scholarly journals COVID-19 and immunocompromised conditions: Ongoing challenging issue

2021 ◽  
Vol 19 ◽  
pp. 205873922110161
Author(s):  
Masoud Mardani ◽  
Atousa Hakamifard
Keyword(s):  
Immune Deficiency ◽  
Severe Acute Respiratory Syndrome ◽  
Morbidity And Mortality ◽  
Challenging Issue ◽  
Present Letter ◽  
Exact Effect

One of the most serious complications of COVID-19 is the development of uncontrolled production of cytokines that poses a major factor contributing to COVID-19 morbidity and mortality. The exact effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on clinical and biochemical course of in patients with underlying immune compromised conditions is not well known with recent available data. The present letter aimed to draw attention to COVID-19 in immune deficiency.

Diabetes mellitus in anaesthesia

2012 ◽  
Vol 12 (2) ◽  
pp. 60-64 ◽  
Author(s):  
Jadelis Giquel ◽  
Yiliam F Rodriguez-Blanco ◽  
Christina Matadial ◽  
Keith Candiotti
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Immune Deficiency ◽  
Autonomic Neuropathy ◽  
Endocrine System ◽  
Morbidity And Mortality ◽  
Cardiovascular Autonomic Neuropathy ◽  
Operative Morbidity ◽  
Endocrine Diseases ◽  
Collagen Tissue

Anaesthesiologists frequently encounter patients with diseases of the endocrine system, in particular diabetes mellitus. The major risk factors for people with diabetes undergoing surgery are the associated end-organ diseases: cardiovascular autonomic neuropathy, joint collagen tissue, and immune deficiency. Due to the fact that endocrine diseases can be associated with significant peri-operative morbidity and mortality, it is critical that anaesthesiologists understand these disorders and when indicated request the appropriate investigations.

scholarly journals COVID-19-Associated Coagulopathy: A Case Report of Thrombosis despite Therapeutic Anticoagulation

2020 ◽  
Vol 2020 ◽  
pp. 1-4 ◽  
Author(s):  
Habiba Hussain ◽  
Matthew Sehring ◽  
Bhagat Singh Aulakh
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Hospital Stay ◽  
Inflammatory Markers ◽  
Morbidity And Mortality ◽  
Management Guidelines ◽  
Disease Prognosis ◽  
Therapeutic Anticoagulation

The Coronavirus disease (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has led to tremendous morbidity and mortality. Various inflammatory markers have been monitored and considered to be associated with disease prognosis. One of the major sources of comorbidity involved has been development of thrombosis alongside the infection. This prothrombotic phenomenon considered, COVID-19-associated coagulopathy (CAC), has been the center of discussion in dealing with this infection. There still remains ambiguity regarding management guidelines for thromboprophylaxis dosing and therapeutic anticoagulation. We present a case of severe SARS-CoV-2 infection complicated by thrombosis despite therapeutic anticoagulation contributing to prolonged intensive care unit and hospital stay.

scholarly journals COVID-19: Knowns, Unknowns, and Questions

mSphere ◽  
2020 ◽  
Vol 5 (2) ◽  
Author(s):  
Stuart Weston ◽  
Matthew B. Frieman
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Hubei Province ◽  
Morbidity And Mortality ◽  
Significant Morbidity ◽  
Current State ◽  
Recent Emergence ◽  
Rapid Spread ◽  
The World ◽  
Current Outbreak ◽  
Answering Questions

ABSTRACT The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from the Hubei province in China in late 2019 demonstrates the epidemic potential of coronaviruses. The rapid spread of this virus across the world in only 2 months highlights the transmissibility of this family of viruses and the significant morbidity and mortality that they can cause. We highlight the current state of knowledge of coronavirus biology while answering questions concerning the current outbreak of SARS-CoV-2.

scholarly journals Severe Acute Respiratory Syndrome-coronavirus 2 Interstitial Bilateral Pneumonia: A Case Report and Review of Literature

2020 ◽  
Vol 8 (T1) ◽  
pp. 229-232
Author(s):  
Danilo Coco ◽  
Silvana Leanza
Keyword(s):  
Infectious Disease ◽  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Clinical Picture ◽  
Older Patients ◽  
Morbidity And Mortality ◽  
Review Of Literature ◽  
Number Of Patients ◽  
The Usa ◽  
Novel Virus

In December 2019, novel cases of pneumonia were reported for the 1st time in Wuhan, Hubei, China. A novel virus of the big family of coronavirus (COV) was identified as the pathogen, which causes severe acute respiratory syndrome (SARS). The disease is called COV Disease-19 and then SARS-COV 2. The infectious disease has spread worldwide with major number of patients in China, Italy, Spain, France, and the USA. On March 11, 2020, the WHO declared the outbreak of SARS-CoV-2 a pandemic. Morbidity and mortality of the disease cannot yet estimate but have already seen that lethality appears to be particularly higher in older patients. The aim of this article is to present a characteristic clinical picture as case report SARS-COV 2 pneumonia and to provide an overview of the existing literature.

Severe Acute Respiratory Syndrome by COVID-19 in pregnant and postpartum women

2021 ◽  
Vol 21 (suppl 2) ◽  
pp. 461-469
Author(s):  
Ana Paula Nogueira Godoi ◽  
Gilcelia Correia Santos Bernardes ◽  
Nivea Aparecida de Almeida ◽  
Saulo Nascimento de Melo ◽  
Vinícius Silva Belo ◽  
...  
Keyword(s):  
Heart Disease ◽  
Severe Acute Respiratory Syndrome ◽  
Pregnant Women ◽  
Descriptive Analysis ◽  
Ventilatory Support ◽  
Clinical Manifestations ◽  
Morbidity And Mortality ◽  
Epidemiological Surveillance ◽  
Postpartum Women ◽  
Risk Of Death

Abstract Objectives: to evaluate the morbidity and mortality profile and factors associated with death due to severe acute respiratory syndrome (SARS) by COVID-19 in pregnant and postpartum women. Methods: this is a quantitative and retrospective research that analyzed the SIVEP-gripe Database (Influenza Epidemiological Surveillance Information System), from 01/01/2020 to 04/01/2021. All pregnant women and postpartum women diagnosed with SARS caused by COVID-19 in the State of Minas Gerais were included. After the descriptive analysis of the hospitalizations profile, the association between different exposure variables and the occurrence of death was evaluated. Results: of the 227 records obtained, 94.3% required hospitalization. Among hospitalizations in the Intensive Care Unit, 29.8% used invasive ventilatory support. Fifteen deaths were recorded. The most frequent clinical manifestations were: cough and fever; the predominant comorbidities were cardiovascular disease and diabetes mellitus. The variables “ICU stay”, “use of ventilatory support” and “heart disease” were associated with the occurrence of deaths. Conclusions: hospitalization was necessary for most pregnant women with SARS and the presence of previous heart disease increased the risk of death. Knowing the SARS morbidity and mortality profile is important in the definition of public health strategies aimed at reducing the impacts of COVID-19 during pregnancy and the puerperium.

scholarly journals ST Elevations in the Era of COVID-19

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Charlie Joseph Sang ◽  
Brittain Heindl ◽  
Gregory Von Mering ◽  
Brigitta Brott ◽  
Robert S. Kopf ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Myocardial Injury ◽  
Morbidity And Mortality ◽  
Front Line ◽  
Cardiac Enzymes ◽  
St Segment ◽  
St Elevation

Myocardial injury, represented by elevated cardiac enzymes, has been associated with increased morbidity and mortality in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections. Coronavirus disease 2019 (COVID-19) has created unique challenges in approaching patients with acute ST-segment changes. We describe two distinct cases of ST elevation on electrocardiogram occurring in patients with COVID-19 and review important diagnostic and management considerations for the front-line clinician.

scholarly journals Analysis of the Factors That Influence the Clinical Outcome of Severe Acute Respiratory Syndrome Caused by SARS-CoV-2 in Pregnant Women

2021 ◽  
Author(s):  
Yuri de Sousa Cavalcante ◽  
Nicolly Castelo Branco Chaves ◽  
Jorge Lucas de Sousa Moreira ◽  
Samuel de Sá Barreto Lima ◽  
Maryana Martins de Freitas ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Clinical Outcome ◽  
Pregnant Women ◽  
Age Groups ◽  
Morbidity And Mortality ◽  
Mortality Data ◽  
Second Trimester ◽  
Significance Level ◽  
Significant Difference ◽  
Before And After

Introduction: The new coronavirus (SARS-CoV-2) pandemic has shown to cause even more severe problems among pregnant women, increasing the incidence of complications before and after childbirth, especially cardiorespiratory problems, such as the Severe Acute Respiratory Syndrome (SARS). Objectives: To describe the clinical outcome of SARS caused by SARS-CoV-2 in Brazilian pregnant women and to compare the rates of morbidity and mortality from other causes in this group, stratified by the following variables: gestational age and age group. Methodology: Observational, analytical study based on documents whose data were collected from the 2020 Epidemiological Report No. 40 in the database of the Brazilian Department of Health, from which morbidity and mortality data were extracted to calculate the lethality rate and compare rates using a binomial test with a significance level of 0.05. Results: Of the total number of pregnant women hospitalized for SARS, 4,467 (46.6%) were confirmed for COVID-19 and, of these, 233 died, corresponding to a lethality rate of 5.2%. Morbidity was higher in the third trimester of pregnancy, but the disease was more severe in the second trimester (7%), being worse in women aged 40 years and older (40–49; 8.7% and 50–59; 15.3%). A significant difference was observed in the rate of cases between the COVID-19 SARS group and the group with other causes in all gestational strata and age groups. As for deaths, a significant difference was found in the rates between the first and third trimesters, and in pregnant women aged 10 to 19 years. Conclusion: Considering the variables under analysis, evidence shows that pregnant women at an advanced age and in the second trimester of pregnancy contribute to the lethal outcome of the disease. Other variables associated with the presence of comorbidities and quality of care for pregnant women should be considered in the model in future studies.

scholarly journals COVID-19 associated viral myocarditis: does it exist?

2020 ◽  
Vol 90 (4) ◽  
Author(s):  
Vaishali Verma ◽  
Sachin Sondhi ◽  
Rajesh Sharma ◽  
Kunal Mahajan
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Myocardial Injury ◽  
Viral Myocarditis ◽  
Morbidity And Mortality ◽  
Elevated Troponin ◽  
Respiratory Involvement

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is a lethal pandemic that has claimed millions of lives worldwide. While respiratory involvement is the most common and most virulent manifestation of COVID-19, there is enough data to suggest that myocardial injury reflected through elevated troponin levels is seen in around 7-28% of patients and is related with increased morbidity and mortality.

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