scholarly journals Association Between Serum Furin and Fasting Glucose: A Cross-Sectional Study in Chinese Adults

2022 ◽  
Vol 12 ◽  
Author(s):  
Yan He ◽  
Hanyun Zhu ◽  
Min Zhang ◽  
Jing Li ◽  
Shengqi Ma ◽  
...  
Keyword(s):  
Sex Education ◽  
Fasting Glucose ◽  
Data Interpretation ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Chinese Adults ◽  
Cross Sectional ◽  
Negatively Associated ◽  
Increased Risk ◽  
Normal Glucose

BackgroundFurin has been associated with glucose metabolic phenotypes in small sampled clinical studies. However, this association has not yet been studied in Chinese. Here, we aimed to examine the association between serum furin and fasting glucose in Chinese adults.MethodsSerum furin and fasting plasma glucose were assayed for 2,172 participants (mean aged 53 years, 38% men) in the Gusu cohort. A median regression model was applied to examine the association between serum furin and fasting glucose, adjusting for age, sex, education level, cigarette smoking, alcohol drinking, obesity, blood pressure, and lipids. To facilitate data interpretation, the association between serum furin and prevalent diabetes was also examined.ResultsSerum furin was negatively associated with fasting glucose (β=-0.18, P<0.001 for log-furin). In participants with diabetes, serum furin was significantly lower than those with normal glucose (median: 0.90 ng/mL vs. 1.05 ng/mL, P=0.001). Compared with participants in the highest quartile of serum furin, those in the lowest quartile had 42% and 80% increased risk of prevalent prediabetes (OR=1.42, 95%CI: 1.05-1.92, P=0.023) and diabetes (OR=1.80, 95%CI: 1.13-2.91, P=0.015), respectively.ConclusionsSerum furin was negatively associated with prediabetes and diabetes in Chinese adults. Our findings suggest that serum furin may be a risk factor or a biomarker of diabetes.

Increased fasting glucose and the prevalence of arterial stiffness: a cross-sectional study in Chinese adults

2014 ◽  
Vol 36 (5) ◽  
pp. 427-433 ◽  
Author(s):  
Jing Wang ◽  
Liping Liu ◽  
Yong Zhou ◽  
Chunxue Wang ◽  
Haitao Hu ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Fasting Glucose ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Chinese Adults ◽  
Cross Sectional

scholarly journals The correlation between lipoprotein associated phospholipase A2 and central overweight status

2021 ◽  
Vol 35 ◽  
pp. 205873842110485
Author(s):  
Yi-Hsuan Chen ◽  
Wen-Cheng Li ◽  
Yi-Chuan Chen ◽  
Wei-Chung Yeh ◽  
Wei Yu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Disease ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Sectional Study ◽  
Chinese Adults ◽  
Cross Sectional ◽  
Overweight Status ◽  
Increased Risk ◽  
Objective Being

Objective: Being overweight is associated with an increased risk of diabetes mellitus, hypertension, and cardiovascular disease. Lipoprotein-associated phospholipase A2 (Lp-PLA2) can independently predict the risk of cardiovascular disease. This study is aimed to investigate whether Lp-PLA2 was associated with an overweight status. Methods: This was a cross-sectional study that enrolled 3760 Chinese adults (age, 18–50 years) who underwent medical examination department of Xiamen Chang-Gung Hospital (XCGH) from 2018 to 2020. To explore the distribution of overweight classifications in the Chinese population, we evaluated the correlation of the overweight status with Lp-PLA2, after correcting for possible influencing factors. Results: The Lp-PLA2 level was greater in male than in female subjects ( p < 0.001). Subjects with a central overweight status had a greater Lp-PLA2 level than those with normal weight and a peripheral overweight status, in both male and female cohorts. The Lp-PLA2 level was significantly greater in those with additional comorbidities (namely diabetes mellitus (DM), hypertension (HTN), overweight, and metabolic syndrome (MetS)). The age-adjusted and LDL-adjusted Lp-PLA2 level also was significantly higher in the DM (+) and HTN (−) subgroups than in the DM (−), HTN (−), DM (−), and HTN (+) subgroups. Conclusion: Lp-PLA2 is associated with sex, central overweight status, diabetes, hypertension, and MetS in adults aged < 50 years and the age-adjusted and LDL-adjusted Lp-PLA2 was significantly higher in the DM (+) and HTN (−) subgroups than in the DM (−) and HTN (−) and DM (−) and HTN (+) subgroups.

scholarly journals Association of hypertriglyceridemic waist phenotype with renal function impairment: a cross-sectional study in a population of Chinese adults

2020 ◽  
Author(s):  
Yun Qiu ◽  
Qi Zhao ◽  
Yian Gu ◽  
Na Wang ◽  
Yuting Yu ◽  
...  
Keyword(s):  
Renal Function ◽  
Risk Factor ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Chinese Adults ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Hypertriglyceridemic Waist ◽  
Increased Risk

Abstract Background: The hypertriglyceridemic waist (HTGW) phenotype has been suggested as a risk factor for chronic kidney disease (CKD), but evidence on relationship of triglyceride waist phenotypes with estimated glomerular filtration rate (eGFR) status and severity is limited. Our aim was to explore the association of triglyceride waist phenotypes with reduced eGFR and various decreased eGFR stages among Chinese adults.Methods: A population-based, cross-sectional study was conducted among Chinese participants aged 20-74 years during June 2016 to December 2017 in Shanghai, China. An eGFR value below 60 mL/min/1.73 m2 was defined as Decreased eGFR. The HTGW phenotype was defined as a triglycerides (TG) level ≥1.7 mmol/L and a waist circumference (WC) ≥90 cm for men and ≥80 cm for women. We examined the association of triglyceride waist phenotypes with decreased eGFR risk using the weighted logistic regression models.Results: A total of 31,296 adults were included in this study. Compared with normal TG level/normal WC (NTNW) phenotype, normal TG level/enlarged WC (NTGW), elevated TG level/normal WC (HTNW), elevated TG level/enlarged WC (HTGW) were associated with the increased risk of decreased eGFR, with an multivariable-adjusted ORs (95% CI) of 1.77 (1.42-2.20), 1.48 (1.16-1.90), and 2.30 (1.80-2.93), respectively. These positive associations between triglyceride waist phenotypes and decreased eGFR risk remained across almost all the subgroups, including sex, age, BMI, T2DM, and hypertension. NTGW, HTNW, and HTGW phenotype were consistently positively associated with the risk of mildly and moderately decreased eGFR, but not with severely decreased eGFR risk.Conclusions: HTGW was consistently associated with the increased risk of decreased eGFR and various decreased eGFR stages except for severely decreased eGFR. The findings imply that HTGW may be an important risk factor for renal dysfunction or an indicator for prevention and control aiming to reduce renal function decline.

Fetuin-B Links Nonalcoholic Fatty Liver Disease to Chronic Kidney Disease in Obese Chinese Adults: A Cross-Sectional Study

2019 ◽  
Vol 74 (4) ◽  
pp. 287-295 ◽  
Author(s):  
Mingzhu Lin ◽  
Changqin Liu ◽  
Yongwen Liu ◽  
Dongmei Wang ◽  
Caiyu Zheng ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Chronic Kidney Disease ◽  
Fatty Liver Disease ◽  
Insulin Resistance Syndrome ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Chinese Adults ◽  
Cross Sectional ◽  
Nonalcoholic Fatty Liver ◽  
Increased Risk

Background: There is no evidence available on the association of Fetuin-B with chronic kidney disease (CKD), and mechanisms linking nonalcoholic fatty liver disease (NAFLD) to CKD are not fully understood. We aimed to explore the independent associations and potential mechanisms of Fetuin-B and NAFLD with CKD. Methods: A cross-sectional study of 1,072 Chinese adults who underwent serum Fetuin-B test and hepatic ultrasonography scanning was conducted in Xiamen, China. CKD was defined as estimated glomerular filtration rate < 60 mL/min/1.73 m2 and/or the presence of albuminuria. Results: Subjects with CKD showed significantly higher prevalence of NAFLD (69.5 vs. 57.2%, p < 0.001) and serum Fetuin-B levels (4.32 ± 1.45 vs. 4.05 ± 1.36 µg/mL, p = 0.007) than their controls. Increased serum Fetuin-B was also significantly associated with increased levels of fasting insulin and homeostasis model assessment – insulin resistance (both p values < 0.05). NAFLD and higher serum Fetuin-B were significantly associated with increased risk of CKD, and the unadjusted ORs (95% CIs) were 1.701 (1.256–2.303, p = 0.001) and 1.213 (1.053–1.399, p = 0.008, per SD increase of Fetuin-B), respectively. With adjustment for potential confounding factors, including metabolic/insulin resistance syndrome, NAFLD but not serum Fetuin-B was still significantly associated with increased risk of CKD, and the adjusted ORs (95% CIs) were 1.820 (1.327–2.496, p < 0.001) and 1.116 (0.959–1.298, p = 0.153, per SD increase of Fetuin-B), respectively. Conclusions: Fetuin-B might link NAFLD to CKD via inducing insulin resistance, and NAFLD contributes independently to the pathogenesis of CKD via multiple mechanisms besides of metabolic/insulin resistance syndrome.

scholarly journals Association Between Elevation, Health Related Lifestyles and the Metabolic Syndrome Among Ecuadorian Adults: A National Cross-Sectional Study

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1423-1423
Author(s):  
Christian Juna ◽  
Dongwoo Ham ◽  
Hyojee Joung ◽  
Yoon Hee Cho
Keyword(s):  
Physical Activity ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Latin American ◽  
Fasting Glucose ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Increased Risk ◽  
Health Related

Abstract Objectives To examine the associations of elevation, health related lifestyles and Metabolic Syndrome Mets in the Ecuadorian adult population. Methods This cross-sectional study used secondary data from the 2012 Ecuador National Health and Nutrition Survey, a total of 6024 adults (1964 men and 4060 women) aged 20 to 60 years were included in the study. Elevation was obtained by georeferencing techniques, dietary intake was measured using a 24-hour dietary recall method and health related lifestyles through risk factors and physical activity standardized questionnaires. MetS was defined using the National Cholesterol Education Program Adult Treatment Panel III and the Latin American Diabetes Association criteria. Multiple logistic regression analysis was used to evaluate the associations between elevation, health related lifestyles and MetS abnormalities. Results Residing at low elevation (0-,2000 masl) showed increased risk of MetS in men (1.42; 95% CI, 1.11–1.81), increased waist circumference in women (1.32; 95% CI, 1.02–1.70) and increased risk of elevated fasting glucose in men (2.08; 95% CI, 1.55–2.79) and women (1.70; 95% CI, 1.38–2.10). Health-related lifestyle factors (alcohol consumption, current smoking, currently working and Estimated Energy Requirement intake) showed increased trend of higher risks of MetS and other components in response to lower elevation. However, only physical activity (Yes vs. No) showed a significant difference, decreased risk of elevated triglycerides in women (0.49; 95% CI, 0.25–0.97). Conclusions Living at low elevation was associated with increased prevalence of MetS in men, increased waist circumference in women and elevated fasting glucose in men and women. Regular physical activity in response to low elevation was associated with decreased risk of elevated triglycerides in women. Funding Sources This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

scholarly journals SARS-CoV-2 seroprevalence and asymptomatic viral carriage in healthcare workers: a cross-sectional study

Thorax ◽  
2020 ◽  
Vol 75 (12) ◽  
pp. 1089-1094 ◽  
Author(s):  
Adrian Shields ◽  
Sian E Faustini ◽  
Marisol Perez-Toledo ◽  
Sian Jossi ◽  
Erin Aldera ◽  
...  
Keyword(s):  
Intensive Care ◽  
Healthcare Workers ◽  
Venous Blood ◽  
Cross Sectional Study ◽  
Nasopharyngeal Swab ◽  
Sectional Study ◽  
University Hospitals ◽  
Cross Sectional ◽  
General Internal ◽  
Increased Risk

ObjectiveTo determine the rates of asymptomatic viral carriage and seroprevalence of SARS-CoV-2 antibodies in healthcare workers.DesignA cross-sectional study of asymptomatic healthcare workers undertaken on 24/25 April 2020.SettingUniversity Hospitals Birmingham NHS Foundation Trust (UHBFT), UK.Participants545 asymptomatic healthcare workers were recruited while at work. Participants were invited to participate via the UHBFT social media. Exclusion criteria included current symptoms consistent with COVID-19. No potential participants were excluded.InterventionParticipants volunteered a nasopharyngeal swab and a venous blood sample that were tested for SARS-CoV-2 RNA and anti-SARS-CoV-2 spike glycoprotein antibodies, respectively. Results were interpreted in the context of prior illnesses and the hospital departments in which participants worked.Main outcome measureProportion of participants demonstrating infection and positive SARS-CoV-2 serology.ResultsThe point prevalence of SARS-CoV-2 viral carriage was 2.4% (n=13/545). The overall seroprevalence of SARS-CoV-2 antibodies was 24.4% (n=126/516). Participants who reported prior symptomatic illness had higher seroprevalence (37.5% vs 17.1%, χ2=21.1034, p<0.0001) and quantitatively greater antibody responses than those who had remained asymptomatic. Seroprevalence was greatest among those working in housekeeping (34.5%), acute medicine (33.3%) and general internal medicine (30.3%), with lower rates observed in participants working in intensive care (14.8%). BAME (Black, Asian and minority ethnic) ethnicity was associated with a significantly increased risk of seropositivity (OR: 1.92, 95% CI 1.14 to 3.23, p=0.01). Working on the intensive care unit was associated with a significantly lower risk of seropositivity compared with working in other areas of the hospital (OR: 0.28, 95% CI 0.09 to 0.78, p=0.02).Conclusions and relevanceWe identify differences in the occupational risk of exposure to SARS-CoV-2 between hospital departments and confirm asymptomatic seroconversion occurs in healthcare workers. Further investigation of these observations is required to inform future infection control and occupational health practices.

scholarly journals Gut Microbiota Profile and Its Association with Clinical Variables and Dietary Intake in Overweight/Obese and Lean Subjects: A Cross-Sectional Study

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2032
Author(s):  
Judit Companys ◽  
Maria José Gosalbes ◽  
Laura Pla-Pagà ◽  
Lorena Calderón-Pérez ◽  
Elisabet Llauradó ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Dietary Intake ◽  
Saturated Fatty Acids ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Anthropometric Parameters ◽  
Cross Sectional ◽  
Negatively Associated ◽  
Clinical Variables ◽  
Obese Subjects

We aimed to differentiate gut microbiota composition of overweight/obese and lean subjects and to determine its association with clinical variables and dietary intake. A cross-sectional study was performed with 96 overweight/obese subjects and 32 lean subjects. Anthropometric parameters were positively associated with Collinsella aerofaciens, Dorea formicigenerans and Dorea longicatena, which had higher abundance the overweight/obese subjects. Moreover, different genera of Lachnospiraceae were negatively associated with body fat, LDL and total cholesterol. Saturated fatty acids (SFAs) were negatively associated with the genus Intestinimonas, a biomarker of the overweight/obese group, whereas SFAs were positively associated with Roseburia, a biomarker for the lean group. In conclusion, Dorea formicigenerans, Dorea longicatena and Collinsella aerofaciens could be considered obesity biomarkers, Lachnospiraceae is associated with lipid cardiovascular risk factors. SFAs exhibited opposite association profiles with butyrate-producing bacteria depending on the BMI. Thus, the relationship between diet and microbiota opens new tools for the management of obesity.

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