Electroencephalographic and perceptual asymmetry differences between responders and nonresponders to an SSRI antidepressant21Data from two treatment protocols were combined so as to yield sufficient samples of female and male fluoxetine responders and nonresponders. With the exception of the initial placebo period in one study, the treatment protocols were comparable in terms of both fluoxetine doses and the raters evaluating treatment response. Most importantly, the differences between fluoxetine responders and nonresponders reported for the total samples were also evident when only the data for the placebo-controlled protocol were analyzed; however, the larger total sample allowed us to also take patient gender into account.22The 18 healthy women were screened for psychopathology using a structured interview schedule and were excluded if they had a hearing loss, substance abuse, a history of head trauma, or other neurologic disorder. They did not differ significantly from the female patients in education (mean = 15.8, SD = 1.3) or handedness (LQ = 84.7, SD = 20.6), but they were somewhat younger than the female patients [mean age = 27.6, SD = 6.9;t(35) = 3.21,p = .001]. Age was not, however, related to perceptual asymmetry scores of either female patients (r = −.01, ns) or male patients (r = −.02, ns) on the fused words test. Nor was age significantly correlated with alpha asymmetry scores of female patients (r = −.09, ns) or male patients (r = .11, ns).

An audit of the treatment of patients (100 men and 90 women) presenting with a first episode of anogenital warts to the Genitourinary Medicine Department at Leeds General Infirmary was performed. Treatment of patients was monitored for a period of 6 months from the time of presentation. The management of patients with genital warts lacked a clearly defined strategy and treatment was unselective and poorly monitored. Excluding patients who defaulted, at follow-up 44 (44%) men and 36 (38%) women still had genital warts at 3 months. Of those patients clear of warts at 3 months, the mean time to remission for men and women was 7.1 and 8.3 weeks respectively. Podophyllin 25% in tincture of benzoin was by far the predominant therapeutic modality used. A total of 96 (96%) men and 76 (84%) women received treatment with podophyllin. Both male and female patients had a mean of 5 treatments with podophyllin 25% (range 1–19 and 1–12 respectively). Physical methods of treatment i.e. cryotherapy and electrocautery, were underutilized, both as primary therapies and when topical agents had failed. Patients saw an average of 3 (range 1–7) doctors over the course of their treatment. Patients with warts affecting 2 or more sites, male patients with anal/perianal warts, and female patients with cervical and vaginal warts had higher failure rates from treatment at 3 months. On the basis of these findings, specific treatment protocols for the management of anogenital warts have been devised.

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Abstract 439: Gender Bias in Prehospital Chest Pain Management: Do female Paramedics Under-treat patients With Chest Pain?

Hypertension ◽

10.1161/hyp.60.suppl_1.a439 ◽

2012 ◽

Vol 60 (suppl_1) ◽

Author(s):

Nabil El Sanadi ◽

Todd Leduc ◽

David Erdman ◽

Jason Mansour ◽

Gabriel Thornton

Keyword(s):

Chest Pain ◽

Pain Score ◽

Gender Bias ◽

Pain Tolerance ◽

Coronary Insufficiency ◽

Female Patients ◽

Patient Gender ◽

Score Difference ◽

Injury Patient ◽

Male Patients

Introduction: Patients with possible coronary insufficiency should undergo aggressive treatment to minimize the pain, since chest pain is a correlate of myocardial ischemia and injury. Patient gender should not affect the intensity of therapy. METHODS: A retrospective run-sheet review from a large prehospital system (684 paramedics E.M.S. approximately 17,000 runs/year) was done to determine the gender of the lead paramedic, the gender of the patient and the chest pain score difference pre-and post-treatment. Treatment included standard therapy of oxygen, nitroglycerin and morphine. A pain score of 0-10 was used. All runs with “chest pain” as the chief complaint were reviewed from 4/2007 to 7/2008. 225 cases were found. 2 sample poison test was used to analyze the data. Results: When female E.M.T.P’s treat female patients vs. Treating male patients, the pain score difference is 1.77 (p=0.010) When male E.M.T.P’s treat male patients vs. Female patients the pain score difference is 0.57 (p=0.063) Conclusions: Female FF/EMTP treat female patients more aggressively for chest pain than when they treat male patients. This may be due to gender bias and expectation of pain tolerance by male patients. Male FF/EMTP treats male and female patients with the same intensity.

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Frequency of HLA-DRB1 Gene Alleles in Patients With Multiple Sclerosis in a Lithuanian Population

Medicina ◽

10.3390/medicina48010002 ◽

2012 ◽

Vol 48 (1) ◽

pp. 2

Author(s):

Renata Balnytė ◽

Daiva Rastenytė ◽

Dalia Mickevičienė ◽

Antanas Vaitkus ◽

Erika Skrodenienė ◽

...

Keyword(s):

Multiple Sclerosis ◽

Case Control Study ◽

Case Control ◽

Chain Reaction ◽

Female Patients ◽

History Of ◽

Male Patients ◽

Polymerase Chain ◽

The Relationship ◽

Control Study

The aim of the present study was to investigate the influence of HLA-DRB1 alleles on the genetic susceptibility to multiple sclerosis in the Lithuanian population. Material and Methods. A total of 120 patients with multiple sclerosis and 120 unrelated healthy controls were enrolled in this case-control study. Allelic frequencies were compared between the groups. HLA-DRB1 alleles were genotyped using the polymerase chain reaction. Results. HLA-DRB1*15 was present in 55.8% of the patients with multiple sclerosis and 10.0% of the controls (OR, 5.58; 95% CI, 3.19–9.77; P<0.0001). The protective alleles that were found to be more prevalent among the controls compared with the patients with multiple sclerosis were HLADRB1* 01 (26.7% vs. 7.5%, P<0.0001), *03 (17.5% vs. 8.3%, P=0.034), and *16 (11.7% vs. 3.3%, P=0.014). HLA-DRB1*15 was more common among the female patients with multiple sclerosis than among the male patients (68.4% vs. 34.1%; OR, 4.18; 95%, CI 1.90–9.22; P=0.001). The heterozygous inheritance of HLA-DRB1*15 allele was more common in the patients with a history of maternal multiple sclerosis than in those with a history of paternal multiple sclerosis (29.4% vs. 9.8%; P=0.045). Conclusions. HLA-DRB1*15 was found to be associated with multiple sclerosis in the Lithuanian population. This allele was more prevalent among the female patients with multiple sclerosis. Maternal multiple sclerosis was more common than paternal multiple sclerosis, but the relationship with HLA-DRB1*15 allele was not established. HLA-DRB1*01, *03, and *16 appeared to be the protective alleles in this series.

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Male Gender is A Risk Factor For Sever Form of COVID-19 Illness and Worse Outcome in The Middle East

10.21203/rs.3.rs-35439/v1 ◽

2020 ◽

Author(s):

Ibrahim Y Hachim ◽

Mahmood Y Hachim ◽

Kashif Bin Naeem ◽

Haifa Hannawi ◽

Issa Al Salmi ◽

...

Keyword(s):

Middle East ◽

Liver Function Tests ◽

P Value ◽

Icu Admission ◽

Female Patients ◽

Wide Range ◽

Significant Impairment ◽

History Of ◽

Male Patients ◽

Novel Coronavirus

Abstract The identification of risk-factors, predicting the disease severity and outcome in novel coronavirus-disease-19 (COVID-19) patients, is essential to improve responsiveness to this pandemic. The association between gender and wide-range of clinical, pathological, and epidemiological factors was studied in 200-patients recruited during March-April 2020. A higher prevalence of COVID-19 infection in male (72%) compared to females (28%). Age and history of previous comorbidities were nearly comparable between genders (P value 0.75 and 0.97, respectively), male-patients had higher incidence of sever-critical form of the disease (44.67%) compared to only 23.22% in female-patients (P < 0.001). A 26.39% and 1.79% of male and female patients needed Intensive-care-unit (ICU) admission(P < 0.001), respectively. Male-patients developed a significant higher rate of lung injury presented as bilateral airspace consolidation in the plain chest X-ray at admission (38.89%) compared to 23.21% in female patient (P = 0.036%). A significant impairment of the renal-function (P = 0.031) and liver-function tests with higher level of lactate-dehydrogenase (LDH) (P < 0.001), serum bilirubin (P < 0.001), alanine-transferase; ALT (P = 0.036), and aspartate-aminotransferase, AST (P = 0.022) in male patients compared to female patients. In conclusion, this is the first detailed analysis in the middle east that thoroughly investigate the role of gender in determining the clinical course and severity of COVID-19 infection. Males compared to their age matched females, with same prevalence of comorbidities were more vulnerable to the sever COVID-19 illness with higher probability for ICU admission.

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Covid-19 infection in patients with a history of everolimus use.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.e18744 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. e18744-e18744

Author(s):

Metin Pehlivan ◽

Adnan Aydiner

Keyword(s):

Breast Cancer ◽

Neuroendocrine Tumor ◽

Mtor Inhibitor ◽

Thymic Carcinoma ◽

Additional Risk ◽

Female Patients ◽

The Past ◽

The World ◽

History Of ◽

Male Patients

e18744 Background: The COVID-19 infection, declared as a pandemic by WHO in March 2020, continues its effects all over the world. Cancer patients also get COVID infection and in some patients this infection is mortal. In our study, we examined the course of COVID-19 infection in patients who actively or in the past used Everolimus. Methods: Patients who used everolimus actively or in the past were examined in our study. Patients who survive after the first cases seen in Turkey March 11, 2020 ; were evaluated in terms of whether they had COVID-19. Demographic characteristics and primary malignancies of the patients were examined. Patients who had COVID-19 infection and died were identified. Results: Our study consists of 50 patients in total. 14 (28%) of the patients were male and 36 (72%) were female. The average age of the patients is 56.72 (28-82), the average age of the male patients is 52.8 (28-80) and the average age of the female patients is 57.58 (36-82). 17 of the patients were treated for breast cancer, 11 for neuroendocrine tumor, 7 for tuberous sclerosis, 5 for renal cell carcinoma, 4 for thymic carcinoma, 2 for thymoma, 2 for ovarian ca, 2 for perivascular ecrine tumor. While it is the most common breast cancer in women (47.2% of female patients), neuroendocrine tumor is the most common in male patients (35.7% of male patients). While 13 patients were actively using everolimus (26%), 37 patients (74%) had discontinued everolimus treatment for 1 year or more.5 of our patients were diagnosed with COVID-19 infection (10% of all patients). 2 of these five patients are actively using everolimus. Of those diagnosed with COVID-19, 3 are women and 2 are men.The average age of the patients is 50.08 (43-66). While 3 patients had mild illness (60%), 2 patients (40%) died. One of the deceased patients is female and one is male. The female patient had a history of using everolimus for breast cancer, while the male patient died at the age of 52 while actively using everolimus for thymoma. Conclusions: Everolimus is a MTOR inhibitor used in many malignancy treatments. In our study, we found that 10% of our patients had COVID infection and 2 of our patients died due to COVID-19. In the group that discontinued everolimus treatment for a year or more, 1 patient died due to COVID-19, and 1 patient in the group still receiving everolimus treatment. Studies with larger patient populations are needed to determine whether everolimus carries an additional risk of COVID-19 infection.

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Patient–physician gender concordance and increased mortality among female heart attack patients

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1800097115 ◽

2018 ◽

Vol 115 (34) ◽

pp. 8569-8574 ◽

Cited By ~ 85

Author(s):

Brad N. Greenwood ◽

Seth Carnahan ◽

Laura Huang

Keyword(s):

Heart Attack ◽

Survival Rates ◽

Myocardial Infarctions ◽

Female Physicians ◽

Heart Attacks ◽

Female Patients ◽

Patient Gender ◽

Gender Concordance ◽

Male Patients ◽

Patients Experience

We examine patient gender disparities in survival rates following acute myocardial infarctions (i.e., heart attacks) based on the gender of the treating physician. Using a census of heart attack patients admitted to Florida hospitals between 1991 and 2010, we find higher mortality among female patients who are treated by male physicians. Male patients and female patients experience similar outcomes when treated by female physicians, suggesting that unique challenges arise when male physicians treat female patients. We further find that male physicians with more exposure to female patients and female physicians have more success treating female patients.

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Abstract 13412: Gender Based Differences in Duration of Cardiopulmonary Resuscitation in the Inpatient Setting

Circulation ◽

10.1161/circ.144.suppl_2.13412 ◽

2021 ◽

Vol 144 (Suppl_2) ◽

Author(s):

Anna Baillie ◽

Rebecca Sell ◽

Victoria Speck ◽

Gabriel Wardi

Keyword(s):

Cardiac Arrest ◽

Cardiopulmonary Resuscitation ◽

Retrospective Chart Review ◽

Spontaneous Circulation ◽

Inpatient Setting ◽

Female Patients ◽

Shockable Rhythm ◽

Patient Gender ◽

Significant Difference ◽

Male Patients

Introduction: The decision to terminate cardiopulmonary resuscitation (CPR) prior to return of spontaneous circulation (ROSC) may be impacted by resuscitation parameters or by patient demographics. Studies show that longer resuscitation efforts have a higher likelihood of ROSC and survival to discharge. It is unclear if gender of the code leader and the patient may be associated with duration of unsuccessful CPR attempt. Methods: Retrospective chart review of inpatient CA that occurred at the UC San Diego Health System between 2011-2019. All adult inpatients with an index cardiac arrest who expired within three days of admission were included. Exclusion criteria included patients who achieved ROSC, CA that occurred outside of the wards or ICU, those with active pre-arrest DNR status, and patients with CA > 3 days after admission (done to minimize provider bias based on prior knowledge of the patient). Data were identified from an internal cardiac arrest quality improvement database. Patient gender was self-reported and code leader gender was identified. Primary outcome was duration of resuscitation efforts. To determine differences in duration of CPR between code leader and patient gender a one-sided ANOVA test was used. A p value < 0.05 was considered statistically significant. Results: We identified 91 patients between 2011 and 2019 that met inclusion criteria. Thirty-eight patients (41.8%) identified as female, fifty-three identified as male (58.2%), the average age was 62.7 years old, and seventeen (18.7%) had initial shockable rhythm. Thirty (33%) of the code leaders identified as female and sixty-one (67%) identified as male. Average duration of CPR was 31.6 minutes (2 - 135 minutes) for male patients with male code leader, 32.2 minutes (9 - 71 minutes) for male patients with female code leader, 27.0 minutes (7 - 60 minutes) for female patients with female code leader, and 33.7 minutes (10 - 73 minutes) for female patients with male code leader. No significant difference in duration of unsuccessful CPR attempt associated with gender of code leader and gender of patient in ANOVA analysis was found (p = 0.512). Conclusions: We did not identify a significant association between code leader and patient gender on duration of CPR in the inpatient setting.

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Study of Predisposing Factor, Clinical Profile, and Complications of Allergic Rhinitis

Clinical Rhinology An International Journal ◽

10.5005/jp-journals-10013-1272 ◽

2016 ◽

Vol 9 (2) ◽

pp. 74-76 ◽

Cited By ~ 1

Author(s):

Vinish Kumar Agarwal ◽

Mamta Goyal ◽

Sampan S Bist

Keyword(s):

Allergic Rhinitis ◽

Nasal Mucosa ◽

Social Life ◽

Work Productivity ◽

Clinical Profile ◽

Nasal Discharge ◽

Predisposing Factor ◽

Female Patients ◽

History Of ◽

Male Patients

ABSTRACT Introduction Allergic rhinitis (AR) is a global health problem that significantly alters patients’ social life and affects learning at school and work productivity. Materials and methods A total of 150 patients suggestive of a history of AR were included in this study. The patients underwent a thorough history, clinical examination, diagnostic nasal endoscopic evaluation, and radiological imaging. Results Out of 150 patients, 65% were male, whereas 35% were female ranging from age 14 to 70 years; 30% of both male and female were between 21 and 25 years; and 85% belonged to urban area, whereas 15% were rural inhabitants. The most significant complaints of patients were mainly paroxysmal sneezing, nasal obstruction, and watery nasal discharge. In the present study, 21% of patients had first-degree relatives with a complaint of AR; 72% of male patients and 75% of female patients had swollen turbinate; 59% of male patients and 62% of female patients had pale edematous nasal mucosa; 68% of male patients and 56% of female patients had granular pharyngitis; and 25% of male patients and 40% of female patients had complications of AR. Conclusion Allergic rhinitis is a disease of youth that affects mostly people in the age group of 21 to 25 years, and it is paroxysmal sneezing that concerns most of the patients and brings them to hospital. About 60% of the patients have a history of contact with the AR patients. Clinical significance Allergic rhinitis involves nearly 600 million people all over the world. Our study suggests three cardinal signs of AR, viz., swollen turbinate, pale and edematous nasal mucosa, and granular pharyngitis. This study also signifies female preponderance for complications of AR. How to cite this article Agarwal VK, Goyal M, Bist SS. Study of Predisposing Factor, Clinical Profile, and Complications of Allergic Rhinitis. Clin Rhinol An Int J 2016;9(2):74-76.

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Pregnancy Outcomes among Patients with Chronic Myeloid Leukemia Treated with Dasatinib

Blood ◽

10.1182/blood.v112.11.3230.3230 ◽

2008 ◽

Vol 112 (11) ◽

pp. 3230-3230 ◽

Cited By ~ 21

Author(s):

Jorge Cortes ◽

Susan O’Brien ◽

Patricia Ault ◽

Gautam Borthakur ◽

Elias Jabbour ◽

...

Keyword(s):

Adverse Reaction ◽

Caesarean Section ◽

Spontaneous Abortion ◽

Birth Defects ◽

Healthy Infant ◽

The Other ◽

Female Patients ◽

Healthy Newborn ◽

History Of ◽

Male Patients

Abstract Dasatinib has been shown in non-clinical studies to cause fetal toxicities in animals, but the effect of exposure during conception and pregnancy in humans is not known. Despite the requirement for contraception while on therapy with dasatinib, occasional pregnancies have been reported. The current study and post-marketing data report the outcomes of pregnancies occurring among 16 patients (8 females and 8 males) who received dasatinib therapy. Among the 8 female patients found to be pregnant while on dasatinib therapy, induced abortion was reported in 3 cases: 2 due to patient decision and 1 for unknown reasons. Two cases of spontaneous abortion were reported. The first was at 8 weeks gestation in a 38-year-old patient (G1P1) with a history of tobacco use. Birth defects of the fetus were not reported; though it is unknown if an autopsy was performed. The other spontaneous abortion was reported at 9 weeks gestation in a 33-year-old patient (G3P3) taking dasatinib for over 2 years. The medical history of this patient includes tobacco and alcohol use. Of the 3 deliveries, one patient had a normal healthy infant. The second patient (age: 29 years, G2P2) delivered a healthy infant by Caesarean section at 7 months gestation (reason for Caesarean section unknown). This patient received dasatinib 140mg/day for approximately 4 months, but was ‘lost to follow up’ for 2 months and study drug compliance was unknown. Upon her return, the patient had a positive pregnancy test with an estimated gestation of 4 weeks. The infant was reported as ‘small for date’ but without obvious birth defects. Apgar scores were also unknown for this infant. In the final case, a patient on dasatinib 100mg/day for approximately 5 months was identified as pregnant (G0P0) at 21 weeks of gestation. The estimated delivery date has not yet occurred at the time of writing, but the pregnancy course has been normal. Among 8 male patients treated with dasatinib with partners becoming pregnant while on treatment, normal newborns were reported for 7 cases, with the outcome of the other case unknown. All male patients remained on treatment during and after the pregnancies. In 1 case, the mother experienced pre-eclampsia but delivered a healthy newborn at 37 weeks, without birth defects or neonatal complications. In summary, although the limited data reported in this study did not show evidence that dasatinib treatment has a negative impact on pregnancy (for the mother or fetus), patients receiving dasatinib should be advised to practice adequate contraception. Table 1. Outcome of Female Patients Electing to C regnancy Duration of Fetal Exposure to Dasatinib Fetal Outcome Maternal Outcome Dasatinib Dose* Duration of Dasatinib Therapy * at time of onset Pt D 5 weeks 8wk spontaneous abortion no adverse reaction reported 180 mg/day approximately 9.5 months Pt E 9 weeks 9wk spontaneous abortion no adverse reaction reported 100 mg BID 30 months Pt F 7 weeks normal healthy no adverse reaction reported 140 mg/day approximately 15 months Pt G unknown “small for date” – healthy newborn C-section at 7 months 140mg/day approximately 4 months Pt H 21 days to be determined 100mg/day 5 months

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HUBUNGAN TUNGAU DEBU RUMAH, PAPARAN ASAP ROKOK DAN RIWAYAT PENYAKIT KELUARGA TERHADAP KEJADIAN ASMA BRONKIAL PADA ANAK USIA 5 – 10 TAHUN DI WILAYAH KERJA PUSKESMAS LEMPAKE KOTA SAMARINDA TAHUN 2016

KESMAS UWIGAMA: Jurnal Kesehatan Masyarakat ◽

10.24903/kujkm.v3i1.327 ◽

2018 ◽

Vol 3 (1) ◽

pp. 1

Author(s):

Sri Evi New Yearsi Pangadongan ◽

Agustina Rahyu ◽

Selvy Pasulu

Keyword(s):

Cigarette Smoke ◽

Bronchial Asthma ◽

Sampling Technique ◽

Total Sample ◽

Control Group ◽

Case Group ◽

Chi Square ◽

History Of ◽

Weather Changes ◽

And Gender

Bronchial Asthma generally starts from childhood which is condition where respiration channel experiences constriction because of hyperactivity with some specific stimulation which cause inflammation. Some risk factors are smoking exposure of cigarette smoke, weather changes, mite on house dirt, pet and history of family sickness. The purpose of this research is to know Relation of mite on house dirt, exposure of cigarette smoke and history of family sickness with bronchial asthma incident to child 5 – 10 years old on working area of Puskesmas Lempake Samarinda City in 2016. Method which used was analytic survey with Case Control approaching. The total sample was 36 children which consisted of 18 case group and 18 control group with matching by using age and gender which submitted with Purposive Sampling technique. Data Analysis used Chi Square with wrong degree α = 0,005. The result showed that there was relation of mite of house dirt (p = 0,006), history of family sickness (p = 0,001) and no relation with exposure of cigarette smoke (p = 0,370) with bronchial asthma incident to child 5 – 10 years old on working area of Puskesmas Lempake Samarinda City in 2016.

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