Synergistic effect of nitrilotriacetate on iron mobilization by desferrioxamine in vivo
Removal of iron from biologically important ligands by desferrioxamine (DF), in vitro, is exceedingly slow because of a kinetic barrier. This kinetic barrier can be overcome by a variety of a small molecular weight anions, of which nitrilotriacetate (NTA) is a prototype. We explored the effect of NTA on DF iron mobilization in vivo. Iron mobilization was increased and the effect was synergistic.
1981 ◽
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1997 ◽
Vol 20
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2016 ◽
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2005 ◽
Vol 289
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pp. E366-E372
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pp. 942-946
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