scholarly journals Effects of Duration and Midpoint of Sleep on Corticolimbic Circuitry in Youth

2019 ◽  
Vol 3 ◽  
pp. 247054701985633 ◽  
Author(s):  
Aneesh Hehr ◽  
Hilary A. Marusak ◽  
Edward D. Huntley ◽  
Christine A. Rabinak
Keyword(s):  
Emotion Regulation ◽  
Children And Adolescents ◽  
Sleep Duration ◽  
Sensory Processing ◽  
Resting State ◽  
Emotional Health ◽  
Neural Circuitry ◽  
Brain Regions ◽  
Interactive Effects ◽  
Older Youth

Introduction Adequate sleep is essential for cognitive and emotion-related functioning, and 9 to 12 hr of sleep is recommended for children ages 6 to 12 years and 8 to 10 hr for children ages 13 to 18 years. However, national survey data indicate that older youth sleep for fewer hours and fall asleep later than younger youth. This shift in sleep duration and timing corresponds with a sharp increase in onset of emotion-related problems (e.g., anxiety, depression) during adolescence. Given that both sleep duration and timing have been linked to emotion-related outcomes, the present study tests the effects of sleep duration and timing, and their interaction, on resting-state functional connectivity (RS-FC) of corticolimbic emotion-related neural circuitry in children and adolescents. Methods A total of 63 children and adolescents (6–17 years, 34 females) completed a weekend overnight sleep journal and a 10-min resting-state functional magnetic resonance imaging scan the next day (Sunday). Whole-brain RS-FC of the amygdala was computed, and the effects of sleep duration, timing (i.e., midpoint of sleep), and their interaction were explored using regression analyses. Results Overall, we found that older youth tended to sleep later and for fewer hours than younger youth. Controlling for age, shorter sleep duration was associated with lower RS-FC between the amygdala and regions implicated in emotion regulation, including ventral anterior cingulate cortex, precentral gyrus, and superior temporal gyrus. Interestingly, midpoint of sleep was associated with altered connectivity in a distinct set of brain regions involved in interoception and sensory processing, including insula, supramarginal gyrus, and postcentral gyrus. Our data also indicate widespread interactive effects of sleep duration and midpoint on brain regions implicated in emotion regulation, sensory processing, and motor control. Conclusion These results suggest that both sleep duration and midpoint of sleep are associated with next-day RS-FC within corticolimbic emotion-related neural circuitry in children and adolescents. The observed interactive effects of sleep duration and timing on RS-FC may reflect how homeostatic and circadian process interact in the brain and explain the complex patterns observed with respect to emotional health when considering sleep duration and timing. Sleep-related changes in corticolimbic circuitry may contribute to the onset of emotion-related problems during adolescence.

scholarly journals The role of pubertal status and sleep satisfaction in emotion reactivity and regulation in children and adolescents

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Kari A Lustig ◽  
Kimberly A Cote ◽  
Teena Willoughby
Keyword(s):  
Emotion Regulation ◽  
Children And Adolescents ◽  
Sleep Duration ◽  
Pubertal Development ◽  
Saliva Sample ◽  
Self Report ◽  
Emotion Reactivity ◽  
Pubertal Status ◽  
Sleep Satisfaction

Abstract Study Objectives This study investigated the role of pubertal status and hormones in the association between sleep satisfaction and self-reported emotion functioning in 256 children and adolescents aged 8–15. Methods Self-report data was provided on sleep duration, sleep satisfaction, and emotion reactivity and regulation, and a saliva sample was obtained for hormone measures. A subset of children also wore an Actigraph watch to measure sleep for a week. Results Latent-class analysis revealed three classes of sleepers: Satisfied, Moderately Satisfied, and Dissatisfied. Dissatisfied sleepers reported more difficulties with emotion regulation and greater emotion reactivity than Satisfied sleepers. High difficulties with emotion regulation was associated with shorter objective sleep duration, and high emotion reactivity was associated with lower sleep efficiency. For girls, Dissatisfied sleepers reported being further through pubertal development than Satisfied sleepers. There were also significant correlations between pubertal development and shorter sleep duration and longer sleep latency in girls, and shorter and more irregular sleep in boys. Finally, pubertal development in girls was a significant moderator in the relationship between sleep satisfaction and difficulties with emotion regulation in Dissatisfied sleepers, such that being further through puberty and having unsatisfactory sleep resulted in the highest emotion regulation difficulties. Conclusions This study expands on previous literature by considering the role of sleep satisfaction and the interaction with puberty development on emotion function. Specifically, a role for pubertal development was identified in the association between unsatisfactory sleep and emotion regulation in girls.

scholarly journals Inferior Frontal Gyrus-Based Resting-State Functional Connectivity and Medium Dispositional Use of Reappraisal Strategy

2021 ◽  
Vol 15 ◽  
Author(s):  
Wenjuan Li ◽  
Ke Xie ◽  
Ronald K. Ngetich ◽  
Junjun Zhang ◽  
Zhenlan Jin ◽  
...  
Keyword(s):  
Emotion Regulation ◽  
Functional Connectivity ◽  
Resting State ◽  
Parietal Lobe ◽  
Inferior Frontal Gyrus ◽  
Cingulate Cortex ◽  
Brain Regions ◽  
Anterior Cingulate ◽  
Resting State Functional Connectivity ◽  
The Relationship

The previous neuroimaging functional connectivity analyses have indicated that the association between the inferior frontal gyrus (IFG) and other brain regions results in better emotion regulation in reappraisal tasks. However, no study has explored the relationship between IFG-based resting-state functional connectivity (rsFC) and the dispositional use of reappraisal strategy. Therefore, the present study examined the potential associations between rsFC patterns of both left and right IFG and dispositional reappraisal use. One hundred healthy participants completed the Emotion Regulation Questionnaire (ERQ) and underwent a resting-state functional magnetic resonance imaging (fMRI) acquisition. An approach of the seed-based rsFC analysis was recruited to estimate the functional connectivity maps of bilateral IFG with other brain regions, and the reappraisal scores from the ERQ were then correlated with the functional maps. Our findings showed that IFG-based rsFC was positively correlated with dispositional reappraisal only in the range of 4 to 5.5 points [medium reappraisal group (MRG)]. Specifically, medium dispositional reappraisal was positively correlated with rsFC between left/right IFG and bilateral temporal gyrus. Besides, medium dispositional reappraisal was positively correlated with rsFC between left IFG and bilateral superior parietal lobe (SPL), middle cingulate cortex (MCC), and right insula, as well as between right IFG and dorsomedial prefrontal cortex (DMPFC) and anterior cingulate cortex (ACC). In conclusion, these results indicate that bilateral IFG plays an important role in the medium use of the reappraisal strategy.

scholarly journals Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex

2012 ◽  
Vol 16 (2) ◽  
pp. 255-260 ◽  
Author(s):  
Chandra Sekhar Sripada ◽  
K. Luan Phan ◽  
Izelle Labuschagne ◽  
Robert Welsh ◽  
Pradeep J. Nathan ◽  
...  
Keyword(s):  
Emotion Regulation ◽  
Social Cognition ◽  
Frontal Cortex ◽  
Resting State ◽  
Brain Regions ◽  
Medial Frontal Cortex ◽  
Double Blind ◽  
Cognition And Emotion ◽  
Cortical Regions ◽  
Cognitive Behaviours

Abstract The neuropeptide oxytocin (OXT) plays an important role in complex socio-affective behaviours such as affiliation, attachment, stress and anxiety. Previous studies have focused on the amygdala as an important target of OXT's effects. However, the effects of OXT on connectivity of the amygdala with cortical regions such as medial frontal cortex, an important mediator of social cognition and emotion regulation, remain unexplored. In a randomized, double-blind, cross-over design, 15 volunteers received intranasal OXT or placebo prior to resting-state functional magnetic resonance imaging. OXT significantly increased connectivity between both amygdalae and rostral medial frontal cortex (rmFC), while having only negligible effects on coupling with other brain regions. These results demonstrate that OXT is a robust and highly selective enhancer of amygdala connectivity with rmFC, a region critical to social cognition and emotion regulation, and add to our understanding of the neural mechanisms by which OXT modulates complex social and cognitive behaviours.

scholarly journals Altered Functional Connectivity and Sensory Processing in Blepharospasm and Hemifacial Spasm: Coexistence and Difference

2021 ◽  
Vol 12 ◽  
Author(s):  
Ting-Chun Fang ◽  
Chun-Ming Chen ◽  
Ming-Hong Chang ◽  
Chen-Hao Wu ◽  
Yi-Jen Guo
Keyword(s):  
Functional Connectivity ◽  
Sensory Processing ◽  
Hemifacial Spasm ◽  
Resting State ◽  
Large Scale ◽  
Detection Threshold ◽  
Image Data ◽  
Brain Regions ◽  
Resting State Functional Connectivity ◽  
The Right

Background: Blepharospasm (BSP) and hemifacial spasm (HFS) are both facial hyperkinesia however BSP is thought to be caused by maladaptation in multiple brain regions in contrast to the peripherally induced cause in HFS. Plausible coexisting pathophysiologies between these two distinct diseases have been proposed.Objectives: In this study, we compared brain resting state functional connectivity (rsFC) and quantitative thermal test (QTT) results between patients with BSP, HFS and heathy controls (HCs).Methods: This study enrolled 12 patients with BSP, 11 patients with HFS, and 15 HCs. All subjects received serial neuropsychiatric evaluations, questionnaires determining disease severity and functional impairment, QTT, and resting state functional MRI. Image data were acquired using seed-based analyses using the CONN toolbox.Results: A higher cold detection threshold was found in the BSP and HFS patients compared to the HCs. The BSP and HFS patients had higher rsFC between the anterior cerebellum network and left occipital regions compared to the HCs. In all subjects, impaired cold detection threshold in the QTT of lower extremities had a correlation with higher rsFC between the anterior cerebellar network and left lingual gyrus. Compared to the HCs, increased rsFC in right postcentral gyrus in the BSP patients and decreased rsFC in the right amygdala and frontal orbital cortex in the HFS subjects were revealed when the anterior cerebellar network was used as seed.Conclusions: Dysfunction of sensory processing detected by the QTT is found in the BSP and HSP patients. Altered functional connectivity between the anterior cerebellar network and left occipital region, especially the Brodmann area 19, may indicate the possibility of shared pathophysiology among BSP, HFS, and impaired cold detection threshold. Further large-scale longitudinal study is needed for testing this theory in the future.

The Coping Scales From the German Stress and Coping Questionnaire for Children and Adolescents

2020 ◽  
Vol 36 (4) ◽  
pp. 545-553 ◽  
Author(s):  
Heike Eschenbeck ◽  
Uwe Heim-Dreger ◽  
Denise Kerkhoff ◽  
Carl-Walter Kohlmann ◽  
Arnold Lohaus ◽  
...  
Keyword(s):  
Emotion Regulation ◽  
Children And Adolescents ◽  
Internal Consistency ◽  
Stress And Coping ◽  
Self Report ◽  
Partial Metric ◽  
Confirmatory Factor Analyses ◽  
Language Version ◽  
English Speaking ◽  
And Coping

Abstract. The coping scales from the Stress and Coping Questionnaire for Children and Adolescents (SSKJ 3–8; Lohaus, Eschenbeck, Kohlmann, & Klein-Heßling, 2018 ) are subscales of a theoretically based and empirically validated self-report instrument for assessing, originally in the German language, the five strategies of seeking social support, problem solving, avoidant coping, palliative emotion regulation, and anger-related emotion regulation. The present study examined factorial structure, measurement invariance, and internal consistency across five different language versions: English, French, Russian, Spanish, and Ukrainian. The original German version was compared to each language version separately. Participants were 5,271 children and adolescents recruited from primary and secondary schools from Germany ( n = 3,177), France ( n = 329), Russia ( n = 378), the Dominican Republic ( n = 243), Ukraine ( n = 437), and several English-speaking countries such as Australia, Great Britain, Ireland, and the USA (English-speaking sample: n = 707). For the five different language versions of the SSKJ 3–8 coping questionnaire, confirmatory factor analyses showed configural as well as metric and partial scalar invariance (French) or partial metric invariance (English, Russian, Spanish, Ukrainian). Internal consistency coefficients of the coping scales were also acceptable to good. Significance of the results was discussed with special emphasis on cross-cultural research on individual differences in coping.

scholarly journals Hippocampal regenerative medicine: neurogenic implications for addiction and mental disorders

2021 ◽  
Author(s):  
Lee Peyton ◽  
Alfredo Oliveros ◽  
Doo-Sup Choi ◽  
Mi-Hyeon Jang
Keyword(s):  
Decision Making ◽  
Prefrontal Cortex ◽  
Executive Function ◽  
General Population ◽  
Mental Disorders ◽  
Psychiatric Illness ◽  
Neural Circuitry ◽  
Brain Regions ◽  
Neuropsychiatric Disease ◽  
Motivated Behavior

AbstractPsychiatric illness is a prevalent and highly debilitating disorder, and more than 50% of the general population in both middle- and high-income countries experience at least one psychiatric disorder at some point in their lives. As we continue to learn how pervasive psychiatric episodes are in society, we must acknowledge that psychiatric disorders are not solely relegated to a small group of predisposed individuals but rather occur in significant portions of all societal groups. Several distinct brain regions have been implicated in neuropsychiatric disease. These brain regions include corticolimbic structures, which regulate executive function and decision making (e.g., the prefrontal cortex), as well as striatal subregions known to control motivated behavior under normal and stressful conditions. Importantly, the corticolimbic neural circuitry includes the hippocampus, a critical brain structure that sends projections to both the cortex and striatum to coordinate learning, memory, and mood. In this review, we will discuss past and recent discoveries of how neurobiological processes in the hippocampus and corticolimbic structures work in concert to control executive function, memory, and mood in the context of mental disorders.

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