scholarly journals Registry of Monoclonal Gammopathies (RMG) in the Czech Republic

Blood ◽  
2015 ◽  
Vol 126 (23) ◽  
pp. 4514-4514 ◽  
Author(s):  
Jakub Radocha ◽  
Ludek Pour ◽  
Ivan Spicka ◽  
Vlastimil Scudla ◽  
Evzen Gregora ◽  
...  
Keyword(s):  
Czech Republic ◽  
Registry Data ◽  
Quality Data ◽  
Current Status ◽  
Al Amyloidosis ◽  
Low Grade ◽  
Ministry Of Education ◽  
The Czech Republic ◽  
Monoclonal Gammopathies

Abstract Introduction: Collection of valid data in patients with hematologic malignancies remains a challenge. Especially low grade malignancies require long term follow-up and valid high quality data. The RMG registry was established in 2007 and has become one of the flagship projects of the Czech Myeloma group. To date, four parts of the registry are active - module for multiple myeloma (MM), monoclonal gammopathies of undetermined significance (MGUS), AL amyloidosis (ALA) and Waldeströms macroglobulinemia. The later two has been started in 2014. Aim: To analyze current status of the registry in terms of amount of contained data. Methods: All patients must sign a written consent before entering their data into the registry. Data concerning diagnosis, demography, treatment and survival are regularly collected and updated into the registry via online system at https://trials.cba.muni.cz/trialdb2/interface_forms/login_rmg.asp. The data from MGUS patients are retrospective and prospective, data from MM patients are only prospective (since 2007). Registry is regularly monitored and data are validated by an external monitor. Results: There are 22 participating centers as of July 2015 (18 from the Czech Republic and 4 from Slovakia). Data from 4549 patients with MM, 2168 with MGUS, 121 patients with WM and 22 with ALA have been collected. Together 6860 patients have been included in the registry as of July 2015. Median follow-up of MGUS patients is 4 years (0-35 years) and median follow-up for MM patients is 2 years (0-32 years). The huge amount of data allowed publication of treatment results of MM patients treated with bortezomid and thalidomide in the Czech Republic and regular analysis of patients treated with lenalidomide. Novel prognostic models for MGUS progression and asymptomatic myeloma have been created based on registry data (manuscripts submitted). Conclusion: The RMG is one of the largest registries in Europe. Its biggest advantage is collection of validated updated data which can be used to create rapid analyses in order to react to changing myeloma field. It helps us to create new guidelines and serves as a potent research tool. It can be also used to negotiate reimbursement with healthcare insurance companies and government regulatory authorities for novel drugs implementation into treatment standards. Supported by The Ministry of Education, Youth and Sports (Specific university research of the Faculty of Medicine, University of Ostrava) project no. SGS01/LF/2014-2015, by the Moravian-Silesian Region - grant no. MSK 02692/2014/RRC, by the Institutional Development Plan of University of Ostrava in 2015, financial resources are allocated by The Ministry of Education, Youth and Sports. Supported by grant NT14575. Disclosures Hajek: Amgen: Honoraria; Celgene: Consultancy; Janssen: Consultancy.

scholarly journals Measuring costs of noise pollution generated by freight transport: Case of the Slovak and Czech Republic

2021 ◽  
pp. 1-18
Author(s):  
Břetislav Andrlík
Keyword(s):  
Czech Republic ◽  
Slovak Republic ◽  
Noise Pollution ◽  
Freight Transport ◽  
Current Status ◽  
Negative Externality ◽  
Actual Measurement ◽  
The Czech Republic ◽  
Marginal Costs ◽  
Negative Impacts

The paper focuses on measuring and quantification of the negative externality of noise pollution generated by freight transport in the Slovak Republic and the Czech Republic. The paper describes negative impacts and significance of noise externalities, whereas it is established that noise causes psychological and physiological harm to affected persons. A separate part of the paper is dedicated to the current status of the European legislation dealing with the issues of the negative externality of noise pollution, in particular Directive 2002/49/EC of the European Parliament and of the Council and Communication COM(2008) 435. The actual measurement of the total, average and marginal costs of noise pollution is implemented in line with the defined methodology and using expert studies defined in the paper. The measurement results show that the costs of the negative externality of noise pollution are high in both countries. According to authors’ calculations, the total costs of the negative externality of noise pollution amount to EUR 100.8 mil in the Czech Republic and EUR 16.9 mil in the Slovak Republic. The paper contains a proposal of internalisation of these costs in the form of performance charges applied to operation of heavy goods vehicles.

scholarly journals Evaluation of the Current Approach to Education of Security Issues at Selected Universities Preparing Future Pedagogues

2021 ◽  
Vol 13 (19) ◽  
pp. 10684
Author(s):  
Stepan Kavan
Keyword(s):  
Czech Republic ◽  
Swot Analysis ◽  
Current Approach ◽  
Ministry Of Education ◽  
Primary Method ◽  
The Czech Republic ◽  
Security Issues ◽  
Minimum Standards ◽  
Current State ◽  
New Knowledge

This paper deals with education in security issues. The aim of this work is to examine and evaluate the current approach to education of future educators in the field of security issues at selected universities in the Czech Republic. The primary method of research was a survey through questionnaires, where information was collected at selected universities. The evaluation is performed using SWOT analysis. The fragmentation and inconsistency of the approach of individual universities is evident from the results of the survey. New knowledge, which is based on the research, is the identification of the current state of training of future teachers in the field of security. The result of the survey is used by an expert group of the Ministry of the Interior and the Ministry of Education, Youth and Sports of the Czech Republic as input information for the development of minimum standards for pedagogical universities.

scholarly journals Presence of Arcobacter species in pet cats and dogs in the Czech Republic

2017 ◽  
Vol 61 (No. 8) ◽  
pp. 449-455
Author(s):  
M. Pejchalova ◽  
S. Zabcikova ◽  
L. Silhova ◽  
D. Silha ◽  
I. Brozkova ◽  
...  
Keyword(s):  
Czech Republic ◽  
Gel Electrophoresis ◽  
Dna Isolation ◽  
Human Infection ◽  
Chain Reaction ◽  
The Czech Republic ◽  
Two Samples ◽  
Arcobacter Butzleri ◽  
Polymerase Chain

This study was conducted to evaluate the occurrence of the genus Arcobacter in cats and dogs in the Czech Republic. These animals may be carriers of the bacteria and potential sources of human infection. Oral smears were collected from animals using smear swabs and brushes. Based on previous studies, commercially available DNA kits were used for DNA isolation. Samples were analysed using polymerase chain reaction (PCR) and evaluated using gel electrophoresis. Overall, 178 oral smears were tested, of which 108 were from dogs and 70 were from cats. Out of all smears, five were positive, of which four samples were from dogs and one from a cat. In all five positive cases, PCR confirmed the presence of Arcobacter butzleri. In follow-up sampling, the presence of Arcobacter butzleri was demonstrated in two samples from a dog.

scholarly journals Study of legislative and administrative obstacles to SMEs business in the Czech Republic and Slovakia

2020 ◽  
Vol 11 (4) ◽  
pp. 689-719
Author(s):  
Beata Gavurova ◽  
Jaroslav Belas ◽  
Yuriy Bilan ◽  
Jakub Horak
Keyword(s):  
Czech Republic ◽  
Value Added ◽  
Business Environment ◽  
The Czech Republic ◽  
Advanced Economies ◽  
Stable Conditions ◽  
The Eu ◽  
Administrative Obstacles

Research background: SMEs represent an integral part of the economy environment in a majority of the countries all over the world. They signify the most efficient, progressive, and important part of the advanced economies. The long-term effort of the EU countries, as well as other advanced economies is to create quality and stable conditions for their development in order to be able to respond to all the possible changes in the business environment that is being changed to more and more comprehensive in the recent time. Purpose of the article: The objective of the contribution is to examine administrative and legislative obstacles to SMEs business in the Czech Republic and Slovakia and the quantification of the differences in perceiving legislative and administrative obstacles to business by entrepreneurs in both countries. Methods: A questionnaire survey was conducted within SMEs in the Czech Republic and Slovakia in 2019. The research sample included 641 SMEs, 312 from the Czech Republic and 329 from Slovakia. We focused on 5 dimensions related to legislative and administrative obstacles to SMEs business within which selected statements were examined. Contingency tables were used to analyze the ratios of the examined variables. Findings & Value added: The differences detected in both countries in the respondents´ perception and assessment are evidence of the changes in the business environment of both countries, giving rise to the questions about the extent to which the legislative and administrative obstacles, as well as the obstacles related to law enforcement and bureaucracy are acceptable and by which groups of entrepreneurs. The results of the research provide valuable findings for the creators of regional and national policies, and represent a valuable basis for the creation of the concepts focused on the SMEs´ development in both countries.  The results of the study also support the implementation of follow-up research in this area that will reveal other determinants affecting the development of SMEs. They also create a valuable platform for the construction of national and international benchmarking indicators in this area and the implementation of comparative analyses. This will also support the methodological area necessary for a creation of high-quality concepts and strategies.

scholarly journals Zpráva o výsledcích Světové konference ke vzdělání pro udržitelný rozvoj uzavírající Dekádu UNESCO pro vzdělávání pro UR

Envigogika ◽  
2014 ◽  
Vol 9 (2) ◽  
Author(s):  
Jana Dlouhá
Keyword(s):  
Sustainable Development ◽  
Czech Republic ◽  
Education For Sustainable Development ◽  
Final Report ◽  
World Conference ◽  
The Czech Republic ◽  
Global Action ◽  
Action Programme

The article presents the results of the UNESCO World Conference on Education for Sustainable Development held in Nagoya, Japan, on 10-12 November 2014. The aim of the Conference was primarily to review the results of the Decade – the final report of the Decade, Shaping the Future We Want, was introduced in which the role of education as a tool for the overall transition towards sustainability was stressed. The Global Action Programme as a follow-up to the Decade was also introduced; commitment to implement it was accepted in the Aichi-Nagoya Declaration. The options for the Czech Republic to become involved in these international activities are briefly reviewed.

Decommissioning of Obsolete Nuclear Facilities in the Nuclear Research Institute Rez

2011 ◽  
Author(s):  
Josef Podlaha ◽  
Karel Svoboda ◽  
Eduard Hansli´k
Keyword(s):  
Czech Republic ◽  
Nuclear Power ◽  
Power Plants ◽  
Nuclear Research ◽  
Current Status ◽  
Joint Stock Company ◽  
Nuclear Facilities ◽  
Nuclear Research Institute ◽  
The Czech Republic ◽  
Research Institute

After more than 55 years of activities of the Nuclear Research Institute Rez (NRI) in the nuclear field, there are some obsolete nuclear facilities that shall be decommissioned. NRI is a leading institution in all areas of nuclear R&D in the Czech Republic. NRI has had a dominant position in the nuclear programme since it was established in 1955 as a state-owned research organization and it has developed to its current status. In December 1992, NRI has been transformed into a joint-stock company. The Institute’s activity encompasses nuclear physics, chemistry, nuclear power, experiments at the research reactor and many other topics. Main issues addressed in NRI in the past decades were concentrated on research, development and services provided to the nuclear power plants operating VVER reactors, development of chemical technologies for fuel cycle and irradiation services to research and development in the industrial sector, agriculture, food processing and medicine. The NRI operates two research nuclear reactors, many facilities as a hot cell facility, research laboratories, technology for radioactive waste (RAW) management, radionuclide irradiators, an electron accelerator, etc. The obsolete facilities to be decommissioned comprise various research facilities and facilities for RAW management. Decommissioning of nuclear facilities NRI is the only ongoing decommissioning project in the Czech Republic. Decommissioning started in 2003 and will be finished in 2014. Some facilities have already been successfully decommissioned.

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