scholarly journals Rapidly Establishing a Hospital-Based Convalescent Plasma Collection Center With the Alyx Apheresis Collection Device

2021 ◽  
Vol 8 ◽  
pp. 237428952098723
Author(s):  
Tovah Klein ◽  
Rita Elue ◽  
Sachie Ikegami ◽  
Christopher Mikkelson ◽  
Gregory Wright ◽  
...  
Keyword(s):  
Vital Signs ◽  
Reaction Rates ◽  
Nasopharyngeal Swab ◽  
Infiltration Rates ◽  
Collection Device ◽  
Target Yield ◽  
Screening Questions ◽  
Access Program ◽  
Plasma Collection ◽  
Collection Program

The effort to collect convalescent plasma from individuals who recovered from COVID-19 began in earnest during the spring of 2020. Either whole blood or apheresis donations were obtained, the latter yielding higher numbers of units per donor per collection and more frequent collections. The NorthShore University HealthSystem blood donor center purchased 2 Alyx (Fresenius Kabi) apheresis plasma collection devices and quickly implemented them in order to collect COVID-19 convalescent plasma. Apheresis-experienced and inexperienced phlebotomists operated the instruments. Donors were collected >14 days from symptom resolution and all donors were negative by SARS-CoV-2 nasopharyngeal swab. Both internal metrics of performance as well as a post donation survey were used to evaluate the feasibility implementing this collection program. During the first 100 days of the collection program, 650 plasma units were collected. In particular, during the first week of the program, 38 units were collected and distributed to hospitals under the emergency investigational new drug and expanded access program. Fifty-one donors (15%) were deferred due to vital signs out of range or donor screening questions. Thirty-one donors (10%) were deferred due to positive nasopharyngeal swab. Lower than target yield occurred in 16.6% of collections due to donor reactions or flow errors. Donors rated the overall program lower, but not the staff, when they reported symptoms related to collection. In conclusion, a hospital-based apheresis convalescent plasma collection program can be rapidly implemented. Donor reaction rates and vein infiltration rates should be carefully monitored for each phlebotomist.

scholarly journals Retinal microvascular signs in COVID-19

2021 ◽  
pp. bjophthalmol-2020-318236
Author(s):  
Ralene Sim ◽  
Gemmy Cheung ◽  
Daniel Ting ◽  
Edmund Wong ◽  
Tien Yin Wong ◽  
...  
Keyword(s):  
Medical History ◽  
Vital Signs ◽  
Plexiform Layer ◽  
Nasopharyngeal Swab ◽  
Inner Plexiform Layer ◽  
Cross Sectional ◽  
Imaging Device ◽  
Asymptomatic Patients ◽  
Significant Difference ◽  
Retinal Microvascular Signs

Background/aimsTo explore if retinal findings are associated with COVID-19 infection.MethodsIn this prospective cross-sectional study, we recruited participants positive for COVID-19 by nasopharyngeal swab, with no medical history. Subjects underwent retinal imaging with an automated imaging device (3D OCT-1 Maestro, Topcon, Tokyo, Japan) to obtain colour fundus photographs (CFP) and optical coherence tomographic (OCT) scans of the macula. Data on personal biodata, medical history and vital signs were collected from electronic medical records.Results108 patients were recruited. Mean age was 36.0±5.4 years. 41 (38.0%) had symptoms of acute respiratory infection (ARI) at presentation. Of 216 eyes, 25 (11.6%) had retinal signs—eight (3.7%) with microhaemorrhages, six (2.8%) with retinal vascular tortuosity and two (0.93%) with cotton wool spots (CWS). 11 eyes (5.1%) had hyper-reflective plaques in the ganglion cell-inner plexiform layer layer on OCT, of which two also had retinal signs visible on CFP (CWS and microhaemorrhage, respectively). There was no significant difference in the prevalence of retinal signs in symptomatic versus asymptomatic patients (12 (15.0%) vs 13 (9.6%), p=0.227). Patients with retinal signs were significantly more likely to have transiently elevated blood pressure than those without (p=0.03).ConclusionOne in nine had retinal microvascular signs on ocular imaging. These signs were observed even in asymptomatic patients with normal vital signs. These retinal microvascular signs may be related to underlying cardiovascular and thrombotic alternations associated with COVID-19 infection.

scholarly journals Use of a Dry-Plasma Collection Device to Overcome Problems with Storage and Transportation of Blood Samples for Epidemiology Studies in Developing Countries

2000 ◽  
Vol 7 (6) ◽  
pp. 882-884 ◽  
Author(s):  
Zhannat Z. Nurgalieva ◽  
R. Almuchambetova ◽  
A. Machmudova ◽  
D. Kapsultanova ◽  
Michael S. Osato ◽  
...  
Keyword(s):  
Developing Countries ◽  
Rural Areas ◽  
Relative Sensitivity ◽  
The United States ◽  
Enzyme Linked Immunosorbent Assay ◽  
Plasma Samples ◽  
Serum Samples ◽  
Collection Device ◽  
Epidemiology Studies ◽  
Plasma Collection

ABSTRACT Studies are difficult in areas lacking modern facilities due to the inability to reliably collect, store, and ship samples. Thus, we sought to evaluate the use of a dry plasma collection device for seroepidemiology studies. Plasma was obtained by fingerstick using a commercial dry plasma collection device (Chemcard Plasma Collection Device) and serum (venipuncture) from individuals in Kazakhstan. Plasma samples were air dried for 15 min and then stored desiccated in foil zip-lock pouches at 4 to 6°C and subsequently shipped to the United States by air at ambient temperature. Serum samples remained frozen at −20°C until assayed. Helicobacter pylori status was determined by enzyme-linked immunosorbent assay (HM-CAP EIA) for the dry plasma and the serum samples. The results were concordant in 250 of the 289 cases (86.5%). In 25 cases (8.6%), the dry plasma samples gave indeterminate results and could not be retested because only one sample was collected. Five serum samples were positive, and the corresponding dry plasma samples were negative; one serum sample was negative, and the corresponding plasma sample was positive. The relative sensitivity and specificity of the Chemcard samples to serum were 97.6 and 97.9%, respectively, excluding those with indeterminate results. Repeated freeze-thawing had no adverse effect on the accuracy of the test. We found the dry plasma collection device to provide an accurate and practical alternative to serum when venipuncture may be difficult or inconvenient and sample storage and handling present difficulties, especially for seroepidemiologic studies in rural areas or developing countries and where freeze-thawing may be unavoidable.

Evaluation of a dried plasma collection device for the detection of H. Pylori antibodies

1998 ◽  
Vol 114 ◽  
pp. A90
Author(s):  
E.H. Cheng ◽  
K. Ashraf ◽  
M. Roeske ◽  
F. Rubenbauer ◽  
R. Shaw ◽  
...  
Keyword(s):  
Collection Device ◽  
H Pylori ◽  
Plasma Collection

scholarly journals RFID Based Vehicle Toll Collection System for Toll Roads

2021 ◽  
Vol 12 (2) ◽  
pp. 2104-2113
Author(s):  
Piyush Singhal, Et. al.
Keyword(s):  
Control Device ◽  
Toll Roads ◽  
Moving Vehicle ◽  
Toll Road ◽  
Collection Device ◽  
Toll Collection ◽  
The Individual ◽  
Machine Readable ◽  
Moving Vehicle Detection ◽  
Collection Program

The RFID-based vehicle collection program is intended to better handle toll operations through technology that aims to streamline the flow of vehicles. The purpose of this work is to plan, introduce and promote the automated operation of the car selection system (VTS). The Vehicle Toll Collection Device in this paper automatically detects vehicles and gathers machine-readable details on tolls for automobiles driving in the toll road. This knowledge is instigated by the modification and installation of at least one vehicle with a moving vehicle detection device. The computerized control device located along the toll line will transmit the registration signal as the car is reaching the registration point and will determine the toll to be debited and transfer the toll electronically to the account of the individual vehicle. This device helps a car to proceed beyond the scan point with no halting, thereby providing commuters with optimum comfort, speeding up traffic movement and reducing the need for human capital on highways

Use of a dry plasma collection device for H. pylori IgG antibodies in Kazakhstan

2000 ◽  
Vol 95 (9) ◽  
pp. 2469-2469
Author(s):  
E. White ◽  
Z.Z. Nurgalieva ◽  
M.S. Osato ◽  
U. Sherwani ◽  
J. Peacock ◽  
...  
Keyword(s):  
Igg Antibodies ◽  
Collection Device ◽  
H Pylori ◽  
Plasma Collection

Membrane-based plasma collection device for point-of-care diagnosis of HIV

2011 ◽  
Vol 173 (1) ◽  
pp. 37-42 ◽  
Author(s):  
Arman Nabatiyan ◽  
Zaheer A. Parpia ◽  
Robert Elghanian ◽  
David M. Kelso
Keyword(s):  
Point Of Care ◽  
Collection Device ◽  
Plasma Collection

scholarly journals „What about the others – differential diagnosis of COVID-19 in a German emergency department“

2020 ◽  
Author(s):  
David Fistera ◽  
Annalena Haertl ◽  
Dirk Pabst ◽  
Randi Manegold ◽  
Carola Holzner ◽  
...  
Keyword(s):  
Emergency Department ◽  
Differential Diagnosis ◽  
Clinical Symptoms ◽  
Respiratory Infections ◽  
Health Care Systems ◽  
Clinical Signs ◽  
Vital Signs ◽  
Nasopharyngeal Swab ◽  
Main Diagnosis ◽  
Airway Infections

Abstract Background: The ongoing COVID-19 pandemia is a major challenge for worldwide health care systems. Especially an early and safe triage in the emergency department (ED) is crucial for proper therapy. Clinical symptoms of COVID-19 comprise those of many common diseases thus differential diagnosis remains challenging.Method: We performed a retrospective study of 314 ED patients presenting with possible symptoms of COVID-19. All were tested for COVID-19 with SARS-Cov2-nasopharyngeal swab. 47 patients were positive for COVID-19. We analyzed the 267 COVID-19 negative patients for their main diagnosis and compared COVID-19 patients with COVID-19 negative respiratory infections for differences in laboratory parameters, symptoms and vital signs. Results: Among the 267 COVID-19 negative patients 42.7% had respiratory, 14.2% other infectious and 11.2% cardiovascular diseases, followed by 9.0% oncological and 6.7% gastroenterological diagnosis. Compared to COVID-19 negative airway infections, COVID-19 patients showed less dyspnea but more dysgeusia. Their hospital stay was significantly longer and their mortality significantly higher. Conclusion: For many common ED diagnoses COVID-19 should be considered as a differential diagnosis. COVID-19 cannot be distinguished from COVID-19 negative respiratory infections by clinical signs, symptoms or laboratory results. When hospitalization is necessary, the clinical course of COVID-19 airway infections seems to be more severe compared to other respiratory infections.

Cross section and thermonuclear reaction rates for the 58Ni(p,γ)59Cu reaction

1980 ◽  
Vol 58 (12) ◽  
pp. 1677-1683 ◽  
Author(s):  
C. W. Cheng ◽  
J. D. King
Keyword(s):  
Cross Section ◽  
Center Of Mass ◽  
Reaction Rates ◽  
Thick Target ◽  
Annihilation Radiation ◽  
Thermonuclear Reaction ◽  
Thin Target ◽  
Target Yield ◽  
Target Rates ◽  
Good Agreement

The yield from the 58Ni(p,γ)59Cu reaction has been measured by detection of annihilation radiation in coincidence from the decay of 82 s 59Cu. Both thin (600 μg cm−2) and thick (117 mg cm−2) targets have been used, the latter being thick enough to stop the proton beam at all incident energies. The cross section calculated from the thin target yield contains much structure and is in reasonably good agreement with previous studies. Thermonuclear reaction rates have been calculated from both thin and thick target yields for temperatures of interest in explosive nucleosynthesis. Both thin and thick target rates are in very good agreement with previous determinations but the thin target rates are, on the average, 35% higher than thick target rates. The reaction rate for T9 ≤ 2 is shown to be strongly dependent on a resonance at 931 MeV (center of mass) whose strength is not well known. A set of rates for T9 ≥ 2 for both ground state and stellar reactions based on thin target measurements is recommended and analytic fits to the recommended rates are given.

scholarly journals Saliva, a relevant alternative sample for SARS-CoV2 detection

2020 ◽  
Author(s):  
Monique Melo Costa ◽  
Nicolas Benoit ◽  
Jerome Dormoi ◽  
Remy Amalvict ◽  
Nicolas Gomez ◽  
...  
Keyword(s):  
Nasopharyngeal Swab ◽  
Test Results ◽  
Relevant Alternative ◽  
Chain Reaction ◽  
Collection Device ◽  
Positive Rate ◽  
Saliva Collection ◽  
Polymerase Chain ◽  
Saliva Test

AbstractBackgroundCurrently, COVID-19 diagnosis relies on quantitative reverse-transcriptase polymerase chain reaction (RT-qPCR) from nasopharyngeal swab (NPS) specimens, but NPSs present several limitations. The simplicity, low invasive and possibility of self-collection of saliva imposed this specimen as a relevant alternative for SARS-CoV-2 detection. However, the discrepancy of saliva test results compared to NPSs made of its use controversial. Here, we proposed to assess Salivettes®, as a standardized saliva collection device, and to compare SARS-CoV-2 positivity on paired NPS and saliva specimens.MethodsA total of 303 individuals randomly selected among those investigated for SARS-CoV-2 were enrolled, including 30 (9.9%) patients previously positively tested using NPS (follow-up group), 90 (29.7%) mildly symptomatic and 183 (60.4%) asymptomatic.ResultsThe RT-qPCR revealed a positive rate of 11.6% (n=35) and 17.2% (n=52) for NPSs and saliva samples, respectively. The sensitivity and specificity of saliva samples were 82.9% and 91.4%, respectively, using NPS as reference. The highest proportion of discordant results concerned the follow-up group (33.3%). Although in the symptomatic and asymptomatic groups the agreement exceeded 90.0%, 17 individuals were detected positive only in saliva samples, with consistent medical arguments.ConclusionSaliva collected with Salivette® demonstrated more sensitive for detecting symptomatic and pre-symptomatic infections.

Sign in / Sign up

Export Citation Format

Share Document