Pregnancy Outcomes among Patients with Chronic Myeloid Leukemia Treated with Dasatinib

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 3230-3230 ◽  
Author(s):  
Jorge Cortes ◽  
Susan O’Brien ◽  
Patricia Ault ◽  
Gautam Borthakur ◽  
Elias Jabbour ◽  
...  
Keyword(s):  
Adverse Reaction ◽  
Caesarean Section ◽  
Spontaneous Abortion ◽  
Birth Defects ◽  
Healthy Infant ◽  
The Other ◽  
Female Patients ◽  
Healthy Newborn ◽  
History Of ◽  
Male Patients

Abstract Dasatinib has been shown in non-clinical studies to cause fetal toxicities in animals, but the effect of exposure during conception and pregnancy in humans is not known. Despite the requirement for contraception while on therapy with dasatinib, occasional pregnancies have been reported. The current study and post-marketing data report the outcomes of pregnancies occurring among 16 patients (8 females and 8 males) who received dasatinib therapy. Among the 8 female patients found to be pregnant while on dasatinib therapy, induced abortion was reported in 3 cases: 2 due to patient decision and 1 for unknown reasons. Two cases of spontaneous abortion were reported. The first was at 8 weeks gestation in a 38-year-old patient (G1P1) with a history of tobacco use. Birth defects of the fetus were not reported; though it is unknown if an autopsy was performed. The other spontaneous abortion was reported at 9 weeks gestation in a 33-year-old patient (G3P3) taking dasatinib for over 2 years. The medical history of this patient includes tobacco and alcohol use. Of the 3 deliveries, one patient had a normal healthy infant. The second patient (age: 29 years, G2P2) delivered a healthy infant by Caesarean section at 7 months gestation (reason for Caesarean section unknown). This patient received dasatinib 140mg/day for approximately 4 months, but was ‘lost to follow up’ for 2 months and study drug compliance was unknown. Upon her return, the patient had a positive pregnancy test with an estimated gestation of 4 weeks. The infant was reported as ‘small for date’ but without obvious birth defects. Apgar scores were also unknown for this infant. In the final case, a patient on dasatinib 100mg/day for approximately 5 months was identified as pregnant (G0P0) at 21 weeks of gestation. The estimated delivery date has not yet occurred at the time of writing, but the pregnancy course has been normal. Among 8 male patients treated with dasatinib with partners becoming pregnant while on treatment, normal newborns were reported for 7 cases, with the outcome of the other case unknown. All male patients remained on treatment during and after the pregnancies. In 1 case, the mother experienced pre-eclampsia but delivered a healthy newborn at 37 weeks, without birth defects or neonatal complications. In summary, although the limited data reported in this study did not show evidence that dasatinib treatment has a negative impact on pregnancy (for the mother or fetus), patients receiving dasatinib should be advised to practice adequate contraception. Table 1. Outcome of Female Patients Electing to C regnancy Duration of Fetal Exposure to Dasatinib Fetal Outcome Maternal Outcome Dasatinib Dose* Duration of Dasatinib Therapy * at time of onset Pt D 5 weeks 8wk spontaneous abortion no adverse reaction reported 180 mg/day approximately 9.5 months Pt E 9 weeks 9wk spontaneous abortion no adverse reaction reported 100 mg BID 30 months Pt F 7 weeks normal healthy no adverse reaction reported 140 mg/day approximately 15 months Pt G unknown “small for date” – healthy newborn C-section at 7 months 140mg/day approximately 4 months Pt H 21 days to be determined 100mg/day 5 months

scholarly journals Mosaicism and incomplete penetrance of PCDH19 mutations

2018 ◽  
Vol 56 (2) ◽  
pp. 81-88 ◽  
Author(s):  
Aijie Liu ◽  
Xiaoxu Yang ◽  
Xiaoling Yang ◽  
Qixi Wu ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Male Patient ◽  
Sanger Sequencing ◽  
De Novo ◽  
Digital Pcr ◽  
The Other ◽  
Incomplete Penetrance ◽  
Female Patients ◽  
Targeted Next Generation Sequencing ◽  
Male Patients ◽  
Patients With Epilepsy

BackgroundMutations in the PCDH19 gene have mainly been reported in female patients with epilepsy. To date, PCDH19 mutations have been reported in hundreds of females and only in 10 mosaic male epileptic patients with mosaicism.ObjectiveWe aimed to investigate the occurrence of mosaic PCDH19 mutations in 42 families comprising at least one patient with PCDH19-related epilepsy.MethodsTwo male patients with mosaic PCDH19 variants were identified using targeted next-generation sequencing. Forty female patients with PCDH19 variants were identified by Sanger sequencing and Multiple Ligation Probe Amplification (MLPA). Microdroplet digital PCR was used to quantify the mutant allelic fractions (MAFs) in 20 families with PCDH19 variants.ResultsFive mosaic individuals, four males and one female, were identified in total. Mosaic variant was confirmed in multiple somatic tissues from one male patient and in blood from the other male patient. Among 22 female patients harbouring a newly occurred PCDH19 variant identified by Sanger sequencing and MLPA, Sanger sequencing revealed two mosaic fathers (9%, 2/22), one with two affected daughters and the other with an affected child. Two asymptomatic mosaic fathers were confirmed as gonosomal mosaicism, with MAFs ranging from 4.16% to 37.38% and from 1.27% to 19.13%, respectively. In 11 families with apparent de novo variants, 1 female patient was identified as a mosaic with a blood MAF of 26.72%.ConclusionOur study provides new insights into phenotype-genotype correlations in PCDH19 related epilepsy and the finding of high-frequency mosaicism has important implications for genetic counselling.

scholarly journals Frequency of HLA-DRB1 Gene Alleles in Patients With Multiple Sclerosis in a Lithuanian Population

Medicina ◽  
2012 ◽  
Vol 48 (1) ◽  
pp. 2
Author(s):  
Renata Balnytė ◽  
Daiva Rastenytė ◽  
Dalia Mickevičienė ◽  
Antanas Vaitkus ◽  
Erika Skrodenienė ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Case Control Study ◽  
Case Control ◽  
Chain Reaction ◽  
Female Patients ◽  
History Of ◽  
Male Patients ◽  
Polymerase Chain ◽  
The Relationship ◽  
Control Study

The aim of the present study was to investigate the influence of HLA-DRB1 alleles on the genetic susceptibility to multiple sclerosis in the Lithuanian population. Material and Methods. A total of 120 patients with multiple sclerosis and 120 unrelated healthy controls were enrolled in this case-control study. Allelic frequencies were compared between the groups. HLA-DRB1 alleles were genotyped using the polymerase chain reaction. Results. HLA-DRB1*15 was present in 55.8% of the patients with multiple sclerosis and 10.0% of the controls (OR, 5.58; 95% CI, 3.19–9.77; P<0.0001). The protective alleles that were found to be more prevalent among the controls compared with the patients with multiple sclerosis were HLADRB1* 01 (26.7% vs. 7.5%, P<0.0001), *03 (17.5% vs. 8.3%, P=0.034), and *16 (11.7% vs. 3.3%, P=0.014). HLA-DRB1*15 was more common among the female patients with multiple sclerosis than among the male patients (68.4% vs. 34.1%; OR, 4.18; 95%, CI 1.90–9.22; P=0.001). The heterozygous inheritance of HLA-DRB1*15 allele was more common in the patients with a history of maternal multiple sclerosis than in those with a history of paternal multiple sclerosis (29.4% vs. 9.8%; P=0.045). Conclusions. HLA-DRB1*15 was found to be associated with multiple sclerosis in the Lithuanian population. This allele was more prevalent among the female patients with multiple sclerosis. Maternal multiple sclerosis was more common than paternal multiple sclerosis, but the relationship with HLA-DRB1*15 allele was not established. HLA-DRB1*01, *03, and *16 appeared to be the protective alleles in this series.

scholarly journals Male Gender is A Risk Factor For Sever Form of COVID-19 Illness and Worse Outcome in The Middle East

2020 ◽  
Author(s):  
Ibrahim Y Hachim ◽  
Mahmood Y Hachim ◽  
Kashif Bin Naeem ◽  
Haifa Hannawi ◽  
Issa Al Salmi ◽  
...  
Keyword(s):  
Middle East ◽  
Liver Function Tests ◽  
P Value ◽  
Icu Admission ◽  
Female Patients ◽  
Wide Range ◽  
Significant Impairment ◽  
History Of ◽  
Male Patients ◽  
Novel Coronavirus

Abstract The identification of risk-factors, predicting the disease severity and outcome in novel coronavirus-disease-19 (COVID-19) patients, is essential to improve responsiveness to this pandemic. The association between gender and wide-range of clinical, pathological, and epidemiological factors was studied in 200-patients recruited during March-April 2020. A higher prevalence of COVID-19 infection in male (72%) compared to females (28%). Age and history of previous comorbidities were nearly comparable between genders (P value 0.75 and 0.97, respectively), male-patients had higher incidence of sever-critical form of the disease (44.67%) compared to only 23.22% in female-patients (P < 0.001). A 26.39% and 1.79% of male and female patients needed Intensive-care-unit (ICU) admission(P < 0.001), respectively. Male-patients developed a significant higher rate of lung injury presented as bilateral airspace consolidation in the plain chest X-ray at admission (38.89%) compared to 23.21% in female patient (P = 0.036%). A significant impairment of the renal-function (P = 0.031) and liver-function tests with higher level of lactate-dehydrogenase (LDH) (P < 0.001), serum bilirubin (P < 0.001), alanine-transferase; ALT (P = 0.036), and aspartate-aminotransferase, AST (P = 0.022) in male patients compared to female patients. In conclusion, this is the first detailed analysis in the middle east that thoroughly investigate the role of gender in determining the clinical course and severity of COVID-19 infection. Males compared to their age matched females, with same prevalence of comorbidities were more vulnerable to the sever COVID-19 illness with higher probability for ICU admission.

Papillary carcinoma of thyroid and pregnancy

2013 ◽  
Vol 34 (3) ◽  
pp. 54-57
Author(s):  
S Rawal ◽  
G Gurung
Keyword(s):  
Caesarean Section ◽  
Total Thyroidectomy ◽  
Papillary Carcinoma ◽  
Multidisciplinary Approach ◽  
Good Health ◽  
The Other ◽  
Institute Of Medicine ◽  
Good Outcome ◽  
History Of ◽  
Uneventful Pregnancy

Two cases of Papillary carcinoma of thyroid and pregnancy were managed, one with the existing disease diagnosed during pregnancy and the other with a history of near total thyroidectomy. A multidisciplinary approach in the management of both the mothers lead to an uneventful pregnancy, caesarean section with good outcome and were discharged in good health. DOI: http://dx.doi.org/10.3126/joim.v34i3.8919   Journal of Institute of Medicine, December, 2012; 34:54-57

Electroencephalographic and perceptual asymmetry differences between responders and nonresponders to an SSRI antidepressant21Data from two treatment protocols were combined so as to yield sufficient samples of female and male fluoxetine responders and nonresponders. With the exception of the initial placebo period in one study, the treatment protocols were comparable in terms of both fluoxetine doses and the raters evaluating treatment response. Most importantly, the differences between fluoxetine responders and nonresponders reported for the total samples were also evident when only the data for the placebo-controlled protocol were analyzed; however, the larger total sample allowed us to also take patient gender into account.22The 18 healthy women were screened for psychopathology using a structured interview schedule and were excluded if they had a hearing loss, substance abuse, a history of head trauma, or other neurologic disorder. They did not differ significantly from the female patients in education (mean = 15.8, SD = 1.3) or handedness (LQ = 84.7, SD = 20.6), but they were somewhat younger than the female patients [mean age = 27.6, SD = 6.9;t(35) = 3.21,p = .001]. Age was not, however, related to perceptual asymmetry scores of either female patients (r = −.01, ns) or male patients (r = −.02, ns) on the fused words test. Nor was age significantly correlated with alpha asymmetry scores of female patients (r = −.09, ns) or male patients (r = .11, ns).

2001 ◽  
Vol 49 (5) ◽  
pp. 416-425 ◽  
Author(s):  
Gerard E Bruder ◽  
Jonathan W Stewart ◽  
Craig E Tenke ◽  
Patrick J McGrath ◽  
Paul Leite ◽  
...  
Keyword(s):  
Total Sample ◽  
Structured Interview ◽  
Treatment Protocols ◽  
Neurologic Disorder ◽  
Female Patients ◽  
Alpha Asymmetry ◽  
Perceptual Asymmetry ◽  
Patient Gender ◽  
History Of ◽  
Male Patients

Covid-19 infection in patients with a history of everolimus use.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e18744-e18744
Author(s):  
Metin Pehlivan ◽  
Adnan Aydiner
Keyword(s):  
Breast Cancer ◽  
Neuroendocrine Tumor ◽  
Mtor Inhibitor ◽  
Thymic Carcinoma ◽  
Additional Risk ◽  
Female Patients ◽  
The Past ◽  
The World ◽  
History Of ◽  
Male Patients

e18744 Background: The COVID-19 infection, declared as a pandemic by WHO in March 2020, continues its effects all over the world. Cancer patients also get COVID infection and in some patients this infection is mortal. In our study, we examined the course of COVID-19 infection in patients who actively or in the past used Everolimus. Methods: Patients who used everolimus actively or in the past were examined in our study. Patients who survive after the first cases seen in Turkey March 11, 2020 ; were evaluated in terms of whether they had COVID-19. Demographic characteristics and primary malignancies of the patients were examined. Patients who had COVID-19 infection and died were identified. Results: Our study consists of 50 patients in total. 14 (28%) of the patients were male and 36 (72%) were female. The average age of the patients is 56.72 (28-82), the average age of the male patients is 52.8 (28-80) and the average age of the female patients is 57.58 (36-82). 17 of the patients were treated for breast cancer, 11 for neuroendocrine tumor, 7 for tuberous sclerosis, 5 for renal cell carcinoma, 4 for thymic carcinoma, 2 for thymoma, 2 for ovarian ca, 2 for perivascular ecrine tumor. While it is the most common breast cancer in women (47.2% of female patients), neuroendocrine tumor is the most common in male patients (35.7% of male patients). While 13 patients were actively using everolimus (26%), 37 patients (74%) had discontinued everolimus treatment for 1 year or more.5 of our patients were diagnosed with COVID-19 infection (10% of all patients). 2 of these five patients are actively using everolimus. Of those diagnosed with COVID-19, 3 are women and 2 are men.The average age of the patients is 50.08 (43-66). While 3 patients had mild illness (60%), 2 patients (40%) died. One of the deceased patients is female and one is male. The female patient had a history of using everolimus for breast cancer, while the male patient died at the age of 52 while actively using everolimus for thymoma. Conclusions: Everolimus is a MTOR inhibitor used in many malignancy treatments. In our study, we found that 10% of our patients had COVID infection and 2 of our patients died due to COVID-19. In the group that discontinued everolimus treatment for a year or more, 1 patient died due to COVID-19, and 1 patient in the group still receiving everolimus treatment. Studies with larger patient populations are needed to determine whether everolimus carries an additional risk of COVID-19 infection.

History of pandemic H1N1-containing influenza vaccination and risk for spontaneous abortion and birth defects

Vaccine ◽  
2021 ◽  
Author(s):  
Celeste J. Romano ◽  
Clinton Hall ◽  
Zeina G. Khodr ◽  
Anna T. Bukowinski ◽  
Gia R. Gumbs ◽  
...  
Keyword(s):  
Influenza Vaccination ◽  
Spontaneous Abortion ◽  
Birth Defects ◽  
Pandemic H1n1 ◽  
History Of

Telomere shortening velocity of patients administered with hypnotics is accelerated in a gender-differential manner

2020 ◽  
pp. 1-6
Author(s):  
Toyoki Maeda ◽  
Takahiko Horiuchi ◽  
Naoki Makino
Keyword(s):  
Telomere Length ◽  
The Other ◽  
Biological Aging ◽  
Shortening Velocity ◽  
Telomere Shortening ◽  
Female Patients ◽  
Associated Diseases ◽  
Other Hand ◽  
Male Patients ◽  
Gender Differential

The telomere length and its distribution were compared between patients administered with and without hypnotics to see if regular administration of hypnotics is associated with their aging-related somatic telomere shortening. Male patients presented significant shortening of telomere length of circulating leukocytes in association with age (–41.9 bp/year, p = 0.045) in contrast with controls (–18.3 kb/year, p = 0.155). On the other hand, female patients presented no significant shortening of telomere length with aging (–16.4 bp/year, p = 0.372) in contrast with controls (–55.9 bp/year, p = 0.00005). These results suggested that regular administration of hypnotics is associated with aging progression in a gender-related manner. The administration of hypnotics could be an indicator as the somatic aging status and for the screening of background lifestyle-associated diseases promoting biological aging.

scholarly journals Study of Predisposing Factor, Clinical Profile, and Complications of Allergic Rhinitis

2016 ◽  
Vol 9 (2) ◽  
pp. 74-76 ◽  
Author(s):  
Vinish Kumar Agarwal ◽  
Mamta Goyal ◽  
Sampan S Bist
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Mucosa ◽  
Social Life ◽  
Work Productivity ◽  
Clinical Profile ◽  
Nasal Discharge ◽  
Predisposing Factor ◽  
Female Patients ◽  
History Of ◽  
Male Patients

ABSTRACT Introduction Allergic rhinitis (AR) is a global health problem that significantly alters patients’ social life and affects learning at school and work productivity. Materials and methods A total of 150 patients suggestive of a history of AR were included in this study. The patients underwent a thorough history, clinical examination, diagnostic nasal endoscopic evaluation, and radiological imaging. Results Out of 150 patients, 65% were male, whereas 35% were female ranging from age 14 to 70 years; 30% of both male and female were between 21 and 25 years; and 85% belonged to urban area, whereas 15% were rural inhabitants. The most significant complaints of patients were mainly paroxysmal sneezing, nasal obstruction, and watery nasal discharge. In the present study, 21% of patients had first-degree relatives with a complaint of AR; 72% of male patients and 75% of female patients had swollen turbinate; 59% of male patients and 62% of female patients had pale edematous nasal mucosa; 68% of male patients and 56% of female patients had granular pharyngitis; and 25% of male patients and 40% of female patients had complications of AR. Conclusion Allergic rhinitis is a disease of youth that affects mostly people in the age group of 21 to 25 years, and it is paroxysmal sneezing that concerns most of the patients and brings them to hospital. About 60% of the patients have a history of contact with the AR patients. Clinical significance Allergic rhinitis involves nearly 600 million people all over the world. Our study suggests three cardinal signs of AR, viz., swollen turbinate, pale and edematous nasal mucosa, and granular pharyngitis. This study also signifies female preponderance for complications of AR. How to cite this article Agarwal VK, Goyal M, Bist SS. Study of Predisposing Factor, Clinical Profile, and Complications of Allergic Rhinitis. Clin Rhinol An Int J 2016;9(2):74-76.

Pregnancy following Renal Transplantation

1979 ◽  
Vol 72 (11) ◽  
pp. 815-817 ◽  
Author(s):  
V Parsons ◽  
M Bewick ◽  
J Elias ◽  
S A Snowden ◽  
M J Weston ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Renal Transplant ◽  
Caesarean Section ◽  
Spontaneous Abortion ◽  
Rejection Episode ◽  
Elective Caesarean Section ◽  
The Other ◽  
Transplant Patients ◽  
The Mean ◽  
Renal Transplant Patients

A series of 7 renal transplant patients with 9 pregnancies is reported. A spontaneous abortion at 10 weeks was the only major problem. Of the other 8 pregnancies, 6 were delivered per vaginam and 2 by elective caesarean section, all after 34 weeks. The birthweights were slightly under the mean for the patients’ age but had been made up to normal by three months. Only one rejection episode occurred during pregnancy. Mild rejection episodes occurred in 4 patients within two months following delivery.

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