The Effect of Nasal Steroid and Antihistamine Use on Total Oxidative Stress and Antioxidant Status in the Treatment of Allergic Rhinitis

2020 ◽  
Vol 35 (1) ◽  
pp. 52-58
Author(s):  
Orhan Kemal Kahveci ◽  
Selçuk Kuzu ◽  
Mustafa Altıntaş ◽  
Ayhan Vurmaz ◽  
Sefa Çelik
Keyword(s):  
Oxidative Stress ◽  
Allergic Rhinitis ◽  
Antioxidant Status ◽  
Mometasone Furoate ◽  
Post Treatment ◽  
Blood Samples ◽  
Nasal Steroids ◽  
Nasal Steroid ◽  
Significant Change ◽  
Total Oxidative Stress

Introduction The purpose of this study is to determine the post-treatment levels of total oxidant status (TOS) and total antioxidant status (TAS), that are increased due to pathophysiology, and to compare those with pre-treatment levels in allergic rhinitis patients. Material-Methods: Among 84 patients clinically diagnosed with allergic rhinitis, 31 patients were started only on nasal steroid treatment (mometasone furoate), and 53 patients were started on nasal steroid and oral antihistamine treatment (mometasone furoate + rupatadine fumarate 10 mg). Blood samples were taken from the patients at the first examination and at post-treatment month 1.TAS and TOS were measured from the blood samples. Results While no significant change was determined in mean TAS levels with treatment, a statistically significant decrease was determined in TOS values in post-treatment period (P < .01). There was no significant change in TAS and TOS values of patients only using nasal steroids, while a significant decrease was determined in post-treatment TOS values of patients using both nasal steroids and oral antihistamines (P < .001). It was determined that TOS values of women were significantly lower compared to men, and it was also reduced in seasonal allergic rhinitis compared to perennial allergic rhinitis (P < .05 for both). Conclusion In allergic rhinitis patients, concomitant use of nasal steroids and antihistamines significantly decreases total oxidative stress. It may be stated that the addition of antihistamines to allergic rhinitis treatment positively affects treatment.

Comparison of Salivary Antioxidants and Oxidative Stress Status in Gestational Diabetes Mellitus and Healthy Pregnant Women

2020 ◽  
Vol 20 ◽  
Author(s):  
Fatemeh Ahmadi-Motamayel ◽  
Shima Fathi ◽  
Mohammad Taghi Goodarzi ◽  
Shiva Borzouei ◽  
Jalal Poorolajal ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Pregnant Women ◽  
Oxidative Stress Markers ◽  
Blood Samples ◽  
Stress Markers ◽  
Total Antioxidant ◽  
Total Oxidative Stress ◽  
And Oxidative Stress

Background: One of the most common complications of pregnant women is gestational diabetes mellitus (GDM). Oxidative stress can play an important role in GDM. Objective: The aim of this study was to evaluate salivary antioxidants and oxidative stress markers in GDM. Method: Twenty pregnant women with GDM and 20 healthy pregnant women with normal blood glucose test participated in this study. Five mL of unstimulated saliva samples were collected. Spectrophotometric assay was carried out for sialochemical analysis. Stata software was used for data analysis. Results: The GDM group exhibited no significant difference in salivary total antioxidant capacity and malondialdehyde compared to the healthy control group. All of antioxidants markers, the uric acid, total antioxidant, peroxidase and catalase, decreased in GDM group that the difference of peroxidase and catalase was statistically significant. All of oxidative stress markers, the salivary malondyaldehid, total oxidative stress and total thiol, increased in GDM group. GDM group exhibited significantly higher salivary total oxidative stress levels. Conclusion: Catalase level was significantly lower and total oxidative stress was significantly higher. These two markers might have significant importance and might exhibit early changes compared to other factors in GDM. . Some of salivary antioxidants might have diagnostic, prognostic or therapeutic implications in GDM. Other studies with large sample size on salivary and blood samples need to be done to confirm this properties and salivary samples using instead of blood samples in GDM biomarkers changes.

scholarly journals Decreased Oxidative Stress in Male Patients with Active Phase Ankylosing Spondylitis Who Underwent Whole-Body Cryotherapy in Closed Cryochamber

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Agata Stanek ◽  
Armand Cholewka ◽  
Tomasz Wielkoszyński ◽  
Ewa Romuk ◽  
Aleksander Sieroń
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Ankylosing Spondylitis ◽  
Antioxidant Status ◽  
Active Phase ◽  
Post Treatment ◽  
Whole Body ◽  
Male Patients ◽  
Whole Body Cryotherapy ◽  
The Impact

Objective. The aim of the study was to estimate the impact of whole body cryotherapy (WBC) on oxidative stress when performed in a closed cryochamber on patients with ankylosing spondylitis (AS). Material and methods. The effect of ten WBC procedures lasting 3 minutes a day with a subsequent 60-minute session kinesiotherapy on oxidative stress in male AS patients (WBC group n=16) was investigated. To assess the disease activity, the Bath Ankylosing Spondylitis Diseases Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI) were calculated. The WBC group was compared to the kinesiotherapy only (KT; n=16) group. The routine parameters of oxidative stress (antioxidant enzymatic and nonenzymatic antioxidant status, lipid peroxidation products, total oxidative status (TOS), and oxidative stress index (OSI)) were estimated one day before the beginning and one day after the completion of the research program. Results. After the completion of the treatment in the WBC group, a significant decrease of oxidative stress markers (TOS and OSI) and a significant increase of total antioxidant status were observed. The erythrocyte activity of glutathione peroxidase, glutathione reductase decreased significantly in both groups, but the differences of activity of that enzymes prior to post treatment values (Δ) in the KT group were significantly higher as compared to the WBC group. The activity of erythrocyte catalase and plasma ZnCu isoenzyme of superoxide dismutase showed a decreased tendency; erythrocyte total superoxide dismutase activity showed an increased tendency in the WBC group after the completion of the treatment. The BASDAI and BASFI decreased significantly in both groups, but the differences of value indexes prior to post treatment (Δ) were significantly higher in the WBC than KT group. Conclusion. WBC performed in a closed cryochamber decreases oxidative stress and improves BASDAI and BASFI indexes in male patients during the active phase of ankylosing spondylitis.

scholarly journals Total oxidative stress and antioxidant status in patients with carpal tunnel syndrome

Redox Report ◽  
2012 ◽  
Vol 17 (6) ◽  
pp. 234-238 ◽  
Author(s):  
Ahmet Demirkol ◽  
Murat Uludag ◽  
Neslihan Soran ◽  
Nurten Aksoy ◽  
Kerem Gun ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Carpal Tunnel Syndrome ◽  
Carpal Tunnel ◽  
Antioxidant Status ◽  
Tunnel Syndrome ◽  
Total Oxidative Stress

scholarly journals Uncaria tomentosafor Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
I. L. G. Farias ◽  
M. C. S. Araújo ◽  
J. G. Farias ◽  
L. V. Rossato ◽  
L. I. Elsenbach ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Clinical Trial ◽  
Side Effects ◽  
Antioxidant Status ◽  
Palliative Chemotherapy ◽  
Uncaria Tomentosa ◽  
Blood Samples ◽  
Oxidative Stress Enzymes ◽  
Stress Enzymes ◽  
Immunologic Parameters

To evaluate the effectiveness ofUncaria tomentosain minimizing the side effects of chemotherapy and improving the antioxidant status of colorectal cancer (CRC) patients, a randomized clinical trial was conducted. Patients (43) undergoing adjuvant/palliative chemotherapy with 5-Fluorouracil/leucovorin + oxaliplatin (FOLFOX4) were split into two groups: the UT group received chemotherapy plus 300 mg ofUncaria tomentosadaily and the C group received only FOLFOX4 and served as a control. Blood samples were collected before each of the 6 cycles of chemotherapy, and hemograms, oxidative stress, enzymes antioxidants, immunologic parameters, and adverse events were analyzed. The use of 300 mg ofUncaria tomentosadaily during 6 cycles of FOLFOX4 did not change the analyzed parameters, and no toxic effects were observed.

scholarly journals Changes in the Rate of Lipid Peroxidation in Plasma and Selected Blood Antioxidants before and during Pregnancy in Ewes

2009 ◽  
Vol 78 (2) ◽  
pp. 237-242 ◽  
Author(s):  
Mine Erişir ◽  
Fulya Benzer ◽  
Fatih M. Kandemir
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Glutathione Peroxidase ◽  
Antioxidant Status ◽  
Healthy Male ◽  
Blood Samples ◽  
Awassi Sheep ◽  
Healthy Female

Pregnancy is a condition that favours oxidative stress. The aim of this study was to evaluate the oxidant and antioxidant status by measuring glutathione peroxidase (GSH-Px), catalase (CAT) activities and malondialdehyde (MDA) and glutathione (GSH) concentrations before and during pregnancy in ewes. Twelve healthy female and two healthy male Awassi sheep, aged 4-5 years, weighing approximately 50 - 55 kg each, were used in the study. The ewes’ blood samples were taken before synchronization and during pregnancy (on 25th days of each month of pregnancy). Plasma MDA concentrations in the 2nd and 3rd months of pregnancy in ewes were lower than in the 1st, 4th, 5th months of pregnancy and in the non-pregnant ewes. GSH concentrations and GSH-Px activities during pregnancy were increased (P < 0.01). GSH concentrations and GSH-Px activities were the highest in the 2nd and 3rd months of pregnancy. CAT activities were decreased after the 1st month of pregnancy in ewes (P < 0.001). They were the lowest in the 2nd and 3rd months of pregnancy. The findings of our study show decreased CAT activities and elevated GSH concentrations and GSH-Px activities after the 1st month of pregnancy in ewes. These changes in the indicators under study may indicate a predisposition to oxidative stress in the 2nd and 3rd month of pregnancy in ewes.

Initial and post-treatment total oxidant–antioxidant status and oxidative stress index in male patients with manic episode

2014 ◽  
Vol 218 (1-2) ◽  
pp. 249-251 ◽  
Author(s):  
Tevfik Kalelioglu ◽  
Abdullah Genc ◽  
Nesrin Karamustafalioglu ◽  
Akif Tasdemir ◽  
Ferda Can Gungor ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Status ◽  
Manic Episode ◽  
Post Treatment ◽  
Stress Index ◽  
Oxidative Stress Index ◽  
Male Patients ◽  
And Oxidative Stress

scholarly journals Prospects of Vitamin C as an Additive in Plasma of Stored Blood

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
R. Vani ◽  
R. Soumya ◽  
H. Carl ◽  
V. A. Chandni ◽  
K. Neha ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Vitamin C ◽  
Antioxidant Status ◽  
Oxidation Products ◽  
Blood Storage ◽  
Advanced Oxidation Protein Products ◽  
Blood Samples ◽  
Storage Solutions ◽  
Stored Blood

There is a dire necessity to improve blood storage and prolong shelf-life of blood. Very few studies have focused on oxidative stress (OS) in blood and its influence on plasma with storage. This study attempts to (i) elucidate the continuous changes occurring in plasma during storage through oxidant levels and antioxidant status and (ii) evaluate the influence of vitamin C (VC) as an additive during blood storage. Blood was drawn from maleWistarrats and stored for 25 days at 4°C. Blood samples were divided into control and experimental groups. Plasma was isolated every 5 days and the OS markers, antioxidant enzymes, lipid peroxidation, and protein oxidation products, were studied. Catalase activity increased in all groups with storage. Lipid peroxidation decreased in VC (10) but was maintained in VC (30) and VC (60). Although there were variations in all groups, carbonyls were maintained towards the end of storage. Advanced oxidation protein products (AOPP) increased in VC (30) and were maintained in VC (10) and VC (60). Sulfhydryls were maintained in all groups. Vitamin C could not sufficiently attenuate OS and hence, this opens the possibilities for further studies on vitamin C in combination with other antioxidants, in storage solutions.

Ascorbic acid supplementation does not alter oxidative stress markers in healthy volunteers engaged in a supervised exercise program

2016 ◽  
Vol 41 (2) ◽  
pp. 175-180 ◽  
Author(s):  
Piyawan Bunpo ◽  
Tracy G. Anthony
Keyword(s):  
Oxidative Stress ◽  
Ascorbic Acid ◽  
Young Adults ◽  
Antioxidant Status ◽  
Exercise Program ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Supervised Exercise ◽  
Significant Change ◽  
Supervised Exercise Program

The purpose of this study was to investigate the impact of ascorbic acid (AA) consumption on the oxidative stress status of untrained volunteers participating in a supervised exercise program. The study included 46 young adults (average age, 23.5 ± 0.59 years; 37 females, 9 males) who remained sedentary (n = 16) or participated in 30 min of outdoor aerobic running (n = 30) at an intensity corresponding to 65%–75% of maximum heart rate for 3 times per week for 12 weeks. Exercised subjects were randomly assigned to an exercise group without AA supplementation (control; n = 10) or received either 250 mg (n = 10) or 500 mg (n = 10) of AA supplementation previous to each exercise session. Blood samples were taken on day 0 and day 84 to evaluate metabolic profiles and antioxidant status. Sedentary subjects underwent in a single bout of aerobic running to determine total antioxidant status (TAS) and malondiadehyde (MDA) at pre- and postexercise with or without AA supplementation. No significant change in TAS was observed. Plasma MDA significantly increased at postexercise (P < 0.05), and AA supplementation decreased MDA level significantly (P < 0.05). After 3 months of exercise, there was no significant change in blood glucose, lipid profile, MDA, TAS, superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase activities amongst groups. Supplementation of AA was associated with minor and inconsistent reductions in SOD, GPx, and catalase activities (P < 0.05). These findings indicate that pre-exercise supplementation of ascorbic acid does not alter oxidative stress markers in the plasma and erythrocytes of young adults engaged in a supervised exercise program.

scholarly journals Age Associated Oxidative Damage in Lymphocytes

2010 ◽  
Vol 3 (4) ◽  
pp. 275-282 ◽  
Author(s):  
Nandeslu Gautam ◽  
Subhasis Das ◽  
Santanu Kar Mahapatra ◽  
Subhankari Prasad Chakraborty ◽  
Pratip Kumar Kundu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Antioxidant Status ◽  
Antioxidant Defenses ◽  
Protein Damage ◽  
Protein Carbonyls ◽  
Elderly Subjects ◽  
Antioxidant Systems ◽  
Healthy Individuals ◽  
Blood Samples

Lymphocytes are an important immunological cell and have been played a significant role in acquired immune system; hence, may play in pivotal role in immunosenescence. Oxidative stress has been reported to increase in elderly subjects, possibly arising from an uncontrolled production of free radicals with aging and decreased antioxidant defenses. This study was aimed to evaluate the level of lipid-protein damage and antioxidant status in lymphocytes of healthy individuals to correlate between oxidative damage with the aging process. Twenty healthy individuals of each age group (11–20; 21–30; 31–40; 41–50; and 51–60 years) were selected randomly. Blood samples were drawn by medical practitioner and lymphocytes were isolated from blood samples. Malondialdehyde (MDA), protein carbonyls (PC) level were evaluated to determine the lipid and protein damage in lymphocytes. Superoxide dismutase (SOD), catalase (CAT), glutathione and glutathione dependent enzymes were estimated to evaluate the antioxidant status in the lymphocytes. Increased MDA and PC levels strongly support the increased oxidative damage in elderly subject than young subjects. The results indicated that, balance of oxidant and antioxidant systems in lymphocytes shifts in favor of accelerated oxidative damage during aging. Thus oxidative stress in lymphocytes may particular interest in aging and may play important role in immunosenescence.

Sign in / Sign up

Export Citation Format

Share Document