scholarly journals Risk Factors for Death in Bangladeshi Children Under 5 Years of Age Hospitalized for Diarrhea and Severe Respiratory Distress in an Urban Critical Care Ward

2017 ◽  
Vol 4 ◽  
pp. 2333794X1769668 ◽  
Author(s):  
Tahmina Alam ◽  
Tahmeed Ahmed ◽  
Monira Sarmin ◽  
Lubaba Shahrin ◽  
Farzana Afroze ◽  
...  
Author(s):  
P Lewis White ◽  
Rishi Dhillon ◽  
Alan Cordey ◽  
Harriet Hughes ◽  
Federica Faggian ◽  
...  

Abstract Background Fungal coinfection is a recognized complication of respiratory virus infections, increasing morbidity and mortality, but can be readily treated if diagnosed early. An increasing number of small studies describing aspergillosis in coronavirus disease 2019 (COVID-19) patients with severe respiratory distress are being reported, but comprehensive data are lacking. The aim of this study was to determine the incidence, risk factors, and impact of invasive fungal disease in adult COVID-19 patients with severe respiratory distress. Methods An evaluation of a national, multicenter, prospective cohort evaluation of an enhanced testing strategy to diagnose invasive fungal disease in COVID-19 intensive care patients. Results were used to generate a mechanism to define aspergillosis in future COVID-19 patients. Results One-hundred and thirty-five adults (median age: 57, M/F: 2.2/1) were screened. The incidence was 26.7% (14.1% aspergillosis, 12.6% yeast infections). The overall mortality rate was 38%; 53% and 31% in patients with and without fungal disease, respectively (P = .0387). The mortality rate was reduced by the use of antifungal therapy (mortality: 38.5% in patients receiving therapy vs 90% in patients not receiving therapy (P = .008). The use of corticosteroids (P = .007) and history of chronic respiratory disease (P = .05) increased the likelihood of aspergillosis. Conclusions Fungal disease occurs frequently in critically ill, mechanically ventilated COVID-19 patients. The survival benefit observed in patients receiving antifungal therapy implies that the proposed diagnostic and defining criteria are appropriate. Screening using a strategic diagnostic approach and antifungal prophylaxis of patients with risk factors will likely enhance the management of COVID-19 patients.


2017 ◽  
Vol 4 ◽  
pp. 2333794X1774022
Author(s):  
Sharifuzzaman ◽  
Monira Sarmin ◽  
Tahmeed Ahmed ◽  
Tahmina Alam ◽  
Shoeb Bin Islam ◽  
...  

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e73728 ◽  
Author(s):  
Mohammod Jobayer Chisti ◽  
Mohammed Abdus Salam ◽  
Hasan Ashraf ◽  
Abu S. G. Faruque ◽  
Pradip Kumar Bardhan ◽  
...  

2019 ◽  
Vol 6 (2) ◽  
pp. 454
Author(s):  
C. P. V. Ramana Sastry ◽  
Maram Padmavathi

Background: The aim is to study the various risk factors associated with development of severe respiratory distress in the new born.Methods: This was a prospective study of 200 new-borns with respiratory distress. Clinical details, etiology for the respiratory distress, system-wise factors responsible for the distress, severity and duration of respiratory distress, oxygen therapy, type of treatment, mortality, maternal and antenatal risk factors, radiological findings were noted in all the cases and were analysed.Results: Of the 200 cases with respiratory distress, 118 (59%) had severe respiratory distress. 154 cases with distress were of respiratory system in origin out of which 45% (70 out of 154) were due to Meconium aspiration syndrome, 42% (64 out of 154) were due to Respiratory distress syndrome, 12% (18 out of 154) were due to transient tachypnea of new-born and 2% were due to congenital pneumonia. More number of female patients had severe respiratory distress. Mortality was 2.5%.Conclusions: Meconium aspiration syndrome is the most common cause of respiratory distress in new born. Almost 60% of new borns with respiratory distress developed severe respiratory distress who required intensive monitoring. Risk factors like meconium stained liquor, vaginal delivered new borns, preterm gestation age, and female gender of new born were associated with severe respiratory distress in new borns.


Author(s):  
Nagarjuna Naik ◽  
Anil Kumar Chaudhary ◽  
Raghu Nandan Chaudhary ◽  
Rakesh Ranjan

Background: Respiratory distress in neonates is the most common cause of admission to NICU in a tertiary care hospital. Identification of risk factors associated with development of severe distress and early diagnosis of cause is very important in the management of neonatal distress. Methods: 110 consecutive born neonates with RD were studied and assessed for development of severe distress against onset, duration, oxygen requirement and outcome in terms of final diagnosis, mortality and treatment. Serial chest X- rays were done at 1 hour and 6 hours of onset of distress. Results: BA (41%) was the commonest cause. Development of severe distress was more when onset is at 6 hours after birth (77%), duration persists more than 24 hours (65.5%)  Ventilation was done in 26 cases and there was17% mortality. Conclusions: Birth Asphyxia is the most common cause of respiratory distress in new-born. Almost 48% of new-born with respiratory distress develop severe respiratory distress which require intensive monitoring. Risk factors like high maternal age, primi-gravida mothers, more than 4 per vaginal examinations, meconium stained liquor, cesarean delivered new-borns, Small for gestation age, and 1 min Apgar score less than 7, birth weight less than 2.5Kg and male sex of new-born were associated with severe respiratory distress in new-borns. Keywords: Respiratory distress, New-born, Risk factors, Chest x rays, Oxygen requirement


Author(s):  
Charles Haviland Mize ◽  
Lhab Dorji ◽  
Ken Zafren

Abstract The population of the Kingdom of Bhutan is scattered in small villages throughout the eastern Himalaya. Infants born prematurely in villages have no access to neonatal intensive care until they are transported to the national referral hospital, a process that once took hours, if not days. After the introduction of a helicopter critical-care retrieval team, we were able to send a trained team to a remote location that successfully administered surfactant and initiated critical care to a premature, extreme low birth weight infant in severe respiratory distress in the first hour of life. Although the infant was in shock and in a near-arrest state at the time the team arrived, he made an excellent recovery after resuscitation by the team.


2018 ◽  
Vol 5 (6) ◽  
pp. 2235
Author(s):  
Sandeep Patil ◽  
Varsha Halkude ◽  
Mahesh Tondare ◽  
Anand Mudaglimath

Background: As Transient tachypnea of newborn is the most common cause of Respiratory distress and significant number of newborns with respiratory distress develops severe respiratory insufficiency requiring intensive monitoring. With these points, we undertake to identify risk factors associated with development of severe respiratory distress in the new born.Methods: Hundred newborns that were having respiratory distress within 72 hours of birth admitted to NICU were included in the present study. The severity of respiratory distress was noted according to risk factors and clinical assessment. The details were noted in all the newborns- General information, history, risk factors and clinical examination findings of mother and newborn were documented.Results: In the present study, 62.5% of the newborns born to Primigravida mothers developed severe respiratory distress. In the present study it was seen that 83.6% of newborns with SGA developed severe respiratory distress compared to 60% and 33.3% newborns with LGA and AGA respectively. It was seen that the risk of neonatal respiratory distress markedly increased with decreasing birth weight (p<0.001).Conclusions: Immediate clinical outcome of newborn respiratory distress in term of mortality rate is variable and depends on the cause of newborn distress. 


2013 ◽  
Vol 1 (2) ◽  
pp. 80-85
Author(s):  
Mohammod Jobayer Chisti ◽  
Mohammed Abdus Salam ◽  
Md Iqbal Hossain ◽  
Hasan Ashraf ◽  
Abu SG Faruque ◽  
...  

Background: Fatal outcome related risks are high when children with pneumonia present with severe acute malnutrition (SAM). However, data are limited on fatality related risk factors from pneumonia in Children with SAM especially those who attended in critical care ward. We evaluated clinically identifiable risks for fatal outcome in under-five Children with SAM with pneumonia at a critical care ward in an urban hospital. Methods: This study was of unmatched case-control design and Children with SAM of either sex, aged 0-59 months, admitted to the Intensive Care Unit (ICU) of Dhaka Hospital of the International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) from April 2011 through July 2012 with radiological pneumonia were studied. The study children who had fatal outcome constituted the cases (n=35), and randomly selected children who survived constituted the controls (n=105). Results: The age (months) among the cases and the controls [median (inter-quartile range)] was comparable [8.0 (4.9, 11.0) vs. 9.7 (5.0, 18.0); p=0.210)]. In multivariate logistic regression analysis, after adjusting for potential confounders, such as abnormal mental status, vomiting, and systolic hypotension (<70 mm of Hg) in absence of dehydration, severely malnourished under-five children with pneumonia having fatal outcome more often had hypoxemia (OR=23.15, 95% CI=4.38-122.42), dehydrating (some/severe) diarrhea (OR=9.48, 95% CI=2.42-37.19), abdominal distension at admission (OR=4.41, 95% CI=1.12-16.52), and received blood transfusion (OR=5.50, 95% CI=1.21-24.99) for the management of crystalloid resistant systolic hypotension. Conclusion: The results of our data revealed hypoxemia, clinical dehydration, and abdominal distension as the independent risk factors for fatal outcome in Children with SAM with pneumonia. Severely malnourished children with pneumonia who required blood transfusion for the management of crystalloid resistant systolic hypotension were also at risk of fatal outcome. Thus, early identification and prompt management of these simple clinically recognizable risk factors for fatal outcome and avoiding the use of blood transfusion for the management of crystalloid resistant systolic hypotension may help reduce death in such population. DOI: http://dx.doi.org/10.3329/bccj.v1i2.17199 Bangladesh Crit Care J September 2013; 1 (2): 80-85


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