–99% cell growth inhibitory activity. Ethyl acetate fraction also produced considerable cytotoxicity against MCF-7 and THP-1 cell lines. The study demonstrates notable antibacterial, antioxidant, and anticancer activities inB. variegataleaf extracts.

scholarly journals A New Xanthone from the Pericarp of Garcinia mangostana

2013 ◽  
Vol 8 (12) ◽  
pp. 1934578X1300801 ◽  
Author(s):  
Manqin Fu ◽  
Samuel X. Qiu ◽  
Yujuan Xu ◽  
Jijun Wu ◽  
Yulong Chen ◽  
...  
Keyword(s):  
Colorimetric Assay ◽  
Human Cancer ◽  
Ethanol Extract ◽  
2D Nmr ◽  
Hep G2 ◽  
Garcinia Mangostana ◽  
Human Cancer Cell Lines ◽  
Mtt Colorimetric Assay ◽  
Mcf 7

A new prenylxanthone, garcimangostanol (1), was isolated from the EtOAc-soluble partition of the ethanol extract of the pericarp of Garcinia mangostana L., along with three known compounds, namely 8-deoxygartanin (2), 1-isomangostin (3), and garcinone C (4). The structure of compound 1 was elucidated on the basis of its 1D, 2D NMR and MS data. Compounds 1–4 exhibited either significant or moderate cytotoxicity against MCF-7, A549, Hep-G2 and CNE human cancer cell lines in vitro with IC50 values from 4.0 ± 0.3 to 23.6 ± 1.5 μM by MTT colorimetric assay.

scholarly journals Ochroborbone, A New Cytotoxic Indole Alkaloid from Ochrosia borbonica

2017 ◽  
Vol 12 (4) ◽  
pp. 1934578X1701200
Author(s):  
Yan-Ping Liu ◽  
A-Hong Chen ◽  
Ruo-Heng Li ◽  
Hui-Wen Yang ◽  
Hai-Nan Bao ◽  
...  
Keyword(s):  
Human Cancer ◽  
Indole Alkaloid ◽  
Spectroscopic Methods ◽  
Inhibitory Effects ◽  
Human Cancer Cell Lines ◽  
Stems And Leaves ◽  
Monoterpenoid Indole Alkaloid ◽  
First Time ◽  
Mcf 7

A new monoterpenoid indole alkaloid, ochroborbone (1), along with five known alkaloids (2–6), were isolated from the stems and leaves of Ochrosia borbonica. Among them, ochroborbone (1) is a rare C17-nor monoterpenoid indole alkaloid, and the known compounds (2-6) were isolated from Ochrosia for the first time. These structures were established on the basis of extensive spectroscopic methods. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1 and 2 exhibited inhibitory effects with IC50 values comparable with those of cisplatin.

scholarly journals Two New Triterpenes from Basidiomata of the Medicinal and Edible Mushroom, Laetiporus sulphureus

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7090
Author(s):  
Khadija Hassan ◽  
Blondelle Matio Kemkuignou ◽  
Marc Stadler
Keyword(s):  
Secondary Metabolites ◽  
Spectroscopic Data ◽  
Human Cancer ◽  
Edible Mushroom ◽  
Mouse Fibroblast ◽  
Human Cancer Cell ◽  
Mucor Hiemalis ◽  
Natural Sources ◽  
Human Cancer Cell Lines ◽  
Mcf 7

In the search for novel anti-infectives from natural sources, fungi, in particular basidiomycetes, have proven to still harbor so much potential in terms of secondary metabolites diversity. There have been numerous reports on isolating numerous secondary metabolites from genus Laetiporus. This study reports on two new triterpenoids, laetiporins C and D, and four known triterpenes from the fruiting body of L. sulphureus. The structures of the isolated compounds were elucidated based on their 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data in combination with high-resolution electrospray mass spectrometric (HR-ESIMS) data. Laetiporin C exhibited weak antifungal activity against Mucor hiemalis. Furthermore, the compounds showed weak antiproliferative activity against the mouse fibroblast L929 and human cancer cell lines, including KB-3-1, A431, MCF-7, PC-3 and A549.

scholarly journals 13α–Hydroxylucilactaene and Other Metabolites of an Endophytic Strain of Fusarium acuminatum

2007 ◽  
Vol 2 (5) ◽  
pp. 1934578X0700200 ◽  
Author(s):  
Bharat P. Bashyal ◽  
Stanley H. Faeth ◽  
A. A. Leslie Gunatilaka
Keyword(s):  
Spectroscopic Data ◽  
Metastatic Prostate Cancer ◽  
Human Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Human Cancer Cell Lines ◽  
Fusarium Acuminatum ◽  
Relative Stereochemistry ◽  
Normal Human ◽  
Mcf 7

A liquid fermentation culture of Fusarium acuminatum, endophytic in the root of Larrea tritentata, afforded a new furanopyrrolidone, 13α–hydroxylucilactaene (1), together with four known metabolites, NG–391 (2), NG–393 (3), enniatin A (4), and enniatin B (5). The structure and relative stereochemistry of 1 was established by extensive NMR spectral analysis and the known compounds 2 – 5 were identified by comparison of their spectroscopic data with those reported in the literature. The cytotoxicity of all compounds was evaluated in a panel of five human cancer cell lines [NCI–H460 (non-small cell lung), MCF–7 (breast), SF–268 (CNS glioma), MIA Pa Ca–2 (pancreatic carcinoma), PC-3M (metastatic prostate cancer)] and normal human fibroblast (WI–38) cells, and only enniatins A (4) and B (5) were shown to have significant cytotoxic activity.

scholarly journals Flavonoids from Twigs of Millettia pubinervis

2014 ◽  
Vol 9 (12) ◽  
pp. 1934578X1400901
Author(s):  
Zhi Na ◽  
Qi-Shi Song ◽  
Hua-Bin Hu
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Spectroscopic Data ◽  
Human Cancer ◽  
Data Interpretation ◽  
2D Nmr ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Phytochemical Investigation ◽  
Mcf 7

A new flavone, 3-methoxy-5-hydroxy-[2”,3”:7,8] furanoflavone, pubinerone (1), was isolated from the twigs of Millettia pubinervis Kurz, together with ten known flavonoids, karanjin (2), kanjone (3), 3,6-dimethoxy-[2”,3”:7,8] furanoflavone (4), pongaglabrone (5), pongapin (6), pongaflavone (7), 3,6-dimethoxy-6”,6”-dimethylchromene-[2”,3”:7,8] flavone (8), pongachromene (9), 3,6-dimethoxy-3′,4′-methylenedioxy-6”,6”-dimethylchromene-[2”,3”:7,8] flavone (10) and demethoxykanugin (11). This is the first phytochemical investigation of this plant. The structure of compound 1 was elucidated on the basis of spectroscopic data interpretation, including 1D and 2D NMR and HREIMS analysis. The cytotoxicity of 1 against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7 and SW480, was evaluated, but it was inactive (IC50>40μM).

Identification of Biflavones in Ethyl Acetate Fraction from Ethanol Extract of Selaginella doederleinii Hieron

2012 ◽  
Vol 550-553 ◽  
pp. 1862-1865
Author(s):  
Yan Zhang ◽  
Li Yang ◽  
Lin Wang
Keyword(s):  
Physicochemical Properties ◽  
Ethyl Acetate ◽  
Dimethyl Ether ◽  
Spectroscopic Data ◽  
Chemical Constituents ◽  
Ethanol Extract ◽  
Ethyl Acetate Fraction ◽  
Chemical Structures ◽  
Trimethyl Ether ◽  
First Time

The chemical constituents were isolated from the ethyl acetate fraction from ethanol extract of Selaginella doederleinii Hieron by column chromatography on silica gel and Sephadex LH-20. The chemical structures of six biflavones were elucidated on the basis of physicochemical properties and spectroscopic data as amentoflavone (1), robustaflavone 7,4',7''-o-trimethyl ether (2), heveaflavone (3), podocarpusflavone A (4), robustaflavone 4',4'''-o-dimethyl ether (5) and robustaflavone 4'-o-methyl ether (6). Biflavones 2, 4 and 5 were obtained from Selaginella doederleinii Hieron for the first time.

scholarly journals STUDY ON THE ANTIOXIDANT, ANTIBACTERIAL, AND CYTOTOXIC ACTIVITIES IN VITRO OF ROOT EXTRACTS FROM CODONOPSIS JAVANICA IN KON TUM PROVINCE, VIETNAM

2020 ◽  
Vol 1 (1) ◽  
pp. 33-35
Author(s):  
Hai Ha Pham Thi ◽  
Kien Cuong Tran ◽  
Thu Nha Nguyen Thi ◽  
Lan Phan- Hoang Nguyen ◽  
Thanh Luan Nguyen
Keyword(s):  
Human Cancer ◽  
Ethanol Extract ◽  
Herbal Remedies ◽  
Cytotoxic Activities ◽  
Specific Analysis ◽  
Ic50 Value ◽  
Medicinal Properties ◽  
First Time ◽  
Mcf 7

Dangshen Codonopsis javanica performed high medicinal properties in herbal remedies; however, there is currently not much specific analysis for phytochemicals and bioactivities of this plant. In this study, the ethanol extract of C. javanica roots obtained from Kon Tum Province, Vietnam contained several substances as saponin, phenolic acid, terpenoid and alkaloid. The antibacterial effect of the extract showed against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus cereus with the IC50 value of 150, 100, 150 and 90 μg/ml, respectively. The antioxidant capacity of the extract also displayed IC50 value of 46.8 ± 6.8 μg/ml. Moreover, the anticancer ability of the extract exhibited on two human cancer HepG2 cells (IC50 = 83.6 ± 2.7 μg/ml), and MCF-7 cells (IC50 = 95.3 ± 2.3 μg/ml). Hence, this study for the first time provide the basic data for further research of bioactivities of natural compounds Dangshen C. javanica.

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