Ingestion of an Oral Hyaluronan Solution Improves Skin Hydration, Wrinkle Reduction, Elasticity, and Skin Roughness: Results of a Clinical Study

Intake of oral supplements with the aim of a cutaneous antiaging effect are increasingly common. Hyaluronic acid (HA) is a promising candidate, as it is the key factor for preserving tissue hydration. In our practice study, we evaluated the effect of an oral HA preparation diluted in a cascade-fermented organic whole food concentrate supplemented with biotin, vitamin C, copper, and zinc (Regulatpro Hyaluron) on skin moisture content, elasticity, skin roughness, and wrinkle depths. Twenty female subjects with healthy skin in the age group of 45 to 60 years took the product once daily for 40 days. Different skin parameters were objectively assessed before the first intake, after 20 and after 40 days. Intake of the HA solution led to a significant increase in skin elasticity, skin hydration, and to a significant decrease in skin roughness and wrinkle depths. The supplement was well tolerated; no side effects were noted throughout the study.

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Effects of Oral Supplementation of TrichovitalsTM on Human Skin, Hair and Nail Physiology

Research Journal of Topical and Cosmetic Sciences ◽

10.52711/2321-5844.2021.00008 ◽

2021 ◽

pp. 52-59

Author(s):

Chandramohan Marimuthu ◽

Jayaganesh Murugan ◽

Srisunmathi Ravichandran ◽

Sruthi Sukumar

Keyword(s):

Hair Loss ◽

Hair Growth ◽

Skin Hydration ◽

Control Group ◽

Type I ◽

Skin Elasticity ◽

Facial Skin ◽

Oral Supplementation ◽

Split Ends ◽

Oral Supplements

In this study, Microcore’s oral supplements of TrichovitalsTM contains Collagen type (I,III,V,X), elastin, ellagic acid, Sabbery b glucogallin, Biotin, Curcumin C3 reduct ODN and Murraya koenigii. ESM ingestion is associated with significant impact on hair thickness, reduction in hair breakage and improvement in hair growth. This study leads to evaluate the impacts of a nutritional intervention as compared to control group (without oral supplements intake) on the appearances of hair, skin, and nails in healthy middle-aged adults. Two pilot studies were run to assess TrichovitalsTM on skin parameter. 1. Self-assessment questionnaire intended to perform an assessment on skin, hair, and nail health after 12 weeks of treatment for a group of 25 female volunteers 2. Evaluated the efficacy of TrichovitalsTM effect of 5-week treatment on hydration of skin by corneometry, on elasticity with the cutometer, and on pigmentation with themexameteron for a group of 7 female volunteers, Microscopic studies of hair strength and nail growth. In study 1-Participants were predominantly satisfied with the effects obtained on general face (100% volunteers satisfied) and (94% volunteers satisfied) body skin condition and skin properties (100% volunteers satisfied) with facial skin softness, 95% ith facial skin hydration, 63% of facial skin brightness and 89% with body skin hydration and significant effects on hair damages (100% volunteers satisfied), hair falls (95% volunteers satisfied) and hair growth (96% volunteers satisfied) and nail appearance (80% volunteers satisfied) and improvement in brittle nails. In this open-label 5 weeks study, Oral Microcore’s TrichovitalsTM ingestion was associated with a significant improvement in skin appearance such as increase skin hydration and skin elasticity, reduces skin pigmentation after 5 weeks treatment and facial skin tone, with significant impact on hair thickness, reduces split ends, hair loss, hair breakage and improvement in hair growth after 5 weeks treatment, increase of 80% nail growth rate and a decrease of 42% brittle nails after 6 weeks. Microcore’s TrichovitalsTM achieved significant change improvement in skin, hair and nail appearance (thickness/density) than control group (without oral supplements intake) by week 12 of the study. From the result analysis, Microcore’s TrichovitalsTM is deemed to be one of the most effective anti-aging products in cosmetic sector and overall physical appearance. Oral supplementation of 500mg/day of Microcore’s TrichovitalsTM for 12 weeks is associated with significant improvement in the appearance of facial skin, hair and nail. Increases in skin hydration and skin elasticity with reduced pigmentation on skin were observed after 5 weeks treatment, which is a very important marker for skin aging. Also significant impact on hair thickness reduces split ends, hair loss, hair breakage and improvement in hair growth and healthy development of nails after 5 weeks treatment.

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Effects of Oral Supplementation of Muttaijow complexTM on Human Skin, Hair and Nail Physiology

Research Journal of Topical and Cosmetic Sciences ◽

10.52711/2321-5844.2021.00005 ◽

2021 ◽

pp. 32-39

Author(s):

Chandramohan Marimuthu ◽

Jayaganesh Murugan ◽

Srisunmathi Ravichandran ◽

Sruthi Sukumar

Keyword(s):

Hair Loss ◽

Hair Growth ◽

Skin Hydration ◽

Control Group ◽

Type I ◽

Skin Elasticity ◽

Facial Skin ◽

Oral Supplementation ◽

Split Ends ◽

Oral Supplements

In this study, Microcore’s oral supplements of Muttaijow ComplexTM obtained from the egg shell that contains naturally occurring collagen Type (I, V, X), Elastin (Desmosine and isodesmosine), Hyaluronic acid, Glucosamine, Chondroitin, Glycosaminoglycans or Muco-polysaccharides, Membrane bound protein molecules, and Calcium are used in a group of volunteers. This study leads to evaluate the impacts of a nutritional intervention as compared to control group (without oral supplements intake) on the appearances of hair, skin, and nails in healthy middle-aged adults. Two pilot studies were run to assess Muttaijow ComplexTM on skin parameter. 1. Self-assessment questionnaire intended to perform an assessment on skin, hair, and nail health after 12 weeks of treatment for a group of 25 female volunteers 2. Evaluated the efficacy of Muttaijow ComplexTM effect of 5-week treatment on hydration of skin by corneometry, on elasticity with the cutometer, and on pigmentation with themexameteron for a group of 7 female volunteers, Microscopic studies of hair strength and nail growth. In study 1-Participants were predominantly satisfied with the effects obtained on general face (100% volunteers satisfied) and body (94% volunteers satisfied) skin condition and skin properties (100% volunteers satisfied with facial skin softness, 95% with facial skin hydration, 83% of facial skin brightness and 89% with body skin hydration) and partly with effects on hair (65-70%volunteers satisfied) and nail appearance (70% volunteers satisfied) and improvement in brittle nails. In this open-label 5 weeks study, Oral Microcore’s Muttaijow ComplexTM ingestion was associated with a significant improvement in skin appearance such as increase skin hydration and skin elasticity, reduces skin pigmentation after 5 weeks treatment and facial skin tone, with significant impact on hair thickness, reduces split ends, hair loss, hair breakage and improvement in hair growth after 5 weeks treatment, increase of 12% nail growth rate and a decrease of 42% brittle nails after 6 weeks. Microcore’s Muttaijow ComplexTM achieved significant change improvement in skin, hair and nail appearance (thickness/density) than control group (without oral supplements intake) by week 12 of the study. From the result analysis, Microcore’s Muttaijow ComplexTM is deemed to be one of the most effective anti-aging products in cosmetic sector and overall physical appearance. Oral supplementation of 500mg/day of Microcore’s Muttaijow ComplexTM for 12 weeks is associated with significant improvement in the appearance of facial skin, hair and nail. Increases in skin hydration and skin elasticity with reduced pigmentation on skin were observed after 5 weeks treatment, which is a very important marker for skin aging. Also, significant impact on hair thickness, reduces split ends, hair loss, hair breakage and improvement in hair growth and healthy development of nails after 5 weeks treatment.

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Collagen Hydrolysate Prepared from Chicken By-Product as a Functional Polymer in Cosmetic Formulation

Molecules ◽

10.3390/molecules26072021 ◽

2021 ◽

Vol 26 (7) ◽

pp. 2021

Author(s):

Aneta Prokopová ◽

Jana Pavlačková ◽

Pavel Mokrejš ◽

Robert Gál

Keyword(s):

Water Loss ◽

Transepidermal Water Loss ◽

Skin Hydration ◽

Skin Elasticity ◽

Cosmetic Products ◽

Collagen Hydrolysate ◽

Carbopol Gel ◽

Cosmetic Formulation ◽

The Right ◽

Positive Effect

Chicken stomachs can be processed into collagen hydrolysate usable in cosmetic products. The aim of the study was to verify the effects of a carbopol gel formulation enriched with 1.0% (w/w) chicken hydrolysate on the properties of the skin in the periorbital area after regular application twice a day for eight weeks in volunteers ageed 50 ± 9 years. Skin hydration, transepidermal water loss (TEWL), skin elasticity and skin relief were evaluated. Overall, skin hydration increased by 11.82% and 9.45%, TEWL decreased by 25.70% and 17.80% (always reported for the right and left area). Generally, there was an increase in skin elasticity, a decrease in skin roughness, as the resonance times decreased by 85%. The average reduction of wrinkles was 35.40% on the right and 41.20% on the left. For all results, it can be seen that the longer the cosmetic gel formulation is applied, the better the results. Due to the positive effect on the quality and functionality of the skin, it is possible to apply the cosmetic gel formulation in the periorbital area. The advantage of the product with chicken collagen hydrolysate is also the biocompatibility with the skin and the biodegradability of the formulation.

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Skin moisture assessment using Hydration Sensor Patches coupled with smartphones via Near Field Communication (NFC). A pilot study with the first generation of patches that allow self‐recordings of skin hydration

Skin Research and Technology ◽

10.1111/srt.13049 ◽

2021 ◽

Author(s):

Frederic Flament ◽

Anthony Galliano ◽

Aurelie Abric ◽

Christoph‐Manuel Matoschitz ◽

Manfred Bammer ◽

...

Keyword(s):

Pilot Study ◽

First Generation ◽

Near Field ◽

Skin Hydration ◽

Near Field Communication ◽

Skin Moisture

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Once-daily versus twice-daily dosing of digoxin in the pediatric age group

The Journal of Pediatrics ◽

10.1016/s0022-3476(05)81665-8 ◽

1990 ◽

Vol 116 (1) ◽

pp. 137-139 ◽

Cited By ~ 4

Author(s):

Eli Zalzstein ◽

Gideon Koren ◽

Maurice Levy ◽

Yedidia Bentur ◽

Stuart MacLeod ◽

...

Keyword(s):

Age Group ◽

Pediatric Age ◽

Once Daily ◽

Pediatric Age Group

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26262 M89, a dermocosmetic combining 89% Vichy volcanic mineralizing water and hyaluronic acid applied once daily for 4 weeks was effective and well tolerated after peeling procedures

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2021.06.390 ◽

2021 ◽

Vol 85 (3) ◽

pp. AB92

Author(s):

Elena Araviiskaia ◽

Martina Kerscher ◽

Julieta Spada ◽

Cecilia Orlandi ◽

Maryna Anfilova ◽

...

Keyword(s):

Hyaluronic Acid ◽

Once Daily

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Oral Intake of Collagen Peptide Attenuates Ultraviolet B Irradiation-Induced Skin Dehydration In Vivo by Regulating Hyaluronic Acid Synthesis

International Journal of Molecular Sciences ◽

10.3390/ijms19113551 ◽

2018 ◽

Vol 19 (11) ◽

pp. 3551 ◽

Cited By ~ 3

Author(s):

Min Kang ◽

Silvia Yumnam ◽

Sun Kim

Keyword(s):

Hyaluronic Acid ◽

Oral Administration ◽

Protein Expression ◽

Ultraviolet B ◽

Skin Hydration ◽

Skin Barrier Function ◽

Hairless Mice ◽

Uvb Irradiation ◽

Collagen Peptide

Collagen peptide (CP) has beneficial effects on functions of the skin, such as skin barrier function and skin elasticity, in vivo. However, there are few studies investigating the mechanism underlying the potential effects of CP in skin epidermal moisturization after ultraviolet B (UVB) irradiation. In this study, we examined whether orally-administered CP affects the loss of skin hydration induced by UVB irradiation in hairless mice. SKH-1 hairless mice were orally administered CP at two doses (500 and 1000 mg/kg) for nine weeks, and the dorsal skin was exposed to UVB. The potential effects of CP were evaluated by measuring the transepidermal water loss (TEWL), skin hydration, wrinkle formation, and hyaluronic acid expression in the dorsal mice skin. We found that oral administration of CP increased skin hydration and decreased wrinkle formation compared to the UVB-irradiated group. Treatment of CP increased the mRNA and protein expression of hyaluronic acid synthases (HAS-1 and -2) concomitant with an increased hyaluronic acid production in skin tissue. The expression of hyaluronidase (HYAL-1 and 2) mRNA was downregulated in the CP-treated group. In addition, the protein expression of skin-hydrating factors, filaggrin and involucrin, was upregulated via oral administration of CP. In summary, these results show that oral administration of CP increases hyaluronic acid levels, which decreases during UVB photoaging. Therefore, we suggest that CP can be used as a nutricosmetic ingredient with potential effects on UVB-induced skin dehydration and moisture loss in addition to wrinkle formation.

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