Increased fasting glucose and the prevalence of arterial stiffness: a cross-sectional study in Chinese adults

BackgroundFurin has been associated with glucose metabolic phenotypes in small sampled clinical studies. However, this association has not yet been studied in Chinese. Here, we aimed to examine the association between serum furin and fasting glucose in Chinese adults.MethodsSerum furin and fasting plasma glucose were assayed for 2,172 participants (mean aged 53 years, 38% men) in the Gusu cohort. A median regression model was applied to examine the association between serum furin and fasting glucose, adjusting for age, sex, education level, cigarette smoking, alcohol drinking, obesity, blood pressure, and lipids. To facilitate data interpretation, the association between serum furin and prevalent diabetes was also examined.ResultsSerum furin was negatively associated with fasting glucose (β=-0.18, P<0.001 for log-furin). In participants with diabetes, serum furin was significantly lower than those with normal glucose (median: 0.90 ng/mL vs. 1.05 ng/mL, P=0.001). Compared with participants in the highest quartile of serum furin, those in the lowest quartile had 42% and 80% increased risk of prevalent prediabetes (OR=1.42, 95%CI: 1.05-1.92, P=0.023) and diabetes (OR=1.80, 95%CI: 1.13-2.91, P=0.015), respectively.ConclusionsSerum furin was negatively associated with prediabetes and diabetes in Chinese adults. Our findings suggest that serum furin may be a risk factor or a biomarker of diabetes.

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Elevated fasting glucose as a potential predictor for asymptomatic cerebral artery stenosis: A cross-sectional study in Chinese adults

Atherosclerosis ◽

10.1016/j.atherosclerosis.2014.10.083 ◽

2014 ◽

Vol 237 (2) ◽

pp. 661-665 ◽

Cited By ~ 8

Author(s):

Jing Wang ◽

Jianwei Wu ◽

Shufeng Zhang ◽

Liqun Zhang ◽

Chunxue Wang ◽

...

Keyword(s):

Cerebral Artery ◽

Fasting Glucose ◽

Cross Sectional Study ◽

Artery Stenosis ◽

Sectional Study ◽

Chinese Adults ◽

Cross Sectional ◽

Potential Predictor

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The relationship between the atherogenic index of plasma and arterial stiffness in essential hypertensive patients from China: a cross-sectional study

BMC Cardiovascular Disorders ◽

10.1186/s12872-021-02049-8 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Juan Yin ◽

Minghui Li ◽

Lingling Yu ◽

Feng Hu ◽

Yu Yu ◽

...

Keyword(s):

Essential Hypertension ◽

Arterial Stiffness ◽

Linear Regression Analysis ◽

Cross Sectional Study ◽

Atherogenic Index ◽

Chinese Patients ◽

Multivariate Linear Regression Analysis ◽

Sectional Study ◽

Cross Sectional ◽

Atherogenic Index Of Plasma

Abstract Background The atherogenic index of plasma (AIP) always remains in a potential association with arterial stiffness, however, this association has not been fully discovered and needs to be studied in depth in large hypertensive patient populations. The present analysis thus sought to further explore the association that exists between AIP and arterial stiffness in Chinese patients diagnosed with arterial hypertension. Methods This cross-sectional study analyzed 4744 Chinese individuals with essential hypertension. AIP was defined as the base 10 logarithm of the ratio of plasma of triglycerides to high-density lipoprotein cholesterol levels indicated in molar concentrations. Measurement of arterial stiffness was carried out via brachial-ankle pulse wave velocity (baPWV). Results Data were adjusted for potential confounding variables, and multivariate linear regression analysis revealed AIP to be positively correlated with baPWV (β = 1.34, 95% CI: 0.96 to 1.72, P < 0.001). When AIP was instead treated as a categorical variable divided into quartiles, the same relationship was observed (P for trend < 0.001). We additionally found AIP and baPWV had a stronger positive association in individuals with a body mass index (BMI) < 24 kg/m2 (P for interaction < 0.05). Conclusion AIP and arterial stiffness were positively correlated in essential hypertension patients in China, especially in those with a BMI < 24 kg/m2. Clinical trial registration ChiCTR1800017274.

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The consumption of wholegrain is related to depressive symptoms among Chinese adults: a cross-sectional study

European Journal of Clinical Nutrition ◽

10.1038/s41430-021-00917-2 ◽

2021 ◽

Author(s):

Hanzhang Wu ◽

Shunming Zhang ◽

Ge Meng ◽

Qing Zhang ◽

Li Liu ◽

...

Keyword(s):

Depressive Symptoms ◽

Cross Sectional Study ◽

Sectional Study ◽

Chinese Adults ◽

Cross Sectional

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Radiation effects on atherosclerosis in atomic bomb survivors: a cross‐sectional study using structural equation modeling

European Journal of Epidemiology ◽

10.1007/s10654-021-00731-x ◽

2021 ◽

Vol 36 (4) ◽

pp. 401-414

Author(s):

Tomoki Nakamizo ◽

John Cologne ◽

Kismet Cordova ◽

Michiko Yamada ◽

Tetsuya Takahashi ◽

...

Keyword(s):

Arterial Stiffness ◽

Radiation Exposure ◽

Structural Equation ◽

Atomic Bomb ◽

Cross Sectional Study ◽

Equation Modeling ◽

Study Cohort ◽

Sectional Study ◽

Cross Sectional ◽

Atomic Bomb Survivors

AbstractPast reports indicated that total-body irradiation at low to moderate doses could be responsible for cardiovascular disease risks, but the mechanism remains unclear. The purpose of this study was to investigate the association between radiation exposure and atherosclerosis, an underlying pathology of cardiovascular diseases, in the Japanese atomic bomb survivors. We performed a cross-sectional study measuring 14 clinical-physiological atherosclerosis indicators during clinical exams from 2010 to 2014 in 3274 participants of the Adult Health Study cohort. Multivariable analyses were performed by using a structural equation model with latent factors representing underlying atherosclerotic pathologies: (1) arterial stiffness, (2) calcification, and (3) plaque　as measured with indicators chosen a priori on the basis of clinical-physiological knowledge. Radiation was linearly associated with calcification (standardized coefficient per Gy 0.15, 95 % confidence interval: CI [0.070, 0.23]) and plaque (0.11, 95 % CI [0.029, 0.20]), small associations that were comparable to about 2 years of aging per Gy of radiation exposure, but not with arterial stiffness (0.036, 95 % CI [− 0.025, 0.095]). The model fitted better and had narrower confidence intervals than separate ordinary regression models explaining individual indicators independently. The associations were less evident when the dose range was restricted to a maximum of 2 or 1 Gy. By combining individual clinical-physiological indicators that are correlated because of common, underlying atherosclerotic pathologies, we found a small, but significant association of radiation with atherosclerosis.

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Low socioeconomic status aggravated associations of exposure to mixture of air pollutants with obesity in rural Chinese adults: A cross-sectional study

Environmental Research ◽

10.1016/j.envres.2020.110632 ◽

2021 ◽

Vol 194 ◽

pp. 110632

Author(s):

Runqi Tu ◽

Jian Hou ◽

Xiaotian Liu ◽

Ruiying Li ◽

Xiaokang Dong ◽

...

Keyword(s):

Socioeconomic Status ◽

Low Socioeconomic Status ◽

Air Pollutants ◽

Cross Sectional Study ◽

Sectional Study ◽

Chinese Adults ◽

Cross Sectional ◽

Low Socioeconomic

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Association of depressive symptoms with ambient PM2.5 in middle-aged and elderly Chinese adults: A cross-sectional study from the China health and Retirement Longitudinal Study wave 4

Environmental Research ◽

10.1016/j.envres.2021.111889 ◽

2022 ◽

Vol 203 ◽

pp. 111889

Author(s):

Yifan Yao ◽

Tianjun Lu ◽

Yisi Liu ◽

Qiujun Qin ◽

Jie Jiang ◽

...

Keyword(s):

Depressive Symptoms ◽

Longitudinal Study ◽

Cross Sectional Study ◽

Sectional Study ◽

Middle Aged ◽

Chinese Adults ◽

Cross Sectional ◽

Elderly Chinese

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Association between Hyperhomocysteinemia and Thyroid Hormones in Euthyroid Diabetic Subjects

BioMed Research International ◽

10.1155/2015/196379 ◽

2015 ◽

Vol 2015 ◽

pp. 1-5

Author(s):

Yun Zhang ◽

Qiong Wang ◽

Quanzhong Li ◽

Ping Lu

Keyword(s):

Blood Pressure ◽

Fasting Glucose ◽

Cross Sectional Study ◽

Thyroid Stimulating Hormone ◽

Diabetic Patients ◽

Biomedical Data ◽

Sectional Study ◽

Free Triiodothyronine ◽

Cross Sectional ◽

Elderly Males

Objectives. The concept now emerging is that higher thyroid-stimulating hormone (TSH) and lower thyroid hormone levels within the euthyroid range may adversely affect atherosclerosis. The present study aimed to investigate the potential associations between thyroid parameters and hyperhomocysteinaemia in a cohort of euthyroid diabetic subjects.Material and Methods. Two hundred and seventy-three euthyroid diabetic subjects (167 males and 106 females) were consecutively recruited in this cross-sectional study. Clinical and biomedical data was collected.Results. TSH level was higher in females than males. Compared to normal-homocysteine group, hyperhomocysteinaemia group was more likely to be elderly, males, with longer diabetes history, and with lower diastolic blood pressure. Free thyroxine (FT4) level was lower in hyperhomocysteinaemia group than in normal-homocysteine group; however, it was not statistically significant. Adjusted for age, sex, body mass index, duration of diabetes, blood pressure, fasting glucose, total cholesterol, and triglyceride in logistic regression analyses, hyperhomocysteinaemia was significantly correlated with FT4 (P=0.021). No significant association was found with TSH or free triiodothyronine. When analyzed in subjects with TSH < 2.5 uIU/mL separately, we got similar results.Conclusions. In conclusion, we identified a relation between hyperhomocysteinemia and FT4 in a group of euthyroid diabetic patients.

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