scholarly journals Alteration of gait parameters in a mouse model of surgically induced knee osteoarthritis

2018 ◽  
Vol 26 (2) ◽  
pp. 230949901876801 ◽  
Author(s):  
Yuma Makii ◽  
Meiko Asaka ◽  
Susumu Setogawa ◽  
Soichiro Fujiki ◽  
Yoko Hosaka ◽  
...  
Keyword(s):  
Mouse Model ◽  
Knee Joint ◽  
Oral Administration ◽  
Joint Pain ◽  
Gait Cycle ◽  
Cyclooxygenase 2 ◽  
Common Symptom ◽  
Gait Parameters ◽  
Significant Difference ◽  
Surgically Induced

Purpose: Joint pain is the most common symptom of osteoarthritis (OA); however, its mechanism remains unclarified. The present study investigated hindlimb motion during locomotion on the treadmill using a three-dimensional (3D) motion analysis system with high-speed cameras to evaluate whether this method can be used as an indication of joint pain in a mouse model of surgically induced OA. Methods: We resected the medial meniscus and medial collateral ligament in 8-week old C57BL/6 male mice and performed locomotion recording 6 months post-operatively. Additionally, we performed the same recording after oral administration of the selective cyclooxygenase-2 inhibitor to determine whether alteration of the parameters were associated with joint pain. Results: OA development, characterized by cartilage degeneration and osteophyte formation, was markedly enhanced in the OA group. There was no significant difference between the sham and OA groups in basic gait parameters, including stance duration, swing duration and gait cycle. However, when we divided the gait cycle into four phases and calculated the joint ranges of motion in each phase, the range of motion of the knee joint during the stepping-in phase and the swing duration were significantly decreased in the OA group. These significant differences between the sham and OA groups were diminished by the oral administration of a selective cyclooxygenase-2 inhibitor to the OA group. Conclusion: The present method may be useful to evaluate joint pain in experimental mice and contribute to elucidating the molecular mechanisms of pain in the OA knee joint in combination with genetically modified mice.

scholarly journals The effectiveness of contrast bath to reduce joint pain in the elderly

MEDISAINS ◽  
2020 ◽  
Vol 17 (3) ◽  
pp. 53
Author(s):  
Esri Rusminingsih ◽  
Nur Wulan Agustina ◽  
Dyah Ayu Nawang Wulan
Keyword(s):  
Knee Joint ◽  
Joint Pain ◽  
Cold Water ◽  
The Elderly ◽  
The Body ◽  
Upper Body ◽  
Bivariate Analysis ◽  
P Value ◽  
Significant Difference ◽  
Pain In The Elderly

Background: The aging process results in changes in the musculoskeletal system causing a decrease in function of joints, loss of elasticity and limited mobility. This condition also causes joint pain, especially in the joints supporting the body weight, namely the knee. The previous studies discussed the method of reducing pain using a contras bath which was implemented by soaking parts of the body that experience pain alternately with hot and cold water, this was difficult to apply if the pain occurs in the upper body. Modifications in contrast baths using compresses to the knee joint have never been implemented before.Objective: This study aimed to figure out the effect of the contras bath method using compresses to reduce knee joint pain in the elderly.Method: The design of this study was pre-experimental with one group of pretest-posttest. The sample used was 16 elderly who were selected by random sampling at Posyandu (a center for pre- and postnatal health care and information for elderly) in village of Sawit Gantiwarno, Klaten. Contrast bath is applied by giving compresses of warm and cold water alternately with a ratio of three minutes: one minute per-day during 20 minutes, for a week. Pain measurement is performed using the Visual Analog Scale (VAS) instrument.Result: The mean of knee pain before giving a contrast bath was 5.44, whereas after a contrast bath was 3.50. Bivariate analysis used Wilcoxon, it showed p value <0.05 which means there was a significant difference in knee joint pain before and after contrast baths were applied.Conclusion: Administration of contrast bath can reduce knee joint pain in the elderly.

scholarly journals Immediate Effect of Restricted Knee Extension on Ground Reaction Force and Trunk Acceleration during Walking

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Hiroshi Osaka ◽  
Daisuke Fujita ◽  
Kenichi Kobara ◽  
Tadanobu Suehiro
Keyword(s):  
Ground Reaction Force ◽  
Stance Phase ◽  
Gait Cycle ◽  
Reaction Force ◽  
Gait Pattern ◽  
Knee Extension ◽  
Measurement Unit ◽  
Gait Parameters ◽  
Significant Difference ◽  
Trunk Acceleration

Gait parameters calculated from trunk acceleration reflect the features of gait; however, they cannot evaluate the gait pattern corresponding to the gait cycle. This study is aimed at investigating the differences in gait parameters calculated from trunk acceleration during gait corresponding to the gait cycle in healthy subjects with restricted knee extension. Participants included eight healthy volunteers who walked normally (NW) and with knee orthosis that restricted knee extension (ER). The ground reaction force (GRF), joint angles, and trunk acceleration during walking were measured using four force plates, a three-dimensional motion analysis system, and an inertial measurement unit. The peak GRF of the vertical components, joint ranges of motion, and moments of force were analyzed. The root mean square (RMS) and amplitude peak ratio (AR) of autocorrelation function were calculated from the trunk acceleration waveform. The first peak GRF and peak ankle dorsiflexion angles significantly increased during ER. The peak hip extension, knee flexion, knee extension angles, and the peak moment of knee extension significantly decreased during ER compared to that during NW. The acceleration AR significantly decreased during ER compared to that during NW. There was no significant difference in the RMS between the two conditions. The acceleration AR may show the temporal postural structure with restricted knee extension from the terminal stance phase for the ipsilateral limb to the initial stance phase for the contralateral limb. These results suggest that novel metrics for accelerometry gait analysis can reveal gait abnormalities, with restricted knee extension corresponding to the gait cycle.

THE USE OF MOTION ANALYSIS SYSTEM AND ORTHOSIS IN PATIENTS WITH NEURO-MUSCULOSKELETAL DISORDERS

2014 ◽  
Vol 14 (02) ◽  
pp. 1450028 ◽  
Author(s):  
MOHAMMAD TAGHI KARIMI ◽  
JAVID MOSTAMAND ◽  
FRANCIS FATOYE
Keyword(s):  
Knee Joint ◽  
Musculoskeletal Disorders ◽  
Motion Analysis ◽  
Hip Joint ◽  
Motion Analysis System ◽  
Flat Foot ◽  
Gait Parameters ◽  
Significant Difference ◽  
Joint Monitoring ◽  
Analysis System

Background: Neuro-musculoskeletal disorders are a major source of physical disability involving more than one joint. Monitoring all joints during walking is achieved by using motion analysis system. There is limited evidence to show the suitability of motion analysis system to monitor neuro-musculoskeletal disorders. This research investigated the feasibility of this system to represent in patients with neuro-musculoskeletal disorders during walking. Method: Five groups of normal subjects with: knee osteoarthritis; avascular necrosis of hip joint; spinal cord injury and flat foot were recruited into this study. Kinetic and kinematic parameters were obtained by the use of motion analysis (Qualysis with seven cameras) and a Kistler force platform. The differences between gait parameters of normal and subjects with these disorders were examined using the independent t-tests. Paired t-test analysis was also used to determine the difference between walking with and without orthosis. Significant value was set at p ≤ 0.05. Results: There was a significant difference between the moment applied on the knee joint, the integral area between center of pressure (COP) and center of knee joint (COJ) graphs of normal and osteoarthritis (OA) subjects (p < 0.05). The area between COP and COJ of the ankle joint significantly differed between normal and flat foot subjects (p < 0.05). However, the force transmitted through the hip joint in subjects with Perthes did not differ significantly while walking with and without orthosis. In paraplegic subjects, the force applied on the limb and the mean values of gait parameters varied while walking with different orthoses which showed the feasibility of the system to monitor the performance of subjects with SCI disorder. Conclusion: The findings of the present study imply that the use of motion analysis is feasibility for assessing and monitoring neuro-musculoskeletal disorders. However, different parameters should be selected for various neuro-musculoskeletal disorders.

Effects of Hormone Replacement Therapy on Plasma and Tissue Fibrinolytic Activity in a Rat Model of Surgically Induced Menopause

2014 ◽  
Vol 37 (2) ◽  
pp. 85 ◽  
Author(s):  
Ata Topcuoglu ◽  
Mustafa Albayrak ◽  
Hayriye Erman ◽  
Huriye Balci ◽  
Mesut Karakus ◽  
...  
Keyword(s):  
Hormone Replacement Therapy ◽  
Oral Administration ◽  
Replacement Therapy ◽  
Plasminogen Activator ◽  
Brain Tissue ◽  
Fibrinolytic Activity ◽  
Hormone Replacement ◽  
17Β Estradiol ◽  
Surgically Induced ◽  
Pai 1

Purpose: The purpose of this study was to analyze the effects of estrogen deficiency and hormone replacement therapy (HRT) on fibrinolytic activity in a rat mode of surgically-induced menopause. Methods: Twelve-week-old, sexually mature female Sprague-Dawley rats, each weighing 200–250 g, were randomly divided into four groups: (1) sham-operated group, (2) ovariectomy group, (3) ovariectomy group followed by oral administration of daily 17β-estradiol (0.02 mg/kg/day) (E2) + norethisterone acetate (0.01 mg/kg/day), and (4) ovariectomy group followed by oral administration of daily 17β-estradiol (0.01 mg/kg/day) + drospirenone (0.02 mg/kg/day). Tissue plasminogen activator (tPA) antigen, plasminogen activator inhibitor-1 (PAI-1) antigen, and PAI-1/tPA levels were measured as markers of fibrinolysis in plasma and liver and brain tissue. Results: Compared with sham-operated rats, ovariectomized rats showed higher levels of fibrinolytic activity; however, the increased fibrinolytic activity in plasma and liver tissue was significantly reduced by HRT regimens. No change was observed in the levels of fibrinolytic activity in brain tissue. Conclusions: HRT showed beneficial effects by decreasing fibrinolytic activity related to surgically-induced menopause. Short-term HRT treatment was associated with a shift in the procoagulant-anticoagulant balance toward a procoagulant state.

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